Title: Repression of acetaminophen-induced hepatotoxicity by a combination of celastrol and brilliant blue G.
Journal: Toxicology letters 20170605
Title: Metabolomics profiles delineate uridine deficiency contributes to mitochondria-mediated apoptosis induced by celastrol in human acute promyelocytic leukemia cells.
Journal: Oncotarget 20160719
Title: Cascade regulation of PPARγ(2) and C/EBPα signaling pathways by celastrol impairs adipocyte differentiation and stimulates lipolysis in 3T3-L1 adipocytes.
Journal: Metabolism: clinical and experimental 20160501
Title: Celastrol enhances Nrf2 mediated antioxidant enzymes and exhibits anti-fibrotic effect through regulation of collagen production against bleomycin-induced pulmonary fibrosis.
Journal: Chemico-biological interactions 20160225
Title: Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids.
Journal: Oncotarget 20151020
Title: Celastrol overcomes HSP72 gene silencing-mediated muscle atrophy and induces myofiber preservation.
Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20150401
Title: The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells.
Journal: The Journal of biological chemistry 20150116
Title: Accumulation of heme oxygenase-1 (HSP32) in Xenopus laevis A6 kidney epithelial cells treated with sodium arsenite, cadmium chloride or proteasomal inhibitors.
Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20141101
Title: Celastrol ameliorates murine colitis via modulating oxidative stress, inflammatory cytokines and intestinal homeostasis.
Journal: Chemico-biological interactions 20140305
Title: Celastrol prevents cadmium-induced neuronal cell death via targeting JNK and PTEN-Akt/mTOR network.
Journal: Journal of neurochemistry 20140101
Title: Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells.
Journal: Pharmacological research 20131001
Title: A critical role for MAPK signalling pathways in the transcriptional regulation of toll like receptors.
Journal: PloS one 20130101
Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Journal: Bioorganic & medicinal chemistry 20121115
Title: Biological activity and safety of Tripterygium extract prepared by sodium carbonate extraction.
Journal: Molecules (Basel, Switzerland) 20120917
Title: Strong inhibition of celastrol towards UDP-glucuronosyl transferase (UGT) 1A6 and 2B7 indicating potential risk of UGT-based herb-drug interaction.
Journal: Molecules (Basel, Switzerland) 20120605
Title: Preparation, characterization, and assessment of the antiglioma effects of liposomal celastrol.
Journal: Anti-cancer drugs 20120601
Title: Celastrol analogues as inducers of the heat shock response. Design and synthesis of affinity probes for the identification of protein targets.
Journal: ACS chemical biology 20120518
Title: Paraptosis accompanied by autophagy and apoptosis was induced by celastrol, a natural compound with influence on proteasome, ER stress and Hsp90.
Journal: Journal of cellular physiology 20120501
Title: Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade in vitro and in vivo.
Journal: Cancer prevention research (Philadelphia, Pa.) 20120401
Title: Sodium arsenite and cadmium chloride induction of proteasomal inhibition and HSP accumulation in Xenopus laevis A6 kidney epithelial cells.
Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20120301
Title: Celastrol nanoparticles inhibit corneal neovascularization induced by suturing in rats.
Journal: International journal of nanomedicine 20120101
Title: Unlike for human monocytes after LPS activation, release of TNF-α by THP-1 cells is produced by a TACE catalytically different from constitutive TACE.
Journal: PloS one 20120101
Title: Development of B cells and erythrocytes is specifically impaired by the drug celastrol in mice.
Journal: PloS one 20120101
Title: Antitumor activity of celastrol nanoparticles in a xenograft retinoblastoma tumor model.
Journal: International journal of nanomedicine 20120101
Title: Alkaloids from Chelidonium majus and their inhibitory effects on LPS-induced NO production in RAW264.7 cells.
Journal: Bioorganic & medicinal chemistry letters 20111201
Title: HSF1-dependent upregulation of Hsp70 by sulfhydryl-reactive inducers of the KEAP1/NRF2/ARE pathway.
Journal: Chemistry & biology 20111123
Title: Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells.
Journal: British journal of pharmacology 20111101
Title: Celastrol regulates innate immunity response via NF-κB and Hsp70 in human retinal pigment epithelial cells.
Journal: Pharmacological research 20111101
Title: Quinone methide tripterine, celastrol, induces apoptosis in human myeloma cells via NF-κB pathway.
Journal: International journal of oncology 20111101
Title: Formulation and evaluation of celastrol-loaded liposomes.
Journal: Molecules (Basel, Switzerland) 20110913
Title: NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action.
Journal: British journal of pharmacology 20110901
Title: Radiosensitization by celastrol is mediated by modification of antioxidant thiol molecules.
Journal: Chemico-biological interactions 20110815
Title: Celastrol induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria- and Fas/FasL-mediated pathways.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20110801
Title: Celastrol inhibits aminoglycoside-induced ototoxicity via heat shock protein 32.
Journal: Cell death & disease 20110801
Title: Celastrol inhibits Tat-mediated human immunodeficiency virus (HIV) transcription and replication.
Journal: Journal of molecular biology 20110729
Title: The main anticancer bullets of the Chinese medicinal herb, thunder god vine.
Journal: Molecules (Basel, Switzerland) 20110623
Title: Gambogic acid, a natural product inhibitor of Hsp90.
Journal: Journal of natural products 20110527
Title: Synthesis of rabdokunmin C analogues and their inhibitory effect on NF-κB activation.
Journal: Bioorganic & medicinal chemistry 20110401
Title: Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers.
Journal: Cancer biology & therapy 20110115
Title: Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs.
Journal: Bioorganic & medicinal chemistry letters 20110115
Title: Celastrol inhibits the growth of estrogen positive human breast cancer cells through modulation of estrogen receptor α.
Journal: Cancer letters 20110101
Title: A systematic protocol for the characterization of Hsp90 modulators.
Journal: Bioorganic & medicinal chemistry 20110101
Title: Celastrol targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells.
Journal: BMC cancer 20110101
Title: Celastrol inhibits breast cancer cell invasion via suppression of NF-ĸB-mediated matrix metalloproteinase-9 expression.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101
Title: Quantitative proteomics reveals cellular targets of celastrol.
Journal: PloS one 20110101
Title: Up-regulation of death receptor 4 and 5 by celastrol enhances the anti-cancer activity of TRAIL/Apo-2L.
Journal: Cancer letters 20101128
Title: Small molecule inhibitors of IkappaB kinase signaling inhibit osteoclast formation in vitro and prevent ovariectomy-induced bone loss in vivo.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20101101
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: Celastrol attenuates hypertension-induced inflammation and oxidative stress in vascular smooth muscle cells via induction of heme oxygenase-1.
Journal: American journal of hypertension 20100801
Title: Synthesis and preliminary evaluation of neuroprotection of celastrol analogues in PC12 cells.
Journal: Bioorganic & medicinal chemistry letters 20100701
Title: An isoaurone and other constituents from Trichosanthes kirilowii seeds inhibit hypoxia-inducible factor-1 and nuclear factor-kappaB.
Journal: Journal of natural products 20100625
Title: Celastrol can inhibit proteasome activity and upregulate the expression of heat shock protein genes, hsp30 and hsp70, in Xenopus laevis A6 cells.
Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20100601
Title: Celastrol, a novel HSP90 inhibitor, depletes Bcr-Abl and induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation.
Journal: Cancer letters 20100428
Title: Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors.
Journal: The Journal of biological chemistry 20100409
Title: Celastrol: Molecular targets of Thunder God Vine.
Journal: Biochemical and biophysical research communications 20100409
Title: Effects of Celastrol on growth inhibition of U937 leukemia cells through the regulation of the Notch1/NF-kappaB signaling pathway in vitro.
Journal: Chinese journal of cancer 20100401
Title: SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii.
Journal: Bioorganic & medicinal chemistry letters 20100315
Title: Pharmacogenomic approach reveals a role for the x(c)- cystine/glutamate antiporter in growth and celastrol resistance of glioma cell lines.
Journal: The Journal of pharmacology and experimental therapeutics 20100301
Title: Celastrol and an EGCG pro-drug exhibit potent chemosensitizing activity in human leukemia cells.
Journal: International journal of molecular medicine 20100301
Title: Targeting tumor proteasome with traditional Chinese medicine.
Journal: Current drug discovery technologies 20100301
Title: Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway.
Journal: Cancer research 20100301
Title: Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23.
Journal: The Journal of biological chemistry 20100205
Title: Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease.
Journal: Journal of neuroinflammation 20100101
Title: HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way.
Journal: Molecular cancer 20100101
Title: Natural product Celastrol destabilizes tubulin heterodimer and facilitates mitotic cell death triggered by microtubule-targeting anti-cancer drugs.
Journal: PloS one 20100101
Title: A cellular viability assay to monitor drug toxicity.
Journal: Methods in molecular biology (Clifton, N.J.) 20100101
Title: Natural proteasome inhibitor celastrol suppresses androgen-independent prostate cancer progression by modulating apoptotic proteins and NF-kappaB.
Journal: PloS one 20100101
Title: Characterization of celastrol to inhibit hsp90 and cdc37 interaction.
Journal: The Journal of biological chemistry 20091218
Title: Celastrol synergistically enhances temozolomide cytotoxicity in melanoma cells.
Journal: Molecular cancer research : MCR 20091201
Title: Suppression of inflammatory responses by celastrol, a quinone methide triterpenoid isolated from Celastrus regelii.
Journal: European journal of clinical investigation 20090901
Title: Celastrol, a triterpene extracted from Tripterygium wilfordii Hook F, inhibits platelet activation.
Journal: Journal of cardiovascular pharmacology 20090901
Title: Pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione derivatives as novel small molecule chaperone amplifiers.
Journal: Bioorganic & medicinal chemistry letters 20090801
Title: Celastrol potentiates radiotherapy by impairment of DNA damage processing in human prostate cancer.
Journal: International journal of radiation oncology, biology, physics 20090715
Title: Tripterine prevents endothelial barrier dysfunction by inhibiting endogenous peroxynitrite formation.
Journal: British journal of pharmacology 20090701
Title: Suppression of the immune response potentiates tadpole tail regeneration during the refractory period.
Journal: Development (Cambridge, England) 20090701
Title: Celastrol binds to ERK and inhibits FcepsilonRI signaling to exert an anti-allergic effect.
Journal: European journal of pharmacology 20090610
Title: Simultaneous determination of triptolide, tripdiolide and tripterine in human urine by high-performance liquid chromatography coupled with ion trap atmospheric-pressure chemical ionization mass spectrometry.
Journal: Biomedical chromatography : BMC 20090301
Title: Neuroprotective activity and evaluation of Hsp90 inhibitors in an immortalized neuronal cell line.
Journal: Bioorganic & medicinal chemistry 20090215
Title: Antiangiogenic activity of Tripterygium wilfordii and its terpenoids.
Journal: Journal of ethnopharmacology 20090112
Title: Activation of the heat shock response in a primary cellular model of motoneuron neurodegeneration-evidence for neuroprotective and neurotoxic effects.
Journal: Cellular & molecular biology letters 20090101
Title: Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease.
Journal: BMC neuroscience 20090101
Title: The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma.
Journal: BMC cancer 20090101
Title: Calpain-mediated androgen receptor breakdown in apoptotic prostate cancer cells.
Journal: Journal of cellular physiology 20081201
Title: Heat shock protein 90 inhibitors suppress aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and DNA adduct formation.
Journal: Cancer prevention research (Philadelphia, Pa.) 20081101
Title: Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression.
Journal: Journal of natural products 20081001
Title: Chemical and biological approaches synergize to ameliorate protein-folding diseases.
Journal: Cell 20080905
Title: Therapeutic effect of tripterine on adjuvant arthritis in rats.
Journal: Journal of ethnopharmacology 20080813
Title: Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data.
Journal: Blood 20080615
Title: Natural compounds with proteasome inhibitory activity for cancer prevention and treatment.
Journal: Current protein & peptide science 20080601
Title: Inhibition of anthrax lethal toxin-induced cytolysis of RAW264.7 cells by celastrol.
Journal: PloS one 20080101
Title: A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells.
Journal: Molecular cancer therapeutics 20080101
Title: Development and validation of a liquid chromatography coupled with atmospheric-pressure chemical ionization ion trap mass spectrometric method for the simultaneous determination of triptolide, tripdiolide, and tripterine in human serum.
Journal: Journal of analytical toxicology 20080101
Title: [Preparation of liposomes containing extracts of Tripterygium wilfordii and evaluation of its stability].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071001
Title: Molecular understanding and modern application of traditional medicines: triumphs and trials.
Journal: Cell 20070907
Title: [Tripterine inhibits all-trans retinoic acid-caused adhesion between leukemia cells and endothelial cells].
Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20070501
Title: Celastrol inhibits polyglutamine aggregation and toxicity though induction of the heat shock response.
Journal: Journal of molecular medicine (Berlin, Germany) 20070101
Title: Inhibition of NF-kappa B activation through targeting I kappa B kinase by celastrol, a quinone methide triterpenoid.
Journal: Biochemical pharmacology 20061115
Title: Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators.
Journal: Cancer cell 20061001
Title: Tripterine inhibits the expression of adhesion molecules in activated endothelial cells.
Journal: Journal of leukocyte biology 20060801
Title: Celastrol, a triterpene extracted from the Chinese 'Thunder of God Vine,' is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice.
Journal: Cancer research 20060501
Title: Chronic inhibition of cardiac Kir2.1 and HERG potassium channels by celastrol with dual effects on both ion conductivity and protein trafficking.
Journal: The Journal of biological chemistry 20060303
Title: Celastrol protects against MPTP- and 3-nitropropionic acid-induced neurotoxicity.
Journal: Journal of neurochemistry 20050801
Title: Beneficial effect of tripterine on systemic lupus erythematosus induced by active chromatin in BALB/c mice.
Journal: European journal of pharmacology 20050411
Title: [The experimental study on the inhibitory effect of tripterine on airway inflammation in asthmatic mice].
Journal: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20040301
Title: Preparative isolation and purification of celastrol from Celastrus orbiculatus Thunb. by a new counter-current chromatography method with an upright coil planet centrifuge.
Journal: Journal of chromatography. A 20040227
Title: Antitumor agents. 228. five new agarofurans, Reissantins A-E, and cytotoxic principles from Reissantia buchananii.
Journal: Journal of natural products 20031101
Title: Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol.
Journal: Bioscience, biotechnology, and biochemistry 20030901
Title: [Advances in the study of tumor angiogenesis and anti-angiogenic Chinese herbal drugs].
Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20030501
Title: Effects of demethylzeylasteral and celastrol on spermatogenic cell Ca2+ channels and progesterone-induced sperm acrosome reaction.
Journal: European journal of pharmacology 20030307
Title: [Several monomes from Tripterygium wilfordii inhibit proliferation of glioma cells in vitro].
Journal: Ai zheng = Aizheng = Chinese journal of cancer 20021001
Title: Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease.
Journal: Progress in neuro-psychopharmacology & biological psychiatry 20011001
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