[1]CurrentPatentAssignee:USVLTD.-WO2009/63504,2009,A2Locationinpatent:Page/Pagecolumn25
[2]CurrentPatentAssignee:ZHAOKEPHARMACEUTICALHEFEIGUANGZHOUBRANCH-CN105153169,2018,BLocationinpatent:Paragraph0122;0127;0132;0137;0139;0141-0143;0147
[3]CurrentPatentAssignee:USVLTD.-WO2009/63504,2009,A2Locationinpatent:Page/Pagecolumn30
[4]CurrentPatentAssignee:HEFEIHUAFANGPHARMACEUTICALSCIENCESTECHNOLOGY-CN107141297,2017,ALocationinpatent:Paragraph0103;0108;0114;0122;0129
[1]CurrentPatentAssignee:USVLTD.-WO2009/63504,2009,A2Locationinpatent:Page/Pagecolumn25
[1]Patent:WO2009/63504,2009,A2.Locationinpatent:Page/Pagecolumn24
Title: Why are most phospholipidosis inducers also hERG blockers?
Journal: Archives of toxicology 20171201
Title: Perturbation of tyraminergic/octopaminergic function inhibits oviposition in the cattle tick Rhipicephalus (Boophilus) microplus.
Journal: Journal of insect physiology 20120501
Title: Amino acid and vitamin supplementation improved health conditions in elderly participants.
Journal: Journal of clinical biochemistry and nutrition 20120301
Title: Pharmacological characterization of adenosine receptors on isolated human bronchi.
Journal: American journal of respiratory cell and molecular biology 20111201
Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Journal: PLoS computational biology 20111201
Title: Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal: Journal of medicinal chemistry 20110714
Title: Octopamine and occupancy: an aminergic mechanism for intruder-resident aggression in crickets.
Journal: Proceedings. Biological sciences 20110622
Title: Reduction of bitterness of antihistaminic drugs by complexation with β-cyclodextrins.
Journal: Journal of pharmaceutical sciences 20110501
Title: Efficacy of epinastine hydrochloride for antigen-provoked nasal symptoms in subjects with orchard grass pollinosis.
Journal: Allergology international : official journal of the Japanese Society of Allergology 20110301
Title: An H1-histamine receptor antagonist decreases serum interleukin-31 levels in patients with atopic dermatitis.
Journal: The British journal of dermatology 20110201
Title: Evaluation of alcaftadine 0.25% ophthalmic solution in acute allergic conjunctivitis at 15 minutes and 16 hours after instillation versus placebo and olopatadine 0.1%.
Journal: Clinical ophthalmology (Auckland, N.Z.) 20110101
Title: [Cautions in usage of generic epinastine].
Journal: Arerugi = [Allergy] 20110101
Title: Multiple endpoint analysis of BAC-preserved and unpreserved antiallergic eye drops on a 3D-reconstituted corneal epithelial model.
Journal: Molecular vision 20110101
Title: Prophylactic effects of the histamine H1 receptor antagonist epinastine and the dual thromboxane A2 receptor and chemoattractant receptor-homologous molecule expressed on Th2 cells antagonist ramatroban on allergic rhinitis model in mice.
Journal: Biological & pharmaceutical bulletin 20110101
Title: Honey bee dopamine and octopamine receptors linked to intracellular calcium signaling have a close phylogenetic and pharmacological relationship.
Journal: PloS one 20110101
Title: Winning fights induces hyperaggression via the action of the biogenic amine octopamine in crickets.
Journal: PloS one 20110101
Title: Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.
Journal: Healthcare informatics research 20101201
Title: The effect of a selective octopamine antagonist, epinastine, on pharyngeal pumping in Caenorhabditis elegans.
Journal: Invertebrate neuroscience : IN 20101101
Title: Antihistamine effects on prefrontal cortex activity during working memory process in preschool children: a near-infrared spectroscopy (NIRS) study.
Journal: Neuroscience research 20100501
Title: Characterization of scratching behavior induced by intradermal administration of morphine and fentanyl in mice.
Journal: European journal of pharmacology 20100210
Title: Effect of epinastine hydrochloride on murine self-scratching behavior after skin-scratching stimulation.
Journal: Archives of dermatological research 20100101
Title: Treatment of allergic conjunctivitis: results of a 1-month, single-masked randomized study.
Journal: European journal of ophthalmology 20100101
Title: Azelastine hydrochloride, a dual-acting anti-inflammatory ophthalmic solution, for treatment of allergic conjunctivitis.
Journal: Clinical ophthalmology (Auckland, N.Z.) 20100101
Title: Roles of aminergic neurons in formation and recall of associative memory in crickets.
Journal: Frontiers in behavioral neuroscience 20100101
Title: Octopaminergic modulation of temporal frequency coding in an identified optic flow-processing interneuron.
Journal: Frontiers in systems neuroscience 20100101
Title: Effects of sedative and nonsedative antihistamines on prefrontal activity during verbal fluency task in young children: a near-infrared spectroscopy (NIRS) study.
Journal: Psychopharmacology 20091101
Title: Multiple action agents and the eye: do they really stabilize mast cells?
Journal: Current opinion in allergy and clinical immunology 20091001
Title: Epinastine: topical ophthalmic second generation antihistamine without significant systemic side effects.
Journal: Expert opinion on drug metabolism & toxicology 20090901
Title: Efficacy of olopatadine HCI 0.1%, ketotifen fumarate 0.025%, epinastine HCI 0.05%, emedastine 0.05% and fluorometholone acetate 0.1% ophthalmic solutions for seasonal allergic conjunctivitis: a placebo-controlled environmental trial.
Journal: Acta ophthalmologica 20090801
Title: Octopamine and tyramine modulate pheromone-sensitive olfactory sensilla of the hawkmoth Manduca sexta in a time-dependent manner.
Journal: Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology 20090601
Title: Suppression of histamine- and allergen-induced skin reactions: comparison of first- and second-generation antihistamines.
Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20090601
Title: Differential effects of octopamine and tyramine on the central pattern generator for Manduca flight.
Journal: Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology 20090301
Title: Epinastine 0.05% ophthalmic solution in contact lens-wearing subjects with a history of allergic conjunctivitis.
Journal: Eye & contact lens 20090101
Title: Influence of epinastine hydrochloride, an H1-receptor antagonist, on the function of mite allergen-pulsed murine bone marrow-derived dendritic cells in vitro and in vivo.
Journal: Mediators of inflammation 20090101
Title: The role of dopamine in Drosophila larval classical olfactory conditioning.
Journal: PloS one 20090101
Title: Contrasting role of octopamine in appetitive and aversive learning in the crab Chasmagnathus.
Journal: PloS one 20090101
Title: Roles of octopaminergic and dopaminergic neurons in appetitive and aversive memory recall in an insect.
Journal: BMC biology 20090101
Title: Management of allergic conjunctivitis: an evaluation of the perceived comfort and therapeutic efficacy of olopatadine 0.2% and azelastine 0.05% from two prospective studies.
Journal: Clinical ophthalmology (Auckland, N.Z.) 20090101
Title: Drugs associated with more suicidal ideations are also associated with more suicide attempts.
Journal: PloS one 20090101
Title: Cleavage of functional IL-2 receptor alpha chain (CD25) from murine corneal and conjunctival epithelia by MMP-9.
Journal: Journal of inflammation (London, England) 20090101
Title: Ebastine in the light of CONGA recommendations for the development of third-generation antihistamines.
Journal: Journal of asthma and allergy 20090101
Title: Repeated pre-treatment with antihistamines suppresses [corrected] transcriptional up-regulations of histamine H(1) receptor and interleukin-4 genes in toluene-2,4-diisocyanate-sensitized rats.
Journal: Journal of pharmacological sciences 20081201
Title: 11H-Dibenzo[b,e]azepine-6-carbonitrile.
Journal: Acta crystallographica. Section E, Structure reports online 20081101
Title: Regulatory effects of antihistamines on the responses to staphylococcal enterotoxin B of human monocyte-derived dendritic cells and CD4+ T cells.
Journal: Journal of dermatological science 20081001
Title: Treatment of allergic conjunctivitis with olopatadine hydrochloride eye drops.
Journal: Clinical ophthalmology (Auckland, N.Z.) 20080901
Title: Development and characterisation of a novel and rapid lung eosinophil influx model in the rat.
Journal: Pulmonary pharmacology & therapeutics 20080801
Title: Arousal facilitates collision avoidance mediated by a looming sensitive visual neuron in a flying locust.
Journal: Journal of neurophysiology 20080801
Title: Ocular comfort and drying effects of three topical antihistamine/mast cell stabilizers in adults with allergic conjunctivitis: a randomized, double-masked crossover study.
Journal: Clinical therapeutics 20080701
Title: Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization.
Journal: Journal of pharmacological sciences 20080501
Title: Analysis of disease-dependent sedative profiles of H(1)-antihistamines by large-scale surveillance using the visual analog scale.
Journal: Methods and findings in experimental and clinical pharmacology 20080401
Title: Suppressive activity of epinastine hydrochloride on eosinophil activation in vitro.
Journal: In vivo (Athens, Greece) 20080101
Title: Inhibition of angiogenic factor production from murine mast cells by an antiallergic agent (epinastine hydrochloride) in vitro.
Journal: Mediators of inflammation 20080101
Title: Modulation of eosinophil survival by epinastine hydrochloride, an H1 receptor antagonist, in vitro.
Journal: In vivo (Athens, Greece) 20080101
Title: Octopamine partially restores walking in hypokinetic cockroaches stung by the parasitoid wasp Ampulex compressa.
Journal: The Journal of experimental biology 20071201
Title: Ocular anti-allergic compounds selectively inhibit human mast cell cytokines in vitro and conjunctival cell infiltration in vivo.
Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20071101
Title: Effects of sedative and non-sedative H1 antagonists on cognitive tasks: behavioral and near-infrared spectroscopy (NIRS) examinations.
Journal: Psychopharmacology 20070901
Title: Duration of action of topical antiallergy drugs in a Guinea pig model of histamine-induced conjunctival vascular permeability.
Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20070801
Title: Simultaneous multiresponse optimization applied to epinastine determination in human serum by using capillary electrophoresis.
Journal: Analytica chimica acta 20070709
Title: Inhibition of IgE-mediated phosphorylation of FcepsilonRIgamma protein by antiallergic drugs in rat basophilic leukemia (RBL-2H3) cells: a novel action of antiallergic drugs.
Journal: International immunopharmacology 20070701
Title: Development of new atopic dermatitis models characterized by not only itching but also inflammatory skin in mice.
Journal: European journal of pharmacology 20070622
Title: Efficacy and comfort of olopatadine 0.2% versus epinastine 0.05% ophthalmic solution for treating itching and redness induced by conjunctival allergen challenge.
Journal: Current medical research and opinion 20070601
Title: Expanding the neuron's calcium signaling repertoire: intracellular calcium release via voltage-induced PLC and IP3R activation.
Journal: PLoS biology 20070401
Title: An open-label, investigator-masked, crossover study of the ocular drying effects of two antihistamines, topical epinastine and systemic loratadine, in adult volunteers with seasonal allergic conjunctivitis.
Journal: Clinical therapeutics 20070401
Title: Influences of histamine H1 receptor antagonists on maximal electroshock seizure in infant rats.
Journal: Biological & pharmaceutical bulletin 20070301
Title: Inhibitory effects of epinastine on chemokine production and MHC class II/CD54 expression in keratinocytes.
Journal: Journal of dermatological science 20070201
Title: Influences of octopamine and juvenile hormone on locomotor behavior and period gene expression in the honeybee, Apis mellifera.
Journal: Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology 20070201
Title: Effect of topical olopatadine and epinastine in the botulinum toxin B-induced mouse model of dry eye.
Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20070201
Title: Distribution to the skin of epinastine hydrochloride in atopic dermatitis patients.
Journal: European journal of dermatology : EJD 20070101
Title: Aversive learning in honeybees revealed by the olfactory conditioning of the sting extension reflex.
Journal: PloS one 20070101
Title: Development and validation of liquid chromatographic and ultraviolet derivative spectrophotometric methods for determination of epinastine hydrochloride in coated tablets.
Journal: Journal of AOAC International 20070101
Title: Octopamine boosts snail locomotion: behavioural and cellular analysis.
Journal: Invertebrate neuroscience : IN 20061201
Title: Effect of topical ophthalmic epinastine and olopatadine on tear volume in mice.
Journal: Eye & contact lens 20061201
Title: Octopamine mediates thermal preconditioning of the locust ventilatory central pattern generator via a cAMP/protein kinase A signaling pathway.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20061122
Title: Antiallergic drugs, azelastine hydrochloride and epinastine hydrochloride, inhibit ongoing IgE secretion of rat IgE-producing hybridoma FE-3 cells.
Journal: European journal of pharmacology 20061010
Title: Roles of octopaminergic and dopaminergic neurons in mediating reward and punishment signals in insect visual learning.
Journal: The European journal of neuroscience 20061001
Title: Efficacy and response with olopatadine versus epinastine in ocular allergic symptoms: a post hoc analysis of data from a conjunctival allergen challenge study.
Journal: Clinical therapeutics 20061001
Title: Inhibition of the antigen provoked nasal reaction by second-generation antihistamines in patients with Japanese cedar pollinosis.
Journal: Allergology international : official journal of the Japanese Society of Allergology 20060901
Title: Nasal congestion model in Brown Norway rats and the effects of some H1-antagonists.
Journal: International immunopharmacology 20060501
Title: [Comparison of clinical efficacy and cost-quality of antihistamines in early treatment for Japanese cedar pollinosis].
Journal: Arerugi = [Allergy] 20060501
Title: Role of substance P in allergic nasal symptoms in rats.
Journal: European journal of pharmacology 20060217
Title: Effects of histamine H(1) receptor antagonists on depressive-like behavior in diabetic mice.
Journal: Pharmacology, biochemistry, and behavior 20060201
Title: Parental use of the term 'Hot Qi' to describe symptoms in their children in Hong Kong: a cross sectional survey 'Hot Qi' in children.
Journal: Journal of ethnobiology and ethnomedicine 20060101
Title: [Pharmacological and clinical profile of epinastine hydrochloride (Alesion Dry Syrup 1%)].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20060101
Title: Epinastine hydrochloride antagonism against interleukin-4-mediated T cell cytokine imbalance in vitro.
Journal: International archives of allergy and immunology 20060101
Title: Epinastine in the management of ocular allergic disease.
Journal: International ophthalmology clinics 20060101
Title: Elestat (epinastine HCl ophthalmic solution 0.05%) as a therapeutic for allergic conjunctivitis.
Journal: International ophthalmology clinics 20060101
Title: Histamine receptors and the conjunctiva.
Journal: Current opinion in allergy and clinical immunology 20051001
Title: The various effects of four H1-antagonists on serum substance P levels in patients with atopic dermatitis.
Journal: The Journal of dermatology 20051001
Title: Participation of octopaminergic reward system and dopaminergic punishment system in insect olfactory learning revealed by pharmacological study.
Journal: The European journal of neuroscience 20050901
Title: Suppressive activity of epinastine hydrochloride on TARC production from human peripheral blood CD4+ T cells in-vitro.
Journal: The Journal of pharmacy and pharmacology 20050801
Title: Exacerbation of palmoplantar pustulosis by granulocyte colony-stimulating factor.
Journal: International journal of dermatology 20050601
Title: Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Journal: Journal of medicinal chemistry 20050505
Title: Octopamine and experience-dependent modulation of aggression in crickets.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050209
Title: Effects of first- and second-generation histamine-H1-receptor antagonists on the pentobarbital-induced loss of the righting reflex in streptozotocin-induced diabetic mice.
Journal: Journal of pharmacological sciences 20050201
Title: Population pharmacokinetics of epinastine, a histamine H1 receptor antagonist, in adults and children.
Journal: British journal of clinical pharmacology 20050101
Title: Efficacy and tolerability of newer antihistamines in the treatment of allergic conjunctivitis.
Journal: Drugs 20050101
Title: Clinical efficacy of olopatadine vs epinastine ophthalmic solution in the conjunctival allergen challenge model.
Journal: Current medical research and opinion 20040801
Title: Epinastine hydrochloride for atopic disease.
Journal: Drugs of today (Barcelona, Spain : 1998) 20040801
Title: Effects of second-generation histamine H1 receptor antagonists on the sleep-wakefulness cycle in rats.
Journal: European journal of pharmacology 20040628
Title: Influx and efflux transport of H1-antagonist epinastine across the blood-brain barrier.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20040501
Title: Epinastine ophthalmic solution (Elestat).
Journal: The Medical letter on drugs and therapeutics 20040426
Title: Efficacy and tolerability of ophthalmic epinastine: a randomized, double-masked, parallel-group, active- and vehicle-controlled environmental trial in patients with seasonal allergic conjunctivitis.
Journal: Clinical therapeutics 20040101
Title: Efficacy and tolerability of ophthalmic epinastine assessed using the conjunctival antigen challenge model in patients with a history of allergic conjunctivitis.
Journal: Clinical therapeutics 20040101
Title: [Assessment of the clinical efficacy and safety of epinastine plus pseudoephedrine vs loratadine plus pseudoephedrine in perennial allergic rhinitis].
Journal: Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20040101
Title: Antitussive effects of the H1-receptor antagonist epinastine in patients with atopic cough (eosinophilic bronchitis).
Journal: Arzneimittel-Forschung 20040101
Title: Interactions of olopatadine and selected antihistamines with model and natural membranes.
Journal: Ocular immunology and inflammation 20031201
Title: Anti-glomerular basement membrane antibody-induced glomerulonephritis with periglomerular granulomatous reaction and massive renal eosinophilic infiltration.
Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20030901
Title: A new histamine measurement system employing a confocal laser microscope and cultured human dermal microvascular endothelial cells.
Journal: Journal of dermatological science 20030901
Title: The effects of certain H(1)-antagonists on visual evoked potential in rats.
Journal: Brain research bulletin 20030830
Title: Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Journal: Bioorganic & medicinal chemistry letters 20030818
Title: A case of type IV solar urticaria identified by reverse in vitro serum test.
Journal: The Tokai journal of experimental and clinical medicine 20030701
Title: Hygienic behavior in the honey bee (Apis mellifera L.) and the modulatory role of octopamine.
Journal: Journal of neurobiology 20030601
Title: On the mechanisms underlying histamine induction of gastric mucosal lesions in rats with partial gastric vascular occlusion.
Journal: Journal of pharmacological sciences 20030601
Title: Characteristics of the antihistamine effect of TAK-427, a novel imidazopyridazine derivative.
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20030501
Title: The role of chemical mediators in eosinophil infiltration in allergic rhinitis in mice.
Journal: International immunopharmacology 20030401
Title: [Efficacy of combined drug therapy using a macrolide antibiotic and an antihistamine for adult patients with chronic paranasal sinusitis].
Journal: The Japanese journal of antibiotics 20030401
Title: Effects of second-generation histamine H1 receptor antagonists on the active avoidance response in rats.
Journal: Clinical and experimental pharmacology & physiology 20030101
Title: Epinastine inhibits eosinophil chemotaxis and adhesion molecules in atopic dermatitis.
Journal: Skin pharmacology and applied skin physiology 20030101
Title: Dermal objective pharmacodynamic profile of cetirizine and epinastine: two controlled, randomised, double-blind, crossover studies.
Journal: International journal of clinical practice 20021001
Title: Participation of chemical mediators other than histamine in nasal allergy signs: a study using mice lacking histamine H(1) receptors.
Journal: European journal of pharmacology 20020809
Title: Histamine H1 receptors are involved in mouse nasal allergic responses: a demonstration with H1 receptor-deficient mice.
Journal: International immunopharmacology 20020501
Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
Journal: The Journal of biological chemistry 20020419
Title: Antihistamines in late-phase clinical development for allergic disease.
Journal: Expert opinion on investigational drugs 20020201
Title: The role of central histaminergic neuron system as an anticonvulsive mechanism in developing brain.
Journal: Brain & development 20011101
Title: Preclinical comparison of ebastine and other second generation H1-antihistamines.
Journal: Pharmacology & toxicology 20011001
Title: Pharmacokinetics of epinastine and a possible mechanism for double peaks in oral plasma concentration profiles.
Journal: Biological & pharmaceutical bulletin 20010701
Title: Effect of H1-antagonists on spatial memory deficit evaluated by 8-arm radial maze in rats.
Journal: Acta pharmacologica Sinica 20010701
Title: Effects of cetirizine and epinastine on the skin response to histamine iontophoresis.
Journal: Journal of dermatological science 20010101
Title: Treatment of urticaria. An evidence-based evaluation of antihistamines.
Journal: American journal of clinical dermatology 20010101
Title: A new model of allergic rhinitis in rats by topical sensitization and evaluation of H(1)-receptor antagonists.
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Title: Epinastine, a nonsedating histamine H1 receptor antagonist, has a negligible effect on HERG channel.
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