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1118-68-9,MFCD00004283
Catalog No.:AA003SID

1118-68-9 | N,N-Dimethylglycine

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5g
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$7.00   $5.00
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10g
98%
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$9.00   $7.00
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25g
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$12.00   $8.00
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100g
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500g
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003SID
Chemical Name:
N,N-Dimethylglycine
CAS Number:
1118-68-9
Molecular Formula:
C4H9NO2
Molecular Weight:
103.1198
MDL Number:
MFCD00004283
SMILES:
CN(CC(=O)O)C
Properties
Properties
 
BP:
175.2°C at 760 mmHg  
Form:
Solid  
MP:
178-182 °C  
Refractive Index:
1.4674 (estimate)  
Stability:
Hygroscopic  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
70.1  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
7  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
-2.9  

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Journal: The Journal of clinical endocrinology and metabolism 20070401

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Journal: Rapid communications in mass spectrometry : RCM 20070101

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Journal: Molecular systems biology 20070101

Title: Immunomodulation of murine collagen-induced arthritis by N, N-dimethylglycine and a preparation of Perna canaliculus.

Journal: BMC complementary and alternative medicine 20070101

Title: Effects of substrate and potassium on the betaine-synthesizing enzyme glycine sarcosine dimethylglycine N-methyltransferase from a halophilic methanoarchaeon Methanohalophilus portucalensis.

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Title: Mechanism of FAD reduction and role of active site residues His-225 and Tyr-259 in Arthrobacter globiformis dimethylglycine oxidase: analysis of mutant structure and catalytic function.

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Title: Design and synthesis of novel sulfonamide-containing bradykinin hB2 receptor antagonists. 1. Synthesis and SAR of alpha,alpha-dimethylglycine sulfonamides.

Journal: Journal of medicinal chemistry 20060615

Title: N,N-dimethyl-beta-alanine as an inexpensive and efficient ligand for palladium-catalyzed Heck reaction.

Journal: Organic letters 20060608

Title: Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver.

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Title: Treatment for mitochondrial disorders.

Journal: The Cochrane database of systematic reviews 20060125

Title: Causes of hyperhomocysteinemia in patients with chronic kidney diseases.

Journal: Seminars in nephrology 20060101

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Journal: Lipids in health and disease 20060101

Title: In silico experimentation with a model of hepatic mitochondrial folate metabolism.

Journal: Theoretical biology & medical modelling 20060101

Title: Weak antiferromagnetic interactions in hydronium diaqua-1kappaO,2kappaO-trichloro-1kappaCl,2kappa2Cl-mu-dimethylglycinato-1kappaO:2kappa2O',N-dimethylglycinato-1kappa2N,O-dicuprate(II).

Journal: Acta crystallographica. Section C, Crystal structure communications 20051201

Title: NMR spectroscopic-based metabonomic investigation on the acute biochemical effects induced by Ce(NO3)3 in rats.

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Journal: The Journal of biological chemistry 20050826

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Title: Sexual dimorphism in urinary metabolite profiles of Han Wistar rats revealed by nuclear-magnetic-resonance-based metabonomics.

Journal: Analytical biochemistry 20050815

Title: Gas-phase structure of N,N-dimethylglycine.

Journal: Chemphyschem : a European journal of chemical physics and physical chemistry 20050812

Title: Guanine and plasmid DNA binding of mono- and trinuclear fac-[Re(CO)3]+ complexes with amino acid ligands.

Journal: Chembiochem : a European journal of chemical biology 20050801

Title: Crystal structure of DMGO provides a prototype for a new tetrahydrofolate-binding fold.

Journal: Biochemical Society transactions 20050801

Title: Di-mu-chloro-1:2kappa2Cl;3:4kappa2Cl-hexachloro-1kappa3Cl,4kappa3Cl-tetra-mu-dimethylglycine-2:3kappa8O:O'-tetracopper(II).

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Title: Amino acid promoted CuI-catalyzed C-N bond formation between aryl halides and amines or N-containing heterocycles.

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Title: Identification, cloning, and expression of Pseudomonas aeruginosa phosphorylcholine phosphatase gene.

Journal: Current microbiology 20050501

Title: Statistical total correlation spectroscopy: an exploratory approach for latent biomarker identification from metabolic 1H NMR data sets.

Journal: Analytical chemistry 20050301

Title: Betaine and folate status as cooperative determinants of plasma homocysteine in humans.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20050201

Title: The structure of the TrmE GTP-binding protein and its implications for tRNA modification.

Journal: The EMBO journal 20050112

Title: Homocysteine, glycine betaine, and N,N-dimethylglycine in patients attending a lipid clinic.

Journal: Metabolism: clinical and experimental 20050101

Title: Profiles of metabolites and gene expression in rats with chemically induced hepatic necrosis.

Journal: Toxicologic pathology 20050101

Title: Organic compatible solutes of halotolerant and halophilic microorganisms.

Journal: Saline systems 20050101

Title: Betaine: a key modulator of one-carbon metabolism and homocysteine status.

Journal: Clinical chemistry and laboratory medicine 20050101

Title: Novel ruthenium complex K2[Ru(dmgly)Cl4].2H2O is toxic to C6 astrocytoma cell line, but not to primary rat astrocytes.

Journal: Journal of inorganic biochemistry 20041201

Title: Chemical aspects of amine oxidation by flavoprotein enzymes.

Journal: Natural product reports 20041201

Title: A novel gamma-N-methylaminobutyrate demethylating oxidase involved in catabolism of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1.

Journal: European journal of biochemistry 20041201

Title: Dimethylglycine supplementation does not affect plasma homocysteine concentrations in pre-dialysis chronic renal failure patients.

Journal: Clinical biochemistry 20041101

Title: Effects of intravenous betaine on methionine-loading-induced plasma homocysteine elevation in rats.

Journal: The Journal of nutritional biochemistry 20041101

Title: The trimethylammonium headgroup of choline is a major determinant for substrate binding and specificity in choline oxidase.

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Title: Over-expression in Escherichia coli, functional characterization and refolding of rat dimethylglycine dehydrogenase.

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Title: Influence of hemodialysis membrane permeability on serum levels of advanced glycation end products (AGEs) and homocysteine metabolites.

Journal: Clinical nephrology 20040301

Title: Betaine as a determinant of postmethionine load total plasma homocysteine before and after B-vitamin supplementation.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20040201

Title: A new class of potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: structure-activity relationships for a series of 9-alkoxymethyl-12-(3-hydroxypropyl)indeno[2,1-a]pyrrolo[3,4-c]carbazole-5-ones and the identification of CEP-5214 and its dimethylglycine ester prodrug clinical candidate CEP-7055.

Journal: Journal of medicinal chemistry 20031204

Title: A single arginine residue is required for the interaction of the electron transferring flavoprotein (ETF) with three of its dehydrogenase partners.

Journal: Molecular and cellular biochemistry 20031201

Title: N,N-dimethyl glycine-promoted Ullmann coupling reaction of phenols and aryl halides.

Journal: Organic letters 20031016

Title: CEP-7055: a novel, orally active pan inhibitor of vascular endothelial growth factor receptor tyrosine kinases with potent antiangiogenic activity and antitumor efficacy in preclinical models.

Journal: Cancer research 20030915

Title: Channelling and formation of 'active' formaldehyde in dimethylglycine oxidase.

Journal: The EMBO journal 20030815

Title: Unusually high phosphodiesterolytic activity of La(III) hydroxide complexes stabilized by glycine derivatives.

Journal: Chemical communications (Cambridge, England) 20030807

Title: Modeling anhydrous and aqua copper(II) amino acid complexes: a new molecular mechanics force field parametrization based on quantum chemical studies and experimental crystal data.

Journal: Inorganic chemistry 20030407

Title: Novel antiviral agent tetraglycylated nordihydroguaiaretic acid hydrochloride as a host-dependent viral inhibitor.

Journal: Antiviral research 20030301

Title: Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica.

Journal: The Journal of biological chemistry 20030214

Title: Determination of choline, betaine, and dimethylglycine in plasma by a high-throughput method based on normal-phase chromatography-tandem mass spectrometry.

Journal: Clinical chemistry 20030201

Title: The effect of short-term dimethylglycine treatment on oxygen consumption in cytochrome oxidase deficiency: a double-blind randomized crossover clinical trial.

Journal: The Journal of pediatrics 20030101

Title: Pharmacokinetics of oral betaine in healthy subjects and patients with homocystinuria.

Journal: British journal of clinical pharmacology 20030101

Title: Autism, an extreme challenge to integrative medicine. Part 2: medical management.

Journal: Alternative medicine review : a journal of clinical therapeutic 20021201

Title: Crystallization and preliminary X-ray study of recombinant betaine-homocysteine S-methyltransferase from rat liver.

Journal: Acta crystallographica. Section D, Biological crystallography 20020901

Title: Flavinylation of the precursor of mitochondrial dimethylglycine dehydrogenase by intact and solubilised mitochondria.

Journal: FEBS letters 20020703

Title: Functional characterization of betaine/proline transporters in betaine-accumulating mangrove.

Journal: The Journal of biological chemistry 20020524

Title: Mechanistic aspects of the covalent flavoprotein dimethylglycine oxidase of Arthrobacter globiformis studied by stopped-flow spectrophotometry.

Journal: Biochemistry 20020409

Title: Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure.

Journal: Kidney international 20020301

Title: Studies of the side chain cleavage of deramciclane in rats with radiolabelled compounds.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20020301

Title: Random mutagenesis of the zinc-binding motif of betaine-homocysteine methyltransferase reveals that Gly 214 is essential.

Journal: Archives of biochemistry and biophysics 20020301

Title: Testosterone 17beta-N,N-dimethylglycinate hydrochloride: A prodrug with a potential for nasal delivery of testosterone.

Journal: Journal of pharmaceutical sciences 20020301

Title: Lysosomotropic N,N- dimethyl alpha-aminoacid N-alkyl esters and their quaternary ammonium salts as plasma membrane and mitochondrial ATPases inhibitors.

Journal: Cellular & molecular biology letters 20020101

Title: Decrease of elevated N,N-dimethylglycine and N-methylglycine in human immunodeficiency virus infection during short-term highly active antiretroviral therapy.

Journal: Metabolism: clinical and experimental 20011101

Title: Investigations into biochemical changes due to diurnal variation and estrus cycle in female rats using high-resolution (1)H NMR spectroscopy of urine and pattern recognition.

Journal: Analytical biochemistry 20010815

Title: Purification and kinetic properties of betaine-homocysteine methyltransferase from Aphanothece halophytica.

Journal: Current microbiology 20010801

Title: Homocysteine metabolism in children with Down syndrome: in vitro modulation.

Journal: American journal of human genetics 20010701

Title: Dimethylglycine accumulates in uremia and predicts elevated plasma homocysteine concentrations.

Journal: Kidney international 20010601

Title: Organization of the genes involved in dimethylglycine and sarcosine degradation in Arthrobacter spp.: implications for glycine betaine catabolism.

Journal: European journal of biochemistry 20010601

Title: Cloning of dimethylglycine dehydrogenase and a new human inborn error of metabolism, dimethylglycine dehydrogenase deficiency.

Journal: American journal of human genetics 20010401

Title: Conformation of cationic N,N-dimethylglycine in dimethylglycinium trifluoroacetate.

Journal: Acta crystallographica. Section C, Crystal structure communications 20010401

Title: Effectiveness of N,N-dimethylglycine in autism and pervasive developmental disorder.

Journal: Journal of child neurology 20010301

Title: Analysis of alcohols, as dimethylglycine esters, by electrospray ionization tandem mass spectrometry.

Journal: Journal of mass spectrometry : JMS 20010301

Title: Betaine:homocysteine methyltransferase from rat liver: purification and inhibition by a boronic acid substrate analog.

Journal: Archives of biochemistry and biophysics 19920101

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Tags:1118-68-9 Molecular Formula|1118-68-9 MDL|1118-68-9 SMILES|1118-68-9 N,N-Dimethylglycine