869288-64-2,MFCD11519967
Catalog No.:AA004L75

869288-64-2 | PF-573228

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$37.00   $26.00
- +
5mg
98%
in stock  
$117.00   $82.00
- +
50mg
98%
in stock  
$313.00   $219.00
- +
100mg
98%
in stock  
$469.00   $328.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA004L75
Chemical Name:
PF-573228
CAS Number:
869288-64-2
Molecular Formula:
C22H20F3N5O3S
Molecular Weight:
491.4861
MDL Number:
MFCD11519967
SMILES:
O=C1CCc2c(N1)ccc(c2)Nc1ncc(c(n1)NCc1cccc(c1)S(=O)(=O)C)C(F)(F)F
Properties
Properties
 
Form:
Solid  
MP:
>242℃ (dec.)  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
822  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.2  

Downstream Synthesis Route

[1]CurrentPatentAssignee:PFIZERINC-US2005/256111,2005,A1Locationinpatent:Page/Pagecolumn26-27;28

[1]Berger,Benedict-Tilman;Amaral,Marta;Kokh,DariaB.;Nunes-Alves,Ariane;Musil,Djordje;Heinrich,Timo;Schröder,Martin;Neil,Rebecca;Wang,Jing;Navratilova,Iva;Bomke,Joerg;Elkins,JonathanM.;Müller,Susanne;Frech,Matthias;Wade,RebeccaC.;Knapp,Stefan[CellChemicalBiology,2021,vol.28,#5,p.686-7,698]

Literature

Title: Salinomycin attenuates liver cancer stem cell motility by enhancing cell stiffness and increasing F-actin formation via the FAK-ERK1/2 signalling pathway.

Journal: Toxicology 20170601

Title: Aryl hydrocarbon receptor-dependent up-regulation of the heterodimeric amino acid transporter LAT1 (SLC7A5)/CD98hc (SLC3A2) by diesel exhaust particle extract in human bronchial epithelial cells.

Journal: Toxicology and applied pharmacology 20160101

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Matrix metalloproteinase-2 stimulates collagen-I expression through phosphorylation of focal adhesion kinase in rat cardiac fibroblasts.

Journal: American journal of physiology. Cell physiology 20121101

Title: Cooperation between c-Met and focal adhesion kinase family members in medulloblastoma and implications for therapy.

Journal: Molecular cancer therapeutics 20120201

Title: Small molecule inhibitors of the Pyk2 and FAK kinases modulate chemoattractant-induced migration, adhesion and Akt activation in follicular and marginal zone B cells.

Journal: Cellular immunology 20120101

Title: Focal adhesion kinase inhibitors are potent anti-angiogenic agents.

Journal: Molecular oncology 20111201

Title: Evidence for activation of BK Ca channels by a known inhibitor of focal adhesion kinase, PF573228.

Journal: Life sciences 20111107

Title: Effect of focal adhesion kinase on the regulation of realignment and tenogenic differentiation of human mesenchymal stem cells by mechanical stretch.

Journal: Connective tissue research 20111001

Title: Both AT₁ and AT₂ receptors mediate proliferation and migration of porcine vascular smooth muscle cells.

Journal: American journal of physiology. Heart and circulatory physiology 20110901

Title: Vascular endothelial growth factor regulates the migration of oligodendrocyte precursor cells.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110720

Title: Oxidative stress-induced degradation of thioredoxin-1 and apoptosis is inhibited by thioredoxin-1-actin interaction in endothelial cells.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20110301

Title: Inhibition of focal adhesion kinase suppresses the adverse phenotype of endocrine-resistant breast cancer cells and improves endocrine response in endocrine-sensitive cells.

Journal: Breast cancer research and treatment 20110201

Title: DNA copy number aberrations in small-cell lung cancer reveal activation of the focal adhesion pathway.

Journal: Oncogene 20101202

Title: Focal adhesion kinase can play unique and opposing roles in regulating the morphology of differentiating oligodendrocytes.

Journal: Journal of neurochemistry 20101001

Title: Density- and serum-dependent regulation of the Reck tumor suppressor in mouse embryo fibroblasts.

Journal: Cellular signalling 20091201

Title: Characterization of a novel focal adhesion kinase inhibitor in human platelets.

Journal: Biochemical and biophysical research communications 20091106

Title: Therapeutic targeting of the focal adhesion complex prevents oncogenic TGF-beta signaling and metastasis.

Journal: Breast cancer research : BCR 20090101

Title: Cellular characterization of a novel focal adhesion kinase inhibitor.

Journal: The Journal of biological chemistry 20070518

Title: Slack-Davis JK, et al. Cellular characterization of a novel focal adhesion kinase inhibitor. J Biol Chem. 2007 May 18;282(20):14845-52.

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Tags:869288-64-2 Molecular Formula|869288-64-2 MDL|869288-64-2 SMILES|869288-64-2 PF-573228
Catalog No.: AA004L75
869288-64-2,MFCD11519967
869288-64-2 | PF-573228
Pack Size: 1mg
Purity: 98%
in stock
$37.00 $26.00
Pack Size: 5mg
Purity: 98%
in stock
$117.00 $82.00
Pack Size: 50mg
Purity: 98%
in stock
$313.00 $219.00
Pack Size: 100mg
Purity: 98%
in stock
$469.00 $328.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA004L75
Chemical Name: PF-573228
CAS Number: 869288-64-2
Molecular Formula: C22H20F3N5O3S
Molecular Weight: 491.4861
MDL Number: MFCD11519967
SMILES: O=C1CCc2c(N1)ccc(c2)Nc1ncc(c(n1)NCc1cccc(c1)S(=O)(=O)C)C(F)(F)F
Properties
Form: Solid  
MP: >242℃ (dec.)  
Storage: Inert atmosphere;2-8℃;  
Complexity: 822  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 34  
Hydrogen Bond Acceptor Count: 10  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 6  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.2  
Downstream Synthesis Route
869288-63-1    855267-50-4    869288-64-2 

[1]CurrentPatentAssignee:PFIZERINC-US2005/256111,2005,A1Locationinpatent:Page/Pagecolumn26-27;28

717907-76-1    855267-50-4    869288-64-2 

[1]Berger,Benedict-Tilman;Amaral,Marta;Kokh,DariaB.;Nunes-Alves,Ariane;Musil,Djordje;Heinrich,Timo;Schröder,Martin;Neil,Rebecca;Wang,Jing;Navratilova,Iva;Bomke,Joerg;Elkins,JonathanM.;Müller,Susanne;Frech,Matthias;Wade,RebeccaC.;Knapp,Stefan[CellChemicalBiology,2021,vol.28,#5,p.686-7,698]

Literature fold

Title: Salinomycin attenuates liver cancer stem cell motility by enhancing cell stiffness and increasing F-actin formation via the FAK-ERK1/2 signalling pathway.

Journal: Toxicology20170601

Title: Aryl hydrocarbon receptor-dependent up-regulation of the heterodimeric amino acid transporter LAT1 (SLC7A5)/CD98hc (SLC3A2) by diesel exhaust particle extract in human bronchial epithelial cells.

Journal: Toxicology and applied pharmacology20160101

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters20130801

Title: Matrix metalloproteinase-2 stimulates collagen-I expression through phosphorylation of focal adhesion kinase in rat cardiac fibroblasts.

Journal: American journal of physiology. Cell physiology20121101

Title: Cooperation between c-Met and focal adhesion kinase family members in medulloblastoma and implications for therapy.

Journal: Molecular cancer therapeutics20120201

Title: Small molecule inhibitors of the Pyk2 and FAK kinases modulate chemoattractant-induced migration, adhesion and Akt activation in follicular and marginal zone B cells.

Journal: Cellular immunology20120101

Title: Focal adhesion kinase inhibitors are potent anti-angiogenic agents.

Journal: Molecular oncology20111201

Title: Evidence for activation of BK Ca channels by a known inhibitor of focal adhesion kinase, PF573228.

Journal: Life sciences20111107

Title: Effect of focal adhesion kinase on the regulation of realignment and tenogenic differentiation of human mesenchymal stem cells by mechanical stretch.

Journal: Connective tissue research20111001

Title: Both AT₁ and AT₂ receptors mediate proliferation and migration of porcine vascular smooth muscle cells.

Journal: American journal of physiology. Heart and circulatory physiology20110901

Title: Vascular endothelial growth factor regulates the migration of oligodendrocyte precursor cells.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20110720

Title: Oxidative stress-induced degradation of thioredoxin-1 and apoptosis is inhibited by thioredoxin-1-actin interaction in endothelial cells.

Journal: Arteriosclerosis, thrombosis, and vascular biology20110301

Title: Inhibition of focal adhesion kinase suppresses the adverse phenotype of endocrine-resistant breast cancer cells and improves endocrine response in endocrine-sensitive cells.

Journal: Breast cancer research and treatment20110201

Title: DNA copy number aberrations in small-cell lung cancer reveal activation of the focal adhesion pathway.

Journal: Oncogene20101202

Title: Focal adhesion kinase can play unique and opposing roles in regulating the morphology of differentiating oligodendrocytes.

Journal: Journal of neurochemistry20101001

Title: Density- and serum-dependent regulation of the Reck tumor suppressor in mouse embryo fibroblasts.

Journal: Cellular signalling20091201

Title: Characterization of a novel focal adhesion kinase inhibitor in human platelets.

Journal: Biochemical and biophysical research communications20091106

Title: Therapeutic targeting of the focal adhesion complex prevents oncogenic TGF-beta signaling and metastasis.

Journal: Breast cancer research : BCR20090101

Title: Cellular characterization of a novel focal adhesion kinase inhibitor.

Journal: The Journal of biological chemistry20070518

Title: Slack-Davis JK, et al. Cellular characterization of a novel focal adhesion kinase inhibitor. J Biol Chem. 2007 May 18;282(20):14845-52.

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