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303-25-3,MFCD00023293
Catalog No.:AA002ZH8

303-25-3 | Piperazine, 1-(diphenylmethyl)-4-methyl-, hydrochloride (1:1)

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250mg
≥98%
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$103.00   $72.00
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500mg
≥98%
in stock  
$173.00   $121.00
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1g
≥98%
in stock  
$326.00   $228.00
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5g
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$1,006.00   $704.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002ZH8
Chemical Name:
Piperazine, 1-(diphenylmethyl)-4-methyl-, hydrochloride (1:1)
CAS Number:
303-25-3
Molecular Formula:
C18H23ClN2
Molecular Weight:
302.8416
MDL Number:
MFCD00023293
SMILES:
CN1CCN(CC1)C(c1ccccc1)c1ccccc1.Cl
NSC Number:
169102
Properties
Computed Properties
 
Complexity:
253  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  

Literature

Title: The pharmacokinetics and pharmacogenetics of the antiemetic cyclizine in palliative care patients.

Journal: Journal of pain and symptom management 20120301

Title: A new cyclizidine analog-JBIR-102-from Saccharopolyspora sp. RL78 isolated from mangrove soil.

Journal: The Journal of antibiotics 20120101

Title: Inhibitory effect of homochlorcyclizine on melanogenesis in α-melanocyte stimulating hormone-stimulated mouse B16 melanoma cells.

Journal: Archives of pharmacal research 20120101

Title: Quantification of cyclizine and norcyclizine in human plasma by liquid chromatography-tandem mass spectrometry (LC-MS/MS).

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110315

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Boosting blood flow: intravenous cyclizine in microsurgery.

Journal: Plastic and reconstructive surgery 20100901

Title: The cautious use of cyclizine in a patient with myasthenia gravis.

Journal: Journal of palliative medicine 20091001

Title: Application of adsorptive voltammetry for the detection of sub-nano molar cyclizine in biological fluids and tablets using fast Fourier transform continuous cyclic voltammetry in a flowing system.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20090401

Title: Synthesis and in vitro antiproliferative activity of novel 1-benzhydrylpiperazine derivatives against human cancer cell lines.

Journal: European journal of medicinal chemistry 20090301

Title: The misuse/abuse of antihistamine antiemetic medication (cyclizine) by cancer patients.

Journal: Palliative medicine 20081001

Title: Mechanistic investigation of N,N-diethyl-4-(phenyl-piperidin-4-ylidenemethyl)-benzamide-induced insulin depletion in the rat and RINm5F cells.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20080901

Title: Management of Ménière's disease in general practice: adherence to the UK National Health Service 'Prodigy' guidelines.

Journal: The Journal of laryngology and otology 20080801

Title: Akathisia and an unusual symptomatic treatment: a case report.

Journal: Palliative medicine 20071201

Title: Transient paralysis after administration of cyclizine.

Journal: Anaesthesia 20061201

Title: A preliminary ecotoxicity study of pharmaceuticals in the marine environment.

Journal: Journal of toxicology and environmental health. Part A 20061101

Title: A comparison of cyclizine and granisetron alone and in combination for the prevention of postoperative nausea and vomiting.

Journal: Anaesthesia 20061101

Title: Use of intravenous cyclizine in cardiac chest pain.

Journal: Emergency medicine journal : EMJ 20060701

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Best evidence topic report. Use of intravenous cyclizine in cardiac chest pain.

Journal: Emergency medicine journal : EMJ 20060101

Title: Acute eosinophilic pneumonia caused by calcium stearate, an additive agent for an oral antihistaminic medication.

Journal: Internal medicine (Tokyo, Japan) 20060101

Title: Transient paralysis after administration of a single dose of cyclizine.

Journal: Anaesthesia 20051201

Title: An LC-MS-MS method for the determination of cyclizine in human serum.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050925

Title: Effect of (+) or (-) camphorsulfonic acid additives to the mobile phase on enantioseparations of some basic drugs on a Chiralcel OD column.

Journal: Journal of chromatography. A 20050812

Title: Percutaneous absorption of cyclizine and its alkyl analogues.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050201

Title: Improving the acceptability of the atrial defibrillator for the treatment of persistent atrial fibrillation: the atrial defibrillator sedation assessment study (ADSAS).

Journal: International journal of cardiology 20040801

Title: The Cyclimorph cough.

Journal: Anaesthesia 20040601

Title: Chlorpheniramine maleate as an alternative to antiemetic cyclizine.

Journal: Journal of pain and symptom management 20040501

Title: Dystonic reaction to cyclizine.

Journal: Anaesthesia 20040401

Title: A capillary zone electrophoresis (CZE) method for the determination of cyclizine hydrochloride in tablets and suppositories.

Journal: Journal of pharmaceutical and biomedical analysis 20040401

Title: A response to 'A comparison of cyclizine, ondansetron and placebo as prophylaxis against postoperative nausea and vomiting in children' O'Brien CM, Titley G, Whitehurst P, Anaesthesia 2003; 58: 707-11.

Journal: Anaesthesia 20031101

Title: Dystonic reaction to cyclizine.

Journal: Anaesthesia 20030901

Title: Dystonic reactions to cyclizine.

Journal: Anaesthesia 20030701

Title: A comparison of cyclizine, ondansetron and placebo as prophylaxis against postoperative nausea and vomiting in children.

Journal: Anaesthesia 20030701

Title: Prevention of postoperative nausea and vomiting after spinal morphine for Caesarean section: comparison of cyclizine, dexamethasone and placebo.

Journal: British journal of anaesthesia 20030501

Title: Cyclizine.

Journal: Emergency medicine journal : EMJ 20030501

Title: Histamine H1-receptor antagonists, promethazine and homochlorcyclizine, increase the steady-state plasma concentrations of haloperidol and reduced haloperidol.

Journal: Therapeutic drug monitoring 20030401

Title: Probable dystonic reaction after a single dose of cyclizine in a patient with a history of encephalitis.

Journal: Anaesthesia 20030301

Title: Biotransformation of cyclizine in greyhounds. 1: Identification and analysis of cyclizine and some basic metabolites in canine urine by gas chromatography-mass spectrometry.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20020901

Title: Biotransformation of cyclizine in greyhounds. 2: N(1)-dealkylation and identification of some neutral and phenolic metabolites in canine urine by gas chromatography-mass spectrometry.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20020901

Title: Comparison of cyclizine and ondansetron for the prevention of postoperative nausea and vomiting in laparoscopic day-case gynaecological surgery.

Journal: Anaesthesia 20020101

Title: Cyclizine and droperidol have comparable efficacy and side effects during patient-controlled analgesia.

Journal: Irish journal of medical science 20020101

Title: Standard treatment: the role of antihistamines.

Journal: The journal of investigative dermatology. Symposium proceedings 20011101

Title: Subcutaneous cyclizine.

Journal: Anaesthesia 20010901

Title: Patterns of ergotamine and sumatriptan use in the Netherlands from 1991 to 1997.

Journal: Cephalalgia : an international journal of headache 20010601

Title: Postoperative nausea management and patient-controlled analgesia.

Journal: British journal of nursing (Mark Allen Publishing) 20010601

Title: Precipitation in Manchester: ketorolac/cyclizine.

Journal: Anaesthesia 20010501

Title: Drugs and syringe drivers: a survey of adult specialist palliative care practice in the United Kingdom and Eire.

Journal: Palliative medicine 20010301

Title: Impact of an antiemetic protocol on postoperative nausea and vomiting in children.

Journal: Paediatric anaesthesia 20010101

Title: Silicone breast implants and drug-induced arthralgia.

Journal: Plastic and reconstructive surgery 19970401

Title: The haemodynamic effects of morphine.

Journal: Archives of emergency medicine 19880601

Title: [Diazepam in the treatment of children with drug induced extrapyramidal symptoms].

Journal: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 19790519

Title: Cyclizine-induced chorea. Observations on the influence of cyclizine on dopamine-related movement disorders.

Journal: Journal of the neurological sciences 19770301

Title: Cyclizine anaphylaxis, when administered with propanidid.

Journal: Anaesthesia 19690101

Title: Studies of drugs given before anaesthesia. X. Two non-phenothiazine anti-emetics--cyclizine and trimethobenzamide.

Journal: British journal of anaesthesia 19660101

Title: PHYSIOLOGICAL DISTRIBUTION AND METABOLIC INACTIVATION OF CHLORCYCLIZINE AND CYCLIZINE.

Journal: The Journal of pharmacology and experimental therapeutics 19650701

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Tags:303-25-3 Molecular Formula|303-25-3 MDL|303-25-3 SMILES|303-25-3 Piperazine, 1-(diphenylmethyl)-4-methyl-, hydrochloride (1:1)