Catalog No.:AA003NCE

78287-27-1 | (19S)-10,19-diethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione

Name: Name:(19S)-10,19-diethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
Brand: AABLOCKS
SKU: AA003NCE
Availability: InStock
Rating: 90 (10 reviews)

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25mg

>98%(HPLC)

in stock

$32.00 $23.00

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100mg

>96.0%(HPLC)

in stock

$40.00 $28.00

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99%

in stock

$71.00 $50.00

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99%

in stock

$350.00 $245.00

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25g

98%

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$1,407.00 $985.00

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Technical Information
Properties
Upstream Synthesis Route
Downstream Synthesis Route
Literature
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Technical Information
Properties
Upstream Synthesis Route
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA003NCE

Chemical Name:

(19S)-10,19-diethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione

CAS Number:

78287-27-1

Molecular Formula:

C22H20N2O4

Molecular Weight:

376.4052

MDL Number:

MFCD06657922

SMILES:

CC[C@@]1(O)C(=O)OCc2c1cc1c3nc4ccccc4c(c3Cn1c2=O)CC

Properties

BP:

752.867 °C at 760 mmHg

Form:

Solid

MP:

236-241°C

Storage:

Keep in dry area;2-8℃;

Computed Properties

Complexity:

787

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

1.8

Upstream Synthesis Route

123-38-6

7689-03-4

78287-27-1

[1]Patent:CN108484624,2018,A,.Locationinpatent:Paragraph0031;0039;0043;0044

[2]ChemicalandPharmaceuticalBulletin,1991,vol.39,#6,p.1446-1454

[3]ChemicalandPharmaceuticalBulletin,1991,vol.39,#10,p.2574-2580

[4]Patent:WO2006/16203,2006,A1,.Locationinpatent:Page/Pagecolumn9-10

[5]EuropeanJournalofPharmaceuticalSciences,2018,vol.123,p.546-559

955939-02-3

78287-27-1

[1]Patent:EP2011797,2009,A1,.Locationinpatent:Page/Pagecolumn10-11

7689-03-4

78287-27-1

[1]Patent:US4399282,1983,A,

3425-61-4

7689-03-4

78287-27-1

[1]SyntheticCommunications,2007,vol.37,#3,p.519-523

123-38-6

7689-03-4

78287-27-1

[1]Patent:US4399282,1983,A,

Downstream Synthesis Route

78287-27-1

86639-51-2

[1]ChemicalandPharmaceuticalBulletin,1991,vol.39,p.1446-1454

[2]ChemicalandPharmaceuticalBulletin,1991,vol.39,p.3183-3188

[3]Patent:CN109796462,2019,A.Locationinpatent:Paragraph0027;0029;0034;0036;0041;0043

78287-27-1

152266-83-6

[1]ChemicalandPharmaceuticalBulletin,1993,vol.41,p.971-974

78287-27-1

2-Amino-4,11-diethyl-2H,12H-2,6,12a-triaza-dibenzob,hfluorene-3,13-dione

[1]ChemicalandPharmaceuticalBulletin,1993,vol.41,p.971-974

78287-27-1

1026285-00-6

[1]ChemicalandPharmaceuticalBulletin,1993,vol.41,p.971-974

123-38-6

7689-03-4

78287-27-1

[1]Patent:CN108484624,2018,A.Locationinpatent:Paragraph0031;0039;0043;0044

[2]ChemicalandPharmaceuticalBulletin,1991,vol.39,p.1446-1454

[3]ChemicalandPharmaceuticalBulletin,1991,vol.39,p.2574-2580

[4]Patent:CN109796462,2019,A.Locationinpatent:Paragraph0027-0028;0034-0035;0041-0042

[5]Patent:WO2006/16203,2006,A1.Locationinpatent:Page/Pagecolumn9-10

[6]EuropeanJournalofPharmaceuticalSciences,2018,vol.123,p.546-559

Literature

Title: 14-Aminocamptothecins: their synthesis, preclinical activity, and potential use for cancer treatment.

Journal: Journal of medicinal chemistry 20110324

Title: The thermodynamic dissociation constants of the anticancer drugs camptothecine, 7-ethyl-10-hydroxycamptothecine, 10-hydroxycamptothecine and 7-ethylcamptothecine by the least-squares nonlinear regression of multiwavelength spectrophotometric pH-titration data.

Journal: Analytica chimica acta 20070219

Title: Wang, X.,et al. New Route for Conversion of Camptothecin to 7-Ethylcamptothecin and 7-Propylcamptothecin. Synthetic Communications, 2007,37(3), 519–523.

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SDS