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7803-88-5,MFCD01723912
Catalog No.:AA005DM6

7803-88-5 | O6-Methylguanosine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
95%
in stock  
$112.00   $78.00
- +
5g
95%
in stock  
$311.00   $218.00
- +
10g
95%
in stock  
$544.00   $381.00
- +
25g
95%
in stock  
$1,075.00   $753.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA005DM6
Chemical Name:
O6-Methylguanosine
CAS Number:
7803-88-5
Molecular Formula:
C11H15N5O5
Molecular Weight:
297.2673
MDL Number:
MFCD01723912
SMILES:
OC[C@H]1O[C@H]([C@H]([C@H]1O)O)n1cnc2c1nc(N)nc2OC
Properties
Properties
 
BP:
721.0±70.0 °C(Predicted)  
Form:
Liquid  
MP:
120 °C(Solv: ethyl ether (60-29-7); methanol (67-56-1))  
Storage:
Keep in dry area;-20 ℃;Inert atmosphere;  

Computed Properties
 
Complexity:
377  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
3  
XLogP3:
-0.7  

Literature

Title: Dietary fish oil reduces DNA adduct formation while estradiol upregulates apoptosis in response to DNA damage in the rat colon.

Journal: Digestive diseases and sciences 20110901

Title: Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates.

Journal: Journal of medicinal chemistry 20110825

Title: The cycad genotoxin MAM modulates brain cellular pathways involved in neurodegenerative disease and cancer in a DNA damage-linked manner.

Journal: PloS one 20110101

Title: Methylated DNA causes a physical block to replication forks independently of damage signalling, O(6)-methylguanine or DNA single-strand breaks and results in DNA damage.

Journal: Journal of molecular biology 20100910

Title: Separation and identification of purine nucleosides in the urine of patients with malignant cancer by reverse phase liquid chromatography/electrospray tandem mass spectrometry.

Journal: Journal of mass spectrometry : JMS 20090501

Title: [Apoptosis induced by base mismatches].

Journal: Fukuoka igaku zasshi = Hukuoka acta medica 20070801

Title: Identification of an in vivo inhibitor of Bacillus anthracis spore germination.

Journal: The Journal of biological chemistry 20070420

Title: Protection against esophageal cancer in rodents with lyophilized berries: potential mechanisms.

Journal: Nutrition and cancer 20060101

Title: Kinetic analysis of steps in the repair of damaged DNA by human O6-alkylguanine-DNA alkyltransferase.

Journal: The Journal of biological chemistry 20050902

Title: Stable isotope labeling-mass spectrometry analysis of methyl- and pyridyloxobutyl-guanine adducts of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in p53-derived DNA sequences.

Journal: Biochemistry 20050215

Title: Synthesis of purin-2-yl carboxylate from O6-methylguanosine.

Journal: Nucleic acids symposium series (2004) 20050101

Title: Intra- and intercellular variations in the repair efficiency of O6-methylguanine, and their contribution to kinetic complexity.

Journal: Mutation research 20041221

Title: Apoptotic signaling in response to a single type of DNA lesion, O(6)-methylguanine.

Journal: Molecular cell 20040409

Title: Mechanisms and consequences of methylating agent-induced SCEs and chromosomal aberrations: a long road traveled and still a far way to go.

Journal: Cytogenetic and genome research 20040101

Title: Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancer.

Journal: Oncogene 20031204

Title: DNA hypermethylation status of multiple genes in prostate adenocarcinomas.

Journal: Japanese journal of cancer research : Gann 20020701

Title: Effect of sequence context on O(6)-methylguanine repair and replication in vivo.

Journal: Biochemistry 20011211

Title: Grasby JA, et al. The synthesis of oligoribonucleotides containing O6-methylguanosine: the role of conserved guanosine residues in hammerhead ribozyme cleavage. Nucleic Acids Res. 1993 Sep 25;21(19):4444-50.

Title: Thielmann HW, et al. 6-Methylguanine and 6-methylguanosine inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line but not in other xeroderma pigmentosum and normal human fibroblast strains after treatment with 1-(2-chloroethyl)-1-nitroso-3-(2-hydroxyethyl)-urea. J Cancer Res Clin Oncol. 1987;113(1):67-72.

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