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6724-53-4,MFCD00057329
Catalog No.:AA003TKR

6724-53-4 | PerheXiline Maleate Salt

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$38.00   $27.00
- +
5mg
≥95%
in stock  
$89.00   $62.00
- +
10mg
98%
in stock  
$133.00   $93.00
- +
25mg
98% by HPLC
in stock  
$310.00   $217.00
- +
50mg
98% by HPLC
in stock  
$483.00   $338.00
- +
100mg
98% by HPLC
in stock  
$788.00   $552.00
- +
500mg
98% by HPLC
in stock  
$2,401.00   $1,681.00
- +
1000mg
98% by HPLC
in stock  
$3,803.00   $2,662.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003TKR
Chemical Name:
PerheXiline Maleate Salt
CAS Number:
6724-53-4
Molecular Formula:
C23H39NO4
Molecular Weight:
393.5601
MDL Number:
MFCD00057329
SMILES:
C1CCC(NC1)CC(C1CCCCC1)C1CCCCC1.OC(=O)/C=C/C(=O)O
NSC Number:
758409
Properties
Properties
 
BP:
574.1°C at 760 mmHg  
Form:
Solid  
MP:
>174°C (dec.)  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
364  
Covalently-Bonded Unit Count:
2  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
1  

Downstream Synthesis Route

[1]CurrentPatentAssignee:PROCTER&GAMBLECO;SANOFI-US4191828,1980,A

Literature

Title: Why are most phospholipidosis inducers also hERG blockers?

Journal: Archives of toxicology 20171201

Title: A case series of concomitant treatment of perhexiline with amiodarone.

Journal: Therapeutic drug monitoring 20120401

Title: Hypoglycaemia after treatment with perhexiline maleate: a case report.

Journal: The New Zealand medical journal 20110304

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Ca2+-dependent functions in peptidoglycan-stimulated mouse dendritic cells.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20090101

Title: Steatohepatitis-inducing drugs trigger cytokeratin cross-links in hepatocytes. Possible contribution to Mallory-Denk body formation.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20080901

Title: Effect of CYP2D6 metabolizer status on the disposition of the (+) and (-) enantiomers of perhexiline in patients with myocardial ischaemia.

Journal: Pharmacogenetics and genomics 20070501

Title: Metabolic therapeutics in angina pectoris: history revisited with perhexiline.

Journal: European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Leustroducsin B activates nuclear factor-kappaB via the acidic sphingomyelinase pathway in human bone marrow-derived stromal cell line KM-102.

Journal: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20020301

Title: [Amphiphilic cationic drug myopathy, drug-induced lysosomal storage lipidosis].

Journal: Ryoikibetsu shokogun shirizu 20010101

Title: Relationship between plasma perhexiline concentration and symptomatic status during short-term perhexiline therapy.

Journal: Therapeutic drug monitoring 19961201

Title: Perhexiline maleate-induced hepatitis.

Journal: Hepato-gastroenterology 19910801

Title: Torsade de pointes associated with perhexiline maleate therapy.

Journal: Australian and New Zealand journal of medicine 19901201

Title: [Myopathy caused by perhexiline maleate].

Journal: Neurologia (Barcelona, Spain) 19870101

Title: Severe ocular side effects of perhexilene maleate: case report.

Journal: The British journal of ophthalmology 19840801

Title: Perhexilene neuropathy: a report of two cases.

Journal: Australian and New Zealand journal of medicine 19831001

Title: Perhexiline maleate induced cirrhosis.

Journal: Pathology 19830401

Title: Cirrhosis of the liver following therapy with perhexiline maleate.

Journal: The New Zealand medical journal 19830323

Title: [Study of thesaurismosis induced by perhexiline maleate. Confirmation of experimental data].

Journal: La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris 19830106

Title: Prediction of subclinical perhexiline neuropathy in a patient with inborn error of debrisoquine hydroxylation.

Journal: American heart journal 19830101

Title: Papilledema without peripheral neuropathy in a patient taking perhexiline maleate.

Journal: Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 19820801

Title: Perhexiline hepatitis and HLA-B8.

Journal: Lancet (London, England) 19820710

Title: Adverse effects of perhexiline.

Journal: Lancet (London, England) 19820227

Title: Impaired oxidation of debrisoquine in patients with perhexiline neuropathy.

Journal: British medical journal (Clinical research ed.) 19820130

Title: [Perhexiline maleate-induced cirrhosis].

Journal: Acta gastro-enterologica Belgica 19820101

Title: Perhexiline maleate induced lipidosis in human peripheral nerve and tissue culture: ultrastructural and biochemical changes.

Journal: Clinical toxicology 19811201

Title: Liver disease induced by perhexiline maleate.

Journal: The Medical journal of Australia 19811114

Title: Perhexiline maleate as a cause of reversible parkinsonism and peripheral neuropathy.

Journal: Journal of the American Geriatrics Society 19810601

Title: [Perhexiline maleate induced cirrhosis (author's transl)].

Journal: Acta gastro-enterologica Belgica 19810101

Title: [Polyneuritis after use of perhexiline maleate: quantimetric and ultrastructural study (author's transl)].

Journal: La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris 19801101

Title: Toxic polyneuritis and toxic hepatitis related to long-term perhexiline maleate therapy.

Journal: American heart journal 19800801

Title: Peripheral neuropathy due to perhexilene maleate.

Journal: Journal of the neurological sciences 19800601

Title: Papilloedema and hepatic dysfunction apparently induced by perhexiline maleate (Pexid).

Journal: British heart journal 19800401

Title: [Complications after perhexiline maleate and amiodarone chlorhydrate treatment in a same patient: hypoglycemia, polyneuritis and hyperthyroidism (author's transl)].

Journal: La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris 19800201

Title: Perhexiline maleate-associated hepatic injury prevalence and characteristics.

Journal: Digestion 19800101

Title: [Neuropathies due to perhexiline maleate and their electromyographic diagnosis].

Journal: Journal belge de medecine physique et de rehabilitation. = Belgisch tijdschrift voor fysische geneeskunde en rehabilitatie 19800101

Title: Prevalence of perhexiline maleate neurotoxicosis.

Journal: The Medical journal of Australia 19791020

Title: Perhexiline maleate in the treatment of severe angina pectoris.

Journal: The Medical journal of Australia 19790602

Title: Perhexiline maleate and peripheral neuropathy.

Journal: Neurology 19790501

Title: Analysis of the major lipid classes in human peripheral nerve biopsies. Age group differences and abnormalities of ganglioside level in perhexiline maleate therapy.

Journal: Journal of the neurological sciences 19790401

Title: [Acute hepatic failure due to perhexiline maleate].

Journal: La Nouvelle presse medicale 19790210

Title: Perhexiline maleate-induced cirrhosis.

Journal: Gastroenterology 19790101

Title: Pharmacokinetics of perhexiline maleate in anginal patients with and without peripheral neuropathy.

Journal: European journal of clinical pharmacology 19781127

Title: Polyneuropathy with normal metabolism of perhexiline maleate.

Journal: Annals of neurology 19781001

Title: [Cirrhogenic hepatitis due to perhexiline maleate: general review based upon one new case with ultrastructural study (author's transl)].

Journal: Annales de medecine interne 19781001

Title: Prevalence of latent perhexiline neuropathy.

Journal: British medical journal 19780520

Title: Perhexilene mimicking bronchial carcinoma.

Journal: Lancet (London, England) 19780415

Title: Perhexilline-induced neuropathy.

Journal: British medical journal 19780401

Title: [Diffuse polymorphous inclusions in a patient treated with perhexiline maleate (author's transl)].

Journal: La Nouvelle presse medicale 19780311

Title: Perhexiline neuropathy: a clinicopathological study.

Journal: Annals of neurology 19780301

Title: [Neurological disorders and perhexiline maleate therapy. Clinical study of 10 cases. Neuropathological, pharmacocinetic and biochemical studies (author's transl)].

Journal: Revue neurologique 19780201

Title: Raised intracranial pressure due to perhexiline maleate.

Journal: British medical journal 19780107

Title: Perhexiline maleate-induced hepatitis.

Journal: Digestion 19780101

Title: [Post-arteriographic thrombosis of the ophthalmic veins in 2 cases of peripheral neuropathy with central neurological signs due to perhexiline maleate].

Journal: La Nouvelle presse medicale 19771112

Title: [Peripheral neuropathies due to perhexiline maleate (author's transl)].

Journal: Annales de cardiologie et d'angeiologie 19771101

Title: [Hepatitis due to perhexiline maleate. Development of cirrhosis after interruption of the drug. Report of two cases (author's transl)].

Journal: Gastroenterologie clinique et biologique 19771001

Title: Peripheral and autonomic neuropathy after treatment with perhexiline maleate.

Journal: British medical journal 19770910

Title: Peripheral-nerve lipid abnormalities in patients on perhexiline maleate.

Journal: Lancet (London, England) 19770611

Title: Proximal myopathy after perhexiline maleate treatment.

Journal: British medical journal 19770521

Title: [Electron microscopic study of nerve, muscle and skin lesions induced by perhexiline maleate (author's transl)].

Journal: Acta neuropathologica 19770429

Title: Liver ganglioside storage after perhexiline maleate.

Journal: Lancet (London, England) 19770226

Title: [A case of polyneuropathy caused by perhexiline maleate].

Journal: Revue d'oto-neuro-ophtalmologie 19770101

Title: [Slow and incomplete regression of peripheral neuropathy due to perhexiline maleate].

Journal: Annales de cardiologie et d'angeiologie 19770101

Title: [Oedematous optic neuropathy from Perhexilline maleate associated with peripheral polyneuropathy (author's transl)].

Journal: Archives d'ophtalmologie 19770101

Title: [Ocular complications of PEXID].

Journal: Bulletin des societes d'ophtalmologie de France 19770101

Title: [A case of polyradiculoneuritis following prolonged treatment with perhexiline maleate].

Journal: La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris 19761109

Title: Polyneuropathy after perhexiline maleate therapy.

Journal: British medical journal 19760522

Title: [Peripheral neuropathies caused by perhexiline maleate. Apropos of 7 cases].

Journal: Coeur et medecine interne 19760101

Title: [Letter: Equilibrium disorders induced by perhexiline maleate].

Journal: La Nouvelle presse medicale 19741026

Title: Perhexiline maleate, a new anti-anginal drug, evaluated by 'modified double blind double cross over study'.

Journal: Angiology 19740601

Title: Kennedy JA, et al. Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by Perhexiline and amiodarone. Biochem Pharmacol. 1996 Jul 26;52(2):273-80.

Title: Vella S, et al. Perhexiline maleate enhances antitumor efficacy of cisplatin in neuroblastoma by inducing over-expression of NDM29 ncRNA. Sci Rep. 2015 Dec 17;5:18144.

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