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2747-05-9,MFCD00006865
Catalog No.:AA003N9Q

2747-05-9 | 7-Acetoxy-4-methylcoumarin

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1g
98%
in stock  
$29.00   $20.00
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5g
98%
in stock  
$38.00   $27.00
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25g
98%
in stock  
$145.00   $102.00
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100g
98%
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$494.00   $346.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003N9Q
Chemical Name:
7-Acetoxy-4-methylcoumarin
CAS Number:
2747-05-9
Molecular Formula:
C12H10O4
Molecular Weight:
218.2054
MDL Number:
MFCD00006865
SMILES:
CC(=O)Oc1ccc2c(c1)oc(=O)cc2C
Properties
Properties
 
BP:
363.3°C at 760 mmHg  
Form:
Solid  
MP:
149-150 °C  
Refractive Index:
1.4270 (estimate)  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
345  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
2  
XLogP3:
2  

Literature

Title: Calreticulin transacetylase mediated upregulation of thioredoxin by 7,8-diacetoxy-4-methylcoumarin enhances the antioxidant potential and the expression of vascular endothelial growth factor in peripheral blood mononuclear cells.

Journal: Chemico-biological interactions 20131125

Title: Identification of the first known inhibitors of O-acetylpeptidoglycan esterase: a potential new antibacterial target.

Journal: Chembiochem : a European journal of chemical biology 20120319

Title: A new family of carbohydrate esterases is represented by a GDSL hydrolase/acetylxylan esterase from Geobacillus stearothermophilus.

Journal: The Journal of biological chemistry 20111209

Title: Nerve agent hydrolysis activity designed into a human drug metabolism enzyme.

Journal: PloS one 20110101

Title: Calreticulin transacetylase catalyzed modification of the TNF-alpha mediated pathway in the human peripheral blood mononuclear cells by polyphenolic acetates.

Journal: Chemico-biological interactions 20100514

Title: Specificities of calreticulin transacetylase to acetoxy derivatives of 3-alkyl-4-methylcoumarins: effect on the activation of nitric oxide synthase.

Journal: Bioorganic & medicinal chemistry 20090215

Title: Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis.

Journal: Bioorganic & medicinal chemistry 20090101

Title: Specificity of procaine and ester hydrolysis by human, minipig, and rat skin and liver.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20071101

Title: Expression and characterization of a human carboxylesterase 2 splice variant.

Journal: The Journal of pharmacology and experimental therapeutics 20071001

Title: Molecular cloning, and characterization of a modular acetyl xylan esterase from the edible straw mushroom Volvariella volvacea.

Journal: FEMS microbiology letters 20070901

Title: Specificities of acetoxy derivatives of coumarins, biscoumarins, chromones, flavones, isoflavones and xanthones for acetoxy drug: protein transacetylase.

Journal: European journal of medicinal chemistry 20070401

Title: Unique regulation of the active site of the serine esterase S-formylglutathione hydrolase.

Journal: Journal of molecular biology 20060602

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Functional characterization of three naturally occurring single nucleotide polymorphisms in the CES2 gene encoding carboxylesterase 2 (HCE-2).

Journal: Drug metabolism and disposition: the biological fate of chemicals 20051001

Title: Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.

Journal: Journal of medicinal chemistry 20050421

Title: Novel thiocoumarins as inhibitors of TNF-alpha induced ICAM-1 expression on human umbilical vein endothelial cells (HUVECs) and microsomal lipid peroxidation.

Journal: Bioorganic & medicinal chemistry 20050301

Title: Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20031015

Title: Evaluation of alpha-cyanoesters as fluorescent substrates for examining interindividual variation in general and pyrethroid-selective esterases in human liver microsomes.

Journal: Analytical biochemistry 20030415

Title: Cloning and characterization of an S-formylglutathione hydrolase from Arabidopsis thaliana.

Journal: Archives of biochemistry and biophysics 20020315

Title: Mechanism of biochemical action of substituted benzopyran-2-ones. Part 8: Acetoxycoumarin: protein transacetylase specificity for aromatic nuclear acetoxy groups in proximity to the oxygen heteroatom.

Journal: Bioorganic & medicinal chemistry 20010501

Title: Chemoprevention of benzene-induced bone marrow and pulmonary genotoxicity.

Journal: Teratogenesis, carcinogenesis, and mutagenesis 20010101

Title: Human liver carboxylesterase hCE-1: binding specificity for cocaine, heroin, and their metabolites and analogs.

Journal: Drug metabolism and disposition: the biological fate of chemicals 19970901

Title: Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin.

Journal: The Journal of biological chemistry 19970606

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