Title: Inactivation of O(6)-alkylguanine-DNA alkyltransferase by folate esters of O(6)-benzyl-2'-deoxyguanosine and of O(6)-[4-(hydroxymethyl)benzyl]guanine.
Journal: Journal of medicinal chemistry 20071018
Title: Modulation of chemotherapy resistance in regional therapy: a novel therapeutic approach to advanced extremity melanoma using intra-arterial temozolomide in combination with systemic O6-benzylguanine.
Journal: Molecular cancer therapeutics 20060301
Title: Kinetic analysis of steps in the repair of damaged DNA by human O6-alkylguanine-DNA alkyltransferase.
Journal: The Journal of biological chemistry 20050902
Title: O6-3-[125I]iodobenzyl-2'-deoxyguanosine ([125I]IBdG): synthesis and evaluation of its usefulness as an agent for quantification of alkylguanine-DNA alkyltransferase (AGT).
Journal: Bioorganic & medicinal chemistry 20050602
Title: Beta-glucuronidase-cleavable prodrugs of O6-benzylguanine and O6-benzyl-2'-deoxyguanosine.
Journal: Journal of medicinal chemistry 20050113
Title: Enhanced in vivo selection of bone marrow cells by retroviral-mediated coexpression of mutant O6-methylguanine-DNA-methyltransferase and HOXB4.
Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20041101
Title: Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations.
Journal: Molecular cancer therapeutics 20040901
Title: O6-benzylguanine suppression of O6-alkylguanine-DNA alkyltransferase in anaplastic gliomas.
Journal: Neuro-oncology 20040101
Title: Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA methyltransferase with O6-benzylguanine or O6-benzyl-2'-deoxyguanosine.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030901
Title: Characterization of O(6)-methylguanine-DNA-methyltransferase (O(6)-MGMT) activity in Xiphophorus fishes.
Journal: Mutation research 20010627
Title: Thresholds of O6-alkylguanine-DNA alkyltransferase which confer significant resistance of human glial tumor xenografts to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea or temozolomide.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010201
Title: Antitumor efficacy of SarCNU in a human glioma xenograft model expressing both MGMT and extraneuronal monoamine transporter.
Journal: Journal of neuro-oncology 20010101
