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Title: Library screening by means of mass spectrometry (MS) binding assays-exemplarily demonstrated for a pseudostatic library addressing γ-aminobutyric acid (GABA) transporter 1 (GAT1).
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Title: Synthesis and evaluation of new polyenic compounds as potential PPARs modulators.
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Title: Involvement of γ-aminobutyric acid transporter 2 in the hepatic uptake of taurine in rats.
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Title: Arousal from sleep in response to intermittent hypoxia in rat pups is modulated by medullary raphe GABAergic mechanisms.
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Title: TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3.
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Title: In vitro maturation of dopaminergic neurons derived from mouse embryonic stem cells: implications for transplantation.
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Title: γ-Aminobutyric acid transporter 2 mediates the hepatic uptake of guanidinoacetate, the creatine biosynthetic precursor, in rats.
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Title: Co-Release of GABA Does Not Occur at Glycinergic Synapses onto Lumbar Motoneurons in Juvenile Mice.
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Title: A steered molecular dynamics study of binding and translocation processes in the GABA transporter.
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Title: Simultaneous quantification of D- vs. L-serine, taurine, kynurenate, phosphoethanolamine and diverse amino acids in frontocortical dialysates of freely-moving rats: differential modulation by N-methyl-D-aspartate (NMDA) and other pharmacological agents.
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Title: 1,5-Substituted nipecotic amides: selective PDE8 inhibitors displaying diastereomer-dependent microsomal stability.
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Title: Methylone and monoamine transporters: correlation with toxicity.
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Title: Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2).
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Title: Stereospecific synthesis and structure-activity relationships of unsymmetrical 4,4-diphenylbut-3-enyl derivatives of nipecotic acid as GAT-1 inhibitors.
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Title: Localization and Function of GABA Transporters GAT-1 and GAT-3 in the Basal Ganglia.
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Title: Manganese exposure inhibits the clearance of extracellular GABA and influences taurine homeostasis in the striatum of developing rats.
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Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships.
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Title: A possible role of the non-GAT1 GABA transporters in transfer of GABA from GABAergic to glutamatergic neurons in mouse cerebellar neuronal cultures.
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Title: Sensory learning differentially affects GABAergic tonic currents in excitatory neurons and fast spiking interneurons in layer 4 of mouse barrel cortex.
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Title: Homology modelling of the GABA transporter and analysis of tiagabine binding.
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Title: An adenosine A(2A) agonist injected in the nucleus of the solitary tract prolongs the laryngeal chemoreflex by a GABAergic mechanism in decerebrate piglets.
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Title: Azetidine derivatives as novel gamma-aminobutyric acid uptake inhibitors: synthesis, biological evaluation, and structure-activity relationship.
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Title: Zolpidem modulation of phasic and tonic GABA currents in the rat dorsal motor nucleus of the vagus.
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Title: Diverse antiepileptic drugs increase the ratio of background synaptic inhibition to excitation and decrease neuronal excitability in neurones of the rat entorhinal cortex in vitro.
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Title: N-methyl phenylalanine-rich peptides as highly versatile blood-brain barrier shuttles.
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Title: Glutamatergic excitation and GABA release from a transplantable cell line.
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Title: Hypertonicity enhances GABA uptake by cultured rat retinal capillary endothelial cells.
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Title: Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures.
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Title: Regulation of tonic GABA inhibitory function, presympathetic neuronal activity and sympathetic outflow from the paraventricular nucleus by astroglial GABA transporters.
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Title: Alterations in extracellular levels of gamma-aminobutyric acid in the rat basolateral amygdala and periaqueductal gray during conditioned fear, persistent pain and fear-conditioned analgesia.
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Title: Carnitine conjugate of nipecotic acid: a new example of dual prodrug.
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Title: Calibration of neurotransmitter release from neural cells for therapeutic implants.
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Title: Stereoselective synthesis of nipecotic acid derivatives via palladium-catalyzed decarboxylative cyclization of gamma-methylidene-delta-valerolactones with imines.
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Title: Synaptically evoked glutamate transporter currents in Spinal Dorsal Horn Astrocytes.
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Title: Temporal requirements of the fragile x mental retardation protein in modulating circadian clock circuit synaptic architecture.
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Title: Gamma-aminobutyric acid-mediated neurotransmission in the pontine reticular formation modulates hypnosis, immobility, and breathing during isoflurane anesthesia.
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Title: Synthesis and biological evaluation of aminomethylphenol derivatives as inhibitors of the murine GABA transporters mGAT1-mGAT4.
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Title: Chronic nicotine modifies the effects of morphine on extracellular striatal dopamine and ventral tegmental GABA.
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Title: On the presence of 3H-GABA uptake mechanism in bovine spermatozoa.
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Title: Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease.
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Title: Water-soluble calix[4]resorcinarenes with hydroxyproline groups as chiral NMR solvating agents.
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Title: Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila.
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Title: Pontine reticular formation (PnO) administration of hypocretin-1 increases PnO GABA levels and wakefulness.
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Title: Synaptosomal GABA uptake decreases in paraoxon-treated rat brain.
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Title: Fast homeostatic plasticity of inhibition via activity-dependent vesicular filling.
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Title: GABA uptake by purified avian Müller glia cells in culture.
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Title: Uptake and release of [(3)H]GABA in human dental pulp.
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Title: Synthesis and biological evaluation of (R)-N-(diarylmethylthio/sulfinyl)ethyl/propyl-piperidine-3-carboxylic acid hydrochlorides as novel GABA uptake inhibitors.
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Title: Selective amino acid substitutions convert the creatine transporter to a gamma-aminobutyric acid transporter.
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Title: Neuropharmacological profile of FrPbAII, purified from the venom of the social spider Parawixia bistriata (Araneae, Araneidae), in Wistar rats.
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Title: Sleep and GABA levels in the oral part of rat pontine reticular formation are decreased by local and systemic administration of morphine.
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Title: [Tiagabine overdose--report of two cases].
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Title: Anticonvulsant and anxiolytic activity of FrPbAII, a novel GABA uptake inhibitor isolated from the venom of the social spider Parawixia bistriata (Araneidae: Araneae).
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Title: Possible expression of a particular gamma-aminobutyric acid transporter isoform responsive to upregulation by hyperosmolarity in rat calvarial osteoblasts.
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Title: Development of GABA-sensitive spasticity and rigidity in rats after transient spinal cord ischemia: a qualitative and quantitative electrophysiological and histopathological study.
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Title: GABAergic mechanisms in regulating the activity state of substantia nigra pars reticulata neurons.
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Title: Influence of a proton gradient on the transport kinetics of the H+/amino acid cotransporter PAT1 in Caco-2 cells.
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Title: GABAergic and glycinergic inhibitory mechanisms in the lamprey respiratory control.
Journal: Brain research 20060523
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: alpha2-Adrenoceptor-mediated modulation of the release of GABA and noradrenaline in the rat substantia nigra pars reticulata.
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Title: Improvement of metabolic competence of isolated nerve terminals by extracellular pyruvate.
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Title: 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.
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Title: Antidystonic efficacy of gamma-aminobutyric acid uptake inhibitors in the dtsz mutant.
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Title: Subtype-specific GABA transporter antagonists synergistically modulate phasic and tonic GABAA conductances in rat neocortex.
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Title: Anterior hypothalamic neurons respond to blood pressure changes via gamma-aminobutyric acid and angiotensins in rats.
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Title: HPLC conditions are critical for the detection of GABA by microdialysis.
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Title: Quinolinic acid toxicity on orexin neurons blocked by gamma aminobutyric acid type A receptor stimulation.
Journal: Neuroreport 20050801
Title: Phospholipids as determinants of membrane protein topology. Phosphatidylethanolamine is required for the proper topological organization of the gamma-aminobutyric acid permease (GabP) of Escherichia coli.
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Title: Nipecotic acid: systemic availability and brain delivery after nasal administration of nipecotic acid and n-butyl nipecotate to rats.
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Title: Nitric oxide stimulates gamma-aminobutyric acid release and inhibits glycine release in retina.
Journal: The Journal of comparative neurology 20050314
Title: Ascorbic and 6-Br-ascorbic acid conjugates as a tool to increase the therapeutic effects of potentially central active drugs.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050301
Title: Thermodynamic study of N-trifluoroacetyl-O-alkyl nipecotic acid ester enantiomers on diluted permethylated beta-cyclodextrin stationary phase.
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Title: Stimulated release of exogenous GABA and glutamate from cerebral cortical synaptosomes and brain slices by bis(acetato)tetrakis(imidazole) copper(II) complex.
Journal: Biological trace element research 20050101
Title: Characterization and crystal structure of cadmium(II) halide complexes with amino acids and their derivatives VI. The comparison of crystal structures of cadmium(II) halide complexes with three kinds of piperidine carboxylic acids.
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Title: Neuronal electrical high frequency stimulation modulates presynaptic GABAergic physiology.
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Title: GABAergic modulation of motor-driven behaviors in juvenile Drosophila and evidence for a nonbehavioral role for GABA transport.
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Title: Design, synthesis and in vitro evaluation on HRPE cells of ascorbic and 6-bromoascorbic acid conjugates with neuroactive molecules.
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Title: The brain-to-blood efflux transport of taurine and changes in the blood-brain barrier transport system by tumor necrosis factor-alpha.
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Title: Effect of a high-salt diet on gamma-aminobutyric acid-mediated responses in the nucleus tractus solitarius of Sprague-Dawley rats.
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Title: Taurine-induced long-lasting potentiation in the rat hippocampus shows a partial dissociation from total hippocampal taurine content and independence from activation of known taurine transporters.
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Title: Lipophilicity-related inhibition of blood platelet aggregation by nipecotic acid anilides.
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Title: Design, synthesis and anticonvulsive activity of analogs of gamma-vinyl GABA.
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Title: Involvement of membrane GABA transporter in alpha-latrotoxin-stimulated [3H]GABA release.
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Title: Role of taurine uptake on the induction of long-term synaptic potentiation.
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Title: Assay for nipecotic acid in small blood samples by gas chromatography-mass spectroscopy.
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Title: Behavioral effects of bicuculline microinjection in the dorsal versus ventral hippocampal formation of rats, and control of seizures by nigral muscimol.
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Title: Transporter-mediated effects of diclofenamic acid and its ascorbyl pro-drug in the in vivo neurotropic activity of ascorbyl nipecotic acid conjugate.
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Title: Changes in rectal temperature and ECoG spectral power of sensorimotor cortex elicited in conscious rabbits by i.c.v. injection of GABA, GABA(A) and GABA(B) agonists and antagonists.
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Title: The 'Transport Specificity Ratio': a structure-function tool to search the protein fold for loci that control transition state stability in membrane transport catalysis.
Journal: BMC biochemistry 20040101
Title: Use of the transport specificity ratio and cysteine-scanning mutagenesis to detect multiple substrate specificity determinants in the consensus amphipathic region of the Escherichia coli GABA (gamma-aminobutyric acid) transporter encoded by gabP.
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Title: Intracerebroventricular injection of muscimol, baclofen or nipecotic acid stimulates food intake in layer-type, but not meat-type, chicks.
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Title: Partial hippocampal kindling increases GABAB receptor-mediated postsynaptic currents in CA1 pyramidal cells.
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Title: Design, synthesis and anticonvulsive activities of potential prodrugs linked by two-carbon chain.
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Title: Differential arithmetic of shunting inhibition for voltage and spike rate in neocortical pyramidal cells.
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Title: Highly water-soluble derivatives of the anesthetic agent propofol: in vitro and in vivo evaluation of cyclic amino acid esters.
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Title: Taurine-induced long-lasting enhancement of synaptic transmission in mice: role of transporters.
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Title: Phenylarsine oxide inhibits alpha-latrotoxin-stimulated [3H]GABA release from rat brain synaptosomes.
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Title: De novo design of non-hydrogen-bonded helical pseudopeptides composed of oxanipecotic acid oligomers.
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Title: Investigation of platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids.
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Title: Role of EphA4 and EphrinB3 in local neuronal circuits that control walking.
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Title: Endogenous GABA in the commissural subnucleus of the NTS inhibits the carotid chemoreceptor reflex via GABA A receptors in rats.
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Title: Effects of 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazol (exo-THPO) and its N-substituted analogs on GABA transport in cultured neurons and astrocytes and by the four cloned mouse GABA transporters.
Journal: Neurochemistry international 20030101
Title: GABA-mediated neurotransmission in the ventrolateral NTS plays a role in respiratory regulation in the rat.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20021201
Title: IL-4 increases GABAergic phenotype in rat retinal cell cultures: involvement of muscarinic receptors and protein kinase C.
Journal: Journal of neuroimmunology 20021201
Title: Expression and functional characterization of GABA transporters in crayfish neurosecretory cells.
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Title: GAT-1 and reversible GABA transport in Bergmann glia in slices.
Journal: Journal of neurophysiology 20020901
Title: Delta-Aminolevulinic acid transport in murine mammary adenocarcinoma cells is mediated by beta transporters.
Journal: British journal of cancer 20020812
Title: Increased synaptosomal [3H] GABA uptake in the rat brainstem after facial carrageenan injections.
Journal: Pain 20020801
Title: GABA is toxic for mouse striatal neurones through a transporter-mediated process.
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Title: Gamma-aminobutyric acid transporter (BGT-1) expressed in human astrocytoma U373 MG cells: pharmacological and molecular characterization and phorbol ester-induced inhibition.
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Title: AMPA receptor activation induces GABA release from neurons migrating tangentially in the intermediate zone of embryonic rat neocortex.
Journal: The European journal of neuroscience 20020701
Title: Involvement of P2X7 receptors in the regulation of neurotransmitter release in the rat hippocampus.
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Title: Effect of cannabinoids on synaptic transmission in the rat hippocampal slice is temperature-dependent.
Journal: European journal of pharmacology 20020503
Title: Effects of GABAergic agents on anesthesia induced by halothane, isoflurane, and thiamylal in mice.
Journal: Pharmacology, biochemistry, and behavior 20020501
Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
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Title: Differential ontogeny of GABA(B)-receptor-mediated pre- and postsynaptic modulation of GABA and glycine transmission in respiratory rhythm-generating network in mouse.
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Title: Functional significance of nitric oxide in ionomycin-evoked [3H]GABA release from mouse cerebral cortical neurons.
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Title: Design, synthesis and activity of ascorbic acid prodrugs of nipecotic, kynurenic and diclophenamic acids, liable to increase neurotropic activity.
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Title: Activation of P2X(7) receptors induced [(3)H]GABA release from the RBA-2 type-2 astrocyte cell line through a Cl(-)/HCO(3)(-)-dependent mechanism.
Journal: Glia 20020101
Title: Bi-directional transport of GABA in human embryonic kidney (HEK-293) cells stably expressing the rat GABA transporter GAT-1.
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Title: [Effect of synaptosomal cytosolic [3H]GABA pool depletion on secretory ability of alpha-latrotoxin].
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Title: Substrate-induced regulation of gamma-aminobutyric acid transporter trafficking requires tyrosine phosphorylation.
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Title: Synthesis of novel GABA uptake inhibitors. Part 6: preparation and evaluation of N-Omega asymmetrically substituted nipecotic acid derivatives.
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Title: Differential modulation of respiratory neuronal discharge patterns by GABA(A) receptor and apamin-sensitive K(+) channel antagonism.
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Title: Serotonin-1B receptor-mediated inhibition of [(3)H]GABA release from rat ventral tegmental area slices.
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Title: Glutamate receptor desensitization block potentiates the stimulated GABA release through external Ca2+-independent mechanisms from granule cells of olfactory bulb.
Journal: Neurochemical research 20011101
Title: Common mechanisms of inhibition for the Na+/glucose (hSGLT1) and Na+/Cl-/GABA (hGAT1) cotransporters.
Journal: British journal of pharmacology 20011001
Title: Efflux of a suppressive neurotransmitter, GABA, across the blood-brain barrier.
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Title: GAT2/BGT-1 as a system responsible for the transport of gamma-aminobutyric acid at the mouse blood-brain barrier.
Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20011001
Title: Creatine transport in brush-border membrane vesicles isolated from rat kidney cortex.
Journal: Journal of the American Society of Nephrology : JASN 20010901
Title: The role of glycineB binding site and glycine transporter (GlyT1) in the regulation of [3H]GABA and [3H]glycine release in the rat brain.
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Title: Nipecotic acid directly activates GABA(A)-like ion channels.
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Title: Synthesis of novel gamma-aminobutyric acid (GABA) uptake inhibitors. 5.(1) Preparation and structure-activity studies of tricyclic analogues of known GABA uptake inhibitors.
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Title: Experimental uremia affects hypothalamic amino acid neurotransmitter milieu.
Journal: Journal of the American Society of Nephrology : JASN 20010601
Title: GABA transaminase inhibition induces spontaneous and enhances depolarization-evoked GABA efflux via reversal of the GABA transporter.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20010415
Title: Monomeric state and ligand binding of recombinant GABA transporter from Escherichia coli.
Journal: FEBS letters 20010413
Title: Attenuation of malonate toxicity in primary mesencephalic cultures using the GABA transport blocker, NO-711.
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Title: Transport of L-carnitine in isolated cerebral cortex neurons.
Journal: European journal of biochemistry 20010401
Title: GABA uptake and heterotransport are impaired in the dentate gyrus of epileptic rats and humans with temporal lobe sclerosis.
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Title: Tiagabine in clinical practice.
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Title: 1-(3-(9H-carbazol-9-yl)-1-propyl)-4-(2-methoxyphenyl)-4-piperidinol, a novel subtype selective inhibitor of the mouse type II GABA-transporter.
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