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Home Amines 51420-72-5
51420-72-5,MFCD00140205
Catalog No.:AA006W4X

51420-72-5 | 5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-amine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
95%
1 week  
$36.00   $26.00
- +
1g
95%
1 week  
$138.00   $97.00
- +
5g
95%
1 week  
$493.00   $345.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA006W4X
Chemical Name:
5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-amine
CAS Number:
51420-72-5
Molecular Formula:
C10H5F6N3
Molecular Weight:
281.1572
MDL Number:
MFCD00140205
SMILES:
Nc1ccc2c(n1)nc(cc2C(F)(F)F)C(F)(F)F
Properties
Properties
 
BP:
288.6°C at 760 mmHg  
Form:
Solid  
MP:
195-197 °C  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
328  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
1  
XLogP3:
2.9  

Downstream Synthesis Route

[1]Ferrarini;Mori;Primofiore[JournalofHeterocyclicChemistry,1986,vol.23,#2,p.501-504]

[2]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2013/59559,2013,A2Locationinpatent:Page/Pagecolumn00185

[3]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2022/49521,2022,A1Locationinpatent:Page/Pagecolumn49;60

[4]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2022/49521,2022,A1Locationinpatent:Page/Pagecolumn49;60

[5]Harada,Naomi;Abe,Yuichiro;Karasawa,Satoru;Koga,Noboru[OrganicLetters,2012,vol.14,#24,p.6282-6285]

[6]Wang,Huan;Wang,Shuo;Cheng,Lili;Chen,Ligong;Wang,Yongguang;Qing,Jie;Huang,Shengdian;Wang,Yuanhao;Lei,Xiaoqiang;Wu,Yunfei;Ma,Zhilong;Zhang,Linqi;Tang,Yefeng[ACSMedicinalChemistryLetters,2015,vol.6,#9,p.977-981]

[7]CurrentPatentAssignee:KUNMINGMEDICALUNIVERSITY-CN108059638,2019,BLocationinpatent:Paragraph0049-0052

[8]CurrentPatentAssignee:KUNMINGMEDICALUNIVERSITY-CN108061725,2020,BLocationinpatent:Paragraph0057-0060

[9]Locationinpatent:experimentalpartVaradi,Linda;Gray,Mark;Groundwater,PaulW.;Hall,AndrewJ.;James,ArthurL.;Orenga,Sylvain;Perry,JohnD.;Anderson,RosaleenJ.[OrganicandBiomolecularChemistry,2012,vol.10,#13,p.2578-2589]

[10]Wu,Yun-Ying;Gou,Gao-Zhang;Mu,Wei-Hua;Du,Mei-Ling;Fu,Wen-Fu;Chen,Yong;Lv,Xiao-Jun[OrganicLetters,2012,vol.14,#20,p.5226-5229,4]

[11]CurrentPatentAssignee:MERCK&COINC-US3962262,1976,A

[1]OrganicLetters,2012,vol.14,p.5226-5229,4

[1]OrganicLetters,2012,vol.14,p.5226-5229,4

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2013/59559,2013,A2

[2]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2022/49521,2022,A1

7425-63-0    51420-72-5   
methyl2,4-bis(trifluoromethyl)imidazo1,2-a1,8naphthyridine-8-carboxylate 

[1]ACSMedicinalChemistryLetters,2015,vol.6,p.977-981

Literature

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

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SDS
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