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869288-64-2,MFCD11519967
Catalog No.:AA004L75

869288-64-2 | PF-573228

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Purity
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Price(USD)
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1mg
98%
in stock  
$36.00   $25.00
- +
5mg
98%
in stock  
$115.00   $81.00
- +
10mg
≥98%
in stock  
$213.00   $149.00
- +
50mg
98%
in stock  
$309.00   $217.00
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100mg
98%
in stock  
$463.00   $324.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA004L75
Chemical Name:
PF-573228
CAS Number:
869288-64-2
Molecular Formula:
C22H20F3N5O3S
Molecular Weight:
491.4861
MDL Number:
MFCD11519967
SMILES:
O=C1CCc2c(N1)ccc(c2)Nc1ncc(c(n1)NCc1cccc(c1)S(=O)(=O)C)C(F)(F)F
Properties
Properties
 
Form:
Solid  
MP:
>242℃ (dec.)  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
822  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
3.2  

Downstream Synthesis Route

[1]CurrentPatentAssignee:PFIZERINC-US2005/256111,2005,A1Locationinpatent:Page/Pagecolumn26-27;28

[1]Berger,Benedict-Tilman;Amaral,Marta;Kokh,DariaB.;Nunes-Alves,Ariane;Musil,Djordje;Heinrich,Timo;Schröder,Martin;Neil,Rebecca;Wang,Jing;Navratilova,Iva;Bomke,Joerg;Elkins,JonathanM.;Müller,Susanne;Frech,Matthias;Wade,RebeccaC.;Knapp,Stefan[CellChemicalBiology,2021,vol.28,#5,p.686-7,698]

Literature

Title: Salinomycin attenuates liver cancer stem cell motility by enhancing cell stiffness and increasing F-actin formation via the FAK-ERK1/2 signalling pathway.

Journal: Toxicology 20170601

Title: Aryl hydrocarbon receptor-dependent up-regulation of the heterodimeric amino acid transporter LAT1 (SLC7A5)/CD98hc (SLC3A2) by diesel exhaust particle extract in human bronchial epithelial cells.

Journal: Toxicology and applied pharmacology 20160101

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Matrix metalloproteinase-2 stimulates collagen-I expression through phosphorylation of focal adhesion kinase in rat cardiac fibroblasts.

Journal: American journal of physiology. Cell physiology 20121101

Title: Cooperation between c-Met and focal adhesion kinase family members in medulloblastoma and implications for therapy.

Journal: Molecular cancer therapeutics 20120201

Title: Small molecule inhibitors of the Pyk2 and FAK kinases modulate chemoattractant-induced migration, adhesion and Akt activation in follicular and marginal zone B cells.

Journal: Cellular immunology 20120101

Title: Focal adhesion kinase inhibitors are potent anti-angiogenic agents.

Journal: Molecular oncology 20111201

Title: Evidence for activation of BK Ca channels by a known inhibitor of focal adhesion kinase, PF573228.

Journal: Life sciences 20111107

Title: Effect of focal adhesion kinase on the regulation of realignment and tenogenic differentiation of human mesenchymal stem cells by mechanical stretch.

Journal: Connective tissue research 20111001

Title: Both AT₁ and AT₂ receptors mediate proliferation and migration of porcine vascular smooth muscle cells.

Journal: American journal of physiology. Heart and circulatory physiology 20110901

Title: Vascular endothelial growth factor regulates the migration of oligodendrocyte precursor cells.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110720

Title: Oxidative stress-induced degradation of thioredoxin-1 and apoptosis is inhibited by thioredoxin-1-actin interaction in endothelial cells.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20110301

Title: Inhibition of focal adhesion kinase suppresses the adverse phenotype of endocrine-resistant breast cancer cells and improves endocrine response in endocrine-sensitive cells.

Journal: Breast cancer research and treatment 20110201

Title: DNA copy number aberrations in small-cell lung cancer reveal activation of the focal adhesion pathway.

Journal: Oncogene 20101202

Title: Focal adhesion kinase can play unique and opposing roles in regulating the morphology of differentiating oligodendrocytes.

Journal: Journal of neurochemistry 20101001

Title: Density- and serum-dependent regulation of the Reck tumor suppressor in mouse embryo fibroblasts.

Journal: Cellular signalling 20091201

Title: Characterization of a novel focal adhesion kinase inhibitor in human platelets.

Journal: Biochemical and biophysical research communications 20091106

Title: Therapeutic targeting of the focal adhesion complex prevents oncogenic TGF-beta signaling and metastasis.

Journal: Breast cancer research : BCR 20090101

Title: Cellular characterization of a novel focal adhesion kinase inhibitor.

Journal: The Journal of biological chemistry 20070518

Title: Slack-Davis JK, et al. Cellular characterization of a novel focal adhesion kinase inhibitor. J Biol Chem. 2007 May 18;282(20):14845-52.

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