71-63-6,MFCD00003686
Catalog No.:AA003PFS

71-63-6 | DigitoXin, USP

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
≥98%
in stock  
$63.00   $44.00
- +
250mg
≥98%
in stock  
$149.00   $104.00
- +
500mg
≥98%
in stock  
$246.00   $172.00
- +
1g
≥98%
in stock  
$398.00   $278.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA003PFS
Chemical Name:
DigitoXin, USP
CAS Number:
71-63-6
Molecular Formula:
C41H64O13
Molecular Weight:
764.9391
MDL Number:
MFCD00003686
SMILES:
O=C1OCC(=C1)[C@H]1CC[C@]2([C@]1(C)CC[C@H]1[C@H]2CC[C@H]2[C@]1(C)CC[C@@H](C2)O[C@H]1C[C@H](O)[C@@H]([C@H](O1)C)O[C@H]1C[C@H](O)[C@@H]([C@H](O1)C)O[C@H]1C[C@H](O)[C@@H]([C@H](O1)C)O)O
Properties
Properties
 
Form:
Solid  
MP:
210-214°C  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
1410  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
20  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
54  
Hydrogen Bond Acceptor Count:
13  
Hydrogen Bond Donor Count:
5  
Isotope Atom Count:
0  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
2.3  

Literature

Title: Identification of anti-viral activity of the cardenolides, Na(+)/K(+)-ATPase inhibitors, against porcine transmissible gastroenteritis virus.

Journal: Toxicology and applied pharmacology 20171001

Title: Heterogeneous transport of digitalis-like compounds by P-glycoprotein in vesicular and cellular assays.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20160401

Title: Utilization of human nuclear receptors as an early counter screen for off-target activity: a case study with a compendium of 615 known drugs.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20150601

Title: A novel cell-based high-throughput screen for inhibitors of HIV-1 gene expression and budding identifies the cardiac glycosides.

Journal: The Journal of antimicrobial chemotherapy 20140401

Title: Interaction of digitalis-like compounds with p-glycoprotein.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20130201

Title: Ouabain, a cardiac glycoside, inhibits the Fanconi anemia/BRCA pathway activated by DNA interstrand cross-linking agents.

Journal: PloS one 20130101

Title: Analysis of drug interactions with modified proteins by high-performance affinity chromatography: binding of glibenclamide to normal and glycated human serum albumin.

Journal: Journal of chromatography. A 20121123

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry 20121115

Title: Digitoxin and a synthetic monosaccharide analog inhibit cell viability in lung cancer cells.

Journal: Toxicology and applied pharmacology 20120101

Title: Assembly of digitoxin by gold(I)-catalyzed glycosidation of glycosyl o-alkynylbenzoates.

Journal: The Journal of organic chemistry 20111202

Title: Termination of refractory focal status epilepticus by the P-glycoprotein inhibitor verapamil.

Journal: European journal of neurology 20111201

Title: Antiherpes activity of glucoevatromonoside, a cardenolide isolated from a Brazilian cultivar of Digitalis lanata.

Journal: Antiviral research 20111001

Title: Arrhythmogenic adverse effects of cardiac glycosides are mediated by redox modification of ryanodine receptors.

Journal: The Journal of physiology 20111001

Title: Biotransformation of extracted digitoxin from Digitalis lanata by Streptomyces.

Journal: Die Pharmazie 20110601

Title: Synthesis and evaluation of cardiac glycoside mimics as potential anticancer drugs.

Journal: Bioorganic & medicinal chemistry 20110401

Title: HPLC method validation for Digitalis and its analogue by pulsed amperometric detection.

Journal: Journal of pharmaceutical and biomedical analysis 20110105

Title: Ex vivo activity of cardiac glycosides in acute leukaemia.

Journal: PloS one 20110101

Title: Cardiac glycosides potently inhibit C-reactive protein synthesis in human hepatocytes.

Journal: Biochemical and biophysical research communications 20100326

Title: Cytotoxic effects of cardiac glycosides in colon cancer cells, alone and in combination with standard chemotherapeutic drugs.

Journal: Journal of natural products 20091101

Title: Digitoxin elicits anti-inflammatory and vasoprotective properties in endothelial cells: Therapeutic implications for the treatment of atherosclerosis?

Journal: Atherosclerosis 20091001

Title: Use of digitoxin and digoxin as internal standards in HPLC analysis of triterpene saponin-containing extracts.

Journal: Phytochemical analysis : PCA 20090101

Title: Cardiac glycosides induce cell death in human cells by inhibiting general protein synthesis.

Journal: PloS one 20090101

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry 20081113

Title: Digoxin-specific Fab fragments as single first-line therapy in digitalis poisoning.

Journal: Critical care medicine 20081101

Title: Sensitive and specific LC-MS assay for quantification of digoxin in human plasma and urine.

Journal: Biomedical chromatography : BMC 20080701

Title: Anti-HSV activity of digitoxin and its possible mechanisms.

Journal: Antiviral research 20080701

Title: Infusion of albumin attenuates changes in serum protein binding of drugs in surgical patients compared with volume replacement with HAES.

Journal: Acta anaesthesiologica Scandinavica 20080301

Title: Heart failure drug digitoxin induces calcium uptake into cells by forming transmembrane calcium channels.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20080219

Title: Digoxin treatment is associated with an increased incidence of breast cancer: a population-based case-control study.

Journal: Breast cancer research : BCR 20080101

Title: Iatrogenic sick sinus syndrome.

Journal: American journal of critical care : an official publication, American Association of Critical-Care Nurses 20070501

Title: De novo approach to 2-deoxy-beta-glycosides: asymmetric syntheses of digoxose and digitoxin.

Journal: The Journal of organic chemistry 20070330

Title: Accumulation of O-GlcNAc-displaying CdTe quantum dots in cells in the presence of ATP.

Journal: Chembiochem : a European journal of chemical biology 20070305

Title: Rhabdomyolysis after addition of digitoxin to chronic simvastatin and amiodarone therapy.

Journal: Drug metabolism and drug interactions 20070101

Title: Role of p-glycoprotein inhibition for drug interactions: evidence from in vitro and pharmacoepidemiological studies.

Journal: Clinical pharmacokinetics 20070101

Title: A stereoselective synthesis of digitoxin and digitoxigen mono- and bisdigitoxoside from digitoxigenin via a palladium-catalyzed glycosylation.

Journal: Organic letters 20060914

Title: Digitoxin, at concentrations commonly found in the plasma of cardiac patients, antagonizes etoposide and idarubicin activity in K562 leukemia cells.

Journal: Leukemia research 20060701

Title: Calcium-dependent regulation of NF-(kappa)B activation in cystic fibrosis airway epithelial cells.

Journal: Cellular signalling 20060501

Title: [Cardiac failure in the geriatric patient].

Journal: MMW Fortschritte der Medizin 20060323

Title: Mechanisms of digoxin and digitoxin on the production of corticosterone in zona fasciculata-reticularis cells of ovariectomized rats.

Journal: Journal of cellular biochemistry 20060201

Title: Nitric-oxide-dependent activation of pig oocytes: the role of the cGMP-signalling pathway.

Journal: Zygote (Cambridge, England) 20060201

Title: Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients.

Journal: Journal of natural products 20051101

Title: Neoglycorandomization and chemoenzymatic glycorandomization: two complementary tools for natural product diversification.

Journal: Journal of natural products 20051101

Title: Inhibiting biosynthesis and/or metabolism of progestins in the ventral tegmental area attenuates lordosis of rats in behavioural oestrus.

Journal: Journal of neuroendocrinology 20050901

Title: Repercussions of digoxin, digitoxin and estradiol on the endometrial histomorphometry of oophorectomized mice.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20050401

Title: Bidirectional ventricular tachycardia due to digitalis intoxication.

Journal: Zeitschrift fur Kardiologie 20050201

Title: A bitter tale.

Journal: The New England journal of medicine 20050106

Title: Electrospray ionization mass spectrometry as a tool for determination of drug binding sites to human serum albumin by noncovalent interaction.

Journal: Rapid communications in mass spectrometry : RCM 20050101

Title: Application of fluorescence correlation spectroscopy to hapten-antibody binding.

Journal: Methods in molecular biology (Clifton, N.J.) 20050101

Title: A new selective population transfer experiment using a double pulsed field gradient spin-echo.

Journal: Magnetic resonance in chemistry : MRC 20041201

Title: Inhibitory effects of digoxin and digitoxin on corticosterone production in rat zona fasciculata-reticularis cells.

Journal: British journal of pharmacology 20040801

Title: Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from cystic fibrosis lung epithelial cells.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20040518

Title: A screen for drugs that protect against the cytotoxicity of polyglutamine-expanded androgen receptor.

Journal: Human molecular genetics 20040215

Title: [Dementia induced by cardiokinetic and anti-hypertensive drugs].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20040101

Title: Pharmaceutical-grade albumin: impaired drug-binding capacity in vitro.

Journal: BMC clinical pharmacology 20040101

Title: Posterior encephalopathy with vasospasm: MRI and angiography.

Journal: Neuroradiology 20031201

Title: Acaricidal effects of cardiac glycosides, azadirachtin and neem oil against the camel tick, Hyalomma dromedarii (Acari: Ixodidae).

Journal: Pest management science 20031101

Title: Impact of left atrial size reduction on chronic atrial fibrillation in mitral valve surgery.

Journal: The Journal of heart valve disease 20030701

Title: The Cuban experience in focusing pharmaceuticals policy to health population needs: initial results of the National Pharmacoepidemiology Network (1996-2001).

Journal: Pharmacoepidemiology and drug safety 20030101

Title: Stereoselective synthesis of L-oliose trisaccharide via iterative alkynol cycloisomerization and acid-catalyzed glycosylation.

Journal: Organic letters 20021031

Title: Bidirectional tachycardia: two cases and a review.

Journal: Anesthesia and analgesia 20020801

Title: Three-dimensional quantitative structure-activity relationship analysis of ligand binding to human sequence antidigoxin monoclonal antibodies using comparative molecular field analysis.

Journal: Journal of medicinal chemistry 20020718

Title: Immunoaffinity screening with capillary electrochromatography.

Journal: Electrophoresis 20020501

Title: A neutrophil multitarget functional bioassay to detect anti-inflammatory natural products.

Journal: Journal of natural products 20020101

Title: Progesterone attenuates the inhibitory effects of cardiotonic digitalis on pregnenolone production in rat luteal cells.

Journal: Journal of cellular biochemistry 20020101

Title: Measurement of serum digitoxin in patients by radioimmunoassay using specific antiserum.

Journal: Clinica chimica acta; international journal of clinical chemistry 20011201

Title: Inhibitory effects of digitalis on the proliferation of androgen dependent and independent prostate cancer cells.

Journal: The Journal of urology 20011101

Title: Uremic sera contain inhibitors that block digitoxin-valproic acid interaction.

Journal: The American journal of the medical sciences 20011001

Title: The reaction of digitoxin and digoxin with cyanoacetic acid hydrazide: synthesis of coumarin, thiazole, thiophene and pyridine derivatives with potential biological activities.

Journal: Archives of pharmacal research 20011001

Title: [Augmentation of left ventricular outflow tract gradient by digitalis glycosides in a case of cardiac (AL-) amyloidosis].

Journal: Deutsche medizinische Wochenschrift (1946) 20010817

Title: Adverse drug reaction monitoring--digitoxin overdosage in the elderly.

Journal: International journal of clinical pharmacology and therapeutics 20010801

Title: Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells.

Journal: Anti-cancer drugs 20010601

Title: Direct inhibitory effect of digitalis on progesterone release from rat granulosa cells.

Journal: British journal of pharmacology 20010401

Title: P-glycoprotein-mediated transport of digitoxin, alpha-methyldigoxin and beta-acetyldigoxin.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20010301

Title: Treatment of congestive heart failure--current status of use of digitoxin.

Journal: European journal of clinical investigation 20010101

Title: Digitoxin medication and cancer; case control and internal dose-response studies.

Journal: BMC cancer 20010101

Title: Hepatorenal syndrome in cirrhotic patients: terlipressine is a safe and efficient treatment; propranolol and digitalic treatments: precipitating and preventing factors?

Journal: The American journal of gastroenterology 20001001

Title: Chronic hypertension induced by ouabain but not digoxin in the rat: antihypertensive effect of digoxin and digitoxin.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20000901

Title: Atrial flutter with 1:1 conduction after administration of the antimalarial drug mefloquine.

Journal: Clinical cardiology 19961201

Title: Prospective, randomized, placebo-controlled, double-blind testing of colour vision and electroretinogram at therapeutic and subtherapeutic digitoxin serum levels.

Journal: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 19940101

Title: Synthesis of 20-hydroxy-, 20-amino-, and 20-nitro-14-hydroxy-21-nor-5 beta,14 beta-pregnane C-3 glycosides and related derivatives: structure-activity relationships of pregnanes that bind to the digitalis receptor.

Journal: Journal of medicinal chemistry 19930108

Title: [Digitoxin-induced thrombocytopenia].

Journal: Wiener klinische Wochenschrift 19930101

Title: Treatment of a patient with severe digitoxin intoxication by Fab fragments of anti-digitalis antibodies.

Journal: Intensive care medicine 19920101

Title: Effects of antiarrhythmic drugs on canine ventricular arrhythmia models: which electrophysiological characteristics of drugs are related to their effectiveness?

Journal: Cardiovascular drugs and therapy 19910801

Title: Effect of digitoxin on cardiac arrhythmias in hemodialysis patients.

Journal: Klinische Wochenschrift 19871116

Title: Quinidine syncope in children.

Journal: Journal of the American College of Cardiology 19870501

Title: [Pharmacologic study of a semisynthetic digitalis derivative lacking the hydroxyl group on position 14 of the steroid nucleus].

Journal: Archivos del Instituto de Cardiologia de Mexico 19860101

Title: Effect of long-term administration of digoxin on exercise performance in chronic airflow obstruction.

Journal: European journal of respiratory diseases 19850401

Title: Study of the factors influencing cardiac growth. II. Digitoxin treatment and isoproterenol-induced cardiac hypertrophy in the rat.

Journal: Acta biologica Hungarica 19850101

Title: [Color perception disorders in therapeutic glycoside serum concentrations].

Journal: Fortschritte der Medizin 19831117

Title: [Digitoxin poisoning: reversing ventricular fibrillation with Fab fragments of anti-digoxin antibody].

Journal: La Nouvelle presse medicale 19821225

Title: Effect of age, clonidine or propranolol on behavioral toxicity induced with digitoxin in mice.

Journal: Pharmacology, biochemistry, and behavior 19820901

Title: Reversal of digitalis-induced mesenteric vasospasm by sodium nitroprusside.

Journal: Archives of internal medicine 19820201

Title: Effects of atropine on the cardiac arrest induced by propranolol and digitoxin in dogs.

Journal: Journal of electrocardiology 19820101

Title: [Ocular side effects of digitalis (author's transl)].

Journal: Klinische Monatsblatter fur Augenheilkunde 19810501

Title: Digitalis delirium: a reminder.

Journal: Southern medical journal 19800301

Title: Digitalis delirium: report of two cases.

Journal: The American journal of psychiatry 19780101

Title: Reversal of advanced digitoxin toxicity and modification of pharmacokinetics by specific antibodies and Fab fragments.

Journal: The Journal of clinical investigation 19771201

Title: [Magnesium--an alternative in treatment resistant tachyarrhythmias].

Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 19770530

Title: Hypotensive and antiarrhythmic effects of a new alkaloid, the 13-hydroxylupanine-2-pyrrolcarbonic acid ester, from the Madagascan plant Cadia ellisiana.

Journal: Arzneimittel-Forschung 19760101

Title: Transient global amnesia associated with cardiac arrhythmia and digitalis intoxication.

Journal: Stroke 19750101

Title: Effect of microsomal enzyme inducers on the biliary excretion of cardiac glycosides.

Journal: The Journal of pharmacology and experimental therapeutics 19741101

Title: His bundle electrocardiography during bidirectional tachycardia.

Journal: Circulation 19730701

Title: The clinical value of serum digitalis glycoside concentrations in the evaluation of drug toxicity.

Journal: Annals of the New York Academy of Sciences 19710706

Title: Protection by spironolactone and oxandrolone against chronic digitoxin or indomethacin intoxication.

Journal: Toxicology and applied pharmacology 19710301

Title: Possible mechanism of the prevention of digitoxin toxicity by spironolactone in the mouse.

Journal: Archives internationales de pharmacodynamie et de therapie 19710101

Title: [Spironolactone protection against experimental cardiopathy due to digitoxin, disodium phosphate and oil].

Journal: Pathologie-biologie 19700201

Title: [Acute digitalic poisoning].

Journal: Les Cahiers de medecine 19700201

Title: Digitoxin induced cardiac necrosis and its inhibition.

Journal: Cardiologia 19690101

Title: Atrial dissociation due to digitalis toxicity.

Journal: Angiology 19680601

Title: [On the treatment of the digitalis-induced atrial tachycardia with AV conduction disorder. Experiences with sodium-magnesium aspartate].

Journal: Medizinische Klinik 19680329

Title: Influence of drugs, implanted into the hypothalamus, on the water consumption of rats.

Journal: The Journal of pharmacology and experimental therapeutics 19680101

Title: [Cardiac arrhythmia in old age caused by digitalis intoxication].

Journal: Nordisk medicin 19670427

Title: Zhang YZ, et al. Compound Library Screening Identified Cardiac Glycoside Digitoxin as an Effective Growth Inhibitor of Gefitinib-Resistant Non-Small Cell Lung Cancer via Downregulation of α-Tubulin and Inhibition of Microtubule Formation. Molecules. 2016 Mar 18;21(3).

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SDS
Tags:71-63-6 Molecular Formula|71-63-6 MDL|71-63-6 SMILES|71-63-6 DigitoXin, USP
Catalog No.: AA003PFS
71-63-6,MFCD00003686
71-63-6 | DigitoXin, USP
Pack Size: 100mg
Purity: ≥98%
in stock
$63.00 $44.00
Pack Size: 250mg
Purity: ≥98%
in stock
$149.00 $104.00
Pack Size: 500mg
Purity: ≥98%
in stock
$246.00 $172.00
Pack Size: 1g
Purity: ≥98%
in stock
$398.00 $278.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA003PFS
Chemical Name: DigitoXin, USP
CAS Number: 71-63-6
Molecular Formula: C41H64O13
Molecular Weight: 764.9391
MDL Number: MFCD00003686
SMILES: O=C1OCC(=C1)[C@H]1CC[C@]2([C@]1(C)CC[C@H]1[C@H]2CC[C@H]2[C@]1(C)CC[C@@H](C2)O[C@H]1C[C@H](O)[C@@H]([C@H](O1)C)O[C@H]1C[C@H](O)[C@@H]([C@H](O1)C)O[C@H]1C[C@H](O)[C@@H]([C@H](O1)C)O)O
Properties
Form: Solid  
MP: 210-214°C  
Storage: -20 ℃;  
Complexity: 1410  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 20  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 54  
Hydrogen Bond Acceptor Count: 13  
Hydrogen Bond Donor Count: 5  
Isotope Atom Count: 0  
Rotatable Bond Count: 7  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 2.3  
Literature fold

Title: Identification of anti-viral activity of the cardenolides, Na(+)/K(+)-ATPase inhibitors, against porcine transmissible gastroenteritis virus.

Journal: Toxicology and applied pharmacology20171001

Title: Heterogeneous transport of digitalis-like compounds by P-glycoprotein in vesicular and cellular assays.

Journal: Toxicology in vitro : an international journal published in association with BIBRA20160401

Title: Utilization of human nuclear receptors as an early counter screen for off-target activity: a case study with a compendium of 615 known drugs.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20150601

Title: A novel cell-based high-throughput screen for inhibitors of HIV-1 gene expression and budding identifies the cardiac glycosides.

Journal: The Journal of antimicrobial chemotherapy20140401

Title: Interaction of digitalis-like compounds with p-glycoprotein.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20130201

Title: Ouabain, a cardiac glycoside, inhibits the Fanconi anemia/BRCA pathway activated by DNA interstrand cross-linking agents.

Journal: PloS one20130101

Title: Analysis of drug interactions with modified proteins by high-performance affinity chromatography: binding of glibenclamide to normal and glycated human serum albumin.

Journal: Journal of chromatography. A20121123

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry20121115

Title: Digitoxin and a synthetic monosaccharide analog inhibit cell viability in lung cancer cells.

Journal: Toxicology and applied pharmacology20120101

Title: Assembly of digitoxin by gold(I)-catalyzed glycosidation of glycosyl o-alkynylbenzoates.

Journal: The Journal of organic chemistry20111202

Title: Termination of refractory focal status epilepticus by the P-glycoprotein inhibitor verapamil.

Journal: European journal of neurology20111201

Title: Antiherpes activity of glucoevatromonoside, a cardenolide isolated from a Brazilian cultivar of Digitalis lanata.

Journal: Antiviral research20111001

Title: Arrhythmogenic adverse effects of cardiac glycosides are mediated by redox modification of ryanodine receptors.

Journal: The Journal of physiology20111001

Title: Biotransformation of extracted digitoxin from Digitalis lanata by Streptomyces.

Journal: Die Pharmazie20110601

Title: Synthesis and evaluation of cardiac glycoside mimics as potential anticancer drugs.

Journal: Bioorganic & medicinal chemistry20110401

Title: HPLC method validation for Digitalis and its analogue by pulsed amperometric detection.

Journal: Journal of pharmaceutical and biomedical analysis20110105

Title: Ex vivo activity of cardiac glycosides in acute leukaemia.

Journal: PloS one20110101

Title: Cardiac glycosides potently inhibit C-reactive protein synthesis in human hepatocytes.

Journal: Biochemical and biophysical research communications20100326

Title: Cytotoxic effects of cardiac glycosides in colon cancer cells, alone and in combination with standard chemotherapeutic drugs.

Journal: Journal of natural products20091101

Title: Digitoxin elicits anti-inflammatory and vasoprotective properties in endothelial cells: Therapeutic implications for the treatment of atherosclerosis?

Journal: Atherosclerosis20091001

Title: Use of digitoxin and digoxin as internal standards in HPLC analysis of triterpene saponin-containing extracts.

Journal: Phytochemical analysis : PCA20090101

Title: Cardiac glycosides induce cell death in human cells by inhibiting general protein synthesis.

Journal: PloS one20090101

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry20081113

Title: Digoxin-specific Fab fragments as single first-line therapy in digitalis poisoning.

Journal: Critical care medicine20081101

Title: Sensitive and specific LC-MS assay for quantification of digoxin in human plasma and urine.

Journal: Biomedical chromatography : BMC20080701

Title: Anti-HSV activity of digitoxin and its possible mechanisms.

Journal: Antiviral research20080701

Title: Infusion of albumin attenuates changes in serum protein binding of drugs in surgical patients compared with volume replacement with HAES.

Journal: Acta anaesthesiologica Scandinavica20080301

Title: Heart failure drug digitoxin induces calcium uptake into cells by forming transmembrane calcium channels.

Journal: Proceedings of the National Academy of Sciences of the United States of America20080219

Title: Digoxin treatment is associated with an increased incidence of breast cancer: a population-based case-control study.

Journal: Breast cancer research : BCR20080101

Title: Iatrogenic sick sinus syndrome.

Journal: American journal of critical care : an official publication, American Association of Critical-Care Nurses20070501

Title: De novo approach to 2-deoxy-beta-glycosides: asymmetric syntheses of digoxose and digitoxin.

Journal: The Journal of organic chemistry20070330

Title: Accumulation of O-GlcNAc-displaying CdTe quantum dots in cells in the presence of ATP.

Journal: Chembiochem : a European journal of chemical biology20070305

Title: Rhabdomyolysis after addition of digitoxin to chronic simvastatin and amiodarone therapy.

Journal: Drug metabolism and drug interactions20070101

Title: Role of p-glycoprotein inhibition for drug interactions: evidence from in vitro and pharmacoepidemiological studies.

Journal: Clinical pharmacokinetics20070101

Title: A stereoselective synthesis of digitoxin and digitoxigen mono- and bisdigitoxoside from digitoxigenin via a palladium-catalyzed glycosylation.

Journal: Organic letters20060914

Title: Digitoxin, at concentrations commonly found in the plasma of cardiac patients, antagonizes etoposide and idarubicin activity in K562 leukemia cells.

Journal: Leukemia research20060701

Title: Calcium-dependent regulation of NF-(kappa)B activation in cystic fibrosis airway epithelial cells.

Journal: Cellular signalling20060501

Title: [Cardiac failure in the geriatric patient].

Journal: MMW Fortschritte der Medizin20060323

Title: Mechanisms of digoxin and digitoxin on the production of corticosterone in zona fasciculata-reticularis cells of ovariectomized rats.

Journal: Journal of cellular biochemistry20060201

Title: Nitric-oxide-dependent activation of pig oocytes: the role of the cGMP-signalling pathway.

Journal: Zygote (Cambridge, England)20060201

Title: Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients.

Journal: Journal of natural products20051101

Title: Neoglycorandomization and chemoenzymatic glycorandomization: two complementary tools for natural product diversification.

Journal: Journal of natural products20051101

Title: Inhibiting biosynthesis and/or metabolism of progestins in the ventral tegmental area attenuates lordosis of rats in behavioural oestrus.

Journal: Journal of neuroendocrinology20050901

Title: Repercussions of digoxin, digitoxin and estradiol on the endometrial histomorphometry of oophorectomized mice.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology20050401

Title: Bidirectional ventricular tachycardia due to digitalis intoxication.

Journal: Zeitschrift fur Kardiologie20050201

Title: A bitter tale.

Journal: The New England journal of medicine20050106

Title: Electrospray ionization mass spectrometry as a tool for determination of drug binding sites to human serum albumin by noncovalent interaction.

Journal: Rapid communications in mass spectrometry : RCM20050101

Title: Application of fluorescence correlation spectroscopy to hapten-antibody binding.

Journal: Methods in molecular biology (Clifton, N.J.)20050101

Title: A new selective population transfer experiment using a double pulsed field gradient spin-echo.

Journal: Magnetic resonance in chemistry : MRC20041201

Title: Inhibitory effects of digoxin and digitoxin on corticosterone production in rat zona fasciculata-reticularis cells.

Journal: British journal of pharmacology20040801

Title: Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from cystic fibrosis lung epithelial cells.

Journal: Proceedings of the National Academy of Sciences of the United States of America20040518

Title: A screen for drugs that protect against the cytotoxicity of polyglutamine-expanded androgen receptor.

Journal: Human molecular genetics20040215

Title: [Dementia induced by cardiokinetic and anti-hypertensive drugs].

Journal: Nihon rinsho. Japanese journal of clinical medicine20040101

Title: Pharmaceutical-grade albumin: impaired drug-binding capacity in vitro.

Journal: BMC clinical pharmacology20040101

Title: Posterior encephalopathy with vasospasm: MRI and angiography.

Journal: Neuroradiology20031201

Title: Acaricidal effects of cardiac glycosides, azadirachtin and neem oil against the camel tick, Hyalomma dromedarii (Acari: Ixodidae).

Journal: Pest management science20031101

Title: Impact of left atrial size reduction on chronic atrial fibrillation in mitral valve surgery.

Journal: The Journal of heart valve disease20030701

Title: The Cuban experience in focusing pharmaceuticals policy to health population needs: initial results of the National Pharmacoepidemiology Network (1996-2001).

Journal: Pharmacoepidemiology and drug safety20030101

Title: Stereoselective synthesis of L-oliose trisaccharide via iterative alkynol cycloisomerization and acid-catalyzed glycosylation.

Journal: Organic letters20021031

Title: Bidirectional tachycardia: two cases and a review.

Journal: Anesthesia and analgesia20020801

Title: Three-dimensional quantitative structure-activity relationship analysis of ligand binding to human sequence antidigoxin monoclonal antibodies using comparative molecular field analysis.

Journal: Journal of medicinal chemistry20020718

Title: Immunoaffinity screening with capillary electrochromatography.

Journal: Electrophoresis20020501

Title: A neutrophil multitarget functional bioassay to detect anti-inflammatory natural products.

Journal: Journal of natural products20020101

Title: Progesterone attenuates the inhibitory effects of cardiotonic digitalis on pregnenolone production in rat luteal cells.

Journal: Journal of cellular biochemistry20020101

Title: Measurement of serum digitoxin in patients by radioimmunoassay using specific antiserum.

Journal: Clinica chimica acta; international journal of clinical chemistry20011201

Title: Inhibitory effects of digitalis on the proliferation of androgen dependent and independent prostate cancer cells.

Journal: The Journal of urology20011101

Title: Uremic sera contain inhibitors that block digitoxin-valproic acid interaction.

Journal: The American journal of the medical sciences20011001

Title: The reaction of digitoxin and digoxin with cyanoacetic acid hydrazide: synthesis of coumarin, thiazole, thiophene and pyridine derivatives with potential biological activities.

Journal: Archives of pharmacal research20011001

Title: [Augmentation of left ventricular outflow tract gradient by digitalis glycosides in a case of cardiac (AL-) amyloidosis].

Journal: Deutsche medizinische Wochenschrift (1946)20010817

Title: Adverse drug reaction monitoring--digitoxin overdosage in the elderly.

Journal: International journal of clinical pharmacology and therapeutics20010801

Title: Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells.

Journal: Anti-cancer drugs20010601

Title: Direct inhibitory effect of digitalis on progesterone release from rat granulosa cells.

Journal: British journal of pharmacology20010401

Title: P-glycoprotein-mediated transport of digitoxin, alpha-methyldigoxin and beta-acetyldigoxin.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20010301

Title: Treatment of congestive heart failure--current status of use of digitoxin.

Journal: European journal of clinical investigation20010101

Title: Digitoxin medication and cancer; case control and internal dose-response studies.

Journal: BMC cancer20010101

Title: Hepatorenal syndrome in cirrhotic patients: terlipressine is a safe and efficient treatment; propranolol and digitalic treatments: precipitating and preventing factors?

Journal: The American journal of gastroenterology20001001

Title: Chronic hypertension induced by ouabain but not digoxin in the rat: antihypertensive effect of digoxin and digitoxin.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension20000901

Title: Atrial flutter with 1:1 conduction after administration of the antimalarial drug mefloquine.

Journal: Clinical cardiology19961201

Title: Prospective, randomized, placebo-controlled, double-blind testing of colour vision and electroretinogram at therapeutic and subtherapeutic digitoxin serum levels.

Journal: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde19940101

Title: Synthesis of 20-hydroxy-, 20-amino-, and 20-nitro-14-hydroxy-21-nor-5 beta,14 beta-pregnane C-3 glycosides and related derivatives: structure-activity relationships of pregnanes that bind to the digitalis receptor.

Journal: Journal of medicinal chemistry19930108

Title: [Digitoxin-induced thrombocytopenia].

Journal: Wiener klinische Wochenschrift19930101

Title: Treatment of a patient with severe digitoxin intoxication by Fab fragments of anti-digitalis antibodies.

Journal: Intensive care medicine19920101

Title: Effects of antiarrhythmic drugs on canine ventricular arrhythmia models: which electrophysiological characteristics of drugs are related to their effectiveness?

Journal: Cardiovascular drugs and therapy19910801

Title: Effect of digitoxin on cardiac arrhythmias in hemodialysis patients.

Journal: Klinische Wochenschrift19871116

Title: Quinidine syncope in children.

Journal: Journal of the American College of Cardiology19870501

Title: [Pharmacologic study of a semisynthetic digitalis derivative lacking the hydroxyl group on position 14 of the steroid nucleus].

Journal: Archivos del Instituto de Cardiologia de Mexico19860101

Title: Effect of long-term administration of digoxin on exercise performance in chronic airflow obstruction.

Journal: European journal of respiratory diseases19850401

Title: Study of the factors influencing cardiac growth. II. Digitoxin treatment and isoproterenol-induced cardiac hypertrophy in the rat.

Journal: Acta biologica Hungarica19850101

Title: [Color perception disorders in therapeutic glycoside serum concentrations].

Journal: Fortschritte der Medizin19831117

Title: [Digitoxin poisoning: reversing ventricular fibrillation with Fab fragments of anti-digoxin antibody].

Journal: La Nouvelle presse medicale19821225

Title: Effect of age, clonidine or propranolol on behavioral toxicity induced with digitoxin in mice.

Journal: Pharmacology, biochemistry, and behavior19820901

Title: Reversal of digitalis-induced mesenteric vasospasm by sodium nitroprusside.

Journal: Archives of internal medicine19820201

Title: Effects of atropine on the cardiac arrest induced by propranolol and digitoxin in dogs.

Journal: Journal of electrocardiology19820101

Title: [Ocular side effects of digitalis (author's transl)].

Journal: Klinische Monatsblatter fur Augenheilkunde19810501

Title: Digitalis delirium: a reminder.

Journal: Southern medical journal19800301

Title: Digitalis delirium: report of two cases.

Journal: The American journal of psychiatry19780101

Title: Reversal of advanced digitoxin toxicity and modification of pharmacokinetics by specific antibodies and Fab fragments.

Journal: The Journal of clinical investigation19771201

Title: [Magnesium--an alternative in treatment resistant tachyarrhythmias].

Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke19770530

Title: Hypotensive and antiarrhythmic effects of a new alkaloid, the 13-hydroxylupanine-2-pyrrolcarbonic acid ester, from the Madagascan plant Cadia ellisiana.

Journal: Arzneimittel-Forschung19760101

Title: Transient global amnesia associated with cardiac arrhythmia and digitalis intoxication.

Journal: Stroke19750101

Title: Effect of microsomal enzyme inducers on the biliary excretion of cardiac glycosides.

Journal: The Journal of pharmacology and experimental therapeutics19741101

Title: His bundle electrocardiography during bidirectional tachycardia.

Journal: Circulation19730701

Title: The clinical value of serum digitalis glycoside concentrations in the evaluation of drug toxicity.

Journal: Annals of the New York Academy of Sciences19710706

Title: Protection by spironolactone and oxandrolone against chronic digitoxin or indomethacin intoxication.

Journal: Toxicology and applied pharmacology19710301

Title: Possible mechanism of the prevention of digitoxin toxicity by spironolactone in the mouse.

Journal: Archives internationales de pharmacodynamie et de therapie19710101

Title: [Spironolactone protection against experimental cardiopathy due to digitoxin, disodium phosphate and oil].

Journal: Pathologie-biologie19700201

Title: [Acute digitalic poisoning].

Journal: Les Cahiers de medecine19700201

Title: Digitoxin induced cardiac necrosis and its inhibition.

Journal: Cardiologia19690101

Title: Atrial dissociation due to digitalis toxicity.

Journal: Angiology19680601

Title: [On the treatment of the digitalis-induced atrial tachycardia with AV conduction disorder. Experiences with sodium-magnesium aspartate].

Journal: Medizinische Klinik19680329

Title: Influence of drugs, implanted into the hypothalamus, on the water consumption of rats.

Journal: The Journal of pharmacology and experimental therapeutics19680101

Title: [Cardiac arrhythmia in old age caused by digitalis intoxication].

Journal: Nordisk medicin19670427

Title: Zhang YZ, et al. Compound Library Screening Identified Cardiac Glycoside Digitoxin as an Effective Growth Inhibitor of Gefitinib-Resistant Non-Small Cell Lung Cancer via Downregulation of α-Tubulin and Inhibition of Microtubule Formation. Molecules. 2016 Mar 18;21(3).

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