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108929-04-0,MFCD00933434
Catalog No.:AA003PUU

108929-04-0 | Epinastine HCl

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10mg
≥98%
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250mg
98%(HPLC)
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1g
98%
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5g
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10g
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003PUU
Chemical Name:
Epinastine HCl
CAS Number:
108929-04-0
Molecular Formula:
C16H16ClN3
Molecular Weight:
285.7713
MDL Number:
MFCD00933434
SMILES:
NC1=NCC2N1c1ccccc1Cc1c2cccc1.Cl
Properties
Properties
 
BP:
428°C at 760 mmHg  
Form:
Solid  
MP:
273-275°C  
Solubility:
H2O: soluble38mg/mL  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
378  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
2  
Undefined Atom Stereocenter Count:
1  

Literature

Title: Efficacy of epinastine hydrochloride for antigen-provoked nasal symptoms in subjects with orchard grass pollinosis.

Journal: Allergology international : official journal of the Japanese Society of Allergology 20110301

Title: An H1-histamine receptor antagonist decreases serum interleukin-31 levels in patients with atopic dermatitis.

Journal: The British journal of dermatology 20110201

Title: [Cautions in usage of generic epinastine].

Journal: Arerugi = [Allergy] 20110101

Title: Prophylactic effects of the histamine H1 receptor antagonist epinastine and the dual thromboxane A2 receptor and chemoattractant receptor-homologous molecule expressed on Th2 cells antagonist ramatroban on allergic rhinitis model in mice.

Journal: Biological & pharmaceutical bulletin 20110101

Title: Honey bee dopamine and octopamine receptors linked to intracellular calcium signaling have a close phylogenetic and pharmacological relationship.

Journal: PloS one 20110101

Title: The effect of a selective octopamine antagonist, epinastine, on pharyngeal pumping in Caenorhabditis elegans.

Journal: Invertebrate neuroscience : IN 20101101

Title: Antihistamine effects on prefrontal cortex activity during working memory process in preschool children: a near-infrared spectroscopy (NIRS) study.

Journal: Neuroscience research 20100501

Title: Effect of epinastine hydrochloride on murine self-scratching behavior after skin-scratching stimulation.

Journal: Archives of dermatological research 20100101

Title: Treatment of allergic conjunctivitis: results of a 1-month, single-masked randomized study.

Journal: European journal of ophthalmology 20100101

Title: Effects of sedative and nonsedative antihistamines on prefrontal activity during verbal fluency task in young children: a near-infrared spectroscopy (NIRS) study.

Journal: Psychopharmacology 20091101

Title: Multiple action agents and the eye: do they really stabilize mast cells?

Journal: Current opinion in allergy and clinical immunology 20091001

Title: Epinastine: topical ophthalmic second generation antihistamine without significant systemic side effects.

Journal: Expert opinion on drug metabolism & toxicology 20090901

Title: Efficacy of olopatadine HCI 0.1%, ketotifen fumarate 0.025%, epinastine HCI 0.05%, emedastine 0.05% and fluorometholone acetate 0.1% ophthalmic solutions for seasonal allergic conjunctivitis: a placebo-controlled environmental trial.

Journal: Acta ophthalmologica 20090801

Title: Suppression of histamine- and allergen-induced skin reactions: comparison of first- and second-generation antihistamines.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20090601

Title: Differential effects of octopamine and tyramine on the central pattern generator for Manduca flight.

Journal: Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology 20090301

Title: Epinastine 0.05% ophthalmic solution in contact lens-wearing subjects with a history of allergic conjunctivitis.

Journal: Eye & contact lens 20090101

Title: Influence of epinastine hydrochloride, an H1-receptor antagonist, on the function of mite allergen-pulsed murine bone marrow-derived dendritic cells in vitro and in vivo.

Journal: Mediators of inflammation 20090101

Title: Repeated pre-treatment with antihistamines suppresses [corrected] transcriptional up-regulations of histamine H(1) receptor and interleukin-4 genes in toluene-2,4-diisocyanate-sensitized rats.

Journal: Journal of pharmacological sciences 20081201

Title: Development and characterisation of a novel and rapid lung eosinophil influx model in the rat.

Journal: Pulmonary pharmacology & therapeutics 20080801

Title: Arousal facilitates collision avoidance mediated by a looming sensitive visual neuron in a flying locust.

Journal: Journal of neurophysiology 20080801

Title: Ocular comfort and drying effects of three topical antihistamine/mast cell stabilizers in adults with allergic conjunctivitis: a randomized, double-masked crossover study.

Journal: Clinical therapeutics 20080701

Title: Analysis of disease-dependent sedative profiles of H(1)-antihistamines by large-scale surveillance using the visual analog scale.

Journal: Methods and findings in experimental and clinical pharmacology 20080401

Title: Suppressive activity of epinastine hydrochloride on eosinophil activation in vitro.

Journal: In vivo (Athens, Greece) 20080101

Title: Inhibition of angiogenic factor production from murine mast cells by an antiallergic agent (epinastine hydrochloride) in vitro.

Journal: Mediators of inflammation 20080101

Title: Modulation of eosinophil survival by epinastine hydrochloride, an H1 receptor antagonist, in vitro.

Journal: In vivo (Athens, Greece) 20080101

Title: Octopamine partially restores walking in hypokinetic cockroaches stung by the parasitoid wasp Ampulex compressa.

Journal: The Journal of experimental biology 20071201

Title: Ocular anti-allergic compounds selectively inhibit human mast cell cytokines in vitro and conjunctival cell infiltration in vivo.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20071101

Title: Effects of sedative and non-sedative H1 antagonists on cognitive tasks: behavioral and near-infrared spectroscopy (NIRS) examinations.

Journal: Psychopharmacology 20070901

Title: Duration of action of topical antiallergy drugs in a Guinea pig model of histamine-induced conjunctival vascular permeability.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20070801

Title: Simultaneous multiresponse optimization applied to epinastine determination in human serum by using capillary electrophoresis.

Journal: Analytica chimica acta 20070709

Title: Inhibition of IgE-mediated phosphorylation of FcepsilonRIgamma protein by antiallergic drugs in rat basophilic leukemia (RBL-2H3) cells: a novel action of antiallergic drugs.

Journal: International immunopharmacology 20070701

Title: Efficacy and comfort of olopatadine 0.2% versus epinastine 0.05% ophthalmic solution for treating itching and redness induced by conjunctival allergen challenge.

Journal: Current medical research and opinion 20070601

Title: An open-label, investigator-masked, crossover study of the ocular drying effects of two antihistamines, topical epinastine and systemic loratadine, in adult volunteers with seasonal allergic conjunctivitis.

Journal: Clinical therapeutics 20070401

Title: Influences of histamine H1 receptor antagonists on maximal electroshock seizure in infant rats.

Journal: Biological & pharmaceutical bulletin 20070301

Title: Inhibitory effects of epinastine on chemokine production and MHC class II/CD54 expression in keratinocytes.

Journal: Journal of dermatological science 20070201

Title: Effect of topical olopatadine and epinastine in the botulinum toxin B-induced mouse model of dry eye.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20070201

Title: Distribution to the skin of epinastine hydrochloride in atopic dermatitis patients.

Journal: European journal of dermatology : EJD 20070101

Title: Development and validation of liquid chromatographic and ultraviolet derivative spectrophotometric methods for determination of epinastine hydrochloride in coated tablets.

Journal: Journal of AOAC International 20070101

Title: Octopamine boosts snail locomotion: behavioural and cellular analysis.

Journal: Invertebrate neuroscience : IN 20061201

Title: Effect of topical ophthalmic epinastine and olopatadine on tear volume in mice.

Journal: Eye & contact lens 20061201

Title: Antiallergic drugs, azelastine hydrochloride and epinastine hydrochloride, inhibit ongoing IgE secretion of rat IgE-producing hybridoma FE-3 cells.

Journal: European journal of pharmacology 20061010

Title: Roles of octopaminergic and dopaminergic neurons in mediating reward and punishment signals in insect visual learning.

Journal: The European journal of neuroscience 20061001

Title: Efficacy and response with olopatadine versus epinastine in ocular allergic symptoms: a post hoc analysis of data from a conjunctival allergen challenge study.

Journal: Clinical therapeutics 20061001

Title: Nasal congestion model in Brown Norway rats and the effects of some H1-antagonists.

Journal: International immunopharmacology 20060501

Title: Role of substance P in allergic nasal symptoms in rats.

Journal: European journal of pharmacology 20060217

Title: Effects of histamine H(1) receptor antagonists on depressive-like behavior in diabetic mice.

Journal: Pharmacology, biochemistry, and behavior 20060201

Title: [Pharmacological and clinical profile of epinastine hydrochloride (Alesion Dry Syrup 1%)].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20060101

Title: Epinastine hydrochloride antagonism against interleukin-4-mediated T cell cytokine imbalance in vitro.

Journal: International archives of allergy and immunology 20060101

Title: Epinastine in the management of ocular allergic disease.

Journal: International ophthalmology clinics 20060101

Title: Elestat (epinastine HCl ophthalmic solution 0.05%) as a therapeutic for allergic conjunctivitis.

Journal: International ophthalmology clinics 20060101

Title: The various effects of four H1-antagonists on serum substance P levels in patients with atopic dermatitis.

Journal: The Journal of dermatology 20051001

Title: Suppressive activity of epinastine hydrochloride on TARC production from human peripheral blood CD4+ T cells in-vitro.

Journal: The Journal of pharmacy and pharmacology 20050801

Title: Exacerbation of palmoplantar pustulosis by granulocyte colony-stimulating factor.

Journal: International journal of dermatology 20050601

Title: Octopamine and experience-dependent modulation of aggression in crickets.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050209

Title: Population pharmacokinetics of epinastine, a histamine H1 receptor antagonist, in adults and children.

Journal: British journal of clinical pharmacology 20050101

Title: Clinical efficacy of olopatadine vs epinastine ophthalmic solution in the conjunctival allergen challenge model.

Journal: Current medical research and opinion 20040801

Title: Epinastine hydrochloride for atopic disease.

Journal: Drugs of today (Barcelona, Spain : 1998) 20040801

Title: Influx and efflux transport of H1-antagonist epinastine across the blood-brain barrier.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20040501

Title: Epinastine ophthalmic solution (Elestat).

Journal: The Medical letter on drugs and therapeutics 20040426

Title: Efficacy and tolerability of ophthalmic epinastine: a randomized, double-masked, parallel-group, active- and vehicle-controlled environmental trial in patients with seasonal allergic conjunctivitis.

Journal: Clinical therapeutics 20040101

Title: Efficacy and tolerability of ophthalmic epinastine assessed using the conjunctival antigen challenge model in patients with a history of allergic conjunctivitis.

Journal: Clinical therapeutics 20040101

Title: [Assessment of the clinical efficacy and safety of epinastine plus pseudoephedrine vs loratadine plus pseudoephedrine in perennial allergic rhinitis].

Journal: Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20040101

Title: Antitussive effects of the H1-receptor antagonist epinastine in patients with atopic cough (eosinophilic bronchitis).

Journal: Arzneimittel-Forschung 20040101

Title: Anti-glomerular basement membrane antibody-induced glomerulonephritis with periglomerular granulomatous reaction and massive renal eosinophilic infiltration.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20030901

Title: A new histamine measurement system employing a confocal laser microscope and cultured human dermal microvascular endothelial cells.

Journal: Journal of dermatological science 20030901

Title: A case of type IV solar urticaria identified by reverse in vitro serum test.

Journal: The Tokai journal of experimental and clinical medicine 20030701

Title: Hygienic behavior in the honey bee (Apis mellifera L.) and the modulatory role of octopamine.

Journal: Journal of neurobiology 20030601

Title: [Efficacy of combined drug therapy using a macrolide antibiotic and an antihistamine for adult patients with chronic paranasal sinusitis].

Journal: The Japanese journal of antibiotics 20030401

Title: Epinastine inhibits eosinophil chemotaxis and adhesion molecules in atopic dermatitis.

Journal: Skin pharmacology and applied skin physiology 20030101

Title: Dermal objective pharmacodynamic profile of cetirizine and epinastine: two controlled, randomised, double-blind, crossover studies.

Journal: International journal of clinical practice 20021001

Title: Pharmacokinetics of epinastine and a possible mechanism for double peaks in oral plasma concentration profiles.

Journal: Biological & pharmaceutical bulletin 20010701

Title: Effect of H1-antagonists on spatial memory deficit evaluated by 8-arm radial maze in rats.

Journal: Acta pharmacologica Sinica 20010701

Title: Effects of cetirizine and epinastine on the skin response to histamine iontophoresis.

Journal: Journal of dermatological science 20010101

Title: A new model of allergic rhinitis in rats by topical sensitization and evaluation of H(1)-receptor antagonists.

Journal: Immunopharmacology 20000601

Title: Epinastine, a nonsedating histamine H1 receptor antagonist, has a negligible effect on HERG channel.

Journal: European journal of pharmacology 19990625

Title: A comparative pharmacokinetic-pharmacodynamic study of the electrocardiographic effects of epinastine and terfenadine in rats.

Journal: The Journal of pharmacy and pharmacology 19970401

Title: Antihistaminic activity and side effect profile of epinastine and terfenadine in healthy volunteers.

Journal: International journal of clinical pharmacology, therapy, and toxicology 19901201

Title: New tetracyclic guanidine derivatives with H1-antihistaminic properties. Chemistry of epinastine.

Journal: Arzneimittel-Forschung 19900401

Title: C Kamei, et al. Antiallergic effect of epinastine (WAL 801 CL) on immediate hypersensitivity reactions: (I). Elucidation of the mechanism for histamine release inhibition. Immunopharmacol Immunotoxicol. 1992;14(1-2):191-205.

Title: T Roeder, et al. Epinastine, a highly specific antagonist of insect neuronal octopamine receptors. ur J Pharmacol. 1998 May 22;349(2-3):171-7.

Title: T Kohyama, et al. A novel antiallergic drug epinastine inhibits IL-8 release from human eosinophils. Biochem Biophys Res Commun. 1997 Jan 3;230(1):125-8.

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