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1258-84-0,MFCD01711331
Catalog No.:AA003TVT

1258-84-0 | Pristimerin

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5mg
≥98%
in stock  
$139.00   $97.00
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10mg
≥98%
in stock  
$263.00   $184.00
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25mg
≥98%
in stock  
$589.00   $412.00
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50mg
≥98% (HPLC)
in stock  
$809.00   $567.00
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100mg
≥98% (HPLC)
in stock  
$1,409.00   $987.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003TVT
Chemical Name:
Pristimerin
CAS Number:
1258-84-0
Molecular Formula:
C30H40O4
Molecular Weight:
464.6362
MDL Number:
MFCD01711331
SMILES:
COC(=O)[C@@]1(C)CC[C@]2([C@@H](C1)[C@]1(C)CC[C@@]3(C(=CC=C4C3=CC(=O)C(=C4C)O)[C@]1(CC2)C)C)C
Properties
Properties
 
Form:
Solid  
MP:
219.5℃  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
1120  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
6.3  

Literature

Title: Pristimerin causes G1 arrest, induces apoptosis, and enhances the chemosensitivity to gemcitabine in pancreatic cancer cells.

Journal: PloS one 20120101

Title: Triterpenoid pristimerin synergizes with taxol to induce cervical cancer cell death through reactive oxygen species-mediated mitochondrial dysfunction.

Journal: Anti-cancer drugs 20110901

Title: Synthesis and preliminary evaluation of neuroprotection of celastrol analogues in PC12 cells.

Journal: Bioorganic & medicinal chemistry letters 20100701

Title: SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii.

Journal: Bioorganic & medicinal chemistry letters 20100315

Title: Targeting tumor proteasome with traditional Chinese medicine.

Journal: Current drug discovery technologies 20100301

Title: Pristimerin induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation by blocking NF-kappaB signaling and depleting Bcr-Abl.

Journal: Molecular cancer 20100101

Title: Discovery of potent and reversible monoacylglycerol lipase inhibitors.

Journal: Chemistry & biology 20091030

Title: Reactive oxygen species-dependent activation of Bax and poly(ADP-ribose) polymerase-1 is required for mitochondrial cell death induced by triterpenoid pristimerin in human cervical cancer cells.

Journal: Molecular pharmacology 20091001

Title: Antiproliferative activity of pristimerin isolated from Maytenus ilicifolia (Celastraceae) in human HL-60 cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20080601

Title: Biomimetic synthesis of xuxuarines Ealpha and Ebeta: structure revision of Rzedowskia bistriterpenoids.

Journal: Bioorganic & medicinal chemistry 20080215

Title: Pristimerin induces apoptosis by targeting the proteasome in prostate cancer cells.

Journal: Journal of cellular biochemistry 20080101

Title: Antigiardial activity of triterpenoids from root bark of Hippocratea excelsa.

Journal: Journal of natural products 20070501

Title: Anticytomegalovirus activity of pristimerin, a triterpenoid quinone methide isolated from Maytenus heterophylla (Eckl. & Zeyh.).

Journal: Antiviral chemistry & chemotherapy 20070101

Title: Pristimerin induces caspase-dependent apoptosis in MDA-MB-231 cells via direct effects on mitochondria.

Journal: Molecular cancer therapeutics 20050801

Title: Antitumor agents. 228. five new agarofurans, Reissantins A-E, and cytotoxic principles from Reissantia buchananii.

Journal: Journal of natural products 20031101

Title: [In vitro activity of the pristinamycin against the isolated staphylococci in the french hospitals in 1999-2000].

Journal: Pathologie-biologie 20030901

Title: King AR, et al. Discovery of potent and reversible monoacylglycerol lipase inhibitors. Chem Biol. 2009 Oct 30;16(10):1045-52.

Title: Deng Q, et al. Pristimerin inhibits angiogenesis in adjuvant-induced arthritic rats by suppressing VEGFR2 signaling pathways. Int Immunopharmacol. 2015 Dec;29(2):302-13.

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