19210-12-9,MFCD00017415
Catalog No.:AA0074G5

19210-12-9 | Harpagoside

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$13.00   $9.00
- +
5mg
98%
in stock  
$32.00   $22.00
- +
250mg
analytical standard,≥98%
in stock  
$1,532.00   $1,073.00
- +
1000mg
98% by HPLC
in stock  
$5,049.00   $3,534.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA0074G5
Chemical Name:
Harpagoside
CAS Number:
19210-12-9
Molecular Formula:
C24H30O11
Molecular Weight:
494.4884
MDL Number:
MFCD00017415
SMILES:
OC[C@H]1O[C@@H](O[C@@H]2OC=C[C@@]3([C@H]2[C@@](C)(OC(=O)/C=C/c2ccccc2)C[C@H]3O)O)[C@@H]([C@H]([C@@H]1O)O)O
Properties
Computed Properties
 
Complexity:
811  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
10  
Defined Bond Stereocenter Count:
1  
Formal Charge:
0  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
6  
Isotope Atom Count:
0  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-0.6  

Downstream Synthesis Route

[1]Patent:US2002/183264,2002,A1

[1]BioorganicandMedicinalChemistry,2011,vol.19,p.4882-4886

Literature

Title: Preparative isolation and purification of harpagoside and angroside C from the root of Scrophularia ningpoensis Hemsley by high-speed counter-current chromatography.

Journal: Journal of separation science 20121001

Title: Effect of silymarin and harpagoside on inflammation reaction of BEAS-2B cells, on ciliary beat frequency (CBF) of trachea explants and on mucociliary clearance (MCC).

Journal: Planta medica 20120501

Title: Antiinflammatory activities of Hungarian Stachys species and their iridoids.

Journal: Phytotherapy research : PTR 20120401

Title: Harpagoside attenuates MPTP/MPP⁺ induced dopaminergic neurodegeneration and movement disorder via elevating glial cell line-derived neurotrophic factor.

Journal: Journal of neurochemistry 20120301

Title: Metabolic differentiations and classification of Verbascum species by NMR-based metabolomics.

Journal: Phytochemistry 20111101

Title: [Determination of harpagide and harpagoside in Scrophulariae Radix by HPLC-UV].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111001

Title: Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro.

Journal: Bioorganic & medicinal chemistry 20110815

Title: Harpagoside variation is positively correlated with temperature in Scrophularia ningpoensis Hemsl.

Journal: Journal of agricultural and food chemistry 20110309

Title: [Simultaneous determination of five constituents in Scrophularia ningpoensis by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110301

Title: The interaction potential of herbal medicinal products: a luminescence-based screening platform assessing effects on cytochrome P450 and its use with devil's claw (Harpagophyti radix) preparations.

Journal: The Journal of pharmacy and pharmacology 20110301

Title: Effect of isolated fractions of Harpagophytum procumbens D.C. (devil's claw) on COX-1, COX-2 activity and nitric oxide production on whole-blood assay.

Journal: Phytotherapy research : PTR 20100901

Title: Inhibitory effects of devil's claw (secondary root of Harpagophytum procumbens) extract and harpagoside on cytokine production in mouse macrophages.

Journal: Journal of natural medicines 20100401

Title: Estimation of the relative antiinflammatory efficacies of six commercial preparations of Harpagophytum procumbens (Devil's Claw).

Journal: Phytotherapy research : PTR 20100301

Title: Effects of Devil's Claw (Harpagophytum procumbens) on the multidrug transporter ABCB1/P-glycoprotein.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20091201

Title: Lamiridosins, hepatitis C virus entry inhibitors from Lamium album.

Journal: Journal of natural products 20091201

Title: An in vivo microdialysis measurement of harpagoside in rat blood and bile for predicting hepatobiliary excretion and its interaction with cyclosporin A and verapamil.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090315

Title: [Study on preparation and quantity determination of Scrophularia ningpoensis dispensing granules].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090101

Title: Study of chemical composition and antimicrobial activity of leaves and roots of Scrophularia ningpoensis.

Journal: Natural product research 20090101

Title: Validated HPTLC methods for the determination of salicin in Salix sp. and of harpagoside in Harpagophytum [corrected] procumbens.

Journal: Journal of pharmaceutical and biomedical analysis 20081104

Title: Cognitive-enhancing and antioxidant activities of iridoid glycosides from Scrophularia buergeriana in scopolamine-treated mice.

Journal: European journal of pharmacology 20080624

Title: Effect of the major glycosides of Harpagophytum procumbens (Devil's Claw) on epidermal cyclooxygenase-2 (COX-2) in vitro.

Journal: Journal of natural products 20080501

Title: Optimization of solid-phase extraction for the liquid chromatography-mass spectrometry analysis of harpagoside, 8-para-coumaroyl harpagide, and harpagide in equine plasma and urine.

Journal: Journal of chromatographic science 20080201

Title: Simultaneous determination of harpagoside and cinnamic acid in rat plasma by liquid chromatography electrospray ionization mass spectrometry and its application to pharmacokinetic studies.

Journal: Biomedical chromatography : BMC 20080101

Title: Simultaneous determination of harpagoside and cinnamic acid in rat plasma by high-performance liquid chromatography: application to a pharmacokinetic study.

Journal: Analytical and bioanalytical chemistry 20071201

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kappa B activation.

Journal: Journal of ethnopharmacology 20060308

Title: High anti-inflammatory activity of harpagoside-enriched extracts obtained from solvent-modified super- and subcritical carbon dioxide extractions of the roots of Harpagophytum procumbens.

Journal: Phytochemical analysis : PCA 20060101

Title: Liquid chromatography/electrospray ionization mass spectrometric characterization of Harpagophytum in equine urine and plasma.

Journal: Rapid communications in mass spectrometry : RCM 20060101

Title: Preparative isolation and purification of harpagoside from Scrophularia ningpoensis hemsley by high-speed counter-current chromatography.

Journal: Phytochemical analysis : PCA 20060101

Title: Rapid measurement and evaluation of the effect of drying conditions on harpagoside content in Harpagophytum procumbens (devil's claw) root.

Journal: Journal of agricultural and food chemistry 20050504

Title: Comparison between HPLC and HPTLC-densitometry for the determination of harpagoside from Harpagophytum procumbens CO(2)-extracts.

Journal: Journal of pharmaceutical and biomedical analysis 20050401

Title: Quality control of Harpagophytum procumbens and its related phytopharmaceutical products by means of NIR-FT-Raman spectroscopy.

Journal: Biopolymers 20050101

Title: A 1-year follow-up after a pilot study with Doloteffin for low back pain.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20050101

Title: Downregulation of iNOS expression in rat mesangial cells by special extracts of Harpagophytum procumbens derives from harpagoside-dependent and independent effects.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20041101

Title: Effectiveness of Harpagophytum extracts and clinical efficacy.

Journal: Phytotherapy research : PTR 20040201

Title: Harpgophytum procumbens for osteoarthritis and low back pain: a systematic review.

Journal: BMC complementary and alternative medicine 20040101

Title: Scropolioside-D2 and harpagoside-B: two new iridoid glycosides from Scrophularia deserti and their antidiabetic and antiinflammatory activity.

Journal: Biological & pharmaceutical bulletin 20030401

Title: Four new neuroprotective iridoid glycosides from Scrophularia buergeriana roots.

Journal: Journal of natural products 20021101

Title: De novo regeneration of Scrophularia yoshimurae Yamazaki (Scrophulariaceae) and quantitative analysis of harpagoside, an iridoid glucoside, formed in aerial and underground parts of in vitro propagated and wild plants by HPLC.

Journal: Biological & pharmaceutical bulletin 20011101

Title: Investigations on the pharmacokinetic properties of Harpagophytum extracts and their effects on eicosanoid biosynthesis in vitro and ex vivo.

Journal: Clinical pharmacology and therapeutics 20010501

Title: Reports of equivalence trials should not mask negative or mediocre results.

Journal: Joint, bone, spine : revue du rhumatisme 20010301

Title: Anauate MC, et al. Effect of isolated fractions of Harpagophytum procumbens D.C. (devil's claw) on COX-1, COX-2 activity and nitric oxide production on whole-blood assay. Phytother Res. 2010 Sep;24(9):1365-9.

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SDS
Tags:19210-12-9 Molecular Formula|19210-12-9 MDL|19210-12-9 SMILES|19210-12-9 Harpagoside
Catalog No.: AA0074G5
19210-12-9,MFCD00017415
19210-12-9 | Harpagoside
Pack Size: 1mg
Purity: 98%
in stock
$13.00 $9.00
Pack Size: 5mg
Purity: 98%
in stock
$32.00 $22.00
Pack Size: 250mg
Purity: analytical standard,≥98%
in stock
$1,532.00 $1,073.00
Pack Size: 1000mg
Purity: 98% by HPLC
in stock
$5,049.00 $3,534.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA0074G5
Chemical Name: Harpagoside
CAS Number: 19210-12-9
Molecular Formula: C24H30O11
Molecular Weight: 494.4884
MDL Number: MFCD00017415
SMILES: OC[C@H]1O[C@@H](O[C@@H]2OC=C[C@@]3([C@H]2[C@@](C)(OC(=O)/C=C/c2ccccc2)C[C@H]3O)O)[C@@H]([C@H]([C@@H]1O)O)O
Properties
Complexity: 811  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 10  
Defined Bond Stereocenter Count: 1  
Formal Charge: 0  
Heavy Atom Count: 35  
Hydrogen Bond Acceptor Count: 11  
Hydrogen Bond Donor Count: 6  
Isotope Atom Count: 0  
Rotatable Bond Count: 7  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: -0.6  
Downstream Synthesis Route
19210-12-9    6926-08-5 

[1]Patent:US2002/183264,2002,A1

19210-12-9    140-10-3    1346708-23-3 

[1]BioorganicandMedicinalChemistry,2011,vol.19,p.4882-4886

Literature fold

Title: Preparative isolation and purification of harpagoside and angroside C from the root of Scrophularia ningpoensis Hemsley by high-speed counter-current chromatography.

Journal: Journal of separation science20121001

Title: Effect of silymarin and harpagoside on inflammation reaction of BEAS-2B cells, on ciliary beat frequency (CBF) of trachea explants and on mucociliary clearance (MCC).

Journal: Planta medica20120501

Title: Antiinflammatory activities of Hungarian Stachys species and their iridoids.

Journal: Phytotherapy research : PTR20120401

Title: Harpagoside attenuates MPTP/MPP⁺ induced dopaminergic neurodegeneration and movement disorder via elevating glial cell line-derived neurotrophic factor.

Journal: Journal of neurochemistry20120301

Title: Metabolic differentiations and classification of Verbascum species by NMR-based metabolomics.

Journal: Phytochemistry20111101

Title: [Determination of harpagide and harpagoside in Scrophulariae Radix by HPLC-UV].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20111001

Title: Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro.

Journal: Bioorganic & medicinal chemistry20110815

Title: Harpagoside variation is positively correlated with temperature in Scrophularia ningpoensis Hemsl.

Journal: Journal of agricultural and food chemistry20110309

Title: [Simultaneous determination of five constituents in Scrophularia ningpoensis by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20110301

Title: The interaction potential of herbal medicinal products: a luminescence-based screening platform assessing effects on cytochrome P450 and its use with devil's claw (Harpagophyti radix) preparations.

Journal: The Journal of pharmacy and pharmacology20110301

Title: Effect of isolated fractions of Harpagophytum procumbens D.C. (devil's claw) on COX-1, COX-2 activity and nitric oxide production on whole-blood assay.

Journal: Phytotherapy research : PTR20100901

Title: Inhibitory effects of devil's claw (secondary root of Harpagophytum procumbens) extract and harpagoside on cytokine production in mouse macrophages.

Journal: Journal of natural medicines20100401

Title: Estimation of the relative antiinflammatory efficacies of six commercial preparations of Harpagophytum procumbens (Devil's Claw).

Journal: Phytotherapy research : PTR20100301

Title: Effects of Devil's Claw (Harpagophytum procumbens) on the multidrug transporter ABCB1/P-glycoprotein.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology20091201

Title: Lamiridosins, hepatitis C virus entry inhibitors from Lamium album.

Journal: Journal of natural products20091201

Title: An in vivo microdialysis measurement of harpagoside in rat blood and bile for predicting hepatobiliary excretion and its interaction with cyclosporin A and verapamil.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20090315

Title: [Study on preparation and quantity determination of Scrophularia ningpoensis dispensing granules].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20090101

Title: Study of chemical composition and antimicrobial activity of leaves and roots of Scrophularia ningpoensis.

Journal: Natural product research20090101

Title: Validated HPTLC methods for the determination of salicin in Salix sp. and of harpagoside in Harpagophytum [corrected] procumbens.

Journal: Journal of pharmaceutical and biomedical analysis20081104

Title: Cognitive-enhancing and antioxidant activities of iridoid glycosides from Scrophularia buergeriana in scopolamine-treated mice.

Journal: European journal of pharmacology20080624

Title: Effect of the major glycosides of Harpagophytum procumbens (Devil's Claw) on epidermal cyclooxygenase-2 (COX-2) in vitro.

Journal: Journal of natural products20080501

Title: Optimization of solid-phase extraction for the liquid chromatography-mass spectrometry analysis of harpagoside, 8-para-coumaroyl harpagide, and harpagide in equine plasma and urine.

Journal: Journal of chromatographic science20080201

Title: Simultaneous determination of harpagoside and cinnamic acid in rat plasma by liquid chromatography electrospray ionization mass spectrometry and its application to pharmacokinetic studies.

Journal: Biomedical chromatography : BMC20080101

Title: Simultaneous determination of harpagoside and cinnamic acid in rat plasma by high-performance liquid chromatography: application to a pharmacokinetic study.

Journal: Analytical and bioanalytical chemistry20071201

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kappa B activation.

Journal: Journal of ethnopharmacology20060308

Title: High anti-inflammatory activity of harpagoside-enriched extracts obtained from solvent-modified super- and subcritical carbon dioxide extractions of the roots of Harpagophytum procumbens.

Journal: Phytochemical analysis : PCA20060101

Title: Liquid chromatography/electrospray ionization mass spectrometric characterization of Harpagophytum in equine urine and plasma.

Journal: Rapid communications in mass spectrometry : RCM20060101

Title: Preparative isolation and purification of harpagoside from Scrophularia ningpoensis hemsley by high-speed counter-current chromatography.

Journal: Phytochemical analysis : PCA20060101

Title: Rapid measurement and evaluation of the effect of drying conditions on harpagoside content in Harpagophytum procumbens (devil's claw) root.

Journal: Journal of agricultural and food chemistry20050504

Title: Comparison between HPLC and HPTLC-densitometry for the determination of harpagoside from Harpagophytum procumbens CO(2)-extracts.

Journal: Journal of pharmaceutical and biomedical analysis20050401

Title: Quality control of Harpagophytum procumbens and its related phytopharmaceutical products by means of NIR-FT-Raman spectroscopy.

Journal: Biopolymers20050101

Title: A 1-year follow-up after a pilot study with Doloteffin for low back pain.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology20050101

Title: Downregulation of iNOS expression in rat mesangial cells by special extracts of Harpagophytum procumbens derives from harpagoside-dependent and independent effects.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology20041101

Title: Effectiveness of Harpagophytum extracts and clinical efficacy.

Journal: Phytotherapy research : PTR20040201

Title: Harpgophytum procumbens for osteoarthritis and low back pain: a systematic review.

Journal: BMC complementary and alternative medicine20040101

Title: Scropolioside-D2 and harpagoside-B: two new iridoid glycosides from Scrophularia deserti and their antidiabetic and antiinflammatory activity.

Journal: Biological & pharmaceutical bulletin20030401

Title: Four new neuroprotective iridoid glycosides from Scrophularia buergeriana roots.

Journal: Journal of natural products20021101

Title: De novo regeneration of Scrophularia yoshimurae Yamazaki (Scrophulariaceae) and quantitative analysis of harpagoside, an iridoid glucoside, formed in aerial and underground parts of in vitro propagated and wild plants by HPLC.

Journal: Biological & pharmaceutical bulletin20011101

Title: Investigations on the pharmacokinetic properties of Harpagophytum extracts and their effects on eicosanoid biosynthesis in vitro and ex vivo.

Journal: Clinical pharmacology and therapeutics20010501

Title: Reports of equivalence trials should not mask negative or mediocre results.

Journal: Joint, bone, spine : revue du rhumatisme20010301

Title: Anauate MC, et al. Effect of isolated fractions of Harpagophytum procumbens D.C. (devil's claw) on COX-1, COX-2 activity and nitric oxide production on whole-blood assay. Phytother Res. 2010 Sep;24(9):1365-9.

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