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110221-53-9,MFCD00871951
Catalog No.:AA007DPY

110221-53-9 | Temocaprilat

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1mg
≥98%
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$312.00   $218.00
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5mg
≥98%
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$1,032.00   $722.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA007DPY
Chemical Name:
Temocaprilat
CAS Number:
110221-53-9
Molecular Formula:
C21H24N2O5S2
Molecular Weight:
448.5557
MDL Number:
MFCD00871951
SMILES:
OC(=O)CN1C[C@H](SC[C@@H](C1=O)N[C@H](C(=O)O)CCc1ccccc1)c1cccs1
Properties
Computed Properties
 
Complexity:
614  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
9  
XLogP3:
0.3  

Downstream Synthesis Route

[1]JournalofMedicinalChemistry,1987,vol.30,p.1984-1991

[1]JournalofMedicinalChemistry,1987,vol.30,p.1984-1991

[1]JournalofMedicinalChemistry,1987,vol.30,p.1984-1991

[1]Yanagisawa,Hiroaki;Ishihara,Sadao;Ando,Akiko;Kanazaki,Takuro;Miyamoto,Shuichi;etal.[JournalofMedicinalChemistry,1987,vol.30,#11,p.1984-1991]

[1]JournalofMedicinalChemistry,1987,vol.30,p.1984-1991

Literature

Title: Prediction of human intestinal absorption of the prodrug temocapril by in situ single-pass perfusion using rat intestine with modified hydrolase activity.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20110701

Title: Blockade of renin-angiotensin system attenuates advanced glycation end products-mediated signaling pathways.

Journal: Journal of atherosclerosis and thrombosis 20100630

Title: Effects of organic anion transporting polypeptide 1B1 haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril.

Journal: Clinical pharmacology and therapeutics 20060501

Title: Identification of esterases expressed in Caco-2 cells and effects of their hydrolyzing activity in predicting human intestinal absorption.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20050801

Title: Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers effectively and directly potentiate superoxide scavenging by polymorphonuclear leukocytes from patients with type 2 diabetes mellitus.

Journal: The American journal of the medical sciences 20050501

Title: Endothelium-derived hydrogen peroxide accounts for the enhancing effect of an angiotensin-converting enzyme inhibitor on endothelium-derived hyperpolarizing factor-mediated responses in mice.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20050401

Title: Functional analysis of dog multidrug resistance-associated protein 2 (Mrp2) in comparison with rat Mrp2.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20050201

Title: Renal artery stenosis emerged after angiotensin-converting enzyme inhibitor treatment for myocardial infarction: a case report.

Journal: Angiology 20050101

Title: Comparison of urinary excretion of pravastatin and temocapril in bile duct-ligated rats and Eisai hyperbilirubinemic rats (EHBR).

Journal: Journal of hepato-biliary-pancreatic surgery 20040101

Title: Converting enzyme inhibitor temocaprilat prevents high glucose-mediated suppression of human aortic endothelial cell proliferation.

Journal: Journal of cardiovascular pharmacology 20031201

Title: An AT1-receptor antagonist and an angiotensin-converting enzyme inhibitor protect against hypoxia-induced apoptosis in human aortic endothelial cells through upregulation of endothelial cell nitric oxide synthase activity.

Journal: Shock (Augusta, Ga.) 20030601

Title: Angiotensin II-induced modulation of endothelium-dependent relaxation in rabbit mesenteric resistance arteries.

Journal: The Journal of physiology 20030501

Title: Angiotensin II receptor antagonists and angiotensin-converting enzyme inhibitors lower in vitro the formation of advanced glycation end products: biochemical mechanisms.

Journal: Journal of the American Society of Nephrology : JASN 20021001

Title: Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers synergistically increase coronary blood flow in canine ischemic myocardium: role of bradykinin.

Journal: Journal of the American College of Cardiology 20020703

Title: Effects of an HMG-CoA reductase inhibitor in combination with an ACE inhibitor or angiotensin II type 1 receptor antagonist on myocardial metabolism in ischemic rabbit hearts.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20020301

Title: Interaction of digoxin with antihypertensive drugs via MDR1.

Journal: Life sciences 20020215

Title: Transporter-mediated Drug Interactions.

Journal: Drug metabolism and pharmacokinetics 20020101

Title: Cardioprotection with angiotensin converting enzyme inhibitor and angiotensin II type 1 receptor antagonist is not abolished by nitric oxide synthase inhibitor in ischemia-reperfused rabbit hearts.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20010701

Title: Biliary excretion of temocapril in zone 1- and zone 3-injured rat.

Journal: Hepatology research : the official journal of the Japan Society of Hepatology 20010601

Title: Trandolaprilat, an angiotensin-converting enzyme inhibitor, is not excreted in bile via an ATP-dependent active transporter (cMOAT).

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20010501

Title: Mechanism of the cardioprotective effect of inhibition of the renin-angiotensin system on ischemia/reperfusion-induced myocardial injury.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20010301

Title: Temocaprilat, a novel angiotensin-converting enzyme inhibitor, is excreted in bile via an ATP-dependent active transporter (cMOAT) that is deficient in Eisai hyperbilirubinemic mutant rats (EHBR).

Journal: The Journal of pharmacology and experimental therapeutics 19970301

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