Home Fluorides 131926-99-3
131926-99-3,MFCD08063665
Catalog No.:AA000ZUT

131926-99-3 | 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)sulfonyl)-1H-benzo[d]imidazole

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1mg
≥98%
in stock  
$53.00   $37.00
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5mg
≥98%
in stock  
$230.00   $161.00
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10mg
≥98%
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$405.00   $283.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000ZUT
Chemical Name:
2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)sulfonyl)-1H-benzo[d]imidazole
CAS Number:
131926-99-3
Molecular Formula:
C16H14F3N3O3S
Molecular Weight:
385.3609
MDL Number:
MFCD08063665
SMILES:
Cc1c(ccnc1CS(=O)(=O)c1nc2c([nH]1)cccc2)OCC(F)(F)F
Properties
Computed Properties
 
Complexity:
582  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
3  

Literature

Title: Pharmacokinetics of lansoprazole and its main metabolites after single intravenous doses in healthy Chinese subjects.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20121101

Title: Effects of CYP2C19 polymorphism on the pharmacokinetics of lansoprazole and its main metabolites in healthy Chinese subjects.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20110601

Title: The effect of CYP2C19 activity on pharmacokinetics of lansoprazole and its active metabolites in healthy subjects.

Journal: Pharmaceutical biology 20100801

Title: Potential of lansoprazole as a novel probe for cytochrome P450 3A activity by measuring lansoprazole sulfone in human liver microsomes.

Journal: Biological & pharmaceutical bulletin 20090801

Title: Simultaneous determination of lansoprazole and its metabolites 5'-hydroxy lansoprazole and lansoprazole sulphone in human plasma by LC-MS/MS: application to a pharmacokinetic study in healthy volunteers.

Journal: Journal of pharmaceutical and biomedical analysis 20081201

Title: Intestinal CYP3A4 is not involved in the enantioselective disposition of lansoprazole.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20060101

Title: Enantioselective disposition of lansoprazole in relation to CYP2C19 genotypes in the presence of fluvoxamine.

Journal: British journal of clinical pharmacology 20050701

Title: Effects of clarithromycin on lansoprazole pharmacokinetics between CYP2C19 genotypes.

Journal: British journal of clinical pharmacology 20050301

Title: Determination of lansoprazole and two of its metabolites by liquid-liquid extraction and automated column-switching high-performance liquid chromatography: application to measuring CYP2C19 activity.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050225

Title: Pharmacokinetic differences between the enantiomers of lansoprazole and its metabolite, 5-hydroxylansoprazole, in relation to CYP2C19 genotypes.

Journal: European journal of clinical pharmacology 20041101

Title: Effects of fluvoxamine on lansoprazole pharmacokinetics in relation to CYP2C19 genotypes.

Journal: Journal of clinical pharmacology 20041101

Title: Simultaneous determination of lansoprazole enantiomers and their metabolites in plasma by liquid chromatography with solid-phase extraction.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040525

Title: A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical.

Journal: The Journal of biological chemistry 20030328

Title: Dose-dependent inhibition of CYP3A activity by clarithromycin during Helicobacter pylori eradication therapy assessed by changes in plasma lansoprazole levels and partial cortisol clearance to 6beta-hydroxycortisol.

Journal: Clinical pharmacology and therapeutics 20020701

Title: Role of CYP3A4 and CYP2C19 in the stereoselective metabolism of lansoprazole by human liver microsomes.

Journal: European journal of clinical pharmacology 20011201

Title: High-performance liquid chromatographic assay for the simultaneous determination of lansoprazole enantiomers and metabolites in human liver microsomes.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010605

Title: Pharmacokinetic differences between lansoprazole enantiomers and contribution of cytochrome P450 isoforms to enantioselective metabolism of lansoprazole in dogs.

Journal: Biological & pharmaceutical bulletin 20010301

Title: Identification of the human P450 enzymes involved in lansoprazole metabolism.

Journal: The Journal of pharmacology and experimental therapeutics 19960501

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Tags:131926-99-3 Molecular Formula|131926-99-3 MDL|131926-99-3 SMILES|131926-99-3 2-(((3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methyl)sulfonyl)-1H-benzo[d]imidazole