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841-77-0,MFCD00038379
Catalog No.:AA003NYL

841-77-0 | 1-Benzhydrylpiperazine

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5g
98%(GC)
in stock  
$26.00   $18.00
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25g
98%(GC)
in stock  
$50.00   $35.00
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100g
≥ 98% (HPLC)
in stock  
$105.00   $74.00
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250g
≥ 98% (HPLC)
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$185.00   $129.00
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  • Technical Information
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA003NYL
Chemical Name:
1-Benzhydrylpiperazine
CAS Number:
841-77-0
Molecular Formula:
C17H20N2
Molecular Weight:
252.3541
MDL Number:
MFCD00038379
SMILES:
N1CCN(CC1)C(c1ccccc1)c1ccccc1
NSC Number:
35536
Properties
Properties
 
BP:
365.1 °C at 760 mmHg  
Form:
Solid  
MP:
90-93 °C  
Refractive Index:
1.5794 (estimate)  
Stability:
Air Sensitive  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
230  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
2.8  

Literature

Title: The pharmacokinetics and pharmacogenetics of the antiemetic cyclizine in palliative care patients.

Journal: Journal of pain and symptom management 20120301

Title: (E)-1-(4-Benzhydrylpiperazin-1-yl)-3-(2-eth-oxy-phen-yl)prop-2-en-1-one.

Journal: Acta crystallographica. Section E, Structure reports online 20111201

Title: Asymmetric synthesis and biological evaluation of N-cyclohexyl-4-[1-(2,4-dichlorophenyl)-1-(p-tolyl)methyl]piperazine-1-carboxamide as hCB1 receptor antagonists.

Journal: European journal of medicinal chemistry 20111101

Title: (E)-1-(4-Benzhydrylpiperazin-1-yl)-3-(3,4-dieth-oxy-phen-yl)prop-2-en-1-one ethanol monosolvate.

Journal: Acta crystallographica. Section E, Structure reports online 20111101

Title: Quantification of cyclizine and norcyclizine in human plasma by liquid chromatography-tandem mass spectrometry (LC-MS/MS).

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110315

Title: Structure-activity relationships of new N-acylanthranilic acid derivatives as plasminogen activator inhibitor-1 inhibitors.

Journal: Chemical & pharmaceutical bulletin 20110101

Title: Alleviation of brain hypoperfusion after preventative treatment with lomerizine in an elderly migraineur with aura.

Journal: International journal of molecular imaging 20110101

Title: Nonpeptidic delta (delta) opioid agonists and antagonists of the diarylmethylpiperazine class: what have we learned?

Journal: Topics in current chemistry 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Discovery of benzhydrylpiperazine derivatives as CB1 receptor inverse agonists via privileged structure-based approach.

Journal: European journal of medicinal chemistry 20100301

Title: Apoptosis of human Burkitt's lymphoma cells induced by 2-N,N-diethylaminocarbonyloxymethyl-1-diphenylmethyl-4-(3,4,5-trimethoxybenzoyl) piperazine hydrochloride (PMS-1077).

Journal: Archives of pharmacal research 20091201

Title: Synthesis and in vitro antiproliferative activity of novel 1-benzhydrylpiperazine derivatives against human cancer cell lines.

Journal: European journal of medicinal chemistry 20090301

Title: Synthesis and evaluation of 1-benzhydryl-sulfonyl-piperazine derivatives as inhibitors of tumor growth and tumor angiogenesis of mouse ehrlich ascites tumor in vivo.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20080901

Title: Copper(I) cyanide networks: synthesis, structure, and luminescence behavior. Part 2. Piperazine ligands and hexamethylenetetramine.

Journal: Inorganic chemistry 20080804

Title: Design, synthesis and biological evaluation of piperazine analogues as CB1 cannabinoid receptor ligands.

Journal: Bioorganic & medicinal chemistry 20080401

Title: 1-Benzhydryl-4-(4-chloro-phenyl-sulfonyl)piperazine.

Journal: Acta crystallographica. Section E, Structure reports online 20080201

Title: [Piperazines as model substrate for oxidations].

Journal: Die Pharmazie 20061001

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: A new calcium channel antagonist, lomerizine, alleviates secondary retinal ganglion cell death after optic nerve injury in the rat.

Journal: Current eye research 20060301

Title: DPI-221 [4-((alpha-s)-alpha-((2s,5r)-2,5-dimethyl-4-(3-fluorobenzyl)-1-piperazinyl)benzyl)-N,N-diethylbenzamide]: a novel nonpeptide delta receptor agonist producing increased micturition interval in normal rats.

Journal: The Journal of pharmacology and experimental therapeutics 20051101

Title: Hydroxyzine and metabolites as a source of interference in carbamazepine particle-enhanced turbidimetric inhibition immunoassay (PETINIA).

Journal: Therapeutic drug monitoring 20050801

Title: [Preparation and physico-chemical properties of alkyl esters of 2-, 3-, 4-(2-hydroxy-3-[4-diphenylmethyl) piperazine-1-yl] propoxy) phenylcarbamide].

Journal: Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20021101

Title: Non-peptide opioid receptor ligands - recent advances. Part I - agonists.

Journal: Current medicinal chemistry 20020901

Title: Biotransformation of cyclizine in greyhounds. 1: Identification and analysis of cyclizine and some basic metabolites in canine urine by gas chromatography-mass spectrometry.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20020901

Title: Biotransformation of cyclizine in greyhounds. 2: N(1)-dealkylation and identification of some neutral and phenolic metabolites in canine urine by gas chromatography-mass spectrometry.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20020901

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