Home Amines 2566-34-9
2566-34-9,MFCD20259663
Catalog No.:AA003T2M

2566-34-9 | 2-(Methylamino)isobutyric acid hydrate

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1g
>98.0%(T)
in stock  
$75.00   $52.00
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5g
>98.0%(T)
in stock  
$220.00   $154.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003T2M
Chemical Name:
2-(Methylamino)isobutyric acid hydrate
CAS Number:
2566-34-9
Molecular Formula:
C5H11NO2
Molecular Weight:
117.1463
MDL Number:
MFCD20259663
SMILES:
CNC(C(=O)O)(C)C
Properties
Properties
 
Form:
Solid  
MP:
300℃  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
98.6  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
8  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
XLogP3:
-2.3  

Literature

Title: Transport mechanism of (11)C-labeled L- and D-methionine in human-derived tumor cells.

Journal: Nuclear medicine and biology 20121101

Title: Functional RNA interference (RNAi) screen identifies system A neutral amino acid transporter 2 (SNAT2) as a mediator of arsenic-induced endoplasmic reticulum stress.

Journal: The Journal of biological chemistry 20120217

Title: The SLC36 family of proton-coupled amino acid transporters and their potential role in drug transport.

Journal: British journal of pharmacology 20111201

Title: Attenuation of inhibitory synaptic transmission by glial dysfunction in rat thalamus.

Journal: Synapse (New York, N.Y.) 20111201

Title: Dihydrotestosterone stimulates amino acid uptake and the expression of LAT2 in mouse skeletal muscle fibres through an ERK1/2-dependent mechanism.

Journal: The Journal of physiology 20110715

Title: Putative transport mechanism and intracellular fate of trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid in human prostate cancer.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20110501

Title: Oxidative stress increases SNAT1 expression and stimulates cysteine uptake in freshly isolated rat cardiomyocytes.

Journal: Amino acids 20110201

Title: Glutamine triggers and potentiates glucagon-like peptide-1 secretion by raising cytosolic Ca2+ and cAMP.

Journal: Endocrinology 20110201

Title: Altered tryptophan and alanine transport in fibroblasts from boys with attention-deficit/hyperactivity disorder (ADHD): an in vitro study.

Journal: Behavioral and brain functions : BBF 20110101

Title: Radioiodinated 4-iodo-L-meta-tyrosine, a system L selective artificial amino acid: molecular design and transport characterization in Chinese hamster ovary cells (CHO-K1 cells).

Journal: Nuclear medicine and biology 20101101

Title: Amino acid sensing by enteroendocrine STC-1 cells: role of the Na+-coupled neutral amino acid transporter 2.

Journal: American journal of physiology. Cell physiology 20100601

Title: Involvement of system A in the retina-to-blood transport of l-proline across the inner blood-retinal barrier.

Journal: Experimental eye research 20100401

Title: Maintenance of thalamic epileptiform activity depends on the astrocytic glutamate-glutamine cycle.

Journal: Journal of neurophysiology 20091101

Title: Glutamine induces epileptiform discharges in superficial layers of the medial entorhinal cortex from pilocarpine-treated chronic epileptic rats in vitro.

Journal: Epilepsia 20090401

Title: Reconstitution into liposomes of the B degrees -like glutamine-neutral amino acid transporter from renal cell plasma membrane.

Journal: Biochimica et biophysica acta 20081001

Title: Glutamine-induced membrane currents in cultured rat hippocampal neurons.

Journal: The European journal of neuroscience 20080801

Title: A glia-neuron alanine/ammonium shuttle is central to energy metabolism in bee retina.

Journal: The Journal of physiology 20080415

Title: Functional activity of a large neutral amino acid transporter (LAT) in rabbit retina: a study involving the in vivo retinal uptake and vitreal pharmacokinetics of L-phenyl alanine.

Journal: International journal of pharmaceutics 20080122

Title: Pharmacokinetics of 3-[125I]iodo-alpha-methyl-L-tyrosine, a tumor imaging agent, after probenecid loading in mice implanted with colon cancer DLD-1 cells.

Journal: Nuclear medicine and biology 20071101

Title: Glutamine uptake by System A transporters maintains neurotransmitter GABA synthesis and inhibitory synaptic transmission.

Journal: Journal of neurochemistry 20070901

Title: Characterization of transport systems for cysteine, lysine, alanine, and leucine in wool follicles of sheep.

Journal: Journal of animal science 20070901

Title: Transport of D-[1-14C]-amino acids into Chinese hamster ovary (CHO-K1) cells: implications for use of labeled d-amino acids as molecular imaging agents.

Journal: Nuclear medicine and biology 20070801

Title: The sodium-coupled neutral amino acid transporter SNAT2 mediates an anion leak conductance that is differentially inhibited by transported substrates.

Journal: Biophysical journal 20070401

Title: In vitro characterization of the thyroidal uptake of O-(2-[(18)F]fluoroethyl)-L-tyrosine.

Journal: Nuclear medicine and biology 20070401

Title: Amino acid transporter ATA2 is stored at the trans-Golgi network and released by insulin stimulus in adipocytes.

Journal: The Journal of biological chemistry 20061222

Title: Regulation of amino acid transporter ATA2 by ubiquitin ligase Nedd4-2.

Journal: The Journal of biological chemistry 20061124

Title: Angiotensin II decreases system A amino acid transporter activity in human placental villous fragments through AT1 receptor activation.

Journal: American journal of physiology. Endocrinology and metabolism 20061101

Title: Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells.

Journal: The Biochemical journal 20061101

Title: Kinetics of glial glutamine efflux and the mechanism of neuronal uptake studied in vivo in mildly hyperammonemic rat brain.

Journal: Journal of neurochemistry 20061101

Title: Cortisol stimulates system A amino acid transport and SNAT2 expression in a human placental cell line (BeWo).

Journal: American journal of physiology. Endocrinology and metabolism 20060901

Title: Dynamic regulation of synaptic GABA release by the glutamate-glutamine cycle in hippocampal area CA1.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060816

Title: Inhibition of amino acid transport system a by interleukin-1beta in trophoblasts.

Journal: Journal of the Society for Gynecologic Investigation 20051001

Title: Interleukin-15 decreases proteolysis in skeletal muscle: a direct effect.

Journal: International journal of molecular medicine 20050901

Title: Differential regulation of amino acid transporter SNAT3 by insulin in hepatocytes.

Journal: The Journal of biological chemistry 20050715

Title: Suppression of glial glutamine release to the extracellular fluid studied in vivo by NMR and microdialysis in hyperammonemic rat brain.

Journal: Journal of neurochemistry 20050701

Title: Functional expression and adaptive regulation of Na+ -dependent neutral amino acid transporter SNAT2/ATA2 in normal human astrocytes under amino acid starved condition.

Journal: Neuroscience letters 20050418

Title: Isolation and function of the amino acid transporter PAT1 (slc36a1) from rabbit and discrimination between transport via PAT1 and system IMINO in renal brush-border membrane vesicles.

Journal: Molecular membrane biology 20050101

Title: Effect of melatonin on the retinal glutamate/glutamine cycle in the golden hamster retina.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20041201

Title: 3-O-methyl-6-18F-fluoro-L-dopa, a new tumor imaging agent: investigation of transport mechanism in vitro.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20041201

Title: A novel physiological mechanism of glycine-induced immunomodulation: Na+-coupled amino acid transporter currents in cultured brain macrophages.

Journal: The Journal of physiology 20040815

Title: Quantitative determination of extracellular glutamine concentration in rat brain, and its elevation in vivo by system A transport inhibitor, alpha-(methylamino)isobutyrate.

Journal: Journal of neurochemistry 20040701

Title: Momordica charantia fruit juice stimulates glucose and amino acid uptakes in L6 myotubes.

Journal: Molecular and cellular biochemistry 20040601

Title: Transcellular transport of radioiodinated 3-iodo-alpha-methyl-L-tyrosine across monolayers of kidney epithelial cell line LLC-PK1.

Journal: Annals of nuclear medicine 20040501

Title: Functional properties and cellular distribution of the system A glutamine transporter SNAT1 support specialized roles in central neurons.

Journal: The Journal of biological chemistry 20030627

Title: Structure, tissue expression pattern, and function of the amino acid transporter rat PAT2.

Journal: Biochemical and biophysical research communications 20030516

Title: Inhibition of glutamine transport depletes glutamate and GABA neurotransmitter pools: further evidence for metabolic compartmentation.

Journal: Journal of neurochemistry 20030401

Title: Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2.

Journal: The Journal of physiology 20030115

Title: Unique antitumour effects of L-2,4 diaminobutyric acid on cultured hepatoma cells.

Journal: Anticancer research 20030101

Title: Glutamine transport in isolated epithelial intestinal cells. Identification of a Na+-dependent transport mechanism, highly specific for glutamine.

Journal: Pflugers Archiv : European journal of physiology 20021201

Title: Changes in expression and function of syncytin and its receptor, amino acid transport system B(0) (ASCT2), in human placental choriocarcinoma BeWo cells during syncytialization.

Journal: Placenta 20020801

Title: Effects of different oxidizing agents on neutral amino acid transport systems in isolated bovine brain microvessels.

Journal: Neurochemistry international 20020701

Title: Inhibition of system A amino acid transport activity by ethanol in BeWo choriocarcinoma cells.

Journal: American journal of obstetrics and gynecology 20020701

Title: Characterization of L-glutamine transport by a human neuroblastoma cell line.

Journal: American journal of physiology. Cell physiology 20020601

Title: ATA2 is predominantly expressed as system A at the blood-brain barrier and acts as brain-to-blood efflux transport for L-proline.

Journal: Molecular pharmacology 20020601

Title: Localization and functional relevance of system a neutral amino acid transporters in cultured hippocampal neurons.

Journal: The Journal of biological chemistry 20020322

Title: Inhibition of hepatic stellate cell collagen synthesis by N-(methylamino)isobutyric acid.

Journal: Biochemical pharmacology 20020215

Title: Physiological importance of system A-mediated amino acid transport to rat fetal development.

Journal: American journal of physiology. Cell physiology 20020101

Title: The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location.

Journal: Genomics 20020101

Title: Cloning and functional characterization of a new subtype of the amino acid transport system N.

Journal: American journal of physiology. Cell physiology 20011201

Title: Transforming growth factor-beta 1 stimulates vascular smooth muscle cell L-proline transport by inducing system A amino acid transporter 2 (SAT2) gene expression.

Journal: The Biochemical journal 20011201

Title: Glutamine transport in C6 glioma cells: substrate specificity and modulation in a glutamine deprived culture medium.

Journal: Journal of neuroscience research 20011201

Title: Differential influence of cAMP on the expression of the three subtypes (ATA1, ATA2, and ATA3) of the amino acid transport system A.

Journal: FEBS letters 20010914

Title: Regulation of glutamate transport and transport proteins in a placental cell line.

Journal: American journal of physiology. Cell physiology 20010901

Title: Insulin-like growth factor-I stimulates amino acid transport in a glutamine-deprived human neuroblastoma cell line.

Journal: Biochimica et biophysica acta 20010216

Title: Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel and liver-specific subtype of amino acid transport system A.

Journal: Biochimica et biophysica acta 20010209

Title: Characterization of the amino acid transport of new immortalized choroid plexus epithelial cell lines: a novel in vitro system for investigating transport functions at the blood-cerebrospinal fluid barrier.

Journal: Pharmaceutical research 20010101

Title: Inhibition of calcium-independent luminal uptake of L-dopa by calmodulin antagonists in immortalized rat capillary cerebral endothelial cells.

Journal: Cell biology international 20010101

Title: Regulation of System A amino acid transport in L6 rat skeletal muscle cells by insulin, chemical and hyperthermic stress.

Journal: FEBS letters 19981211

Title: Effects of phenylarsine oxide on insulin-stimulated system A amino acid uptake in skeletal muscle.

Journal: The American journal of physiology 19911001

Title: Effects of insulin and phospholipase C in control and denervated rat skeletal muscle.

Journal: The American journal of physiology 19910201

Title: M Sugawara, et al. Structure and function of ATA3, a new subtype of amino acid transport system A, primarily expressed in the liver and skeletal muscle. Biochim Biophys Acta. 2000 Dec 20;1509(1-2):7-13.

Title: Y Kudo, et al. Changes in expression and function of syncytin and its receptor, amino acid transport system B(0) (ASCT2), in human placental choriocarcinoma BeWo cells during syncytialization. Placenta. 2002 Aug;23(7):536-41.

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Tags:2566-34-9 Molecular Formula|2566-34-9 MDL|2566-34-9 SMILES|2566-34-9 2-(Methylamino)isobutyric acid hydrate