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54-96-6,MFCD00006401
Catalog No.:AA003ICP

54-96-6 | 3,4-Diaminopyridine

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100mg
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$6.00   $4.00
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1g
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5g
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003ICP
Chemical Name:
3,4-Diaminopyridine
CAS Number:
54-96-6
Molecular Formula:
C5H7N3
Molecular Weight:
109.1292
MDL Number:
MFCD00006401
SMILES:
Nc1cnccc1N
NSC Number:
521760
Properties
Properties
 
BP:
369.3°C at 760 mmHg  
Form:
Solid  
MP:
215 - 216 °C  
Refractive Index:
1.5340 (estimate)  
Solubility:
30g/l  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
74.1  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
8  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
XLogP3:
-0.5  

Literature

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Title: Ectopic uterine tissue as a chronic pain generator.

Journal: Neuroscience 20121206

Title: Reversal of BoNT/A-mediated inhibition of muscle paralysis by 3,4-diaminopyridine and roscovitine in mouse phrenic nerve-hemidiaphragm preparations.

Journal: Neurochemistry international 20121101

Title: Mutations in DPAGT1 cause a limb-girdle congenital myasthenic syndrome with tubular aggregates.

Journal: American journal of human genetics 20120713

Title: The safety profile of dalfampridine extended release in multiple sclerosis clinical trials.

Journal: Clinical therapeutics 20120501

Title: 3,4-Diaminopyridine improves neuromuscular transmission in a MuSK antibody-induced mouse model of myasthenia gravis.

Journal: Journal of neuroimmunology 20120401

Title: Recurrent COLQ mutation in congenital myasthenic syndrome.

Journal: Pediatric neurology 20120401

Title: The dynamic relationships between the three events that release individual Na⁺ ions from the Na⁺/K⁺-ATPase.

Journal: Nature communications 20120214

Title: Content variability of active drug substance in compounded oral 3,4-diaminopyridine products.

Journal: Journal of clinical pharmacy and therapeutics 20120201

Title: Clinical features in a series of fast channel congenital myasthenia syndrome.

Journal: Neuromuscular disorders : NMD 20120201

Title: Long-term disease history, clinical symptoms, health status, and healthcare utilization in patients suffering from Lambert Eaton myasthenic syndrome: Results of a patient interview survey in Germany.

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Title: Hypotension due to Chemotherapy in a Patient with Small Cell Lung Cancer and Lambert-Eaton Myasthenic Syndrome Undergoing Hemodialysis: A First Case Report.

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Title: The use of aminopyridines in neurological disorders.

Journal: Clinical neuropharmacology 20120101

Title: The Effects of K(+) Channel Blockade on Eccentric and Isotonic Twitch and Fatiguing Contractions in situ.

Journal: Frontiers in physiology 20120101

Title: [Aminopyridines for symptomatic treatment of multiple sclerosis].

Journal: Ugeskrift for laeger 20111212

Title: Comparison of 10-mg doses of 4-aminopyridine and 3,4-diaminopyridine for the treatment of downbeat nystagmus.

Journal: Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 20111201

Title: John Newsom-Davis: clinician-scientist and so much more.

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Title: Evidence-based guideline update: treatment of essential tremor: report of the Quality Standards subcommittee of the American Academy of Neurology.

Journal: Neurology 20111108

Title: Formulating a new basis for the treatment against botulinum neurotoxin intoxication: 3,4-Diaminopyridine prodrug design and characterization.

Journal: Bioorganic & medicinal chemistry 20111101

Title: One collective case of type A foodborne botulism in Corsica.

Journal: Clinical toxicology (Philadelphia, Pa.) 20111001

Title: Role of calcium-activated potassium channels in the genesis of 3,4-diaminopyridine-induced periodic contractions in isolated canine coronary artery smooth muscles.

Journal: The Journal of pharmacology and experimental therapeutics 20110901

Title: Autoimmune neuromuscular disorders.

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Title: Autoimmune channelopathies of the nervous system.

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Title: Aminopyridines correct early dysfunction and delay neurodegeneration in a mouse model of spinocerebellar ataxia type 1.

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Title: Single-pixel optical fluctuation analysis of calcium channel function in active zones of motor nerve terminals.

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Title: Effects of 3-4 diaminopyridine (DAP) in motor neuron diseases.

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Title: Treatment for Lambert-Eaton myasthenic syndrome.

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Title: 3,4-Diaminopyridinium 2-carboxy-4,6-dinitrophenolate.

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Title: State of the art in hereditary muscle channelopathies.

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Title: Anharmonic vibrational analysis of 3,4-diaminopyridine and 3-aminopyridine by density functional theory calculations.

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Title: Mutations in MUSK causing congenital myasthenic syndrome impair MuSK-Dok-7 interaction.

Journal: Human molecular genetics 20100615

Title: 3,4-diaminopyridine safety in clinical practice: an observational, retrospective cohort study.

Journal: Journal of neurology 20100601

Title: Effects of hydroxamate metalloendoprotease inhibitors on botulinum neurotoxin A poisoned mouse neuromuscular junctions.

Journal: Neuropharmacology 20100601

Title: Current therapy for Lambert-Eaton myasthenic syndrome: development of 3,4-diaminopyridine phosphate salt as first-line symptomatic treatment.

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Title: 3,4-Diaminopyridine is more effective than placebo in a randomized, double-blind, cross-over drug study in LEMS.

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Title: {2,2'-[Pyridine-3,4-diylbis(nitrilo-methyl-idyne)]diphenolato}zinc(II).

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Title: 3,4-Diamino-pyridinium 4-nitro-benzoate-4-nitro-benzoic acid (1/1).

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Title: Novel truncating RAPSN mutations causing congenital myasthenic syndrome responsive to 3,4-diaminopyridine.

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Title: Lambert-Eaton myasthenic syndrome.

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Title: Wheel-running exercise alters rat diaphragm action potentials and their regulation by K+ channels.

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Title: Potassium channels, the cerebellum, and treatment for downbeat nystagmus.

Journal: Neurology 20030722

Title: Treatment of downbeat nystagmus with 3,4-diaminopyridine: a placebo-controlled study.

Journal: Neurology 20030722

Title: Rational modelling of the voltage-dependent K+ channel inactivation by aminopyridines.

Journal: Biophysical chemistry 20030601

Title: Therapy in myasthenia gravis and Lambert-Eaton myasthenic syndrome.

Journal: Seminars in neurology 20030601

Title: The vascular response to the K+ channel inhibitor 4-aminopyridine in hypertensive rats.

Journal: European journal of pharmacology 20030418

Title: Streptozotocin-diabetes alters action potentials in rat diaphragm.

Journal: Respiratory physiology & neurobiology 20030415

Title: Quantitative estimate of mitochondrial [Ca2+] in stimulated motor nerve terminals.

Journal: Cell calcium 20030301

Title: Membrane properties related to the firing behavior of zebrafish motoneurons.

Journal: Journal of neurophysiology 20030201

Title: Exacerbation of Lambert-Eaton myasthenic syndrome caused by an L-type Ca2+ channel antagonist.

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Title: Effect of thymol on kinetic properties of Ca and K currents in rat skeletal muscle.

Journal: BMC pharmacology 20030101

Title: Raphé grafts and 3,4-diaminopyridine-evoked overflow of serotonin in the rat hippocampus after 5,7-dihydroxytryptamine lesions: evidence for 5-HT1A autoreceptors.

Journal: Neuroreport 20021028

Title: Analysis of the pressor response to the K+ channel inhibitor 4-aminopyridine.

Journal: European journal of pharmacology 20021011

Title: Preparation of 3,4-diaminopyridine microparticles by solvent-evaporation methods.

Journal: International journal of pharmaceutics 20020821

Title: Improvement of dy/dy dystrophic diaphragm by 3,4-diaminopyridine.

Journal: Muscle & nerve 20020701

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Title: Potassium channel KV alpha1 subunit expression and function in human detrusor muscle.

Journal: The Journal of urology 20020401

Title: Action of Micrurus dumerilii carinicauda coral snake venom on the mammalian neuromuscular junction.

Journal: Toxicon : official journal of the International Society on Toxinology 20020201

Title: Activation thresholds of K(V), BK andCl(Ca) channels in smooth muscle cells in pial precapillary arterioles.

Journal: Journal of vascular research 20020101

Title: Role of K+ channels in L-6 myoblast migration.

Journal: Journal of muscle research and cell motility 20020101

Title: Aminopyridines for symptomatic treatment in multiple sclerosis.

Journal: The Cochrane database of systematic reviews 20020101

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Journal: Clinical calcium 20011101

Title: Expression and function of native potassium channel [K(V)alpha1] subunits in terminal arterioles of rabbit.

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Journal: Rinsho shinkeigaku = Clinical neurology 20010801

Title: Theoretical analysis of the molecular determinants responsible for the K(+) channel blocking by aminopyridines.

Journal: Biophysical chemistry 20010615

Title: Neuromuscular monitoring in myasthenic syndrome.

Journal: Anaesthesia 20010601

Title: Electrophysiological analysis of the neurotoxic action of a funnel-web spider toxin, delta-atracotoxin-HV1a, on insect voltage-gated Na+ channels.

Journal: The Journal of experimental biology 20010201

Title: Modulation of diaphragm action potentials by K(+) channel blockers.

Journal: Respiration physiology 20010201

Title: Validation of a CE assay for the analysis of isomeric aminopyridines and diaminopyridines.

Journal: Journal of pharmaceutical and biomedical analysis 20010201

Title: Neurogenic bladder in Lambert-Eaton myasthenic syndrome and its response to 3,4-diaminopyridine.

Journal: Journal of the neurological sciences 20010115

Title: [Proximal muscle weakness, depressed tendon reflexes and autonomic dysfunction: the Lambert-Eaton myasthenic syndrome].

Journal: Nederlands tijdschrift voor geneeskunde 20010113

Title: Development and validation of a capillary electrophoresis assay for the determination of 3,4-diaminopyridine and 4-aminopyridine including related substances.

Journal: Journal of chromatography. A 20010112

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Title: Antagonism of botulinum toxin A-mediated muscle paralysis by 3, 4-diaminopyridine delivered via osmotic minipumps.

Journal: Toxicon : official journal of the International Society on Toxinology 20001001

Title: Antagonism of botulinum toxin-induced muscle weakness by 3,4-diaminopyridine in rat phrenic nerve-hemidiaphragm preparations.

Journal: Toxicon : official journal of the International Society on Toxinology 19950401

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Title: T L Harris, et al. Lycopodium clavatum exine microcapsules enable safe oral delivery of 3,4-diaminopyridine for treatment of botulinum neurotoxin A intoxication. Chem Commun (Camb). 2016 Mar 18;52(22):4187-90.

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Tags:54-96-6 Molecular Formula|54-96-6 MDL|54-96-6 SMILES|54-96-6 3,4-Diaminopyridine |Heterocyclic_Building_Blocks