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88546-55-8,MFCD00869772
Catalog No.:AA004DMD

88546-55-8 | Omeprazole sulfone

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%(HPLC)powder
in stock  
$43.00   $30.00
- +
25mg
98%(HPLC)powder
in stock  
$78.00   $55.00
- +
100mg
98%
in stock  
$122.00   $86.00
- +
250mg
98%
in stock  
$216.00   $151.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA004DMD
Chemical Name:
Omeprazole sulfone
CAS Number:
88546-55-8
Molecular Formula:
C17H19N3O4S
Molecular Weight:
361.4155
MDL Number:
MFCD00869772
SMILES:
COc1ccc2c(c1)nc([nH]2)S(=O)(=O)Cc1ncc(c(c1C)OC)C
Properties
Properties
 
BP:
599.3°C at 760 mmHg  
Form:
Solid  
MP:
>70°C (dec.)  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
553  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
2.2  

Downstream Synthesis Route
73590-85-9    73590-58-6   
omeprazolesulphone 

[1]Patent:US2004/138466,2004,A1.Locationinpatent:Page5

[2]Patent:JP2004/524303,2004,A.Locationinpatent:Page/Pagecolumn12-13

[3]Patent:JP2004/524303,2004,A.Locationinpatent:Page/Pagecolumn13

[4]Patent:US2004/138466,2004,A1.Locationinpatent:Page5

[5]Patent:US2004/138466,2004,A1.Locationinpatent:Page5

[6]Patent:US2004/138466,2004,A1.Locationinpatent:Page4-5

[7]Patent:US2004/138466,2004,A1.Locationinpatent:Page5

[8]Patent:JP2004/524303,2004,A.Locationinpatent:Page/Pagecolumn13

[9]Patent:US2004/138466,2004,A1.Locationinpatent:Page5

[10]Patent:US2004/138466,2004,A1.Locationinpatent:Page5

[11]Patent:US2004/138466,2004,A1.Locationinpatent:Page5

[12]Patent:US2004/138466,2004,A1.Locationinpatent:Page5

73590-85-9    119141-89-8   
omeprazolesulphone 
  119141-88-7 

[1]Patent:WO2009/66321,2009,A2.Locationinpatent:Page/Pagecolumn19

[2]Patent:WO2009/66321,2009,A2.Locationinpatent:Page/Pagecolumn19-20

[3]Patent:WO2010/43601,2010,A1.Locationinpatent:Page/Pagecolumn31

[4]Patent:WO2010/43601,2010,A1.Locationinpatent:Page/Pagecolumn30;31

[5]SyntheticCommunications,2015,vol.45,p.70-77

[6]Patent:US10307748,2019,B2.Locationinpatent:Page/Pagecolumn12;13

73590-85-9   
omeprazolesulphone 
  119141-88-7 

[1]SyntheticCommunications,2015,vol.45,p.70-77

[2]Patent:US10307748,2019,B2.Locationinpatent:Page/Pagecolumn12;13;14;15;17;18

[1]Kern,Fredy;Khatri,Yogan;Litzenburger,Martin;Bernhardt,Rita[DrugMetabolismandDisposition,2016,vol.44,#4,p.495-504]

Literature

Title: Omeprazole limited sampling strategies to predict area under the concentration-time curve ratios: implications for cytochrome P450 2C19 and 3A phenotyping.

Journal: European journal of clinical pharmacology 20120401

Title: Induction of CYP2C19 and CYP3A activity following repeated administration of efavirenz in healthy volunteers.

Journal: Clinical pharmacology and therapeutics 20120301

Title: Prediction of relative in vivo metabolite exposure from in vitro data using two model drugs: dextromethorphan and omeprazole.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120101

Title: Sex and CYP3A5 genotype influence total CYP3A activity: high CYP3A activity and a unique distribution of CYP3A5 variant alleles in Ethiopians.

Journal: The pharmacogenomics journal 20110401

Title: CYP2C19 haplotypes in Koreans as a marker of enzyme activity evaluated with omeprazole.

Journal: Journal of clinical pharmacy and therapeutics 20090801

Title: Effects of the CYP3A5 genotype on omeprazole sulfoxidation in CYP2C19 PMs.

Journal: European journal of clinical pharmacology 20080601

Title: Herbal medicine yin zhi huang induces CYP3A4-mediated sulfoxidation and CYP2C19-dependent hydroxylation of omeprazole.

Journal: Acta pharmacologica Sinica 20071001

Title: Validation of chromatographic methods: evaluation of detection and quantification limits in the determination of impurities in omeprazole.

Journal: Journal of chromatography. A 20070713

Title: Determination of esomeprazole and its two main metabolites in human, rat and dog plasma by liquid chromatography with tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070401

Title: A simple and sensitive bioanalytical assay for simultaneous determination of omeprazole and its three major metabolites in human blood plasma using RP-HPLC after a simple liquid-liquid extraction procedure.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061205

Title: Determination of omeprazole, hydroxyomeprazole and omeprazole sulfone using automated solid phase extraction and micellar electrokinetic capillary chromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20060911

Title: Use of omeprazole sulfone in a single plasma sample as a probe for CYP3A4.

Journal: European journal of clinical pharmacology 20060801

Title: Use of omeprazole as a CYP3A probe drug: effect of sex and menstrual cycle phase on CYP3A activity in healthy Caucasian adults.

Journal: Journal of clinical pharmacology 20060301

Title: Esomeprazole-induced healing of gastroesophageal reflux disease is unrelated to the genotype of CYP2C19: evidence from clinical and pharmacokinetic data.

Journal: Clinical pharmacology and therapeutics 20051201

Title: The effect of aging on the relationship between the cytochrome P450 2C19 genotype and omeprazole pharmacokinetics.

Journal: Clinical pharmacokinetics 20050101

Title: Metabolism of omeprazole after two oral doses in children 1 to 9 months old.

Journal: Proceedings of the Western Pharmacology Society 20050101

Title: Pharmacogenetics and herb-drug interactions: experience with Ginkgo biloba and omeprazole.

Journal: Pharmacogenetics 20041201

Title: Omeprazole treatment of Korean patients: effects on gastric pH and gastrin release in relation to CYP2C19 geno- and phenotypes.

Journal: Basic & clinical pharmacology & toxicology 20040901

Title: Omeprazole as a CYP2C19 marker in Chinese subjects: assessment of its gene-dose effect and intrasubject variability.

Journal: Journal of clinical pharmacology 20040601

Title: Assay of omeprazole and omeprazole sulfone by semi-microcolumn liquid chromatography with mixed-function precolumn.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010425

Title: Omeprazole and lansoprazole are mixed inducers of CYP1A and CYP3A in human hepatocytes in primary culture.

Journal: The Journal of pharmacology and experimental therapeutics 19940401

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