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84468-24-6,MFCD00209852
Catalog No.:AA004VZ5

84468-24-6 | Isoquinoline,5-(1-piperazinylsulfonyl)-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
50mg
≥98%
in stock  
$906.00   $634.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA004VZ5
Chemical Name:
Isoquinoline,5-(1-piperazinylsulfonyl)-
CAS Number:
84468-24-6
Molecular Formula:
C13H15N3O2S
Molecular Weight:
277.3421
MDL Number:
MFCD00209852
SMILES:
O=S(=O)(c1cccc2c1ccnc2)N1CCNCC1
Properties
Properties
 
Form:
Solid  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
401  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
0.6  

Downstream Synthesis Route

[1]CurrentPatentAssignee:HIDAKA;ASAHIKASEICORPORATION-US4456757,1984,A

[2]Ricouart,A.;Gesquiere,J.C.;Tartar,A.;Sergheraet,C.[JournalofMedicinalChemistry,1991,vol.34,#1,p.73-78]

[3]Martín-Cámara,Olmo;Arribas,Marina;Wells,Geoffrey;Morales-Tenorio,Marcos;Martín-Requero,Ángeles;Porras,Gracia;Martínez,Ana;Giorgi,Giorgio;López-Alvarado,Pilar;Lastres-Becker,Isabel;Menéndez,J.Carlos[JournalofMedicinalChemistry,2022,vol.65,#3,p.1867-1882]

[4]Collins,Ian;Caldwell,John;Fonseca,Tatiana;Donald,Alastair;Bavetsias,Vassilios;Hunter,Lisa-JaneK.;Garrett,MichelleD.;Rowlands,MartinG.;Aherne,G.Wynne;Davies,ThomasG.;Berdini,Valerio;Woodhead,StevenJ.;Davis,Deborah;Seavers,LisaC.A.;Wyatt,PaulG.;Workman,Paul;McDonald,Edward[BioorganicandMedicinalChemistry,2006,vol.14,#4,p.1255-1273]

[1]Morikawa;Sone;Asano[ChemicalandPharmaceuticalBulletin,1992,vol.40,#3,p.770-773]

[1]Ricouart,A.;Gesquiere,J.C.;Tartar,A.;Sergheraet,C.[JournalofMedicinalChemistry,1991,vol.34,#1,p.73-78]

[1]Ricouart,A.;Gesquiere,J.C.;Tartar,A.;Sergheraet,C.[JournalofMedicinalChemistry,1991,vol.34,#1,p.73-78]

[1]Morikawa;Sone;Asano[ChemicalandPharmaceuticalBulletin,1992,vol.40,#3,p.770-773]

Literature

Title: Evaluation of broad spectrum protein kinase inhibitors to probe the architecture of the malarial cyclin dependent protein kinase Pfmrk.

Journal: Bioorganic & medicinal chemistry letters 20070901

Title: Acridone derivatives are selective inhibitors of HIV-1 replication in chronically infected cells.

Journal: Antiviral research 19991001

Title: Isoquinolinesulphonamide derivatives inhibit transcriptional elongation of human immunodeficiency virus type 1 RNA in a promyelocytic model of latency.

Journal: Antiviral chemistry & chemotherapy 19990901

Title: P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro.

Journal: Genes & development 19971015

Title: Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists.

Journal: Journal of medicinal chemistry 19960607

Title: Hagiwara M, et al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32(1):7-12.

Title: Yu J, et, al. Efficient feeder-free episomal reprogramming with small molecules. PLoS One. 2011 Mar 1;6(3):e17557.

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SDS
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Tags:84468-24-6 Molecular Formula|84468-24-6 MDL|84468-24-6 SMILES|84468-24-6 Isoquinoline,5-(1-piperazinylsulfonyl)-
Catalog No.: AA004VZ5
84468-24-6,MFCD00209852
84468-24-6 | Isoquinoline,5-(1-piperazinylsulfonyl)-
Pack Size： 50mg
Purity： ≥98%
in stock
$906.00 $634.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA004VZ5
Chemical Name: Isoquinoline,5-(1-piperazinylsulfonyl)-
CAS Number: 84468-24-6
Molecular Formula: C13H15N3O2S
Molecular Weight: 277.3421
MDL Number: MFCD00209852
SMILES: O=S(=O)(c1cccc2c1ccnc2)N1CCNCC1
Properties
Form: Solid  
Storage: Keep in dry area;2-8℃;  
Complexity: 401  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 19  
Hydrogen Bond Acceptor Count: 5  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 2  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 0.6  
Downstream Synthesis Route
110-85-0    84468-15-5    84468-24-6 

[1]CurrentPatentAssignee:HIDAKA;ASAHIKASEICORPORATION-US4456757,1984,A

[2]Ricouart,A.;Gesquiere,J.C.;Tartar,A.;Sergheraet,C.[JournalofMedicinalChemistry,1991,vol.34,#1,p.73-78]

[3]Martín-Cámara,Olmo;Arribas,Marina;Wells,Geoffrey;Morales-Tenorio,Marcos;Martín-Requero,Ángeles;Porras,Gracia;Martínez,Ana;Giorgi,Giorgio;López-Alvarado,Pilar;Lastres-Becker,Isabel;Menéndez,J.Carlos[JournalofMedicinalChemistry,2022,vol.65,#3,p.1867-1882]

[4]Collins,Ian;Caldwell,John;Fonseca,Tatiana;Donald,Alastair;Bavetsias,Vassilios;Hunter,Lisa-JaneK.;Garrett,MichelleD.;Rowlands,MartinG.;Aherne,G.Wynne;Davies,ThomasG.;Berdini,Valerio;Woodhead,StevenJ.;Davis,Deborah;Seavers,LisaC.A.;Wyatt,PaulG.;Workman,Paul;McDonald,Edward[BioorganicandMedicinalChemistry,2006,vol.14,#4,p.1255-1273]

2745-27-9    84468-24-6    141543-76-2 

[1]Morikawa;Sone;Asano[ChemicalandPharmaceuticalBulletin,1992,vol.40,#3,p.770-773]

3395-91-3    84468-24-6    129786-35-2 

[1]Ricouart,A.;Gesquiere,J.C.;Tartar,A.;Sergheraet,C.[JournalofMedicinalChemistry,1991,vol.34,#1,p.73-78]

5454-83-1    84468-24-6    129786-36-3 

[1]Ricouart,A.;Gesquiere,J.C.;Tartar,A.;Sergheraet,C.[JournalofMedicinalChemistry,1991,vol.34,#1,p.73-78]

60773-92-4    84468-24-6    141543-77-3 

[1]Morikawa;Sone;Asano[ChemicalandPharmaceuticalBulletin,1992,vol.40,#3,p.770-773]

Literature fold

Title: Evaluation of broad spectrum protein kinase inhibitors to probe the architecture of the malarial cyclin dependent protein kinase Pfmrk.

Journal: Bioorganic & medicinal chemistry letters20070901

Title: Acridone derivatives are selective inhibitors of HIV-1 replication in chronically infected cells.

Journal: Antiviral research19991001

Title: Isoquinolinesulphonamide derivatives inhibit transcriptional elongation of human immunodeficiency virus type 1 RNA in a promyelocytic model of latency.

Journal: Antiviral chemistry & chemotherapy19990901

Title: P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro.

Journal: Genes & development19971015

Title: Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists.

Journal: Journal of medicinal chemistry19960607

Title: Hagiwara M, et al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32(1):7-12.

Title: Yu J, et, al. Efficient feeder-free episomal reprogramming with small molecules. PLoS One. 2011 Mar 1;6(3):e17557.

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