498-95-3,MFCD00005992
Catalog No.:AA003T1H

498-95-3 | Piperidine-3-carboxylic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5g
98%
in stock  
$6.00   $4.00
- +
10g
98%
in stock  
$7.00   $5.00
- +
25g
98%
in stock  
$12.00   $8.00
- +
100g
98%
in stock  
$44.00   $31.00
- +
500g
98%
in stock  
$183.00   $128.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA003T1H
Chemical Name:
Piperidine-3-carboxylic acid
CAS Number:
498-95-3
Molecular Formula:
C6H11NO2
Molecular Weight:
129.1570
MDL Number:
MFCD00005992
SMILES:
OC(=O)C1CCCNC1
Properties
Properties
 
BP:
265.8°C at 760 mmHg  
Form:
Solid  
MP:
261 °C (dec.);(lit.);  
Refractive Index:
1.4587 (estimate)  
Solubility:
water: soluble50mg/mL, clear, colorless to faintly yellow  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
114  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-2.9  

Literature

Title: Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents.

Journal: Bioorganic & medicinal chemistry letters 20130701

Title: Library screening by means of mass spectrometry (MS) binding assays-exemplarily demonstrated for a pseudostatic library addressing γ-aminobutyric acid (GABA) transporter 1 (GAT1).

Journal: ChemMedChem 20120901

Title: Synthesis and evaluation of new polyenic compounds as potential PPARs modulators.

Journal: Organic & biomolecular chemistry 20120814

Title: Involvement of γ-aminobutyric acid transporter 2 in the hepatic uptake of taurine in rats.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20120801

Title: Arousal from sleep in response to intermittent hypoxia in rat pups is modulated by medullary raphe GABAergic mechanisms.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20120301

Title: TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3.

Journal: Nature neuroscience 20120101

Title: In vitro maturation of dopaminergic neurons derived from mouse embryonic stem cells: implications for transplantation.

Journal: PloS one 20120101

Title: γ-Aminobutyric acid transporter 2 mediates the hepatic uptake of guanidinoacetate, the creatine biosynthetic precursor, in rats.

Journal: PloS one 20120101

Title: Co-Release of GABA Does Not Occur at Glycinergic Synapses onto Lumbar Motoneurons in Juvenile Mice.

Journal: Frontiers in cellular neuroscience 20120101

Title: A steered molecular dynamics study of binding and translocation processes in the GABA transporter.

Journal: PloS one 20120101

Title: Simultaneous quantification of D- vs. L-serine, taurine, kynurenate, phosphoethanolamine and diverse amino acids in frontocortical dialysates of freely-moving rats: differential modulation by N-methyl-D-aspartate (NMDA) and other pharmacological agents.

Journal: Journal of neuroscience methods 20111115

Title: 1,5-Substituted nipecotic amides: selective PDE8 inhibitors displaying diastereomer-dependent microsomal stability.

Journal: Bioorganic & medicinal chemistry letters 20110515

Title: Methylone and monoamine transporters: correlation with toxicity.

Journal: Current neuropharmacology 20110301

Title: Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2).

Journal: Biochimica et biophysica acta 20110101

Title: Stereospecific synthesis and structure-activity relationships of unsymmetrical 4,4-diphenylbut-3-enyl derivatives of nipecotic acid as GAT-1 inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20110101

Title: Localization and Function of GABA Transporters GAT-1 and GAT-3 in the Basal Ganglia.

Journal: Frontiers in systems neuroscience 20110101

Title: Manganese exposure inhibits the clearance of extracellular GABA and influences taurine homeostasis in the striatum of developing rats.

Journal: Neurotoxicology 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships.

Journal: Bioorganic & medicinal chemistry 20101101

Title: A possible role of the non-GAT1 GABA transporters in transfer of GABA from GABAergic to glutamatergic neurons in mouse cerebellar neuronal cultures.

Journal: Neurochemical research 20100901

Title: Sensory learning differentially affects GABAergic tonic currents in excitatory neurons and fast spiking interneurons in layer 4 of mouse barrel cortex.

Journal: Journal of neurophysiology 20100801

Title: Homology modelling of the GABA transporter and analysis of tiagabine binding.

Journal: ChemMedChem 20100705

Title: An adenosine A(2A) agonist injected in the nucleus of the solitary tract prolongs the laryngeal chemoreflex by a GABAergic mechanism in decerebrate piglets.

Journal: Experimental physiology 20100701

Title: Azetidine derivatives as novel gamma-aminobutyric acid uptake inhibitors: synthesis, biological evaluation, and structure-activity relationship.

Journal: European journal of medicinal chemistry 20100601

Title: Zolpidem modulation of phasic and tonic GABA currents in the rat dorsal motor nucleus of the vagus.

Journal: Neuropharmacology 20100601

Title: Diverse antiepileptic drugs increase the ratio of background synaptic inhibition to excitation and decrease neuronal excitability in neurones of the rat entorhinal cortex in vitro.

Journal: Neuroscience 20100505

Title: N-methyl phenylalanine-rich peptides as highly versatile blood-brain barrier shuttles.

Journal: Journal of medicinal chemistry 20100325

Title: Glutamatergic excitation and GABA release from a transplantable cell line.

Journal: Cell transplantation 20100101

Title: Hypertonicity enhances GABA uptake by cultured rat retinal capillary endothelial cells.

Journal: Drug metabolism and pharmacokinetics 20100101

Title: Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures.

Journal: Epilepsy research 20091001

Title: Regulation of tonic GABA inhibitory function, presympathetic neuronal activity and sympathetic outflow from the paraventricular nucleus by astroglial GABA transporters.

Journal: The Journal of physiology 20091001

Title: Alterations in extracellular levels of gamma-aminobutyric acid in the rat basolateral amygdala and periaqueductal gray during conditioned fear, persistent pain and fear-conditioned analgesia.

Journal: The journal of pain : official journal of the American Pain Society 20091001

Title: Carnitine conjugate of nipecotic acid: a new example of dual prodrug.

Journal: Molecules (Basel, Switzerland) 20090831

Title: Calibration of neurotransmitter release from neural cells for therapeutic implants.

Journal: International journal of neural systems 20090601

Title: Stereoselective synthesis of nipecotic acid derivatives via palladium-catalyzed decarboxylative cyclization of gamma-methylidene-delta-valerolactones with imines.

Journal: Organic letters 20090115

Title: Synaptically evoked glutamate transporter currents in Spinal Dorsal Horn Astrocytes.

Journal: Molecular pain 20090101

Title: Temporal requirements of the fragile x mental retardation protein in modulating circadian clock circuit synaptic architecture.

Journal: Frontiers in neural circuits 20090101

Title: Gamma-aminobutyric acid-mediated neurotransmission in the pontine reticular formation modulates hypnosis, immobility, and breathing during isoflurane anesthesia.

Journal: Anesthesiology 20081201

Title: Synthesis and biological evaluation of aminomethylphenol derivatives as inhibitors of the murine GABA transporters mGAT1-mGAT4.

Journal: European journal of medicinal chemistry 20081101

Title: Chronic nicotine modifies the effects of morphine on extracellular striatal dopamine and ventral tegmental GABA.

Journal: Journal of neurochemistry 20081101

Title: On the presence of 3H-GABA uptake mechanism in bovine spermatozoa.

Journal: Animal reproduction science 20081001

Title: Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease.

Journal: Neurobiology of disease 20080601

Title: Water-soluble calix[4]resorcinarenes with hydroxyproline groups as chiral NMR solvating agents.

Journal: The Journal of organic chemistry 20080404

Title: Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila.

Journal: Nature chemical biology 20080401

Title: Pontine reticular formation (PnO) administration of hypocretin-1 increases PnO GABA levels and wakefulness.

Journal: Sleep 20080401

Title: Synaptosomal GABA uptake decreases in paraoxon-treated rat brain.

Journal: Toxicology 20080203

Title: Fast homeostatic plasticity of inhibition via activity-dependent vesicular filling.

Journal: PloS one 20080101

Title: GABA uptake by purified avian Müller glia cells in culture.

Journal: Neurotoxicity research 20070901

Title: Uptake and release of [(3)H]GABA in human dental pulp.

Journal: Archives of oral biology 20070701

Title: Synthesis and biological evaluation of (R)-N-(diarylmethylthio/sulfinyl)ethyl/propyl-piperidine-3-carboxylic acid hydrochlorides as novel GABA uptake inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20070701

Title: Selective amino acid substitutions convert the creatine transporter to a gamma-aminobutyric acid transporter.

Journal: The Journal of biological chemistry 20070525

Title: Neuropharmacological profile of FrPbAII, purified from the venom of the social spider Parawixia bistriata (Araneae, Araneidae), in Wistar rats.

Journal: Life sciences 20070116

Title: Sleep and GABA levels in the oral part of rat pontine reticular formation are decreased by local and systemic administration of morphine.

Journal: Neuroscience 20070105

Title: [Tiagabine overdose--report of two cases].

Journal: Przeglad lekarski 20070101

Title: Anticonvulsant and anxiolytic activity of FrPbAII, a novel GABA uptake inhibitor isolated from the venom of the social spider Parawixia bistriata (Araneidae: Araneae).

Journal: Brain research 20061208

Title: Possible expression of a particular gamma-aminobutyric acid transporter isoform responsive to upregulation by hyperosmolarity in rat calvarial osteoblasts.

Journal: European journal of pharmacology 20061121

Title: Development of GABA-sensitive spasticity and rigidity in rats after transient spinal cord ischemia: a qualitative and quantitative electrophysiological and histopathological study.

Journal: Neuroscience 20060901

Title: GABAergic mechanisms in regulating the activity state of substantia nigra pars reticulata neurons.

Journal: Neuroscience 20060721

Title: Influence of a proton gradient on the transport kinetics of the H+/amino acid cotransporter PAT1 in Caco-2 cells.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20060701

Title: GABAergic and glycinergic inhibitory mechanisms in the lamprey respiratory control.

Journal: Brain research 20060523

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: alpha2-Adrenoceptor-mediated modulation of the release of GABA and noradrenaline in the rat substantia nigra pars reticulata.

Journal: Neuroscience letters 20060306

Title: Improvement of metabolic competence of isolated nerve terminals by extracellular pyruvate.

Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20060101

Title: 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.

Journal: Journal of medicinal chemistry 20051103

Title: Antidystonic efficacy of gamma-aminobutyric acid uptake inhibitors in the dtsz mutant.

Journal: European journal of pharmacology 20051003

Title: Subtype-specific GABA transporter antagonists synergistically modulate phasic and tonic GABAA conductances in rat neocortex.

Journal: Journal of neurophysiology 20050901

Title: Anterior hypothalamic neurons respond to blood pressure changes via gamma-aminobutyric acid and angiotensins in rats.

Journal: Neuroscience letters 20050826

Title: HPLC conditions are critical for the detection of GABA by microdialysis.

Journal: Journal of neurochemistry 20050801

Title: Quinolinic acid toxicity on orexin neurons blocked by gamma aminobutyric acid type A receptor stimulation.

Journal: Neuroreport 20050801

Title: Phospholipids as determinants of membrane protein topology. Phosphatidylethanolamine is required for the proper topological organization of the gamma-aminobutyric acid permease (GabP) of Escherichia coli.

Journal: The Journal of biological chemistry 20050715

Title: Nipecotic acid: systemic availability and brain delivery after nasal administration of nipecotic acid and n-butyl nipecotate to rats.

Journal: Pharmaceutical research 20050401

Title: Nitric oxide stimulates gamma-aminobutyric acid release and inhibits glycine release in retina.

Journal: The Journal of comparative neurology 20050314

Title: Ascorbic and 6-Br-ascorbic acid conjugates as a tool to increase the therapeutic effects of potentially central active drugs.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050301

Title: Thermodynamic study of N-trifluoroacetyl-O-alkyl nipecotic acid ester enantiomers on diluted permethylated beta-cyclodextrin stationary phase.

Journal: Journal of chromatography. A 20050204

Title: Stimulated release of exogenous GABA and glutamate from cerebral cortical synaptosomes and brain slices by bis(acetato)tetrakis(imidazole) copper(II) complex.

Journal: Biological trace element research 20050101

Title: Characterization and crystal structure of cadmium(II) halide complexes with amino acids and their derivatives VI. The comparison of crystal structures of cadmium(II) halide complexes with three kinds of piperidine carboxylic acids.

Journal: Journal of inorganic biochemistry 20041201

Title: Neuronal electrical high frequency stimulation modulates presynaptic GABAergic physiology.

Journal: Neuroscience letters 20041123

Title: GABAergic modulation of motor-driven behaviors in juvenile Drosophila and evidence for a nonbehavioral role for GABA transport.

Journal: Journal of neurobiology 20041101

Title: Design, synthesis and in vitro evaluation on HRPE cells of ascorbic and 6-bromoascorbic acid conjugates with neuroactive molecules.

Journal: Bioorganic & medicinal chemistry 20041015

Title: The brain-to-blood efflux transport of taurine and changes in the blood-brain barrier transport system by tumor necrosis factor-alpha.

Journal: Brain research 20041008

Title: Effect of a high-salt diet on gamma-aminobutyric acid-mediated responses in the nucleus tractus solitarius of Sprague-Dawley rats.

Journal: Brain research bulletin 20040930

Title: Taurine-induced long-lasting potentiation in the rat hippocampus shows a partial dissociation from total hippocampal taurine content and independence from activation of known taurine transporters.

Journal: Journal of neurochemistry 20040601

Title: Lipophilicity-related inhibition of blood platelet aggregation by nipecotic acid anilides.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20040601

Title: Design, synthesis and anticonvulsive activity of analogs of gamma-vinyl GABA.

Journal: Farmaco (Societa chimica italiana : 1989) 20040501

Title: Involvement of membrane GABA transporter in alpha-latrotoxin-stimulated [3H]GABA release.

Journal: Neurochemistry international 20040401

Title: Role of taurine uptake on the induction of long-term synaptic potentiation.

Journal: The European journal of neuroscience 20040401

Title: Assay for nipecotic acid in small blood samples by gas chromatography-mass spectroscopy.

Journal: Journal of pharmaceutical and biomedical analysis 20040310

Title: Behavioral effects of bicuculline microinjection in the dorsal versus ventral hippocampal formation of rats, and control of seizures by nigral muscimol.

Journal: Epilepsy research 20040201

Title: Transporter-mediated effects of diclofenamic acid and its ascorbyl pro-drug in the in vivo neurotropic activity of ascorbyl nipecotic acid conjugate.

Journal: Journal of pharmaceutical sciences 20040101

Title: Changes in rectal temperature and ECoG spectral power of sensorimotor cortex elicited in conscious rabbits by i.c.v. injection of GABA, GABA(A) and GABA(B) agonists and antagonists.

Journal: British journal of pharmacology 20040101

Title: The 'Transport Specificity Ratio': a structure-function tool to search the protein fold for loci that control transition state stability in membrane transport catalysis.

Journal: BMC biochemistry 20040101

Title: Use of the transport specificity ratio and cysteine-scanning mutagenesis to detect multiple substrate specificity determinants in the consensus amphipathic region of the Escherichia coli GABA (gamma-aminobutyric acid) transporter encoded by gabP.

Journal: The Biochemical journal 20031215

Title: Intracerebroventricular injection of muscimol, baclofen or nipecotic acid stimulates food intake in layer-type, but not meat-type, chicks.

Journal: Brain research 20031212

Title: Partial hippocampal kindling increases GABAB receptor-mediated postsynaptic currents in CA1 pyramidal cells.

Journal: Epilepsy research 20031101

Title: Design, synthesis and anticonvulsive activities of potential prodrugs linked by two-carbon chain.

Journal: Archives of pharmacal research 20031001

Title: Differential arithmetic of shunting inhibition for voltage and spike rate in neocortical pyramidal cells.

Journal: The European journal of neuroscience 20031001

Title: Highly water-soluble derivatives of the anesthetic agent propofol: in vitro and in vivo evaluation of cyclic amino acid esters.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20030901

Title: Taurine-induced long-lasting enhancement of synaptic transmission in mice: role of transporters.

Journal: The Journal of physiology 20030801

Title: Phenylarsine oxide inhibits alpha-latrotoxin-stimulated [3H]GABA release from rat brain synaptosomes.

Journal: Neurochemistry international 20030601

Title: De novo design of non-hydrogen-bonded helical pseudopeptides composed of oxanipecotic acid oligomers.

Journal: Chemical communications (Cambridge, England) 20030421

Title: Investigation of platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids.

Journal: Bioorganic & medicinal chemistry 20030403

Title: Role of EphA4 and EphrinB3 in local neuronal circuits that control walking.

Journal: Science (New York, N.Y.) 20030321

Title: Endogenous GABA in the commissural subnucleus of the NTS inhibits the carotid chemoreceptor reflex via GABA A receptors in rats.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20030301

Title: Effects of 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazol (exo-THPO) and its N-substituted analogs on GABA transport in cultured neurons and astrocytes and by the four cloned mouse GABA transporters.

Journal: Neurochemistry international 20030101

Title: GABA-mediated neurotransmission in the ventrolateral NTS plays a role in respiratory regulation in the rat.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20021201

Title: IL-4 increases GABAergic phenotype in rat retinal cell cultures: involvement of muscarinic receptors and protein kinase C.

Journal: Journal of neuroimmunology 20021201

Title: Expression and functional characterization of GABA transporters in crayfish neurosecretory cells.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20021101

Title: GAT-1 and reversible GABA transport in Bergmann glia in slices.

Journal: Journal of neurophysiology 20020901

Title: Delta-Aminolevulinic acid transport in murine mammary adenocarcinoma cells is mediated by beta transporters.

Journal: British journal of cancer 20020812

Title: Increased synaptosomal [3H] GABA uptake in the rat brainstem after facial carrageenan injections.

Journal: Pain 20020801

Title: GABA is toxic for mouse striatal neurones through a transporter-mediated process.

Journal: Journal of neurochemistry 20020801

Title: Gamma-aminobutyric acid transporter (BGT-1) expressed in human astrocytoma U373 MG cells: pharmacological and molecular characterization and phorbol ester-induced inhibition.

Journal: Journal of neuroscience research 20020701

Title: AMPA receptor activation induces GABA release from neurons migrating tangentially in the intermediate zone of embryonic rat neocortex.

Journal: The European journal of neuroscience 20020701

Title: Involvement of P2X7 receptors in the regulation of neurotransmitter release in the rat hippocampus.

Journal: Journal of neurochemistry 20020601

Title: Effect of cannabinoids on synaptic transmission in the rat hippocampal slice is temperature-dependent.

Journal: European journal of pharmacology 20020503

Title: Effects of GABAergic agents on anesthesia induced by halothane, isoflurane, and thiamylal in mice.

Journal: Pharmacology, biochemistry, and behavior 20020501

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Differential ontogeny of GABA(B)-receptor-mediated pre- and postsynaptic modulation of GABA and glycine transmission in respiratory rhythm-generating network in mouse.

Journal: The Journal of physiology 20020415

Title: Does extracellular calcium determine what pool of GABA is the target for alpha-latrotoxin?

Journal: Neurochemistry international 20020401

Title: Functional significance of nitric oxide in ionomycin-evoked [3H]GABA release from mouse cerebral cortical neurons.

Journal: Journal of neurochemistry 20020401

Title: Design, synthesis and activity of ascorbic acid prodrugs of nipecotic, kynurenic and diclophenamic acids, liable to increase neurotropic activity.

Journal: Journal of medicinal chemistry 20020131

Title: Activation of P2X(7) receptors induced [(3)H]GABA release from the RBA-2 type-2 astrocyte cell line through a Cl(-)/HCO(3)(-)-dependent mechanism.

Journal: Glia 20020101

Title: Bi-directional transport of GABA in human embryonic kidney (HEK-293) cells stably expressing the rat GABA transporter GAT-1.

Journal: British journal of pharmacology 20020101

Title: [Effect of synaptosomal cytosolic [3H]GABA pool depletion on secretory ability of alpha-latrotoxin].

Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20020101

Title: Substrate-induced regulation of gamma-aminobutyric acid transporter trafficking requires tyrosine phosphorylation.

Journal: The Journal of biological chemistry 20011116

Title: Synthesis of novel GABA uptake inhibitors. Part 6: preparation and evaluation of N-Omega asymmetrically substituted nipecotic acid derivatives.

Journal: Bioorganic & medicinal chemistry 20011101

Title: Differential modulation of respiratory neuronal discharge patterns by GABA(A) receptor and apamin-sensitive K(+) channel antagonism.

Journal: Journal of neurophysiology 20011101

Title: Serotonin-1B receptor-mediated inhibition of [(3)H]GABA release from rat ventral tegmental area slices.

Journal: Journal of neurochemistry 20011101

Title: Glutamate receptor desensitization block potentiates the stimulated GABA release through external Ca2+-independent mechanisms from granule cells of olfactory bulb.

Journal: Neurochemical research 20011101

Title: Common mechanisms of inhibition for the Na+/glucose (hSGLT1) and Na+/Cl-/GABA (hGAT1) cotransporters.

Journal: British journal of pharmacology 20011001

Title: Efflux of a suppressive neurotransmitter, GABA, across the blood-brain barrier.

Journal: Journal of neurochemistry 20011001

Title: GAT2/BGT-1 as a system responsible for the transport of gamma-aminobutyric acid at the mouse blood-brain barrier.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20011001

Title: Creatine transport in brush-border membrane vesicles isolated from rat kidney cortex.

Journal: Journal of the American Society of Nephrology : JASN 20010901

Title: The role of glycineB binding site and glycine transporter (GlyT1) in the regulation of [3H]GABA and [3H]glycine release in the rat brain.

Journal: Neurochemical research 20010901

Title: Nipecotic acid directly activates GABA(A)-like ion channels.

Journal: British journal of pharmacology 20010701

Title: Synthesis of novel gamma-aminobutyric acid (GABA) uptake inhibitors. 5.(1) Preparation and structure-activity studies of tricyclic analogues of known GABA uptake inhibitors.

Journal: Journal of medicinal chemistry 20010621

Title: Experimental uremia affects hypothalamic amino acid neurotransmitter milieu.

Journal: Journal of the American Society of Nephrology : JASN 20010601

Title: GABA transaminase inhibition induces spontaneous and enhances depolarization-evoked GABA efflux via reversal of the GABA transporter.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20010415

Title: Monomeric state and ligand binding of recombinant GABA transporter from Escherichia coli.

Journal: FEBS letters 20010413

Title: Attenuation of malonate toxicity in primary mesencephalic cultures using the GABA transport blocker, NO-711.

Journal: Journal of neuroscience research 20010401

Title: Transport of L-carnitine in isolated cerebral cortex neurons.

Journal: European journal of biochemistry 20010401

Title: GABA uptake and heterotransport are impaired in the dentate gyrus of epileptic rats and humans with temporal lobe sclerosis.

Journal: Journal of neurophysiology 20010401

Title: Tiagabine in clinical practice.

Journal: Epilepsia 20010101

Title: GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects.

Journal: Current pharmaceutical design 20000801

Title: 1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter.

Journal: British journal of pharmacology 19970301

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:498-95-3 Molecular Formula|498-95-3 MDL|498-95-3 SMILES|498-95-3 Piperidine-3-carboxylic acid
Catalog No.: AA003T1H
498-95-3,MFCD00005992
498-95-3 | Piperidine-3-carboxylic acid
Pack Size: 5g
Purity: 98%
in stock
$6.00 $4.00
Pack Size: 10g
Purity: 98%
in stock
$7.00 $5.00
Pack Size: 25g
Purity: 98%
in stock
$12.00 $8.00
Pack Size: 100g
Purity: 98%
in stock
$44.00 $31.00
Pack Size: 500g
Purity: 98%
in stock
$183.00 $128.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA003T1H
Chemical Name: Piperidine-3-carboxylic acid
CAS Number: 498-95-3
Molecular Formula: C6H11NO2
Molecular Weight: 129.1570
MDL Number: MFCD00005992
SMILES: OC(=O)C1CCCNC1
Properties
BP: 265.8°C at 760 mmHg  
Form: Solid  
MP: 261 °C (dec.);(lit.);  
Refractive Index: 1.4587 (estimate)  
Solubility: water: soluble50mg/mL, clear, colorless to faintly yellow  
Storage: Keep in dry area;Room Temperature;  
Complexity: 114  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 9  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 1  
Undefined Atom Stereocenter Count: 1  
Undefined Bond Stereocenter Count: 0  
XLogP3: -2.9  
Literature fold

Title: Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents.

Journal: Bioorganic & medicinal chemistry letters20130701

Title: Library screening by means of mass spectrometry (MS) binding assays-exemplarily demonstrated for a pseudostatic library addressing γ-aminobutyric acid (GABA) transporter 1 (GAT1).

Journal: ChemMedChem20120901

Title: Synthesis and evaluation of new polyenic compounds as potential PPARs modulators.

Journal: Organic & biomolecular chemistry20120814

Title: Involvement of γ-aminobutyric acid transporter 2 in the hepatic uptake of taurine in rats.

Journal: American journal of physiology. Gastrointestinal and liver physiology20120801

Title: Arousal from sleep in response to intermittent hypoxia in rat pups is modulated by medullary raphe GABAergic mechanisms.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology20120301

Title: TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3.

Journal: Nature neuroscience20120101

Title: In vitro maturation of dopaminergic neurons derived from mouse embryonic stem cells: implications for transplantation.

Journal: PloS one20120101

Title: γ-Aminobutyric acid transporter 2 mediates the hepatic uptake of guanidinoacetate, the creatine biosynthetic precursor, in rats.

Journal: PloS one20120101

Title: Co-Release of GABA Does Not Occur at Glycinergic Synapses onto Lumbar Motoneurons in Juvenile Mice.

Journal: Frontiers in cellular neuroscience20120101

Title: A steered molecular dynamics study of binding and translocation processes in the GABA transporter.

Journal: PloS one20120101

Title: Simultaneous quantification of D- vs. L-serine, taurine, kynurenate, phosphoethanolamine and diverse amino acids in frontocortical dialysates of freely-moving rats: differential modulation by N-methyl-D-aspartate (NMDA) and other pharmacological agents.

Journal: Journal of neuroscience methods20111115

Title: 1,5-Substituted nipecotic amides: selective PDE8 inhibitors displaying diastereomer-dependent microsomal stability.

Journal: Bioorganic & medicinal chemistry letters20110515

Title: Methylone and monoamine transporters: correlation with toxicity.

Journal: Current neuropharmacology20110301

Title: Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2).

Journal: Biochimica et biophysica acta20110101

Title: Stereospecific synthesis and structure-activity relationships of unsymmetrical 4,4-diphenylbut-3-enyl derivatives of nipecotic acid as GAT-1 inhibitors.

Journal: Bioorganic & medicinal chemistry letters20110101

Title: Localization and Function of GABA Transporters GAT-1 and GAT-3 in the Basal Ganglia.

Journal: Frontiers in systems neuroscience20110101

Title: Manganese exposure inhibits the clearance of extracellular GABA and influences taurine homeostasis in the striatum of developing rats.

Journal: Neurotoxicology20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships.

Journal: Bioorganic & medicinal chemistry20101101

Title: A possible role of the non-GAT1 GABA transporters in transfer of GABA from GABAergic to glutamatergic neurons in mouse cerebellar neuronal cultures.

Journal: Neurochemical research20100901

Title: Sensory learning differentially affects GABAergic tonic currents in excitatory neurons and fast spiking interneurons in layer 4 of mouse barrel cortex.

Journal: Journal of neurophysiology20100801

Title: Homology modelling of the GABA transporter and analysis of tiagabine binding.

Journal: ChemMedChem20100705

Title: An adenosine A(2A) agonist injected in the nucleus of the solitary tract prolongs the laryngeal chemoreflex by a GABAergic mechanism in decerebrate piglets.

Journal: Experimental physiology20100701

Title: Azetidine derivatives as novel gamma-aminobutyric acid uptake inhibitors: synthesis, biological evaluation, and structure-activity relationship.

Journal: European journal of medicinal chemistry20100601

Title: Zolpidem modulation of phasic and tonic GABA currents in the rat dorsal motor nucleus of the vagus.

Journal: Neuropharmacology20100601

Title: Diverse antiepileptic drugs increase the ratio of background synaptic inhibition to excitation and decrease neuronal excitability in neurones of the rat entorhinal cortex in vitro.

Journal: Neuroscience20100505

Title: N-methyl phenylalanine-rich peptides as highly versatile blood-brain barrier shuttles.

Journal: Journal of medicinal chemistry20100325

Title: Glutamatergic excitation and GABA release from a transplantable cell line.

Journal: Cell transplantation20100101

Title: Hypertonicity enhances GABA uptake by cultured rat retinal capillary endothelial cells.

Journal: Drug metabolism and pharmacokinetics20100101

Title: Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures.

Journal: Epilepsy research20091001

Title: Regulation of tonic GABA inhibitory function, presympathetic neuronal activity and sympathetic outflow from the paraventricular nucleus by astroglial GABA transporters.

Journal: The Journal of physiology20091001

Title: Alterations in extracellular levels of gamma-aminobutyric acid in the rat basolateral amygdala and periaqueductal gray during conditioned fear, persistent pain and fear-conditioned analgesia.

Journal: The journal of pain : official journal of the American Pain Society20091001

Title: Carnitine conjugate of nipecotic acid: a new example of dual prodrug.

Journal: Molecules (Basel, Switzerland)20090831

Title: Calibration of neurotransmitter release from neural cells for therapeutic implants.

Journal: International journal of neural systems20090601

Title: Stereoselective synthesis of nipecotic acid derivatives via palladium-catalyzed decarboxylative cyclization of gamma-methylidene-delta-valerolactones with imines.

Journal: Organic letters20090115

Title: Synaptically evoked glutamate transporter currents in Spinal Dorsal Horn Astrocytes.

Journal: Molecular pain20090101

Title: Temporal requirements of the fragile x mental retardation protein in modulating circadian clock circuit synaptic architecture.

Journal: Frontiers in neural circuits20090101

Title: Gamma-aminobutyric acid-mediated neurotransmission in the pontine reticular formation modulates hypnosis, immobility, and breathing during isoflurane anesthesia.

Journal: Anesthesiology20081201

Title: Synthesis and biological evaluation of aminomethylphenol derivatives as inhibitors of the murine GABA transporters mGAT1-mGAT4.

Journal: European journal of medicinal chemistry20081101

Title: Chronic nicotine modifies the effects of morphine on extracellular striatal dopamine and ventral tegmental GABA.

Journal: Journal of neurochemistry20081101

Title: On the presence of 3H-GABA uptake mechanism in bovine spermatozoa.

Journal: Animal reproduction science20081001

Title: Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease.

Journal: Neurobiology of disease20080601

Title: Water-soluble calix[4]resorcinarenes with hydroxyproline groups as chiral NMR solvating agents.

Journal: The Journal of organic chemistry20080404

Title: Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila.

Journal: Nature chemical biology20080401

Title: Pontine reticular formation (PnO) administration of hypocretin-1 increases PnO GABA levels and wakefulness.

Journal: Sleep20080401

Title: Synaptosomal GABA uptake decreases in paraoxon-treated rat brain.

Journal: Toxicology20080203

Title: Fast homeostatic plasticity of inhibition via activity-dependent vesicular filling.

Journal: PloS one20080101

Title: GABA uptake by purified avian Müller glia cells in culture.

Journal: Neurotoxicity research20070901

Title: Uptake and release of [(3)H]GABA in human dental pulp.

Journal: Archives of oral biology20070701

Title: Synthesis and biological evaluation of (R)-N-(diarylmethylthio/sulfinyl)ethyl/propyl-piperidine-3-carboxylic acid hydrochlorides as novel GABA uptake inhibitors.

Journal: Bioorganic & medicinal chemistry letters20070701

Title: Selective amino acid substitutions convert the creatine transporter to a gamma-aminobutyric acid transporter.

Journal: The Journal of biological chemistry20070525

Title: Neuropharmacological profile of FrPbAII, purified from the venom of the social spider Parawixia bistriata (Araneae, Araneidae), in Wistar rats.

Journal: Life sciences20070116

Title: Sleep and GABA levels in the oral part of rat pontine reticular formation are decreased by local and systemic administration of morphine.

Journal: Neuroscience20070105

Title: [Tiagabine overdose--report of two cases].

Journal: Przeglad lekarski20070101

Title: Anticonvulsant and anxiolytic activity of FrPbAII, a novel GABA uptake inhibitor isolated from the venom of the social spider Parawixia bistriata (Araneidae: Araneae).

Journal: Brain research20061208

Title: Possible expression of a particular gamma-aminobutyric acid transporter isoform responsive to upregulation by hyperosmolarity in rat calvarial osteoblasts.

Journal: European journal of pharmacology20061121

Title: Development of GABA-sensitive spasticity and rigidity in rats after transient spinal cord ischemia: a qualitative and quantitative electrophysiological and histopathological study.

Journal: Neuroscience20060901

Title: GABAergic mechanisms in regulating the activity state of substantia nigra pars reticulata neurons.

Journal: Neuroscience20060721

Title: Influence of a proton gradient on the transport kinetics of the H+/amino acid cotransporter PAT1 in Caco-2 cells.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V20060701

Title: GABAergic and glycinergic inhibitory mechanisms in the lamprey respiratory control.

Journal: Brain research20060523

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: alpha2-Adrenoceptor-mediated modulation of the release of GABA and noradrenaline in the rat substantia nigra pars reticulata.

Journal: Neuroscience letters20060306

Title: Improvement of metabolic competence of isolated nerve terminals by extracellular pyruvate.

Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 )20060101

Title: 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.

Journal: Journal of medicinal chemistry20051103

Title: Antidystonic efficacy of gamma-aminobutyric acid uptake inhibitors in the dtsz mutant.

Journal: European journal of pharmacology20051003

Title: Subtype-specific GABA transporter antagonists synergistically modulate phasic and tonic GABAA conductances in rat neocortex.

Journal: Journal of neurophysiology20050901

Title: Anterior hypothalamic neurons respond to blood pressure changes via gamma-aminobutyric acid and angiotensins in rats.

Journal: Neuroscience letters20050826

Title: HPLC conditions are critical for the detection of GABA by microdialysis.

Journal: Journal of neurochemistry20050801

Title: Quinolinic acid toxicity on orexin neurons blocked by gamma aminobutyric acid type A receptor stimulation.

Journal: Neuroreport20050801

Title: Phospholipids as determinants of membrane protein topology. Phosphatidylethanolamine is required for the proper topological organization of the gamma-aminobutyric acid permease (GabP) of Escherichia coli.

Journal: The Journal of biological chemistry20050715

Title: Nipecotic acid: systemic availability and brain delivery after nasal administration of nipecotic acid and n-butyl nipecotate to rats.

Journal: Pharmaceutical research20050401

Title: Nitric oxide stimulates gamma-aminobutyric acid release and inhibits glycine release in retina.

Journal: The Journal of comparative neurology20050314

Title: Ascorbic and 6-Br-ascorbic acid conjugates as a tool to increase the therapeutic effects of potentially central active drugs.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences20050301

Title: Thermodynamic study of N-trifluoroacetyl-O-alkyl nipecotic acid ester enantiomers on diluted permethylated beta-cyclodextrin stationary phase.

Journal: Journal of chromatography. A20050204

Title: Stimulated release of exogenous GABA and glutamate from cerebral cortical synaptosomes and brain slices by bis(acetato)tetrakis(imidazole) copper(II) complex.

Journal: Biological trace element research20050101

Title: Characterization and crystal structure of cadmium(II) halide complexes with amino acids and their derivatives VI. The comparison of crystal structures of cadmium(II) halide complexes with three kinds of piperidine carboxylic acids.

Journal: Journal of inorganic biochemistry20041201

Title: Neuronal electrical high frequency stimulation modulates presynaptic GABAergic physiology.

Journal: Neuroscience letters20041123

Title: GABAergic modulation of motor-driven behaviors in juvenile Drosophila and evidence for a nonbehavioral role for GABA transport.

Journal: Journal of neurobiology20041101

Title: Design, synthesis and in vitro evaluation on HRPE cells of ascorbic and 6-bromoascorbic acid conjugates with neuroactive molecules.

Journal: Bioorganic & medicinal chemistry20041015

Title: The brain-to-blood efflux transport of taurine and changes in the blood-brain barrier transport system by tumor necrosis factor-alpha.

Journal: Brain research20041008

Title: Effect of a high-salt diet on gamma-aminobutyric acid-mediated responses in the nucleus tractus solitarius of Sprague-Dawley rats.

Journal: Brain research bulletin20040930

Title: Taurine-induced long-lasting potentiation in the rat hippocampus shows a partial dissociation from total hippocampal taurine content and independence from activation of known taurine transporters.

Journal: Journal of neurochemistry20040601

Title: Lipophilicity-related inhibition of blood platelet aggregation by nipecotic acid anilides.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences20040601

Title: Design, synthesis and anticonvulsive activity of analogs of gamma-vinyl GABA.

Journal: Farmaco (Societa chimica italiana : 1989)20040501

Title: Involvement of membrane GABA transporter in alpha-latrotoxin-stimulated [3H]GABA release.

Journal: Neurochemistry international20040401

Title: Role of taurine uptake on the induction of long-term synaptic potentiation.

Journal: The European journal of neuroscience20040401

Title: Assay for nipecotic acid in small blood samples by gas chromatography-mass spectroscopy.

Journal: Journal of pharmaceutical and biomedical analysis20040310

Title: Behavioral effects of bicuculline microinjection in the dorsal versus ventral hippocampal formation of rats, and control of seizures by nigral muscimol.

Journal: Epilepsy research20040201

Title: Transporter-mediated effects of diclofenamic acid and its ascorbyl pro-drug in the in vivo neurotropic activity of ascorbyl nipecotic acid conjugate.

Journal: Journal of pharmaceutical sciences20040101

Title: Changes in rectal temperature and ECoG spectral power of sensorimotor cortex elicited in conscious rabbits by i.c.v. injection of GABA, GABA(A) and GABA(B) agonists and antagonists.

Journal: British journal of pharmacology20040101

Title: The 'Transport Specificity Ratio': a structure-function tool to search the protein fold for loci that control transition state stability in membrane transport catalysis.

Journal: BMC biochemistry20040101

Title: Use of the transport specificity ratio and cysteine-scanning mutagenesis to detect multiple substrate specificity determinants in the consensus amphipathic region of the Escherichia coli GABA (gamma-aminobutyric acid) transporter encoded by gabP.

Journal: The Biochemical journal20031215

Title: Intracerebroventricular injection of muscimol, baclofen or nipecotic acid stimulates food intake in layer-type, but not meat-type, chicks.

Journal: Brain research20031212

Title: Partial hippocampal kindling increases GABAB receptor-mediated postsynaptic currents in CA1 pyramidal cells.

Journal: Epilepsy research20031101

Title: Design, synthesis and anticonvulsive activities of potential prodrugs linked by two-carbon chain.

Journal: Archives of pharmacal research20031001

Title: Differential arithmetic of shunting inhibition for voltage and spike rate in neocortical pyramidal cells.

Journal: The European journal of neuroscience20031001

Title: Highly water-soluble derivatives of the anesthetic agent propofol: in vitro and in vivo evaluation of cyclic amino acid esters.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences20030901

Title: Taurine-induced long-lasting enhancement of synaptic transmission in mice: role of transporters.

Journal: The Journal of physiology20030801

Title: Phenylarsine oxide inhibits alpha-latrotoxin-stimulated [3H]GABA release from rat brain synaptosomes.

Journal: Neurochemistry international20030601

Title: De novo design of non-hydrogen-bonded helical pseudopeptides composed of oxanipecotic acid oligomers.

Journal: Chemical communications (Cambridge, England)20030421

Title: Investigation of platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids.

Journal: Bioorganic & medicinal chemistry20030403

Title: Role of EphA4 and EphrinB3 in local neuronal circuits that control walking.

Journal: Science (New York, N.Y.)20030321

Title: Endogenous GABA in the commissural subnucleus of the NTS inhibits the carotid chemoreceptor reflex via GABA A receptors in rats.

Journal: Journal of neural transmission (Vienna, Austria : 1996)20030301

Title: Effects of 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazol (exo-THPO) and its N-substituted analogs on GABA transport in cultured neurons and astrocytes and by the four cloned mouse GABA transporters.

Journal: Neurochemistry international20030101

Title: GABA-mediated neurotransmission in the ventrolateral NTS plays a role in respiratory regulation in the rat.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology20021201

Title: IL-4 increases GABAergic phenotype in rat retinal cell cultures: involvement of muscarinic receptors and protein kinase C.

Journal: Journal of neuroimmunology20021201

Title: Expression and functional characterization of GABA transporters in crayfish neurosecretory cells.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20021101

Title: GAT-1 and reversible GABA transport in Bergmann glia in slices.

Journal: Journal of neurophysiology20020901

Title: Delta-Aminolevulinic acid transport in murine mammary adenocarcinoma cells is mediated by beta transporters.

Journal: British journal of cancer20020812

Title: Increased synaptosomal [3H] GABA uptake in the rat brainstem after facial carrageenan injections.

Journal: Pain20020801

Title: GABA is toxic for mouse striatal neurones through a transporter-mediated process.

Journal: Journal of neurochemistry20020801

Title: Gamma-aminobutyric acid transporter (BGT-1) expressed in human astrocytoma U373 MG cells: pharmacological and molecular characterization and phorbol ester-induced inhibition.

Journal: Journal of neuroscience research20020701

Title: AMPA receptor activation induces GABA release from neurons migrating tangentially in the intermediate zone of embryonic rat neocortex.

Journal: The European journal of neuroscience20020701

Title: Involvement of P2X7 receptors in the regulation of neurotransmitter release in the rat hippocampus.

Journal: Journal of neurochemistry20020601

Title: Effect of cannabinoids on synaptic transmission in the rat hippocampal slice is temperature-dependent.

Journal: European journal of pharmacology20020503

Title: Effects of GABAergic agents on anesthesia induced by halothane, isoflurane, and thiamylal in mice.

Journal: Pharmacology, biochemistry, and behavior20020501

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry20020419

Title: Differential ontogeny of GABA(B)-receptor-mediated pre- and postsynaptic modulation of GABA and glycine transmission in respiratory rhythm-generating network in mouse.

Journal: The Journal of physiology20020415

Title: Does extracellular calcium determine what pool of GABA is the target for alpha-latrotoxin?

Journal: Neurochemistry international20020401

Title: Functional significance of nitric oxide in ionomycin-evoked [3H]GABA release from mouse cerebral cortical neurons.

Journal: Journal of neurochemistry20020401

Title: Design, synthesis and activity of ascorbic acid prodrugs of nipecotic, kynurenic and diclophenamic acids, liable to increase neurotropic activity.

Journal: Journal of medicinal chemistry20020131

Title: Activation of P2X(7) receptors induced [(3)H]GABA release from the RBA-2 type-2 astrocyte cell line through a Cl(-)/HCO(3)(-)-dependent mechanism.

Journal: Glia20020101

Title: Bi-directional transport of GABA in human embryonic kidney (HEK-293) cells stably expressing the rat GABA transporter GAT-1.

Journal: British journal of pharmacology20020101

Title: [Effect of synaptosomal cytosolic [3H]GABA pool depletion on secretory ability of alpha-latrotoxin].

Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 )20020101

Title: Substrate-induced regulation of gamma-aminobutyric acid transporter trafficking requires tyrosine phosphorylation.

Journal: The Journal of biological chemistry20011116

Title: Synthesis of novel GABA uptake inhibitors. Part 6: preparation and evaluation of N-Omega asymmetrically substituted nipecotic acid derivatives.

Journal: Bioorganic & medicinal chemistry20011101

Title: Differential modulation of respiratory neuronal discharge patterns by GABA(A) receptor and apamin-sensitive K(+) channel antagonism.

Journal: Journal of neurophysiology20011101

Title: Serotonin-1B receptor-mediated inhibition of [(3)H]GABA release from rat ventral tegmental area slices.

Journal: Journal of neurochemistry20011101

Title: Glutamate receptor desensitization block potentiates the stimulated GABA release through external Ca2+-independent mechanisms from granule cells of olfactory bulb.

Journal: Neurochemical research20011101

Title: Common mechanisms of inhibition for the Na+/glucose (hSGLT1) and Na+/Cl-/GABA (hGAT1) cotransporters.

Journal: British journal of pharmacology20011001

Title: Efflux of a suppressive neurotransmitter, GABA, across the blood-brain barrier.

Journal: Journal of neurochemistry20011001

Title: GAT2/BGT-1 as a system responsible for the transport of gamma-aminobutyric acid at the mouse blood-brain barrier.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism20011001

Title: Creatine transport in brush-border membrane vesicles isolated from rat kidney cortex.

Journal: Journal of the American Society of Nephrology : JASN20010901

Title: The role of glycineB binding site and glycine transporter (GlyT1) in the regulation of [3H]GABA and [3H]glycine release in the rat brain.

Journal: Neurochemical research20010901

Title: Nipecotic acid directly activates GABA(A)-like ion channels.

Journal: British journal of pharmacology20010701

Title: Synthesis of novel gamma-aminobutyric acid (GABA) uptake inhibitors. 5.(1) Preparation and structure-activity studies of tricyclic analogues of known GABA uptake inhibitors.

Journal: Journal of medicinal chemistry20010621

Title: Experimental uremia affects hypothalamic amino acid neurotransmitter milieu.

Journal: Journal of the American Society of Nephrology : JASN20010601

Title: GABA transaminase inhibition induces spontaneous and enhances depolarization-evoked GABA efflux via reversal of the GABA transporter.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20010415

Title: Monomeric state and ligand binding of recombinant GABA transporter from Escherichia coli.

Journal: FEBS letters20010413

Title: Attenuation of malonate toxicity in primary mesencephalic cultures using the GABA transport blocker, NO-711.

Journal: Journal of neuroscience research20010401

Title: Transport of L-carnitine in isolated cerebral cortex neurons.

Journal: European journal of biochemistry20010401

Title: GABA uptake and heterotransport are impaired in the dentate gyrus of epileptic rats and humans with temporal lobe sclerosis.

Journal: Journal of neurophysiology20010401

Title: Tiagabine in clinical practice.

Journal: Epilepsia20010101

Title: GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects.

Journal: Current pharmaceutical design20000801

Title: 1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter.

Journal: British journal of pharmacology19970301

Building Blocks More >
109531-96-6
109531-96-6
N-Methylfurohydroxamic acid
AA003T4Z | MFCD00144939
55-57-2
55-57-2
1-Phenylbiguanide hydrochloride
AA003T8K | MFCD00035040
1028432-04-3
1028432-04-3
O-(tert-Butyldimethylsilyl)-n-tosylhydroxylamine
AA003TC8 | MFCD11976059
1949-20-8
1949-20-8
Oxolamine citrate salt
AA003TG2 | MFCD00083457
6724-53-4
6724-53-4
PerheXiline Maleate Salt
AA003TKR | MFCD00057329
78902-09-7
78902-09-7
Phthalimidoacetaldehyde diethyl acetal
AA003TOV | MFCD00005901
871-58-9
871-58-9
Potassium (butoxycarbonothioyl)sulfide
AA003TT5 | MFCD00059688
2571-00-8
2571-00-8
P-TOLUALDEHYDE 2,4-DINITROPHENYLHYDRAZONE
AA003TY1 | MFCD00024382
25470-96-6
25470-96-6
Acetylacetonatocarbonyl triphenylphosphine Rhodium(I)
AA003U1V | MFCD00064611
6994-45-2
6994-45-2
Sodium tetradecane-1-sulfonate
AA003U7O | MFCD00043415
Submit
© 2017 AA BLOCKS, INC. All rights reserved.