Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Journal: The Biochemical journal 20130415
Title: PI3Kγ activation is required for LPS-induced reactive oxygen species generation in respiratory epithelial cells.
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20121101
Title: PI3Kδ and PI3Kγ as targets for autoimmune and inflammatory diseases.
Journal: Journal of medicinal chemistry 20121025
Title: The novel therapeutic effect of phosphoinositide 3-kinase-γ inhibitor AS605240 in autoimmune diabetes.
Journal: Diabetes 20120601
Title: A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation.
Journal: Nature chemical biology 20120429
Title: PI3K-γ inhibition ameliorates acute lung injury through regulation of IκBα/NF-κB pathway and innate immune responses.
Journal: Journal of clinical immunology 20120401
Title: PI3Kγ inhibition reduces blood pressure by a vasorelaxant Akt/L-type calcium channel mechanism.
Journal: Cardiovascular research 20120101
Title: Murine bone marrow-derived macrophages differentiated with GM-CSF become foam cells by PI3Kγ-dependent fluid-phase pinocytosis of native LDL.
Journal: Journal of lipid research 20120101
Title: Inhibition of phosphatidylinositol-3 kinase γ reduces pruriceptive, inflammatory, and nociceptive responses induced by trypsin in mice.
Journal: Pain 20111201
Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.
Journal: Nature biotechnology 20111101
Title: PI3Kγ is required for NMDA receptor-dependent long-term depression and behavioral flexibility.
Journal: Nature neuroscience 20111023
Title: A novel binding assay identifies high affinity ligands to the rosiglitazone binding site of mitoNEET.
Journal: Bioorganic & medicinal chemistry letters 20110915
Title: Semaphorin-PlexinD1 signaling limits angiogenic potential via the VEGF decoy receptor sFlt1.
Journal: Developmental cell 20110816
Title: Structure-activity relationship and docking studies of thiazolidinedione-type compounds with monoamine oxidase B.
Journal: Bioorganic & medicinal chemistry letters 20110815
Title: [The antagonistic effect of PI3K-gamma inhibitor AS605240 on cardiac hypertrophy and cardiac fibrosis induced by isoproterenol in rats].
Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20110701
Title: Acylated and unacylated ghrelin attenuate isoproterenol-induced lipolysis in isolated rat visceral adipocytes through activation of phosphoinositide 3-kinase γ and phosphodiesterase 3B.
Journal: Biochimica et biophysica acta 20110601
Title: Inhibitor of PI3Kγ ameliorates TNBS-induced colitis in mice by affecting the functional activity of CD4+CD25+FoxP3+ regulatory T cells.
Journal: British journal of pharmacology 20110501
Title: Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.
Journal: Molecular cell 20110408
Title: Remodeling of VE-cadherin junctions by the human herpes virus 8 G-protein coupled receptor.
Journal: Oncogene 20110113
Title: Targeting PI3K in neuroblastoma.
Journal: Journal of cancer research and clinical oncology 20101201
Title: Fibroblast growth factor 2 and platelet-derived growth factor, but not platelet lysate, induce proliferation-dependent, functional class II major histocompatibility complex antigen in human mesenchymal stem cells.
Journal: Arthritis and rheumatism 20101201
Title: Pharmacologic inhibition of phosphoinositide 3-kinase gamma (PI3Kγ) promotes infarct resorption and prevents adverse cardiac remodeling after myocardial infarction in mice.
Journal: Journal of cardiovascular pharmacology 20101201
Title: Identification of novel monoamine oxidase B inhibitors by structure-based virtual screening.
Journal: Bioorganic & medicinal chemistry letters 20100901
Title: Effects of PI3Kgamma inhibition using AS-605240 in acute myocardial infarction.
Journal: Circulation research 20100723
Title: A phosphoinositide 3-kinase-gamma inhibitor, AS605240 prevents bleomycin-induced pulmonary fibrosis in rats.
Journal: Biochemical and biophysical research communications 20100625
Title: Phosphoinositide 3-kinase gamma required for lipopolysaccharide-induced transepithelial neutrophil trafficking in the lung.
Journal: The European respiratory journal 20100501
Title: Involvement of phosphoinositide 3-kinase gamma in angiogenesis and healing of experimental myocardial infarction in mice.
Journal: Circulation research 20100305
Title: Discovery of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione, a readily available and orally active glitazone for the treatment of concanavalin A-induced acute liver injury of BALB/c mice.
Journal: Journal of medicinal chemistry 20100114
Title: Inhibition of phosphoinositide 3-kinase ameliorates dextran sodium sulfate-induced colitis in mice.
Journal: The Journal of pharmacology and experimental therapeutics 20100101
Title: Phosphoinositol 3-kinase-gamma mediates antineutrophil cytoplasmic autoantibody-induced glomerulonephritis.
Journal: Kidney international 20100101
Title: Phosphoinositide 3-kinase gamma inhibitor ameliorates concanavalin A-induced hepatic injury in mice.
Journal: Biochemical and biophysical research communications 20090904
Title: Insulin granule recruitment and exocytosis is dependent on p110gamma in insulinoma and human beta-cells.
Journal: Diabetes 20090901
Title: [Intervention effect of PI3Kgamma inhibitor AS605240 on autoimmune myocarditis in mice].
Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20090901
Title: PI3Kgamma differentially regulates FcepsilonRI-mediated degranulation and migration of mast cells by and toward antigen.
Journal: International archives of allergy and immunology 20090101
Title: Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes.
Journal: Circulation 20080311
Title: [Therapeutic potential of phosphoinositide 3-kinase inhibitors in rheumatoid arthritis].
Journal: Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 20071001
Title: Importance of phosphoinositide 3-kinase gamma in the host defense against pneumococcal infection.
Journal: American journal of respiratory and critical care medicine 20070501
Title: Phosphoinositide 3-kinase-gamma as a target in rheumatoid arthritis and systemic lupus.
Journal: Expert opinion on therapeutic targets 20060801
Title: PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus.
Journal: Nature medicine 20050901
Title: Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.
Journal: Nature medicine 20050901
Title: Modulating autoimmunity: pick your PI3 kinase.
Journal: Nature medicine 20050901
Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
Journal: The Journal of biological chemistry 20020419
Title: Huang X, et al. Endothelial p110γPI3K Mediates Endothelial Regeneration and Vascular Repair After Inflammatory Vascular Injury. Circulation. 2016 Mar 15;133(11):1093-103.
Title: Camps M, et al. Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat Med. 2005 Sep;11(9):936-43.
Title: Azzi J, et al. The novel therapeutic effect of phosphoinositide 3-kinase-γ inhibitor AS605240 in autoimmune diabetes. Diabetes. 2012 Jun;61(6):1509-18. Epub 2012 Mar 8.
Title: Wei X, et al. A phosphoinositide 3-kinase-gamma inhibitor, AS605240 prevents bleomycin-induced pulmonary fibrosis in rats. Biochem Biophys Res Commun. 2010 Jun 25;397(2):311-7. Epub 2010 May 26.
