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Title: Discovery of 4-morpholino-pyrimidin-6-one and 4-morpholino-pyrimidin-2-one-containing Phosphoinositide 3-kinase (PI3K) p110β isoform inhibitors through structure-based fragment optimisation.
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Title: Regulation of CD38 expression in human airway smooth muscle cells: role of class I phosphatidylinositol 3 kinases.
Journal: American journal of respiratory cell and molecular biology 20121001
Title: PI3K p110α/Akt signaling negatively regulates secretion of the intestinal peptide neurotensin through interference of granule transport.
Journal: Molecular endocrinology (Baltimore, Md.) 20120801
Title: Discovery and optimization of new benzimidazole- and benzoxazole-pyrimidone selective PI3Kβ inhibitors for the treatment of phosphatase and TENsin homologue (PTEN)-deficient cancers.
Journal: Journal of medicinal chemistry 20120524
Title: Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent.
Journal: Cancer discovery 20120501
Title: A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation.
Journal: Nature chemical biology 20120429
Title: Combined blockade of ADP receptors and PI3-kinase p110β fully prevents platelet and leukocyte activation during hypothermic extracorporeal circulation.
Journal: PloS one 20120101
Title: Phosphoinositide-3-kinase/akt - dependent signaling is required for maintenance of [Ca(2+)](i), I(Ca), and Ca(2+) transients in HL-1 cardiomyocytes.
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Title: Discovery of new aminopyrimidine-based phosphoinositide 3-kinase beta (PI3Kβ) inhibitors with selectivity over PI3Kα.
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Title: Bleeding response induced by anti-thrombotic doses of a phosphoinositide 3-kinase (PI3K)-β inhibitor in mice.
Journal: Thrombosis research 20110601
Title: Phosphatidylinositol 3-kinase isoform-specific effects in airway mesenchymal cell function.
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Title: Role of protein kinase C and epidermal growth factor receptor signalling in growth stimulation by neurotensin in colon carcinoma cells.
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Title: Role of phosphoinositide 3-kinase beta in platelet aggregation and thromboxane A2 generation mediated by Gi signalling pathways.
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Title: Advantages of a selective beta-isoform phosphoinositide 3-kinase antagonist, an anti-thrombotic agent devoid of other cardiovascular actions in the rat.
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Title: Selective inhibition of the platelet phosphoinositide 3-kinase p110beta as promising new strategy for platelet protection during extracorporeal circulation.
Journal: Thrombosis and haemostasis 20080301
Title: PI 3-kinase p110beta: a new target for antithrombotic therapy.
Journal: Nature medicine 20050501
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