Title: A reconstructed human epidermal keratinization culture model to characterize ceramide metabolism in the stratum corneum.
Journal: Archives of dermatological research 20120901
Title: Membrane raft disruption results in neuritic retraction prior to neuronal death in cortical neurons.
Journal: Bioscience trends 20120801
Title: Cholesterol level influences opioid signaling in cell models and analgesia in mice and humans.
Journal: Journal of lipid research 20120601
Title: Involvement of ganglioside GT1b in glutamate release from neuroblastoma cells.
Journal: Neuroscience letters 20120531
Title: Increasing ceramides sensitizes genistein-induced melanoma cell apoptosis and growth inhibition.
Journal: Biochemical and biophysical research communications 20120511
Title: Dissociation of ERK signalling inhibition from the anti-amyloidogenic action of synthetic ceramide analogues.
Journal: Clinical science (London, England : 1979) 20120501
Title: Relevance of the salvage pathway to N-hexanoylsphingosine metabolic downregulation in human neurotumor cells: implications for apoptosis.
Journal: Drug metabolism letters 20120301
Title: 1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) facilitates curcumin-induced melanoma cell apoptosis by enhancing ceramide accumulation, JNK activation, and inhibiting PI3K/AKT activation.
Journal: Molecular and cellular biochemistry 20120201
Title: Property-based design of a glucosylceramide synthase inhibitor that reduces glucosylceramide in the brain.
Journal: Journal of lipid research 20120201
Title: Imiglucerase in the treatment of Gaucher disease: a history and perspective.
Journal: Drug design, development and therapy 20120101
Title: GD1a modulates GM-CSF-induced cell proliferation.
Journal: Cytokine 20111201
Title: Glucosylceramide synthase inhibitor PDMP sensitizes chronic myeloid leukemia T315I mutant to Bcr-Abl inhibitor and cooperatively induces glycogen synthase kinase-3-regulated apoptosis.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20111001
Title: Combinatorial therapies improve the therapeutic efficacy of nanoliposomal ceramide for pancreatic cancer.
Journal: Cancer biology & therapy 20111001
Title: Targeting glucosylceramide synthase sensitizes imatinib-resistant chronic myeloid leukemia cells via endogenous ceramide accumulation.
Journal: Journal of cancer research and clinical oncology 20111001
Title: D,L-Threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (DL-PDMP) increases endoplasmic reticulum stress, autophagy and apoptosis accompanying ceramide accumulation via ceramide synthase 5 protein expression in A549 cells.
Journal: Biochimie 20110901
Title: Roles of ceramide synthase and ceramide clearence genes in nilotinib-induced cell death in chronic myeloid leukemia cells.
Journal: Leukemia & lymphoma 20110801
Title: Physiopathological function of hematoside (GM3 ganglioside).
Journal: Proceedings of the Japan Academy. Series B, Physical and biological sciences 20110511
Title: The roles of bioactive sphingolipids in resveratrol-induced apoptosis in HL60: acute myeloid leukemia cells.
Journal: Journal of cancer research and clinical oncology 20110201
Title: Effect of D, L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol and tetrandrine on the reversion of multidrug resistance in K562/A02 cells.
Journal: Hematology (Amsterdam, Netherlands) 20110101
Title: C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and α-tubulin hyperacetylation both in vitro and in vivo.
Journal: Cell death & disease 20110101
Title: Resveratrol triggers apoptosis through regulating ceramide metabolizing genes in human K562 chronic myeloid leukemia cells.
Journal: Nutrition and cancer 20110101
Title: Isofagomine in vivo effects in a neuronopathic Gaucher disease mouse.
Journal: PloS one 20110101
Title: Production of multiple brain-like ganglioside species is dispensable for fas-induced apoptosis of lymphoid cells.
Journal: PloS one 20110101
Title: Modulation of amyloid precursor protein processing by synthetic ceramide analogues.
Journal: Biochimica et biophysica acta 20100801
Title: How adhesion/growth-regulatory galectins-1 and -3 attain cell specificity: case study defining their target on neuroblastoma cells (SK-N-MC) and marked affinity regulation by affecting microdomain organization of the membrane.
Journal: IUBMB life 20100801
Title: Inhibition of glucosylceramide synthase reversibly decreases the capsaicin-induced activation and TRPV1 expression of cultured dorsal root ganglion neurons.
Journal: Pain 20100701
Title: Insulin inhibits Abeta fibrillogenesis through a decrease of the GM1 ganglioside-rich microdomain in neuronal membranes.
Journal: Journal of neurochemistry 20100501
Title: Direct quantitative determination of ceramide glycosylation in vivo: a new approach to evaluate cellular enzyme activity of glucosylceramide synthase.
Journal: Journal of lipid research 20100401
Title: Hypoxia-induced neuronal apoptosis is mediated by de novo synthesis of ceramide through activation of serine palmitoyltransferase.
Journal: Cellular signalling 20100401
Title: Myriocin-mediated up-regulation of hepatocyte apoA-I synthesis is associated with ERK inhibition.
Journal: Clinical science (London, England : 1979) 20100330
Title: [Effect of PDMP, a glucosylceramide synthase inhibitor, on reversion of daunorubicin resistance in human leukemia cell line K562/A02].
Journal: Zhongguo shi yan xue ye xue za zhi 20100201
Title: P-Glycoprotein is not a key target for the chemosensitizing effect of 1-phenyl-2-decanoylamino-3-morpholino-1-propanol in HepG2 cells exposed to doxorubicin.
Journal: Drug metabolism letters 20100101
Title: Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling.
Journal: Molecular cancer 20100101
Title: Increased hepatic insulin action in diet-induced obese mice following inhibition of glucosylceramide synthase.
Journal: PloS one 20100101
Title: Gaucher disease: clinical profile and therapeutic developments.
Journal: Biologics : targets & therapy 20100101
Title: Use of a novel anti-proliferative compound coated on a biopolymer to mitigate platelet-derived growth factor-induced proliferation in human aortic smooth muscle cells: comparison with sirolimus.
Journal: Glycoconjugate journal 20090801
Title: VEGF recruits lactosylceramide to induce endothelial cell adhesion molecule expression and angiogenesis in vitro and in vivo.
Journal: Glycoconjugate journal 20090701
Title: Glycosphingolipid requirements for endosome-to-Golgi transport of Shiga toxin.
Journal: Traffic (Copenhagen, Denmark) 20090701
Title: Neurotrophic and neuroprotective actions of an enhancer of ganglioside biosynthesis.
Journal: International review of neurobiology 20090101
Title: L-PDMP improves glucosylceramide synthesis and behavior in rats with focal ischemia.
Journal: Neurological research 20081101
Title: Membrane type sialidase inhibits the megakaryocytic differentiation of human leukemia K562 cells.
Journal: Biochimica et biophysica acta 20080501
Title: Review of miglustat for clinical management in Gaucher disease type 1.
Journal: Therapeutics and clinical risk management 20080401
Title: Depletion of the lipid raft constituents, sphingomyelin and ganglioside, decreases serotonin binding at human 5-HT7(a) receptors in HeLa cells.
Journal: Acta physiologica (Oxford, England) 20070501
Title: [Effect of endogeneous gangliosides on integrin alpha2beta1-mediated adhesion of neuroblastoma cells to collagen].
Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20070201
Title: A study of the xenoantigenicity of neonatal porcine islet-like cell clusters (NPCC) and the efficiency of adenovirus-mediated DAF (CD55) expression.
Journal: Xenotransplantation 20060901
Title: Synthesis and biological evaluation of novel PDMP analogues.
Journal: Bioorganic & medicinal chemistry 20060801
Title: The synthetic ceramide analog L-PDMP partially protects striatal dopamine levels but does not promote dopamine neuron survival in murine models of parkinsonism.
Journal: Brain research 20060712
Title: Lipid rafts serve as a signaling platform for nicotinic acetylcholine receptor clustering.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060503
Title: Lactosylceramide is required in apoptosis induced by N-Smase.
Journal: Glycoconjugate journal 20060501
Title: D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol alters cellular cholesterol homeostasis by modulating the endosome lipid domains.
Journal: Biochemistry 20060411
Title: Role of gangliosides in the association of ErbB2 with lipid rafts in mammary epithelial HC11 cells.
Journal: The FEBS journal 20060401
Title: PDMP sensitizes neuroblastoma to paclitaxel by inducing aberrant cell cycle progression leading to hyperploidy.
Journal: Molecular cancer therapeutics 20060301
Title: Substrate reduction therapy of glycosphingolipid storage disorders.
Journal: Journal of inherited metabolic disease 20060101
Title: Inhibition of sphingolipid synthesis impairs cellular activation, cytokine production and proliferation in human lymphocytes.
Journal: Biochemical pharmacology 20051219
Title: Human T-cell lymphotropic virus type I-transformed T-cells have a partial defect in ceramide synthesis in response to N-(4-hydroxyphenyl)retinamide.
Journal: The Biochemical journal 20051115
Title: Novel role of lactosylceramide in vascular endothelial growth factor-mediated angiogenesis in human endothelial cells.
Journal: Circulation research 20051014
Title: Glycosphingolipid accumulation inhibits cholesterol efflux via the ABCA1/apolipoprotein A-I pathway: 1-phenyl-2-decanoylamino-3-morpholino-1-propanol is a novel cholesterol efflux accelerator.
Journal: The Journal of biological chemistry 20050701
Title: A novel role of lactosylceramide in the regulation of tumor necrosis factor alpha-mediated proliferation of rat primary astrocytes. Implications for astrogliosis following neurotrauma.
Journal: The Journal of biological chemistry 20050408
Title: Sphingosine 1-phosphate acts as a signal molecule in ceramide signal transduction of TNF-alpha-induced activator protein-1 in osteoblastic cell line MC3T3-E1 cells.
Journal: Journal of oral science 20050301
Title: Inhibition of sphingolipid biosynthesis decreases phosphorylated ERK2 in LLC-PK1 cells.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20050101
Title: Effect of the modulation of the membrane lipid composition on the localization and function of P-glycoprotein in MDR1-MDCK cells.
Journal: In vitro cellular & developmental biology. Animal 20050101
Title: Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells.
Journal: The Journal of biological chemistry 20040924
Title: Sialic acid acts as a receptor for equine rhinitis A virus binding and infection.
Journal: The Journal of general virology 20040901
Title: Gangliosides link the acidic sphingomyelinase-mediated induction of ceramide to 12-lipoxygenase-dependent apoptosis of neuroblastoma in response to fenretinide.
Journal: Journal of the National Cancer Institute 20040901
Title: In vivo influence of ceramide accumulation induced by treatment with a glucosylceramide synthase inhibitor on ischemic neuronal cell death.
Journal: Brain research 20040820
Title: The combinatorial extension method reveals a sphingolipid binding domain on pancreatic bile salt-dependent lipase: role in secretion.
Journal: Structure (London, England : 1993) 20040801
Title: A novel role of lactosylceramide in the regulation of lipopolysaccharide/interferon-gamma-mediated inducible nitric oxide synthase gene expression: implications for neuroinflammatory diseases.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040630
Title: Mechanism for the negative regulation of cell proliferation by ganglioside GM3 in high glucose-treated glomerular mesangial cells.
Journal: Life sciences 20040521
Title: Cytoprotective effect of glucosylceramide synthase inhibition against daunorubicin-induced apoptosis in human leukemic cell lines.
Journal: The Journal of biological chemistry 20040430
Title: Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1.
Journal: The Journal of biological chemistry 20040430
Title: New PDMP analogues inhibit process outgrowth in an insect cell line.
Journal: Bioorganic & medicinal chemistry letters 20040322
Title: A turn in the road: How studies on the pharmacology of glucosylceramide synthase inhibitors led to the identification of a lysosomal phospholipase A2 with ceramide transacylase activity.
Journal: Glycoconjugate journal 20040101
Title: Apoptosis of human carcinoma cells in the presence of inhibitors of glycosphingolipid biosynthesis: I. Treatment of Colo-205 and SKBR3 cells with isomers of PDMP and PPMP.
Journal: Glycoconjugate journal 20040101
Title: Apoptosis of human carcinoma cells in the presence of potential anti-cancer drugs: III. Treatment of Colo-205 and SKBR3 cells with: cis -platin, Tamoxifen, Melphalan, Betulinic acid, L-PDMP, L-PPMP, and GD3 ganglioside.
Journal: Glycoconjugate journal 20040101
Title: Reduction of glycosphingolipid levels in lipid rafts affects the expression state and function of glycosylphosphatidylinositol-anchored proteins but does not impair signal transduction via the T cell receptor.
Journal: The Journal of biological chemistry 20031219
Title: The significance of N-linked glycosylation in pig endogenous retrovirus infectivity.
Journal: Biochemical and biophysical research communications 20031017
Title: Ceramide accumulation precedes caspase-3 activation during apoptosis of A549 human lung adenocarcinoma cells.
Journal: American journal of physiology. Lung cellular and molecular physiology 20030601
Title: Gangliosides regulate tumor cell adhesion to collagen.
Journal: Clinical & experimental metastasis 20030101
Title: Increased biosynthesis of glycosphingolipids in congenital disorder of glycosylation Ia (CDG-Ia) fibroblasts.
Journal: Pediatric research 20021101
Title: Increasing endogenous ceramide using inhibitors of sphingolipid metabolism maximizes ionizing radiation-induced mitochondrial injury and apoptotic cell killing.
Journal: International journal of cancer 20021020
Title: Glycosphingolipid lysosomal storage diseases: therapy and pathogenesis.
Journal: Neuropathology and applied neurobiology 20021001
Title: Ceramide induces activation of the mitochondrial/caspases pathway in Jurkat and SCC61 cells sensitive to gamma-radiation but activation of this sequence is defective in radioresistant SQ20B cells.
Journal: International journal of radiation biology 20020901
Title: Modulation of the expression of membrane-bound CD54 (mCD54) and soluble form of CD54 (sCD54) in endothelial cells by glucosyl transferase inhibitor: possible role of ceramide for the shedding of mCD54.
Journal: Biochemical and biophysical research communications 20020809
Title: Influence of ceramide metabolism on P-glycoprotein function in immature acute myeloid leukemia KG1a cells.
Journal: Molecular pharmacology 20020801
Title: Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells.
Journal: Biological chemistry 20020601
Title: The lysosomal transport of prosaposin requires the conditional interaction of its highly conserved d domain with sphingomyelin.
Journal: The Journal of biological chemistry 20020510
Title: Possible implication of Golgi-nucleating function for the centrosome.
Journal: Biochemical and biophysical research communications 20020301
Title: P-glycoprotein modulates ceramide-mediated sensitivity of human breast cancer cells to tubulin-binding anticancer drugs.
Journal: Molecular cancer therapeutics 20020101
Title: Ceramide attenuates high glucose-induced cardiac contractile abnormalities in cultured adult rat ventricular myocytes.
Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20020101
Title: Sialosyl Le(a)-carrying gangliosides present on the surface of colon carcinoma cells are not directly involved in adhesion to E-selectin.
Journal: European journal of cell biology 20011201
Title: Differential chemosensitizing effect of two glucosylceramide synthase inhibitors in hepatoma cells.
Journal: Biochemical and biophysical research communications 20011019
Title: Ceramide mediates tumor-induced dendritic cell apoptosis.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20011001
Title: Agents for the treatment of glycosphingolipid storage disorders.
Journal: Current drug metabolism 20010901
Title: Glucosylceramide synthesis inhibitors block pharmacologically induced dispersal of the Golgi and anterograde membrane flow from the endoplasmic reticulum: implication of sphingolipid metabolism in maintenance of the Golgi architecture and anterograde membrane flow.
Journal: Bioscience, biotechnology, and biochemistry 20010601
Title: Activation of the endothelial nitric-oxide synthase by tumor necrosis factor-alpha. A novel feedback mechanism regulating cell death.
Journal: The Journal of biological chemistry 20010302
Title: Ceramide dissociates 3'-phosphoinositide production from pleckstrin homology domain translocation.
Journal: The Biochemical journal 20010301
Title: Lactosylceramide mediates shear-induced endothelial superoxide production and intercellular adhesion molecule-1 expression.
Journal: Journal of vascular research 20010101
Title: Doxorubicin induces slow ceramide accumulation and late apoptosis in cultured adult rat ventricular myocytes.
Journal: Cardiovascular research 19990801
Title: Differential effects of glycolipid biosynthesis inhibitors on ceramide-induced cell death in neuroblastoma cells.
Journal: Journal of neurochemistry 19990301
Title: Rationales for cancer chemotherapy with PDMP, a specific inhibitor of glucosylceramide synthase.
Journal: Molecular and chemical neuropathology 19940101
