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Home Amines 1173900-33-8
1173900-33-8,MFCD16659062
Catalog No.:AA000E4O

1173900-33-8 | 2-{[(1R)-1-[7-methyl-2-(morpholin-4-yl)-4-oxopyrido[1,2-a]pyrimidin-9-yl]ethyl]amino}benzoic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$188.00   $131.00
- +
10mg
>98% (or refer to the Certificate of Analysis)
in stock  
$325.00   $228.00
- +
25mg
>98% (or refer to the Certificate of Analysis)
in stock  
$504.00   $353.00
- +
50mg
>98% (or refer to the Certificate of Analysis)
in stock  
$861.00   $603.00
- +
100mg
>98% (or refer to the Certificate of Analysis)
in stock  
$1,397.00   $978.00
- +
200mg
>98% (or refer to the Certificate of Analysis)
in stock  
$2,290.00   $1,603.00
- +
500mg
>98% (or refer to the Certificate of Analysis)
in stock  
$4,790.00   $3,353.00
- +
1g
>98% (or refer to the Certificate of Analysis)
in stock  
$6,754.00   $4,728.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000E4O
Chemical Name:
2-{[(1R)-1-[7-methyl-2-(morpholin-4-yl)-4-oxopyrido[1,2-a]pyrimidin-9-yl]ethyl]amino}benzoic acid
CAS Number:
1173900-33-8
Molecular Formula:
C22H24N4O4
Molecular Weight:
408.4504
MDL Number:
MFCD16659062
SMILES:
Cc1cc([C@H](Nc2ccccc2C(=O)O)C)c2n(c1)c(=O)cc(n2)N1CCOCC1
Properties
Computed Properties
 
Complexity:
838  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
2  

Downstream Synthesis Route

[1]CurrentPatentAssignee:SUZHOUMIRACPHARMATECHNOLOGYCOLTD-CN104592222,2016,BLocationinpatent:Paragraph0020;0052-0053

[1]Giordanetto,Fabrizio;Barlaam,Bernard;Berglund,Susanne;Edman,Karl;Karlsson,Olle;Lindberg,Jan;Nylander,Sven;Inghardt,Tord[BioorganicandMedicinalChemistryLetters,2014,vol.24,#16,p.3936-3943]

[1]Giordanetto,Fabrizio;Barlaam,Bernard;Berglund,Susanne;Edman,Karl;Karlsson,Olle;Lindberg,Jan;Nylander,Sven;Inghardt,Tord[BioorganicandMedicinalChemistryLetters,2014,vol.24,#16,p.3936-3943]

9-(1R-aminoethyl)-7-methyl-2-(morpholin-4-yl)-4H-pyrido1,2-apyrimidin-4-one 
  88-65-3    1173900-33-8 

[1]CurrentPatentAssignee:SUZHOUMIRACPHARMATECHNOLOGYCOLTD-CN104592222,2016,BLocationinpatent:Paragraph0020;0048-0049

3-acetyl-5-methyl-2-pyridone 
  1173900-33-8 

[1]CurrentPatentAssignee:SUZHOUMIRACPHARMATECHNOLOGYCOLTD-CN104592222,2016,B

[2]CurrentPatentAssignee:SUZHOUMIRACPHARMATECHNOLOGYCOLTD-CN104592222,2016,B

Literature

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Discovery of phosphoinositide 3-kinases (PI3K) p110β isoform inhibitor 4-[2-hydroxyethyl(1-naphthylmethyl)amino]-6-[(2S)-2-methylmorpholin-4-yl]-1H-pyrimidin-2-one, an effective antithrombotic agent without associated bleeding and insulin resistance.

Journal: Bioorganic & medicinal chemistry letters 20121101

Title: Human target validation of phosphoinositide 3-kinase (PI3K)β: effects on platelets and insulin sensitivity, using AZD6482 a novel PI3Kβ inhibitor.

Journal: Journal of thrombosis and haemostasis : JTH 20121001

Title: Ni J, et al. Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent. Cancer Discov. 2012 May;2(5):425-33.

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SDS
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Tags:1173900-33-8 Molecular Formula|1173900-33-8 MDL|1173900-33-8 SMILES|1173900-33-8 2-{[(1R)-1-[7-methyl-2-(morpholin-4-yl)-4-oxopyrido[1,2-a]pyrimidin-9-yl]ethyl]amino}benzoic acid