652-67-5,MFCD00064827
Catalog No.:AA003R2T

652-67-5 | Isosorbide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5g
98%
in stock  
$6.00   $4.00
- +
10g
98%
in stock  
$9.00   $6.00
- +
25g
98%
in stock  
$15.00   $10.00
- +
100g
98%
in stock  
$45.00   $31.00
- +
250g
98%
in stock  
$76.00   $53.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA003R2T
Chemical Name:
Isosorbide
CAS Number:
652-67-5
Molecular Formula:
C6H10O4
Molecular Weight:
146.1412
MDL Number:
MFCD00064827
SMILES:
O[C@@H]1CO[C@H]2[C@@H]1OC[C@@H]2O
NSC Number:
40725
Properties
Properties
 
BP:
372.1°C at 760 mmHg  
Form:
Solid  
MP:
60-63°C(lit.);  
Refractive Index:
45 ° (C=5, H2O)  
Stability:
Hygroscopic  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
122  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
0  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-1.4  

Upstream Synthesis Route

[1]Patent:EP2615093,2013,A1,.Locationinpatent:Paragraph0109

[2]Patent:WO2013/107735,2013,A1,.Locationinpatent:Paragraph00111

[3]Patent:US2014/371472,2014,A1,.Locationinpatent:Paragraph0041-0055

[4]ChemSusChem,2013,vol.6,#4,p.693-700

[5]Patent:WO2016/137833,2016,A1,.Locationinpatent:Paragraph00110-00113

[6]AdvancedSynthesisandCatalysis,2018,vol.360,#12,p.2358-2363

[1]ChemSusChem,2010,vol.3,#5,p.566-570

[2]Patent:US2009/253920,2009,A1,.Locationinpatent:Page/Pagecolumn3

[3]Patent:WO2012/15616,2012,A1,.Locationinpatent:Page/Pagecolumn23

[1]Patent:CN105646514,2016,A,.Locationinpatent:Paragraph0041;0042;0043;0044;0045;0046

[2]RSCAdvances,2015,vol.5,#31,p.24139-24143

[1]Patent:CN105646514,2016,A,.Locationinpatent:Paragraph0029;0030;0031;0032;0033;0034

[1]Patent:CN105646514,2016,A,.Locationinpatent:Paragraph0029;0030;0031;0032;0033;0034

Literature

Title: Design and synthesis of highly potent HIV-1 protease inhibitors with novel isosorbide-derived P2 ligands.

Journal: Bioorganic & medicinal chemistry letters 20140601

Title: Rheological characterization and permeation behavior of poloxamer 407-based systems containing 5-aminolevulinic acid for potential application in photodynamic therapy.

Journal: International journal of pharmaceutics 20121101

Title: Effect of direction (epidermis-to-dermis and dermis-to-epidermis) on the permeation of several chemical compounds through full-thickness skin and stripped skin.

Journal: Pharmaceutical research 20120901

Title: Synthesis of five-membered cyclic ethers by reaction of 1,4-diols with dimethyl carbonate.

Journal: ChemSusChem 20120801

Title: Synthesis and biocompatibility properties of polyester containing various diacid based on isosorbide.

Journal: Journal of biomaterials applications 20120701

Title: Vasospastic angina with J-wave pattern and polymorphic ventricular tachycardia effectively treated with quinidine.

Journal: Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 20120701

Title: Differential inhibition of tumour cell-induced platelet aggregation by the nicotinate aspirin prodrug (ST0702) and aspirin.

Journal: British journal of pharmacology 20120601

Title: Formulation optimization, skin irritation, and efficacy characterization of a novel skin-lightening agent.

Journal: Journal of cosmetic dermatology 20120601

Title: Urgent need for WHO's reform to prioritise core functions.

Journal: Lancet (London, England) 20120519

Title: Investigation on synthesis and properties of isosorbide based bis-GMA analogue.

Journal: Journal of materials science. Materials in medicine 20120501

Title: A homochiral luminescent 2D porous coordination polymer with collagen-type triple helices showing selective guest inclusion.

Journal: Inorganic chemistry 20120416

Title: In vivo impact of prodrug isosorbide-5-nicotinate-2-aspirinate on lipids and prostaglandin D2: is this a new immediate-release therapeutic option for niacin?

Journal: Atherosclerosis 20120401

Title: Characterization of polysorbate 80 with liquid chromatography mass spectrometry and nuclear magnetic resonance spectroscopy: specific determination of oxidation products of thermally oxidized polysorbate 80.

Journal: Journal of pharmaceutical and biomedical analysis 20120325

Title: Bleeding from ruptured oesophageal varices: propranolol for primary prevention.

Journal: Prescrire international 20120301

Title: Subarachnoid hemorrhage mimicking leakage of contrast media after coronary angiography.

Journal: Korean circulation journal 20120301

Title: Non surgical therapy for anal fissure.

Journal: The Cochrane database of systematic reviews 20120215

Title: Isosorbide as a renewable platform chemical for versatile applications--quo vadis?

Journal: ChemSusChem 20120109

Title: Trends in qualifying biomarkers in drug safety. Consensus of the 2011 meeting of the spanish society of clinical pharmacology.

Journal: Frontiers in pharmacology 20120101

Title: Oral drug delivery systems comprising altered geometric configurations for controlled drug delivery.

Journal: International journal of molecular sciences 20120101

Title: Metoprolol-induced visual hallucinations: a case series.

Journal: Journal of medical case reports 20120101

Title: Prostaglandin-induced cervical remodelling in humans in the first trimester is associated with increased expression of specific tight junction, but not gap junction proteins.

Journal: Journal of translational medicine 20120101

Title: Computable features required to evaluate the efficacy of drugs and a universal algorithm to find optimally effective drug in a drug complex.

Journal: PloS one 20120101

Title: Sulfotanshinone sodium injection for unstable angina pectoris: a systematic review of randomized controlled trials.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Trial of Chinese medicine Wu-Ling-San for acute low-tone hearing loss.

Journal: ORL; journal for oto-rhino-laryngology and its related specialties 20120101

Title: Cardiorenal benefits of early versus late cyclosporine to sirolimus conversion in a rat model.

Journal: Journal of pharmacology & pharmacotherapeutics 20120101

Title: A comprehensive review of hypertension in pregnancy.

Journal: Journal of pregnancy 20120101

Title: The molecular mechanism of action of the CR6261-Azichromycin combination found through computational analysis.

Journal: PloS one 20120101

Title: Renewable rigid diamines: efficient, stereospecific synthesis of high purity isohexide diamines.

Journal: ChemSusChem 20111216

Title: Spinal epidural hematoma related to an epidural catheter in a cardiac surgery patient -A case report-.

Journal: Korean journal of anesthesiology 20111201

Title: Characterization of a pseudo ternary phase diagram of poloxamer 407 systems for potential application of 5-aminolevulinic acid in photodynamic therapy.

Journal: International journal of pharmaceutics 20111128

Title: Randomized controlled trial of the efficacy of isosorbide-SR addition to current treatment in medical expulsive therapy for ureteral calculi.

Journal: Urological research 20111001

Title: A dual acting compound releasing nitric oxide (NO) and ibuprofen, NCX 320, shows significant therapeutic effects in a mouse model of muscular dystrophy.

Journal: Pharmacological research 20110901

Title: Pituitary apoplexy.

Journal: Indian journal of endocrinology and metabolism 20110901

Title: Telomerisation of 1,3-butadiene with 1,4:3,6-dianhydrohexitols: an atom-economic and selective synthesis of amphiphilic monoethers from agro-based diols.

Journal: ChemSusChem 20110822

Title: Renewable chemicals: dehydroxylation of glycerol and polyols.

Journal: ChemSusChem 20110822

Title: Synthesis and characterization of chiral compounds containing cationic groups as chiral dopants in liquid crystals.

Journal: Journal of colloid and interface science 20110815

Title: Synthesis and foaming properties of new anionic surfactants based on a renewable building block: sodium dodecyl isosorbide sulfates.

Journal: Journal of colloid and interface science 20110815

Title: Influence of anti-inflammatory and vasoactive drugs on microcirculation and angiogenesis after burn in mice.

Journal: Burns : journal of the International Society for Burn Injuries 20110601

Title: Separation of polysorbates by liquid chromatography on a HILIC column and identification of peaks by MALDI-TOF MS.

Journal: Analytical and bioanalytical chemistry 20110601

Title: Soybean oil-isosorbide-based waterborne polyurethane-urea dispersions.

Journal: ChemSusChem 20110321

Title: Association of GSTM1 null polymorphism with isosorbide-5-mononitrate cardiovascular response and involvement of CGRP in healthy Chinese male volunteers.

Journal: Pharmacogenetics and genomics 20110301

Title: Depressogenic effects of medications: a review.

Journal: Dialogues in clinical neuroscience 20110301

Title: Management of angle closure glaucoma.

Journal: Indian journal of ophthalmology 20110101

Title: Improvement of primary care for patients with chronic heart failure: a study protocol for a cluster randomised trial comparing two strategies.

Journal: Implementation science : IS 20110101

Title: Development and Validation of a Reversed-phase HPLC Method for Simultaneous Determination of Aspirin, Atorvastatin Calcium and Clopidogrel Bisulphate in Capsules.

Journal: Indian journal of pharmaceutical sciences 20110101

Title: Lipase-catalyzed synthesis of isosorbide monoricinoleate: process optimization by response surface methodology.

Journal: Bioresource technology 20101101

Title: Chest pain during upper endoscopy.

Journal: Journal of neurogastroenterology and motility 20101001

Title: Differences between nitrates: role of isosorbide 2-mononitrate.

Journal: Journal of cardiovascular medicine (Hagerstown, Md.) 20100701

Title: Intracranial hemorrhage in full-term newborns: a hospital-based cohort study.

Journal: Neuroradiology 20100601

Title: Norepinephrine remains increased in the six-minute walking test after heart transplantation.

Journal: Clinics (Sao Paulo, Brazil) 20100601

Title: Green synthesis of dimethyl isosorbide.

Journal: ChemSusChem 20100525

Title: Synthesis and glycosidase inhibitory activity of 1-amino-3,6-anhydro-1-deoxy-D-sorbitol derivatives.

Journal: Bioorganic chemistry 20100401

Title: Chronic thromboembolic pulmonary hypertension.

Journal: Current treatment options in cardiovascular medicine 20100401

Title: Arterial stiffness in the young: assessment, determinants, and implications.

Journal: Korean circulation journal 20100401

Title: Cellulose conversion to isosorbide in molten salt hydrate media.

Journal: ChemSusChem 20100322

Title: Isosorbide-2-benzyl carbamate-5-salicylate, a peripheral anionic site binding subnanomolar selective butyrylcholinesterase inhibitor.

Journal: Journal of medicinal chemistry 20100211

Title: Comparison of FTIR and particle mass spectrometry for the measurement of particulate organic nitrates.

Journal: Environmental science & technology 20100201

Title: Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability.

Journal: Bioorganic & medicinal chemistry 20100201

Title: Outcome of coronary plaque burden: a 10-year follow-up of aggressive medical management.

Journal: Cardiovascular ultrasound 20100101

Title: Effects of sitagliptin treatment on dysmetabolism, inflammation, and oxidative stress in an animal model of type 2 diabetes (ZDF rat).

Journal: Mediators of inflammation 20100101

Title: A comparison of the short-term outcome in patients with acute low-tone sensorineural hearing loss.

Journal: ORL; journal for oto-rhino-laryngology and its related specialties 20100101

Title: Recent advances in the management of chronic stable angina II. Anti-ischemic therapy, options for refractory angina, risk factor reduction, and revascularization.

Journal: Vascular health and risk management 20100101

Title: Effects of Withania somnifera (Ashwagandha) and Terminalia arjuna (Arjuna) on physical performance and cardiorespiratory endurance in healthy young adults.

Journal: International journal of Ayurveda research 20100101

Title: Mechanical valve dysfunction in yemen.

Journal: Heart views : the official journal of the Gulf Heart Association 20100101

Title: Is tetrahydrobiopterin a therapeutic option in diabetic hypertensive patients?

Journal: Integrated blood pressure control 20100101

Title: Gender differences in tail-skin flushing induced by nitrates and phosphodiesterase type 5 inhibitors in a climacteric mouse model.

Journal: European journal of pharmacology 20091210

Title: Amphiphilic properties of hydrotropes derived from isosorbide: endo/exo isomeric effects and temperature dependence.

Journal: Langmuir : the ACS journal of surfaces and colloids 20091201

Title: Isosorbide-based aspirin prodrugs: integration of nitric oxide releasing groups.

Journal: Journal of medicinal chemistry 20091112

Title: Novel Ti(IV) and Zr(IV) complexes and their application in the ring-opening polymerisation of cyclic esters.

Journal: Dalton transactions (Cambridge, England : 2003) 20091107

Title: Endolymphatic hydrops and therapeutic effects are visualized in 'atypical' Meniere's disease.

Journal: Acta oto-laryngologica 20091101

Title: (1S,4S,5S,8R)-8-Nitro-oxy-2,6-dioxa-bicyclo-[3.3.0]octan-4-yl 3,4,5-triacetoxy-benzoate.

Journal: Acta crystallographica. Section E, Structure reports online 20091101

Title: A Case of Dropped Head plus Syndrome.

Journal: Journal of clinical medicine research 20091001

Title: Microporous biodegradable polyurethane membranes for tissue engineering.

Journal: Journal of materials science. Materials in medicine 20090801

Title: Expression of COX-2, NF-kappaB-p65, NF-kappaB-p50 and IKKalpha in malignant and adjacent normal human colorectal tissue.

Journal: British journal of cancer 20090707

Title: Carotid intima-media thickness and pulse wave velocity after recovery from kawasaki disease.

Journal: Korean circulation journal 20090701

Title: Vestibular type of Mondini anomalies with BPPV and Meniere's disease-like symptoms.

Journal: Auris, nasus, larynx 20090401

Title: Effect of nicorandil on proteinuria in well controlled hypertensive patients.

Journal: Journal of hypertension 20090301

Title: Too young to talk of vertigo?

Journal: Lancet (London, England) 20090207

Title: Myocardial infarction with normal coronary arteries: a case report and review of the literature.

Journal: Journal of medical case reports 20090101

Title: High dose nitroglycerin treatment in a patient with cardiac arrest: a case report.

Journal: Journal of medical case reports 20090101

Title: Vardenafil for the treatment of erectile dysfunction: an overview of the clinical evidence.

Journal: Clinical interventions in aging 20090101

Title: Discovery of a 'true' aspirin prodrug.

Journal: Journal of medicinal chemistry 20081225

Title: The relationship between heart rate reserve and oxygen uptake reserve in heart failure patients on optimized and non-optimized beta-blocker therapy.

Journal: Clinics (Sao Paulo, Brazil) 20081201

Title: Incorporation of isosorbide into poly(butylene terephthalate) via solid-state polymerization.

Journal: Biomacromolecules 20081101

Title: Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors.

Journal: Journal of medicinal chemistry 20081023

Title: Novel isosorbide di-ester compounds as inhibitors of acetylcholinesterase.

Journal: Chemico-biological interactions 20080925

Title: Pharmacological effects of a novel isosorbide-based butyrylcholinesterase inhibitor.

Journal: Chemico-biological interactions 20080925

Title: Head-up tilt table testing in syncope: safety and efficiency of isosorbide versus isoproterenol in pediatric population.

Journal: American heart journal 20080901

Title: Heart rate dynamics during a treadmill cardiopulmonary exercise test in optimized beta-blocked heart failure patients.

Journal: Clinics (Sao Paulo, Brazil) 20080801

Title: [A cost-effectiveness study of hepatic venous pressure gradient measurement in the secondary prevention of variceal bleeding].

Journal: Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 20080701

Title: Combined effect of liposomalization and addition of glycerol on the transdermal delivery of isosorbide 5-nitrate in rat skin.

Journal: International journal of pharmaceutics 20080605

Title: Physicochemical characterisation of a novel thermogelling formulation for percutaneous penetration of 5-aminolevulinic acid.

Journal: Journal of pharmaceutical sciences 20080601

Title: Photofabrication of two-dimensional quasi-crystal patterns on UV-curable molecular azo glass films.

Journal: Langmuir : the ACS journal of surfaces and colloids 20080318

Title: Case report: a case of intractable Meniere's disease treated with autogenic training.

Journal: BioPsychoSocial medicine 20080101

Title: Current endoscopic therapy of variceal bleeding.

Journal: Best practice & research. Clinical gastroenterology 20080101

Title: Intracoronary administration of isosorbide dinitrate induced severely slow flow and transient ST-segment elevation.

Journal: Angiology 20080101

Title: Oxidative stress in children late after Kawasaki disease: relationship with carotid atherosclerosis and stiffness.

Journal: BMC pediatrics 20080101

Title: Effect of penetration modifiers on the dermal and transdermal delivery of drugs and cosmetic active ingredients.

Journal: Skin pharmacology and physiology 20080101

Title: Value of symptoms to predict tilt testing outcome in patients with clinical suspicion of vasovagal syncope.

Journal: Archives of medical research 20070701

Title: Neuropsychiatric consequences of cardiovascular medications.

Journal: Dialogues in clinical neuroscience 20070301

Title: High performance liquid chromatography-electrospray ionization mass spectrometric determination of isosorbide 5-mononitrate in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070201

Title: Potential and utilization of thermophiles and thermostable enzymes in biorefining.

Journal: Microbial cell factories 20070101

Title: Inhibition of NAD(P)H oxidase reduces apoptosis and avascular retina in an animal model of retinopathy of prematurity.

Journal: Molecular vision 20070101

Title: [Milestones of cardiovascular therapy. III. Nitroglycerin].

Journal: Casopis lekaru ceskych 20070101

Title: Occlusal management for a patient with aural symptoms of unknown etiology: a case report.

Journal: Journal of medical case reports 20070101

Title: Prevention of recurrent esophageal variceal hemorrhage: review and current recommendations.

Journal: Journal of clinical gastroenterology 20070101

Title: Stability of benzoyl peroxide in aromatic ester-containing topical formulations.

Journal: Pharmaceutical development and technology 20070101

Title: Co- and terpolyesters based on isosorbide and succinic acid for coating applications: synthesis and characterization.

Journal: Biomacromolecules 20061201

Title: Effects of simple and complex motion patterns on gene expression of chondrocytes seeded in 3D scaffolds.

Journal: Tissue engineering 20061101

Title: Vestibular evoked myogenic potentials in acute acoustic trauma.

Journal: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 20061001

Title: Organic solvents as vehicles for precipitating liquid embolics: a comparative angiotoxicity study with superselective injections of swine rete mirabile.

Journal: AJNR. American journal of neuroradiology 20061001

Title: [Prevention of variceal bleeding and measurement of hepatic vein pressure gradient].

Journal: The Korean journal of hepatology 20060901

Title: Effectiveness of oral route isosorbide 5-mononitrate on peritoneal solute and fluid transports in CAPD patients.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20060801

Title: Aortic responsiveness to nitric oxide is affected by seasonal variation.

Journal: Pathophysiology : the official journal of the International Society for Pathophysiology 20060501

Title: Endolymphatic hydrops as a cause of audio-vestibular manifestations in relapsing polychondritis.

Journal: Acta oto-laryngologica 20060501

Title: Coronary artery spasm and the polymorphisms of the endothelial nitric oxide synthase gene.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20060401

Title: Composition analysis of two batches of polysorbate 60 using MS and NMR techniques.

Journal: Journal of pharmaceutical and biomedical analysis 20060318

Title: Quantification of isosorbide 5-mononitrate in human plasma by liquid chromatography-tandem mass spectrometry using atmospheric pressure photoionization.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060307

Title: Should drug therapy be personalized based on race?

Journal: The Annals of pharmacotherapy 20060301

Title: Endothelial dysfunction in patients with ulcerative colitis.

Journal: Inflammatory bowel diseases 20060301

Title: Pharmacological reduction of portal pressure and long-term risk of first variceal bleeding in patients with cirrhosis.

Journal: The American journal of gastroenterology 20060301

Title: Cerebrovascular blood flow during the near syncopal phase of head-up tilt test: a comparative study in different types of neurally mediated syncope.

Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20060301

Title: Cholesteric polymer guest-host mixture with circularly polarized fluorescence: two ways for phototuning of polarization and its intensity.

Journal: The journal of physical chemistry. A 20060223

Title: Low serum bilirubin levels are independently and inversely related to impaired flow-mediated vasodilation and increased carotid intima-media thickness in both men and women.

Journal: Atherosclerosis 20060201

Title: Use of simultaneous pressure and velocity measurements to estimate arterial wave speed at a single site in humans.

Journal: American journal of physiology. Heart and circulatory physiology 20060201

Title: [Usefulness of sublingual isosorbide to assess the reversibility of pulmonary hypertension in cardiac transplant candidates].

Journal: Revista medica de Chile 20060201

Title: Antidiuretic hormone and osmolality in isosorbide therapy and glycerol test.

Journal: ORL; journal for oto-rhino-laryngology and its related specialties 20060101

Title: IMOP: randomised placebo controlled trial of outpatient cervical ripening with isosorbide mononitrate (IMN) prior to induction of labour - clinical trial with analyses of efficacy, cost effectiveness and acceptability.

Journal: BMC pregnancy and childbirth 20060101

Title: Allergic and nonallergic reactions to nitroglycerin.

Journal: Allergy and asthma proceedings 20060101

Title: Novel isosorbide-based substrates for human butyrylcholinesterase.

Journal: Chemico-biological interactions 20051215

Title: Synthesis and structure activity relationships (SAR) of a new class of potent and selective butyrylcholinesterase inhibitors.

Journal: Chemico-biological interactions 20051215

Title: Isosorbide dinitrate and hydralazine hydrochloride: a review of efficacy and safety.

Journal: Expert review of cardiovascular therapy 20051101

Title: Preservation of platelet responsiveness to nitroglycerine despite development of vascular nitrate tolerance.

Journal: British journal of clinical pharmacology 20051001

Title: Effect of preventive and regressive isosorbide 5-mononitrate treatment on catecholamine levels in plasma, platelets, adrenals, left ventricle and aorta in cyclosporin A-induced hypertensive rats.

Journal: Life sciences 20050930

Title: Cerebral blood flow during supine rest and the first minute of head-up tilt in patients with orthostatic intolerance.

Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20050901

Title: Cooperative type of platelet hypersensitivity to ADP.

Journal: Bulletin of experimental biology and medicine 20050901

Title: The impact of race on response to RAAS inhibition.

Journal: Current heart failure reports 20050801

Title: Short-term medical management of hydrocephalus.

Journal: Expert opinion on pharmacotherapy 20050801

Title: BiDil raises questions about race as a marker.

Journal: Nature reviews. Drug discovery 20050801

Title: Direct gas measurements indicate that the novel cyclooxygenase inhibitor AZD3582 is an effective nitric oxide donor in vivo.

Journal: British journal of pharmacology 20050701

Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.

Journal: Chemical research in toxicology 20050601

Title: Hydrogen peroxide overload increases adriamycin-induced apoptosis of SaOS(2)FM, a manganese superoxide dismutase-overexpressing human osteosarcoma cell line.

Journal: International journal of oncology 20050501

Title: [Nitric oxide and cardiologic drugs].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20050501

Title: Manganese superoxide dismutase overexpression changes plating efficiency bidirectionally according to change in redox for SaOS2 human osteosarcoma cell line.

Journal: International journal of oncology 20050401

Title: The coming of age of multicultural medicine.

Journal: PLoS medicine 20050301

Title: Isosorbide delays gentamicin-induced vestibular sensory cell death.

Journal: ORL; journal for oto-rhino-laryngology and its related specialties 20050101

Title: BiDil: false promises: faulty statistics and reasoning have lead to the first 'racial medicine'.

Journal: Genewatch : a bulletin of the Committee for Responsible Genetics 20050101

Title: [Comparative study of propranolol versus propranolol plus isosorbide 5-mononitrate in portal hypertension in cirrhotics. Evaluating splanchnic hemodynamics with color Doppler ultrasound].

Journal: Revista de gastroenterologia de Mexico 20050101

Title: Vestibular evoked myogenic potentials in acute low-tone sensorineural hearing loss.

Journal: The Laryngoscope 20041201

Title: Glycosylation of l,4:3,6-dianhydro-D-glucitol (isosorbide).

Journal: Carbohydrate research 20041004

Title: Locally applied isosorbide decreases bone resorption in experimental periodontitis in rats.

Journal: Journal of periodontology 20040901

Title: Cepharanthin enhances adriamycin sensitivity by synergistically accelerating apoptosis for adriamycin-resistant osteosarcoma cell lines, SaOS2-AR and SaOS2 F-AR.

Journal: International journal of oncology 20040701

Title: [Therapy with NO donors-antiatherogenic and antioxidant actions].

Journal: Herz 20040201

Title: Treatment of aphthous stomatitis with saturated potassium nitrate/dimethyl isosorbide.

Journal: Quintessence international (Berlin, Germany : 1985) 20040201

Title: Comparison of the relaxant effects of a new oxime-nitrate derived from isosorbide-5-mononitrate and the parent drug.

Journal: Arzneimittel-Forschung 20040101

Title: Pharmacokinetics of three organic nitrates in Chinese healthy male volunteers.

Journal: Arzneimittel-Forschung 20040101

Title: Treatment of portal hypertension with NCX-1000, a liver-specific NO donor. A review of its current status.

Journal: Cardiovascular drug reviews 20040101

Title: Endothelial dysfunction and nitric oxide enhancing therapy: a new approach to the treatment of heart failure.

Journal: Congestive heart failure (Greenwich, Conn.) 20040101

Title: Time course of dehydrating effects of isosorbide on experimentally induced endolymphatic hydrops in guinea pigs.

Journal: ORL; journal for oto-rhino-laryngology and its related specialties 20040101

Title: Single oral dose study of two isosorbide-based aspirin prodrugs in the dog.

Journal: The Journal of pharmacy and pharmacology 20031001

Title: Simultaneous determination of aspirin and isosorbide 5-mononitrate in formulation by reversed phase high pressure liquid chromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20030821

Title: Effect of different intensities of exercise on endothelium-dependent vasodilation in humans: role of endothelium-dependent nitric oxide and oxidative stress.

Journal: Circulation 20030805

Title: Comparative study of the use of diltiazem as an antispasmodic drug in coronary angiography via the transradial approach.

Journal: Arquivos brasileiros de cardiologia 20030701

Title: Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-kappa B and I kappa B kinase-alpha in human colorectal cancer epithelial cells.

Journal: British journal of cancer 20030519

Title: In vivo cardioprotection by N-acetylcysteine and isosorbide 5-mononitrate in a rat model of ischemia-reperfusion.

Journal: Cardiovascular drugs and therapy 20030501

Title: Early vasoreactive profile of skeletonized versus pedicled internal thoracic artery grafts.

Journal: The Journal of thoracic and cardiovascular surgery 20030301

Title: Capping carious exposed pulps with potassium nitrate, dimethyl isosorbide, polycarboxylate cement.

Journal: Dentistry today 20030101

Title: [Clinical study on 'sini' decoction in treating stenocardia for coronary heart disease].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20030101

Title: Possible mechanisms of hypotension produced 70% alcoholic extract of Terminalia arjuna (L.) in anaesthetized dogs.

Journal: BMC complementary and alternative medicine 20030101

Title: Coronary artery spasm associated with a moderately severe atherosclerotic stenosis in the proximal LAD.

Journal: The Journal of invasive cardiology 20021201

Title: MDR1-mediated interaction of digoxin with antiarrhythmic or antianginal drugs.

Journal: Biological & pharmaceutical bulletin 20021201

Title: Medical treatment of myocardial ischemia in coronary artery disease: effect of drug regime and irregular dosing in the CAPE II trial.

Journal: Journal of the American College of Cardiology 20020904

Title: Isosorbide-based aspirin prodrugs. II. Hydrolysis kinetics of isosorbide diaspirinate.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20020901

Title: A long-term transdermal nitric oxide donor improves uteroplacental circulation in women with preeclampsia.

Journal: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 20020801

Title: Transdermal delivery of highly lipophilic drugs: in vitro fluxes of antiestrogens, permeation enhancers, and solvents from liquid formulations.

Journal: Pharmaceutical research 20020501

Title: Dual effect of local application of nitric oxide donors in a model of incision pain in rats.

Journal: European journal of pharmacology 20020419

Title: Nitric oxide induced cervical ripening in the human: Involvement of cyclic guanosine monophosphate, prostaglandin F(2 alpha), and prostaglandin E(2).

Journal: American journal of obstetrics and gynecology 20020401

Title: Crystal structure of the cyclomaltohexaose (alpha-cyclodextrin) complex with isosorbide dinitrate. Guest-modulated channel-type structure.

Journal: Carbohydrate research 20020315

Title: Prevention of varices rebleeding: are drugs better after all?

Journal: Gastroenterology 20020301

Title: Role of race in the pharmacotherapy of heart failure.

Journal: The Annals of pharmacotherapy 20020301

Title: [Pulmonary hypertension and pregnancy].

Journal: Revista medica de Chile 20020201

Title: [Benign intracranial hypertension resulting from corticosteroid withdrawal: case report].

Journal: No shinkei geka. Neurological surgery 20020101

Title: Nadolol and isosorbide prevented recurrent variceal bleeding better than did endoscopic ligation in cirrhosis.

Journal: ACP journal club 20020101

Title: [Contemporary approaches to diagnosis and management of chronic heart failure (summary of the American College of Cardiology/American Heart Association Guidelines)].

Journal: Kardiologiia 20020101

Title: Pharmacological modulation of human gastric volumes demonstrated noninvasively using SPECT imaging.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20011201

Title: Appropriateness of nitrate use in a general medicine population.

Journal: The Annals of pharmacotherapy 20011101

Title: [A case of primary antiphospholipid syndrome complicated with pulmonary hypertension].

Journal: Ryumachi. [Rheumatism] 20011001

Title: Endoscopic ligation compared with combined treatment with nadolol and isosorbide mononitrate to prevent recurrent variceal bleeding.

Journal: The New England journal of medicine 20010830

Title: Development of a new reaction system for the synthesis of highly optically active alpha,gamma-substituted gamma-butyrolactones.

Journal: The Journal of organic chemistry 20010601

Title: Antimitogenic actions of organic nitrates are potentiated by sildenafil and mediated via activation of protein kinase A.

Journal: Molecular pharmacology 20010501

Title: The human G-protein beta3 subunit C825T polymorphism is associated with coronary artery vasoconstriction.

Journal: European heart journal 20010501

Title: Relative bioavailability of two isosorbide dinitrate sublingual tablet formulations administered as single doses in healthy subjects.

Journal: International journal of clinical pharmacology and therapeutics 20010501

Title: Isosorbide dinitrate in the treatment of anal fissure: a randomised, prospective, double blind, placebo-controlled trial.

Journal: The European journal of surgery = Acta chirurgica 20010501

Title: Variant angina with a strong spasmodic trait.

Journal: International journal of cardiology 20010101

Title: [Utility of echo enhancers in the study of pulmonary circulation time].

Journal: Gaceta medica de Mexico 20010101

Title: [The effect of long-term administration of isosorbide 5-mononitrate (Mononit), nitric oxide donor, on gallbladder emptying in patients with chronic stable angina].

Journal: Wiadomosci lekarskie (Warsaw, Poland : 1960) 20010101

Title: Internet-based prescription of sildenafil: a 2104-patient series.

Journal: Journal of medical Internet research 20010101

Title: Potentiating potassium nitrate's desensitization with dimethyl isosorbide.

Journal: General dentistry 20010101

Title: Life threatening coronary artery spasm in childhood Kimura's disease.

Journal: Heart (British Cardiac Society) 20000801

Title: Smooth muscle cell expression of type I cyclic GMP-dependent protein kinase is suppressed by continuous exposure to nitrovasodilators, theophylline, cyclic GMP, and cyclic AMP.

Journal: The Journal of clinical investigation 19971115

Title: Relationship between nitric oxide and platelet-activating factor in castor-oil induced mucosal injury in the rat duodenum.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19960501

Title: Myocardial ischemia induced by topical use of 5-fluorouracil.

Journal: International journal of cardiology 19950501

Title: Renal and hepatic impairment in association with diclofenac administration.

Journal: Postgraduate medical journal 19890701

Title: Experimental gentamicin nephrotoxicity: effect of streptozotocin-induced diabetes.

Journal: The Journal of pharmacology and experimental therapeutics 19850401

Title: Rose M, et, al. Isosorbide as a renewable platform chemical for versatile applications--quo vadis? ChemSusChem. 2012 Jan 9;5(1):167-76.

Title: Nozawa I, et, al. Efficacy of long-term administration of isosorbide for Ménière's disease. ORL J Otorhinolaryngol Relat Spec. May-Jun 1995;57(3):135-40.

Title: Newman RA, et, al. Gallium nitrate (NSC-15200) induced toxicity in the rat: a pharmacologic, histopathologic and microanalytical investigation. Cancer. 1979 Nov;44(5):1728-40.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:652-67-5 Molecular Formula|652-67-5 MDL|652-67-5 SMILES|652-67-5 Isosorbide
Catalog No.: AA003R2T
652-67-5,MFCD00064827
652-67-5 | Isosorbide
Pack Size: 5g
Purity: 98%
in stock
$6.00 $4.00
Pack Size: 10g
Purity: 98%
in stock
$9.00 $6.00
Pack Size: 25g
Purity: 98%
in stock
$15.00 $10.00
Pack Size: 100g
Purity: 98%
in stock
$45.00 $31.00
Pack Size: 250g
Purity: 98%
in stock
$76.00 $53.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA003R2T
Chemical Name: Isosorbide
CAS Number: 652-67-5
Molecular Formula: C6H10O4
Molecular Weight: 146.1412
MDL Number: MFCD00064827
SMILES: O[C@@H]1CO[C@H]2[C@@H]1OC[C@@H]2O
NSC Number: 40725
Properties
BP: 372.1°C at 760 mmHg  
Form: Solid  
MP: 60-63°C(lit.);  
Refractive Index: 45 ° (C=5, H2O)  
Stability: Hygroscopic  
Storage: Inert atmosphere;Room Temperature;  
Complexity: 122  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 4  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 10  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 0  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: -1.4  
Upstream Synthesis Route
652-67-5    641-74-7    641-74-7 

[1]Patent:EP2615093,2013,A1,.Locationinpatent:Paragraph0109

[2]Patent:WO2013/107735,2013,A1,.Locationinpatent:Paragraph00111

[3]Patent:US2014/371472,2014,A1,.Locationinpatent:Paragraph0041-0055

[4]ChemSusChem,2013,vol.6,#4,p.693-700

[5]Patent:WO2016/137833,2016,A1,.Locationinpatent:Paragraph00110-00113

[6]AdvancedSynthesisandCatalysis,2018,vol.360,#12,p.2358-2363

616-38-6    652-67-5    5306-85-4 

[1]ChemSusChem,2010,vol.3,#5,p.566-570

[2]Patent:US2009/253920,2009,A1,.Locationinpatent:Page/Pagecolumn3

[3]Patent:WO2012/15616,2012,A1,.Locationinpatent:Page/Pagecolumn23

110-71-4    652-67-5    162426-86-0    6941-54-4    5306-85-4 

[1]Patent:CN105646514,2016,A,.Locationinpatent:Paragraph0041;0042;0043;0044;0045;0046

[2]RSCAdvances,2015,vol.5,#31,p.24139-24143

150-78-7    652-67-5    162426-86-0    6941-54-4    5306-85-4 

[1]Patent:CN105646514,2016,A,.Locationinpatent:Paragraph0029;0030;0031;0032;0033;0034

109-87-5    652-67-5    162426-86-0    6941-54-4    5306-85-4 

[1]Patent:CN105646514,2016,A,.Locationinpatent:Paragraph0029;0030;0031;0032;0033;0034

Literature fold

Title: Design and synthesis of highly potent HIV-1 protease inhibitors with novel isosorbide-derived P2 ligands.

Journal: Bioorganic & medicinal chemistry letters20140601

Title: Rheological characterization and permeation behavior of poloxamer 407-based systems containing 5-aminolevulinic acid for potential application in photodynamic therapy.

Journal: International journal of pharmaceutics20121101

Title: Effect of direction (epidermis-to-dermis and dermis-to-epidermis) on the permeation of several chemical compounds through full-thickness skin and stripped skin.

Journal: Pharmaceutical research20120901

Title: Synthesis of five-membered cyclic ethers by reaction of 1,4-diols with dimethyl carbonate.

Journal: ChemSusChem20120801

Title: Synthesis and biocompatibility properties of polyester containing various diacid based on isosorbide.

Journal: Journal of biomaterials applications20120701

Title: Vasospastic angina with J-wave pattern and polymorphic ventricular tachycardia effectively treated with quinidine.

Journal: Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc20120701

Title: Differential inhibition of tumour cell-induced platelet aggregation by the nicotinate aspirin prodrug (ST0702) and aspirin.

Journal: British journal of pharmacology20120601

Title: Formulation optimization, skin irritation, and efficacy characterization of a novel skin-lightening agent.

Journal: Journal of cosmetic dermatology20120601

Title: Urgent need for WHO's reform to prioritise core functions.

Journal: Lancet (London, England)20120519

Title: Investigation on synthesis and properties of isosorbide based bis-GMA analogue.

Journal: Journal of materials science. Materials in medicine20120501

Title: A homochiral luminescent 2D porous coordination polymer with collagen-type triple helices showing selective guest inclusion.

Journal: Inorganic chemistry20120416

Title: In vivo impact of prodrug isosorbide-5-nicotinate-2-aspirinate on lipids and prostaglandin D2: is this a new immediate-release therapeutic option for niacin?

Journal: Atherosclerosis20120401

Title: Characterization of polysorbate 80 with liquid chromatography mass spectrometry and nuclear magnetic resonance spectroscopy: specific determination of oxidation products of thermally oxidized polysorbate 80.

Journal: Journal of pharmaceutical and biomedical analysis20120325

Title: Bleeding from ruptured oesophageal varices: propranolol for primary prevention.

Journal: Prescrire international20120301

Title: Subarachnoid hemorrhage mimicking leakage of contrast media after coronary angiography.

Journal: Korean circulation journal20120301

Title: Non surgical therapy for anal fissure.

Journal: The Cochrane database of systematic reviews20120215

Title: Isosorbide as a renewable platform chemical for versatile applications--quo vadis?

Journal: ChemSusChem20120109

Title: Trends in qualifying biomarkers in drug safety. Consensus of the 2011 meeting of the spanish society of clinical pharmacology.

Journal: Frontiers in pharmacology20120101

Title: Oral drug delivery systems comprising altered geometric configurations for controlled drug delivery.

Journal: International journal of molecular sciences20120101

Title: Metoprolol-induced visual hallucinations: a case series.

Journal: Journal of medical case reports20120101

Title: Prostaglandin-induced cervical remodelling in humans in the first trimester is associated with increased expression of specific tight junction, but not gap junction proteins.

Journal: Journal of translational medicine20120101

Title: Computable features required to evaluate the efficacy of drugs and a universal algorithm to find optimally effective drug in a drug complex.

Journal: PloS one20120101

Title: Sulfotanshinone sodium injection for unstable angina pectoris: a systematic review of randomized controlled trials.

Journal: Evidence-based complementary and alternative medicine : eCAM20120101

Title: Trial of Chinese medicine Wu-Ling-San for acute low-tone hearing loss.

Journal: ORL; journal for oto-rhino-laryngology and its related specialties20120101

Title: Cardiorenal benefits of early versus late cyclosporine to sirolimus conversion in a rat model.

Journal: Journal of pharmacology & pharmacotherapeutics20120101

Title: A comprehensive review of hypertension in pregnancy.

Journal: Journal of pregnancy20120101

Title: The molecular mechanism of action of the CR6261-Azichromycin combination found through computational analysis.

Journal: PloS one20120101

Title: Renewable rigid diamines: efficient, stereospecific synthesis of high purity isohexide diamines.

Journal: ChemSusChem20111216

Title: Spinal epidural hematoma related to an epidural catheter in a cardiac surgery patient -A case report-.

Journal: Korean journal of anesthesiology20111201

Title: Characterization of a pseudo ternary phase diagram of poloxamer 407 systems for potential application of 5-aminolevulinic acid in photodynamic therapy.

Journal: International journal of pharmaceutics20111128

Title: Randomized controlled trial of the efficacy of isosorbide-SR addition to current treatment in medical expulsive therapy for ureteral calculi.

Journal: Urological research20111001

Title: A dual acting compound releasing nitric oxide (NO) and ibuprofen, NCX 320, shows significant therapeutic effects in a mouse model of muscular dystrophy.

Journal: Pharmacological research20110901

Title: Pituitary apoplexy.

Journal: Indian journal of endocrinology and metabolism20110901

Title: Telomerisation of 1,3-butadiene with 1,4:3,6-dianhydrohexitols: an atom-economic and selective synthesis of amphiphilic monoethers from agro-based diols.

Journal: ChemSusChem20110822

Title: Renewable chemicals: dehydroxylation of glycerol and polyols.

Journal: ChemSusChem20110822

Title: Synthesis and characterization of chiral compounds containing cationic groups as chiral dopants in liquid crystals.

Journal: Journal of colloid and interface science20110815

Title: Synthesis and foaming properties of new anionic surfactants based on a renewable building block: sodium dodecyl isosorbide sulfates.

Journal: Journal of colloid and interface science20110815

Title: Influence of anti-inflammatory and vasoactive drugs on microcirculation and angiogenesis after burn in mice.

Journal: Burns : journal of the International Society for Burn Injuries20110601

Title: Separation of polysorbates by liquid chromatography on a HILIC column and identification of peaks by MALDI-TOF MS.

Journal: Analytical and bioanalytical chemistry20110601

Title: Soybean oil-isosorbide-based waterborne polyurethane-urea dispersions.

Journal: ChemSusChem20110321

Title: Association of GSTM1 null polymorphism with isosorbide-5-mononitrate cardiovascular response and involvement of CGRP in healthy Chinese male volunteers.

Journal: Pharmacogenetics and genomics20110301

Title: Depressogenic effects of medications: a review.

Journal: Dialogues in clinical neuroscience20110301

Title: Management of angle closure glaucoma.

Journal: Indian journal of ophthalmology20110101

Title: Improvement of primary care for patients with chronic heart failure: a study protocol for a cluster randomised trial comparing two strategies.

Journal: Implementation science : IS20110101

Title: Development and Validation of a Reversed-phase HPLC Method for Simultaneous Determination of Aspirin, Atorvastatin Calcium and Clopidogrel Bisulphate in Capsules.

Journal: Indian journal of pharmaceutical sciences20110101

Title: Lipase-catalyzed synthesis of isosorbide monoricinoleate: process optimization by response surface methodology.

Journal: Bioresource technology20101101

Title: Chest pain during upper endoscopy.

Journal: Journal of neurogastroenterology and motility20101001

Title: Differences between nitrates: role of isosorbide 2-mononitrate.

Journal: Journal of cardiovascular medicine (Hagerstown, Md.)20100701

Title: Intracranial hemorrhage in full-term newborns: a hospital-based cohort study.

Journal: Neuroradiology20100601

Title: Norepinephrine remains increased in the six-minute walking test after heart transplantation.

Journal: Clinics (Sao Paulo, Brazil)20100601

Title: Green synthesis of dimethyl isosorbide.

Journal: ChemSusChem20100525

Title: Synthesis and glycosidase inhibitory activity of 1-amino-3,6-anhydro-1-deoxy-D-sorbitol derivatives.

Journal: Bioorganic chemistry20100401

Title: Chronic thromboembolic pulmonary hypertension.

Journal: Current treatment options in cardiovascular medicine20100401

Title: Arterial stiffness in the young: assessment, determinants, and implications.

Journal: Korean circulation journal20100401

Title: Cellulose conversion to isosorbide in molten salt hydrate media.

Journal: ChemSusChem20100322

Title: Isosorbide-2-benzyl carbamate-5-salicylate, a peripheral anionic site binding subnanomolar selective butyrylcholinesterase inhibitor.

Journal: Journal of medicinal chemistry20100211

Title: Comparison of FTIR and particle mass spectrometry for the measurement of particulate organic nitrates.

Journal: Environmental science & technology20100201

Title: Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability.

Journal: Bioorganic & medicinal chemistry20100201

Title: Outcome of coronary plaque burden: a 10-year follow-up of aggressive medical management.

Journal: Cardiovascular ultrasound20100101

Title: Effects of sitagliptin treatment on dysmetabolism, inflammation, and oxidative stress in an animal model of type 2 diabetes (ZDF rat).

Journal: Mediators of inflammation20100101

Title: A comparison of the short-term outcome in patients with acute low-tone sensorineural hearing loss.

Journal: ORL; journal for oto-rhino-laryngology and its related specialties20100101

Title: Recent advances in the management of chronic stable angina II. Anti-ischemic therapy, options for refractory angina, risk factor reduction, and revascularization.

Journal: Vascular health and risk management20100101

Title: Effects of Withania somnifera (Ashwagandha) and Terminalia arjuna (Arjuna) on physical performance and cardiorespiratory endurance in healthy young adults.

Journal: International journal of Ayurveda research20100101

Title: Mechanical valve dysfunction in yemen.

Journal: Heart views : the official journal of the Gulf Heart Association20100101

Title: Is tetrahydrobiopterin a therapeutic option in diabetic hypertensive patients?

Journal: Integrated blood pressure control20100101

Title: Gender differences in tail-skin flushing induced by nitrates and phosphodiesterase type 5 inhibitors in a climacteric mouse model.

Journal: European journal of pharmacology20091210

Title: Amphiphilic properties of hydrotropes derived from isosorbide: endo/exo isomeric effects and temperature dependence.

Journal: Langmuir : the ACS journal of surfaces and colloids20091201

Title: Isosorbide-based aspirin prodrugs: integration of nitric oxide releasing groups.

Journal: Journal of medicinal chemistry20091112

Title: Novel Ti(IV) and Zr(IV) complexes and their application in the ring-opening polymerisation of cyclic esters.

Journal: Dalton transactions (Cambridge, England : 2003)20091107

Title: Endolymphatic hydrops and therapeutic effects are visualized in 'atypical' Meniere's disease.

Journal: Acta oto-laryngologica20091101

Title: (1S,4S,5S,8R)-8-Nitro-oxy-2,6-dioxa-bicyclo-[3.3.0]octan-4-yl 3,4,5-triacetoxy-benzoate.

Journal: Acta crystallographica. Section E, Structure reports online20091101

Title: A Case of Dropped Head plus Syndrome.

Journal: Journal of clinical medicine research20091001

Title: Microporous biodegradable polyurethane membranes for tissue engineering.

Journal: Journal of materials science. Materials in medicine20090801

Title: Expression of COX-2, NF-kappaB-p65, NF-kappaB-p50 and IKKalpha in malignant and adjacent normal human colorectal tissue.

Journal: British journal of cancer20090707

Title: Carotid intima-media thickness and pulse wave velocity after recovery from kawasaki disease.

Journal: Korean circulation journal20090701

Title: Vestibular type of Mondini anomalies with BPPV and Meniere's disease-like symptoms.

Journal: Auris, nasus, larynx20090401

Title: Effect of nicorandil on proteinuria in well controlled hypertensive patients.

Journal: Journal of hypertension20090301

Title: Too young to talk of vertigo?

Journal: Lancet (London, England)20090207

Title: Myocardial infarction with normal coronary arteries: a case report and review of the literature.

Journal: Journal of medical case reports20090101

Title: High dose nitroglycerin treatment in a patient with cardiac arrest: a case report.

Journal: Journal of medical case reports20090101

Title: Vardenafil for the treatment of erectile dysfunction: an overview of the clinical evidence.

Journal: Clinical interventions in aging20090101

Title: Discovery of a 'true' aspirin prodrug.

Journal: Journal of medicinal chemistry20081225

Title: The relationship between heart rate reserve and oxygen uptake reserve in heart failure patients on optimized and non-optimized beta-blocker therapy.

Journal: Clinics (Sao Paulo, Brazil)20081201

Title: Incorporation of isosorbide into poly(butylene terephthalate) via solid-state polymerization.

Journal: Biomacromolecules20081101

Title: Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors.

Journal: Journal of medicinal chemistry20081023

Title: Novel isosorbide di-ester compounds as inhibitors of acetylcholinesterase.

Journal: Chemico-biological interactions20080925

Title: Pharmacological effects of a novel isosorbide-based butyrylcholinesterase inhibitor.

Journal: Chemico-biological interactions20080925

Title: Head-up tilt table testing in syncope: safety and efficiency of isosorbide versus isoproterenol in pediatric population.

Journal: American heart journal20080901

Title: Heart rate dynamics during a treadmill cardiopulmonary exercise test in optimized beta-blocked heart failure patients.

Journal: Clinics (Sao Paulo, Brazil)20080801

Title: [A cost-effectiveness study of hepatic venous pressure gradient measurement in the secondary prevention of variceal bleeding].

Journal: Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva20080701

Title: Combined effect of liposomalization and addition of glycerol on the transdermal delivery of isosorbide 5-nitrate in rat skin.

Journal: International journal of pharmaceutics20080605

Title: Physicochemical characterisation of a novel thermogelling formulation for percutaneous penetration of 5-aminolevulinic acid.

Journal: Journal of pharmaceutical sciences20080601

Title: Photofabrication of two-dimensional quasi-crystal patterns on UV-curable molecular azo glass films.

Journal: Langmuir : the ACS journal of surfaces and colloids20080318

Title: Case report: a case of intractable Meniere's disease treated with autogenic training.

Journal: BioPsychoSocial medicine20080101

Title: Current endoscopic therapy of variceal bleeding.

Journal: Best practice & research. Clinical gastroenterology20080101

Title: Intracoronary administration of isosorbide dinitrate induced severely slow flow and transient ST-segment elevation.

Journal: Angiology20080101

Title: Oxidative stress in children late after Kawasaki disease: relationship with carotid atherosclerosis and stiffness.

Journal: BMC pediatrics20080101

Title: Effect of penetration modifiers on the dermal and transdermal delivery of drugs and cosmetic active ingredients.

Journal: Skin pharmacology and physiology20080101

Title: Value of symptoms to predict tilt testing outcome in patients with clinical suspicion of vasovagal syncope.

Journal: Archives of medical research20070701

Title: Neuropsychiatric consequences of cardiovascular medications.

Journal: Dialogues in clinical neuroscience20070301

Title: High performance liquid chromatography-electrospray ionization mass spectrometric determination of isosorbide 5-mononitrate in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20070201

Title: Potential and utilization of thermophiles and thermostable enzymes in biorefining.

Journal: Microbial cell factories20070101

Title: Inhibition of NAD(P)H oxidase reduces apoptosis and avascular retina in an animal model of retinopathy of prematurity.

Journal: Molecular vision20070101

Title: [Milestones of cardiovascular therapy. III. Nitroglycerin].

Journal: Casopis lekaru ceskych20070101

Title: Occlusal management for a patient with aural symptoms of unknown etiology: a case report.

Journal: Journal of medical case reports20070101

Title: Prevention of recurrent esophageal variceal hemorrhage: review and current recommendations.

Journal: Journal of clinical gastroenterology20070101

Title: Stability of benzoyl peroxide in aromatic ester-containing topical formulations.

Journal: Pharmaceutical development and technology20070101

Title: Co- and terpolyesters based on isosorbide and succinic acid for coating applications: synthesis and characterization.

Journal: Biomacromolecules20061201

Title: Effects of simple and complex motion patterns on gene expression of chondrocytes seeded in 3D scaffolds.

Journal: Tissue engineering20061101

Title: Vestibular evoked myogenic potentials in acute acoustic trauma.

Journal: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology20061001

Title: Organic solvents as vehicles for precipitating liquid embolics: a comparative angiotoxicity study with superselective injections of swine rete mirabile.

Journal: AJNR. American journal of neuroradiology20061001

Title: [Prevention of variceal bleeding and measurement of hepatic vein pressure gradient].

Journal: The Korean journal of hepatology20060901

Title: Effectiveness of oral route isosorbide 5-mononitrate on peritoneal solute and fluid transports in CAPD patients.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet20060801

Title: Aortic responsiveness to nitric oxide is affected by seasonal variation.

Journal: Pathophysiology : the official journal of the International Society for Pathophysiology20060501

Title: Endolymphatic hydrops as a cause of audio-vestibular manifestations in relapsing polychondritis.

Journal: Acta oto-laryngologica20060501

Title: Coronary artery spasm and the polymorphisms of the endothelial nitric oxide synthase gene.

Journal: Circulation journal : official journal of the Japanese Circulation Society20060401

Title: Composition analysis of two batches of polysorbate 60 using MS and NMR techniques.

Journal: Journal of pharmaceutical and biomedical analysis20060318

Title: Quantification of isosorbide 5-mononitrate in human plasma by liquid chromatography-tandem mass spectrometry using atmospheric pressure photoionization.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20060307

Title: Should drug therapy be personalized based on race?

Journal: The Annals of pharmacotherapy20060301

Title: Endothelial dysfunction in patients with ulcerative colitis.

Journal: Inflammatory bowel diseases20060301

Title: Pharmacological reduction of portal pressure and long-term risk of first variceal bleeding in patients with cirrhosis.

Journal: The American journal of gastroenterology20060301

Title: Cerebrovascular blood flow during the near syncopal phase of head-up tilt test: a comparative study in different types of neurally mediated syncope.

Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology20060301

Title: Cholesteric polymer guest-host mixture with circularly polarized fluorescence: two ways for phototuning of polarization and its intensity.

Journal: The journal of physical chemistry. A20060223

Title: Low serum bilirubin levels are independently and inversely related to impaired flow-mediated vasodilation and increased carotid intima-media thickness in both men and women.

Journal: Atherosclerosis20060201

Title: Use of simultaneous pressure and velocity measurements to estimate arterial wave speed at a single site in humans.

Journal: American journal of physiology. Heart and circulatory physiology20060201

Title: [Usefulness of sublingual isosorbide to assess the reversibility of pulmonary hypertension in cardiac transplant candidates].

Journal: Revista medica de Chile20060201

Title: Antidiuretic hormone and osmolality in isosorbide therapy and glycerol test.

Journal: ORL; journal for oto-rhino-laryngology and its related specialties20060101

Title: IMOP: randomised placebo controlled trial of outpatient cervical ripening with isosorbide mononitrate (IMN) prior to induction of labour - clinical trial with analyses of efficacy, cost effectiveness and acceptability.

Journal: BMC pregnancy and childbirth20060101

Title: Allergic and nonallergic reactions to nitroglycerin.

Journal: Allergy and asthma proceedings20060101

Title: Novel isosorbide-based substrates for human butyrylcholinesterase.

Journal: Chemico-biological interactions20051215

Title: Synthesis and structure activity relationships (SAR) of a new class of potent and selective butyrylcholinesterase inhibitors.

Journal: Chemico-biological interactions20051215

Title: Isosorbide dinitrate and hydralazine hydrochloride: a review of efficacy and safety.

Journal: Expert review of cardiovascular therapy20051101

Title: Preservation of platelet responsiveness to nitroglycerine despite development of vascular nitrate tolerance.

Journal: British journal of clinical pharmacology20051001

Title: Effect of preventive and regressive isosorbide 5-mononitrate treatment on catecholamine levels in plasma, platelets, adrenals, left ventricle and aorta in cyclosporin A-induced hypertensive rats.

Journal: Life sciences20050930

Title: Cerebral blood flow during supine rest and the first minute of head-up tilt in patients with orthostatic intolerance.

Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology20050901

Title: Cooperative type of platelet hypersensitivity to ADP.

Journal: Bulletin of experimental biology and medicine20050901

Title: The impact of race on response to RAAS inhibition.

Journal: Current heart failure reports20050801

Title: Short-term medical management of hydrocephalus.

Journal: Expert opinion on pharmacotherapy20050801

Title: BiDil raises questions about race as a marker.

Journal: Nature reviews. Drug discovery20050801

Title: Direct gas measurements indicate that the novel cyclooxygenase inhibitor AZD3582 is an effective nitric oxide donor in vivo.

Journal: British journal of pharmacology20050701

Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.

Journal: Chemical research in toxicology20050601

Title: Hydrogen peroxide overload increases adriamycin-induced apoptosis of SaOS(2)FM, a manganese superoxide dismutase-overexpressing human osteosarcoma cell line.

Journal: International journal of oncology20050501

Title: [Nitric oxide and cardiologic drugs].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego20050501

Title: Manganese superoxide dismutase overexpression changes plating efficiency bidirectionally according to change in redox for SaOS2 human osteosarcoma cell line.

Journal: International journal of oncology20050401

Title: The coming of age of multicultural medicine.

Journal: PLoS medicine20050301

Title: Isosorbide delays gentamicin-induced vestibular sensory cell death.

Journal: ORL; journal for oto-rhino-laryngology and its related specialties20050101

Title: BiDil: false promises: faulty statistics and reasoning have lead to the first 'racial medicine'.

Journal: Genewatch : a bulletin of the Committee for Responsible Genetics20050101

Title: [Comparative study of propranolol versus propranolol plus isosorbide 5-mononitrate in portal hypertension in cirrhotics. Evaluating splanchnic hemodynamics with color Doppler ultrasound].

Journal: Revista de gastroenterologia de Mexico20050101

Title: Vestibular evoked myogenic potentials in acute low-tone sensorineural hearing loss.

Journal: The Laryngoscope20041201

Title: Glycosylation of l,4:3,6-dianhydro-D-glucitol (isosorbide).

Journal: Carbohydrate research20041004

Title: Locally applied isosorbide decreases bone resorption in experimental periodontitis in rats.

Journal: Journal of periodontology20040901

Title: Cepharanthin enhances adriamycin sensitivity by synergistically accelerating apoptosis for adriamycin-resistant osteosarcoma cell lines, SaOS2-AR and SaOS2 F-AR.

Journal: International journal of oncology20040701

Title: [Therapy with NO donors-antiatherogenic and antioxidant actions].

Journal: Herz20040201

Title: Treatment of aphthous stomatitis with saturated potassium nitrate/dimethyl isosorbide.

Journal: Quintessence international (Berlin, Germany : 1985)20040201

Title: Comparison of the relaxant effects of a new oxime-nitrate derived from isosorbide-5-mononitrate and the parent drug.

Journal: Arzneimittel-Forschung20040101

Title: Pharmacokinetics of three organic nitrates in Chinese healthy male volunteers.

Journal: Arzneimittel-Forschung20040101

Title: Treatment of portal hypertension with NCX-1000, a liver-specific NO donor. A review of its current status.

Journal: Cardiovascular drug reviews20040101

Title: Endothelial dysfunction and nitric oxide enhancing therapy: a new approach to the treatment of heart failure.

Journal: Congestive heart failure (Greenwich, Conn.)20040101

Title: Time course of dehydrating effects of isosorbide on experimentally induced endolymphatic hydrops in guinea pigs.

Journal: ORL; journal for oto-rhino-laryngology and its related specialties20040101

Title: Single oral dose study of two isosorbide-based aspirin prodrugs in the dog.

Journal: The Journal of pharmacy and pharmacology20031001

Title: Simultaneous determination of aspirin and isosorbide 5-mononitrate in formulation by reversed phase high pressure liquid chromatography.

Journal: Journal of pharmaceutical and biomedical analysis20030821

Title: Effect of different intensities of exercise on endothelium-dependent vasodilation in humans: role of endothelium-dependent nitric oxide and oxidative stress.

Journal: Circulation20030805

Title: Comparative study of the use of diltiazem as an antispasmodic drug in coronary angiography via the transradial approach.

Journal: Arquivos brasileiros de cardiologia20030701

Title: Upregulation of cyclooxygenase-2 is accompanied by increased expression of nuclear factor-kappa B and I kappa B kinase-alpha in human colorectal cancer epithelial cells.

Journal: British journal of cancer20030519

Title: In vivo cardioprotection by N-acetylcysteine and isosorbide 5-mononitrate in a rat model of ischemia-reperfusion.

Journal: Cardiovascular drugs and therapy20030501

Title: Early vasoreactive profile of skeletonized versus pedicled internal thoracic artery grafts.

Journal: The Journal of thoracic and cardiovascular surgery20030301

Title: Capping carious exposed pulps with potassium nitrate, dimethyl isosorbide, polycarboxylate cement.

Journal: Dentistry today20030101

Title: [Clinical study on 'sini' decoction in treating stenocardia for coronary heart disease].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials20030101

Title: Possible mechanisms of hypotension produced 70% alcoholic extract of Terminalia arjuna (L.) in anaesthetized dogs.

Journal: BMC complementary and alternative medicine20030101

Title: Coronary artery spasm associated with a moderately severe atherosclerotic stenosis in the proximal LAD.

Journal: The Journal of invasive cardiology20021201

Title: MDR1-mediated interaction of digoxin with antiarrhythmic or antianginal drugs.

Journal: Biological & pharmaceutical bulletin20021201

Title: Medical treatment of myocardial ischemia in coronary artery disease: effect of drug regime and irregular dosing in the CAPE II trial.

Journal: Journal of the American College of Cardiology20020904

Title: Isosorbide-based aspirin prodrugs. II. Hydrolysis kinetics of isosorbide diaspirinate.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences20020901

Title: A long-term transdermal nitric oxide donor improves uteroplacental circulation in women with preeclampsia.

Journal: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine20020801

Title: Transdermal delivery of highly lipophilic drugs: in vitro fluxes of antiestrogens, permeation enhancers, and solvents from liquid formulations.

Journal: Pharmaceutical research20020501

Title: Dual effect of local application of nitric oxide donors in a model of incision pain in rats.

Journal: European journal of pharmacology20020419

Title: Nitric oxide induced cervical ripening in the human: Involvement of cyclic guanosine monophosphate, prostaglandin F(2 alpha), and prostaglandin E(2).

Journal: American journal of obstetrics and gynecology20020401

Title: Crystal structure of the cyclomaltohexaose (alpha-cyclodextrin) complex with isosorbide dinitrate. Guest-modulated channel-type structure.

Journal: Carbohydrate research20020315

Title: Prevention of varices rebleeding: are drugs better after all?

Journal: Gastroenterology20020301

Title: Role of race in the pharmacotherapy of heart failure.

Journal: The Annals of pharmacotherapy20020301

Title: [Pulmonary hypertension and pregnancy].

Journal: Revista medica de Chile20020201

Title: [Benign intracranial hypertension resulting from corticosteroid withdrawal: case report].

Journal: No shinkei geka. Neurological surgery20020101

Title: Nadolol and isosorbide prevented recurrent variceal bleeding better than did endoscopic ligation in cirrhosis.

Journal: ACP journal club20020101

Title: [Contemporary approaches to diagnosis and management of chronic heart failure (summary of the American College of Cardiology/American Heart Association Guidelines)].

Journal: Kardiologiia20020101

Title: Pharmacological modulation of human gastric volumes demonstrated noninvasively using SPECT imaging.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society20011201

Title: Appropriateness of nitrate use in a general medicine population.

Journal: The Annals of pharmacotherapy20011101

Title: [A case of primary antiphospholipid syndrome complicated with pulmonary hypertension].

Journal: Ryumachi. [Rheumatism]20011001

Title: Endoscopic ligation compared with combined treatment with nadolol and isosorbide mononitrate to prevent recurrent variceal bleeding.

Journal: The New England journal of medicine20010830

Title: Development of a new reaction system for the synthesis of highly optically active alpha,gamma-substituted gamma-butyrolactones.

Journal: The Journal of organic chemistry20010601

Title: Antimitogenic actions of organic nitrates are potentiated by sildenafil and mediated via activation of protein kinase A.

Journal: Molecular pharmacology20010501

Title: The human G-protein beta3 subunit C825T polymorphism is associated with coronary artery vasoconstriction.

Journal: European heart journal20010501

Title: Relative bioavailability of two isosorbide dinitrate sublingual tablet formulations administered as single doses in healthy subjects.

Journal: International journal of clinical pharmacology and therapeutics20010501

Title: Isosorbide dinitrate in the treatment of anal fissure: a randomised, prospective, double blind, placebo-controlled trial.

Journal: The European journal of surgery = Acta chirurgica20010501

Title: Variant angina with a strong spasmodic trait.

Journal: International journal of cardiology20010101

Title: [Utility of echo enhancers in the study of pulmonary circulation time].

Journal: Gaceta medica de Mexico20010101

Title: [The effect of long-term administration of isosorbide 5-mononitrate (Mononit), nitric oxide donor, on gallbladder emptying in patients with chronic stable angina].

Journal: Wiadomosci lekarskie (Warsaw, Poland : 1960)20010101

Title: Internet-based prescription of sildenafil: a 2104-patient series.

Journal: Journal of medical Internet research20010101

Title: Potentiating potassium nitrate's desensitization with dimethyl isosorbide.

Journal: General dentistry20010101

Title: Life threatening coronary artery spasm in childhood Kimura's disease.

Journal: Heart (British Cardiac Society)20000801

Title: Smooth muscle cell expression of type I cyclic GMP-dependent protein kinase is suppressed by continuous exposure to nitrovasodilators, theophylline, cyclic GMP, and cyclic AMP.

Journal: The Journal of clinical investigation19971115

Title: Relationship between nitric oxide and platelet-activating factor in castor-oil induced mucosal injury in the rat duodenum.

Journal: Naunyn-Schmiedeberg's archives of pharmacology19960501

Title: Myocardial ischemia induced by topical use of 5-fluorouracil.

Journal: International journal of cardiology19950501

Title: Renal and hepatic impairment in association with diclofenac administration.

Journal: Postgraduate medical journal19890701

Title: Experimental gentamicin nephrotoxicity: effect of streptozotocin-induced diabetes.

Journal: The Journal of pharmacology and experimental therapeutics19850401

Title: Rose M, et, al. Isosorbide as a renewable platform chemical for versatile applications--quo vadis? ChemSusChem. 2012 Jan 9;5(1):167-76.

Title: Nozawa I, et, al. Efficacy of long-term administration of isosorbide for Ménière's disease. ORL J Otorhinolaryngol Relat Spec. May-Jun 1995;57(3):135-40.

Title: Newman RA, et, al. Gallium nitrate (NSC-15200) induced toxicity in the rat: a pharmacologic, histopathologic and microanalytical investigation. Cancer. 1979 Nov;44(5):1728-40.

Building Blocks More >
2442-49-1
2442-49-1
Lignoceric acid methyl ester
AA003R7K | MFCD00009351
58356-65-3
58356-65-3
Manganese(iii) acetate meso-tetraphenylporphine
AA003RDG | MFCD00216548
2703-17-5
2703-17-5
Methyl 1H-pyrrole-3-carboxylate
AA003RHN | MFCD00967074
75358-89-3
75358-89-3
2-Cyano-3-pyridinecarboxylic acid methyl ester
AA003RKX | MFCD00128863
46064-79-3
46064-79-3
Methyl 3-amino-4-bromobenzoate
AA003ROA | MFCD00553090
7767-60-4
7767-60-4
4,6-Dihydrothieno[3,4-b]thiophene-2-carboxylic acid methyl ester
AA003RRF | MFCD15096514
1186663-43-3
1186663-43-3
Methyl 5-hydroxypiperidine-3-carboxylate, HCl
AA003RV5 | MFCD12198897
406212-51-9
406212-51-9
Methyl n-boc-4-hydroxypiperidine-3-carboxylate
AA003RYH | MFCD18651699
84216-71-7
84216-71-7
MONO-2-O-(P-TOLUENESULFONYL)-BETA-CYCLODEXTRIN
AA003S2H | MFCD08276403
74732-00-6
74732-00-6
N-(2-Chloroethyl)-1,8-naphthalimide
AA003S6A | MFCD00012444
Submit
© 2017 AA BLOCKS, INC. All rights reserved.