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5273-86-9,MFCD00009281
Catalog No.:AA003OV5

5273-86-9 | Beta-asarone

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5mg
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$46.00   $32.00
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10mg
≥98%
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$82.00   $57.00
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50mg
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100mg
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003OV5
Chemical Name:
Beta-asarone
CAS Number:
5273-86-9
Molecular Formula:
C12H16O3
Molecular Weight:
208.2536
MDL Number:
MFCD00009281
SMILES:
C/C=C\c1cc(OC)c(cc1OC)OC
Properties
Properties
 
BP:
296°C at 760 mmHg  
Refractive Index:
n20/D 1.558(lit.)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
203  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
4  
XLogP3:
3  

Literature

Title: β-Asarone (cis-2,4,5-trimethoxy-1-allyl phenyl), attenuates pro-inflammatory mediators by inhibiting NF-κB signaling and the JNK pathway in LPS activated BV-2 microglia cells.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20141001

Title: Cerebrovascular protection of β-asarone in Alzheimer's disease rats: a behavioral, cerebral blood flow, biochemical and genic study.

Journal: Journal of ethnopharmacology 20121121

Title: Anxiolytic-like effect of α-asarone in mice.

Journal: Phytotherapy research : PTR 20121001

Title: β-Asarone protects PC12 cells against OGD/R-induced injury via attenuating Beclin-1-dependent autophagy.

Journal: Acta pharmacologica Sinica 20120601

Title: Beta-asarone attenuates ischemia-reperfusion-induced autophagy in rat brains via modulating JNK, p-JNK, Bcl-2 and Beclin 1.

Journal: European journal of pharmacology 20120405

Title: Pharmacokinetics of beta-asarone in rabbit blood, hippocampus, cortex, brain stem, thalamus and cerebellum.

Journal: Die Pharmazie 20120201

Title: Chemical composition of the essential oil of aerial parts of Haussknechtia elymaitica Boiss. from Iran: a good natural source for trans-asaron.

Journal: Natural product research 20120101

Title: Cognitive enhancing effects of alpha asarone in amnesic mice by influencing cholinergic and antioxidant defense mechanisms.

Journal: Bioscience, biotechnology, and biochemistry 20120101

Title: Terpenoid composition and antifungal activity of three commercially important essential oils against Aspergillus flavus and Aspergillus niger.

Journal: Natural product research 20111201

Title: An efficient combination of supercritical fluid extraction and high-speed counter-current chromatography to extract and purify (E)- and (Z)-diastereomers of α-asarone and β-asarone from Acorus tatarinowii Schott.

Journal: Journal of separation science 20111201

Title: Alpha-Asarone incorporated in mixed micelles suitable for intravenous administration: formulation, in-vivo distribution and anaphylaxis study.

Journal: Die Pharmazie 20111101

Title: [Study on relationship of properties and drug release rate of hot melt pressure sensitive adhesive].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111101

Title: Beta-asarone inhibits synaptic inputs to airway preganglionic parasympathetic motoneurons.

Journal: Respiratory physiology & neurobiology 20110815

Title: Phenolic constituents of Acorus gramineus.

Journal: Archives of pharmacal research 20110801

Title: Radioprotection by α-asarone: prevention of genotoxicity and hematopoietic injury in mammalian organism.

Journal: Mutation research 20110518

Title: Metabolism mediated interaction of α-asarone and Acorus calamus with CYP3A4 and CYP2D6.

Journal: Fitoterapia 20110401

Title: Development of drug-in-adhesive transdermal patch for α-asarone and in vivo pharmacokinetics and efficacy evaluation.

Journal: Drug delivery 20110101

Title: Beta-asarone attenuates beta-amyloid-induced apoptosis through the inhibition of the activation of apoptosis signal-regulating kinase 1 in SH-SY5Y cells.

Journal: Die Pharmazie 20110101

Title: Activities of α-asarone in various animal seizure models and in biochemical assays might be essentially accounted for by antioxidant properties.

Journal: Neuroscience research 20101201

Title: Reinvestigation of structure-activity relationship of methoxylated chalcones as antimalarials: synthesis and evaluation of 2,4,5-trimethoxy substituted patterns as lead candidates derived from abundantly available natural β-asarone.

Journal: European journal of medicinal chemistry 20101101

Title: Design, synthesis, and docking of highly hypolipidemic agents: Schizosaccharomyces pombe as a new model for evaluating alpha-asarone-based HMG-CoA reductase inhibitors.

Journal: Bioorganic & medicinal chemistry 20100615

Title: Beta-asarone protection against beta-amyloid-induced neurotoxicity in PC12 cells via JNK signaling and modulation of Bcl-2 family proteins.

Journal: European journal of pharmacology 20100610

Title: Beta-asarone attenuates neuronal apoptosis induced by Beta amyloid in rat hippocampus.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20100501

Title: Effects of alpha-asarone on the glutamate transporter EAAC1 in Xenopus oocytes.

Journal: Planta medica 20100401

Title: Standardization and in vivo antioxidant activity of ethanol extracts of fruit and leaf of Piper sarmentosum.

Journal: Planta medica 20100301

Title: Asarone inhibits adipogenesis and stimulates lipolysis in 3T3-L1 adipocytes.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20100124

Title: [Research on liposoluble ingredients of Quchiling].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100101

Title: Beta-asarone improves cognitive function by suppressing neuronal apoptosis in the beta-amyloid hippocampus injection rats.

Journal: Biological & pharmaceutical bulletin 20100101

Title: Supplemental ultraviolet-B induced changes in essential oil composition and total phenolics of Acorus calamus L. (sweet flag).

Journal: Ecotoxicology and environmental safety 20091001

Title: Reduction of beta-asarone in acori rhizoma by decoction.

Journal: Planta medica 20091001

Title: Inhibitors of HMG-CoA Reductase: Current and Future Prospects.

Journal: Mini reviews in medicinal chemistry 20091001

Title: 2,4,5-trimethoxycinnamic acid: the major metabolite of alpha-asarone, retains most of the pharmacological properties of alpha-asarone.

Journal: Journal of enzyme inhibition and medicinal chemistry 20090601

Title: Neuroprotective effect of alpha-asarone on spatial memory and nitric oxide levels in rats injected with amyloid-beta((25-35)).

Journal: Neuroscience letters 20090403

Title: Compositional variations and anthelmentic activity of essential oils from rhizomes of different wild populations of Acorus calamus L. and its major component, beta-Asarone.

Journal: Natural product communications 20090201

Title: Bioanalytical investigation of asarone in connection with Acorus calamus oil intoxications.

Journal: Journal of analytical toxicology 20090101

Title: Nematicidal activity of plant essential oils and components from coriander (Coriandrum sativum), Oriental sweetgum (Liquidambar orientalis), and valerian (Valeriana wallichii) essential oils against pine wood nematode (Bursaphelenchus xylophilus).

Journal: Journal of agricultural and food chemistry 20080827

Title: Genotoxicity of alpha-asarone analogues.

Journal: Bioorganic & medicinal chemistry 20080601

Title: Systematic study of beta-asarone-rich volatile oil from Acori graminei rhizoma by off-line supercritical CO2 extraction-gas chromatography-mass spectrometry.

Journal: Journal of separation science 20080301

Title: [Effects of beta-asarone on expression of c-fos in kindling epilepsy rat brain].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080301

Title: [Comparison of kinetic behavior in both plasma and tissue after intravenous administration of alpha-asarone in lipid emulsion and aqueous solution in rats and mice].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080101

Title: Preparation and characterization of solid lipid nanoparticles loaded with alpha-Asarone.

Journal: PDA journal of pharmaceutical science and technology 20080101

Title: [Effects of beta-asarone on expression of FOS and GAD65 in cortex of epileptic rat induced by penicillin].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080101

Title: [Studies on chemical constituents of green algae Ulva pertusa].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070801

Title: [GC-MS analysis of essential oil from nutmeg processed by different traditional methods].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070801

Title: A fraction of Acorus calamus L. extract devoid of beta-asarone enhances adipocyte differentiation in 3T3-L1 cells.

Journal: Phytotherapy research : PTR 20070601

Title: [A review of recent ten-year study on alpha-asarone].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070401

Title: [Protective effects of beta-asarone on cultured rat cortical neurons damage induced by glutamate].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070401

Title: In vitro acetylcholinesterase inhibitory activity of the essential oil from Acorus calamus and its main constituents.

Journal: Planta medica 20070301

Title: [Study on alpha-asarone reservoir-type patch].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070301

Title: Effect of alpha-asarone and a derivative on lipids, bile flow and Na+/K+-ATPase in ethinyl estradiol-induced cholestasis in the rat.

Journal: Fundamental & clinical pharmacology 20070201

Title: Hypolipidaemic and antiplatelet activity of phenoxyacetic acid derivatives related to alpha-asarone.

Journal: The Journal of pharmacy and pharmacology 20061001

Title: [Effects of annao tablet on S100B and NPY of cortex in chronic epilepsy rats].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061001

Title: Suppression of MeIQ-induced SOS response by allylbenzenes from Asiasarum heterotropoides in the Salmonella typhimurium OY1001/1A2 umu test.

Journal: Natural product research 20060601

Title: 3D QSAR study of hypolipidemic asarones by comparative molecular surface analysis.

Journal: Bioorganic & medicinal chemistry 20060301

Title: Development of gas chromatography/mass spectrometry following headspace solid-phase microextraction for fast determination of asarones in plasma.

Journal: Rapid communications in mass spectrometry : RCM 20060101

Title: Development of self-microemulsifying drug delivery systems for oral bioavailability enhancement of alpha-Asarone in beagle dogs.

Journal: PDA journal of pharmaceutical science and technology 20060101

Title: Antioxidant property of alpha-asarone against noise-stress-induced changes in different regions of rat brain.

Journal: Pharmacological research 20051201

Title: In vitro genotoxic evaluation of three alpha-asarone analogues.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20050601

Title: Identification of an EcoRI restriction site for a rapid and precise determination of beta-asarone-free Acorus calamus cytotypes.

Journal: Phytochemistry 20050301

Title: Molecular docking of the highly hypolipidemic agent alpha-asarone with the catalytic portion of HMG-CoA reductase.

Journal: Bioorganic & medicinal chemistry letters 20050215

Title: Rapid assessment of beta-asarone content of Acorus calamus by micellar electrokinetic capillary chromatography.

Journal: Electrophoresis 20050201

Title: Quantitative determination of beta-asarone in calamus by high-performance thin-layer chromatography.

Journal: Journal of AOAC International 20050101

Title: [Pharmacokinetics of beta-asarone in rats].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20041001

Title: [Study on GC-MS fingerprint analysis in rhizome of volatile oil of Acorus tatarinowii].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040801

Title: Ultrasound-assisted conversion of toxic beta-asarone into nontoxic bioactive phenylpropanoid: isoacoramone, a metabolite of Piper marginatum and Acorus tararinowii.

Journal: Natural product research 20040601

Title: Antifungal activity of beta-asarone from rhizomes of Acorus gramineus.

Journal: Journal of agricultural and food chemistry 20040225

Title: [Effects of beta-asaron on gene expression in mouse brain].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20030901

Title: Rhizoma acori graminei and its active principles protect PC-12 cells from the toxic effect of amyloid-beta peptide.

Journal: Brain research 20030214

Title: Alpha-asarone inhibits HMG-CoA reductase, lowers serum LDL-cholesterol levels and reduces biliary CSI in hypercholesterolemic rats.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20030101

Title: Pest-managing efficacy of trans-asarone isolated from Daucus carota L. seeds.

Journal: Journal of agricultural and food chemistry 20020731

Title: Protection of cultured rat cortical neurons from excitotoxicity by asarone, a major essential oil component in the rhizomes of Acorus gramineus.

Journal: Life sciences 20020621

Title: A mild and convenient procedure for the conversion of toxic beta-asarone into rare phenylpropanoids: 2,4,5-trimethoxycinnamaldehyde and gamma-asarone.

Journal: Journal of natural products 20020501

Title: [Studies on the chemical constituents of Asarum longerhizomatosum C. F. Liang et C. S. Yang].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20011101

Title: Synthesis and hypolipidemic activity of modified side chain alpha-asarone homologues.

Journal: Arzneimittel-Forschung 20010101

Title: One step conversion of toxic beta-asarone from Acorus calamus into 1-(2,4,5-trimethoxyphenyl)-1,2-dihydroxypropane and asaronaldehyde occurring in Piper clusii.

Journal: Natural product letters 20010101

Title: Genotoxicity of the alkenylbenzenes alpha- and beta-asarone, myristicin and elimicin as determined by the UDS assay in cultured rat hepatocytes.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 19940301

Title: Zhang QS, et al. Beta-asarone protects against MPTP-induced Parkinson's disease via regulating long non-coding RNA MALAT1 and inhibiting α-synuclein protein expression. Biomed Pharmacother. 2016 Oct;83:153-159.

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