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681136-29-8,MFCD00209157
Catalog No.:AA003T8A

681136-29-8 | JNJ-1661010

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Purity
Availability
Price(USD)
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5mg
≥98%
in stock  
$105.00   $73.00
- +
10mg
≥98%
in stock  
$158.00   $110.00
- +
25mg
≥98%
in stock  
$283.00   $198.00
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50mg
≥98%
in stock  
$513.00   $359.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003T8A
Chemical Name:
JNJ-1661010
CAS Number:
681136-29-8
Molecular Formula:
C19H19N5OS
Molecular Weight:
365.4521
MDL Number:
MFCD00209157
SMILES:
O=C(N1CCN(CC1)c1snc(n1)c1ccccc1)Nc1ccccc1
Properties
Properties
 
Form:
Solid  
Solubility:
DMSO: ≥28mg/mL  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
459  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
3.5  

Literature

Title: The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).

Journal: Bioorganic & medicinal chemistry letters 20110815

Title: Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20110415

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.

Journal: Bioorganic & medicinal chemistry letters 20090801

Title: Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase.

Journal: Anesthesia and analgesia 20090101

Title: Dynamic regulation of the endocannabinoid system: implications for analgesia.

Journal: Molecular pain 20090101

Title: Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase.

Journal: Bioorganic & medicinal chemistry letters 20080901

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Keith JM, et al. Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4838-43.

Title: Karbarz MJ, et al. Biochemical and biological properties of 4-(3-phenyl-,2,4 thiadiazol-5-yl)-piperazine-1-carboxylicacid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase. Anesth Analg. 2009 Jan;108(1):316-29.

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