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Home Amines 110025-28-0
110025-28-0,MFCD09840374
Catalog No.:AA007E15

110025-28-0 | Phenol,4-[1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-

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1mg
≥98% (mixture of isomers)
in stock  
$65.00   $45.00
- +
100mg
95%
in stock  
$114.00   $80.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA007E15
Chemical Name:
Phenol,4-[1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-
CAS Number:
110025-28-0
Molecular Formula:
C25H27NO2
Molecular Weight:
373.4874
MDL Number:
MFCD09840374
SMILES:
CNCCOc1ccc(cc1)C(=C(c1ccccc1)CC)c1ccc(cc1)O
Properties
Computed Properties
 
Complexity:
467  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
8  
XLogP3:
6.3  

Downstream Synthesis Route

[1]Burke,PatrickJ.;Koch,TadH.[JournalofMedicinalChemistry,2004,vol.47,#5,p.1193-1206]

[2]Burke,PatrickJ.;Kalet,BrianT.;Koch,TadH.[JournalofMedicinalChemistry,2004,vol.47,#26,p.6509-6518]

[3]CurrentPatentAssignee:ACCUTARBIOTECHNOLOGYINC;ACCUTARBIOTECHNOLOGYINC-US2020/157078,2020,A1Locationinpatent:Paragraph0575;0578

4-(2-bromoethoxy)-4-azatricyclo5.2.1.02,6dec-8-ene-3,5-dione 
  110025-28-0   
E/Z-4-{2-(2-{4-1-(4-hydroxyphenyl)-2-phenylbut-1-enylphenoxy}ethyl)methylaminoethoxy}-4-azatricyclo5.2.1.02,6dec-8-ene-3,5-dione 

[1]Burke,PatrickJ.;Koch,TadH.[JournalofMedicinalChemistry,2004,vol.47,#5,p.1193-1206]

4-2-(2-bromoethoxy)ethoxy-4-azatricyclo5.2.1.02,6dec-8-ene-3,5-dione 
  110025-28-0   
E/Z-4-(2-{2-(2-{4-1-(4-hydroxyphenyl)-2-phenylbut-1-enylphenoxy}ethyl)methylaminoethoxy}ethoxy)-4-azatricyclo5.2.1.02,6dec-8-ene-3,5-dione 

[1]Burke,PatrickJ.;Koch,TadH.[JournalofMedicinalChemistry,2004,vol.47,#5,p.1193-1206]

671791-63-2    110025-28-0   
E/Z-4-2-(2-{2-(2-{4-1-(4-hydroxyphenyl)-2-phenylbut-1-enylphenoxy}ethyl)methylaminoethoxy}ethoxy)ethoxy-4-azatricyclo5.2.1.02,6dec-8-ene-3,5-dione 

[1]Burke,PatrickJ.;Koch,TadH.[JournalofMedicinalChemistry,2004,vol.47,#5,p.1193-1206]

[1]Burke,PatrickJ.;Kalet,BrianT.;Koch,TadH.[JournalofMedicinalChemistry,2004,vol.47,#26,p.6509-6518]

Literature

Title: Goetz MP, et al. Tamoxifen, endoxifen, and CYP2D6: the rules for evaluating a predictive factor. Oncology (Williston Park). 2009 Dec;23(14):1233-4, 1236.

Title: Wu X, et al. The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells. Cancer Res. 2009 Mar 1;69(5):1722-7.

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Tags:110025-28-0 Molecular Formula|110025-28-0 MDL|110025-28-0 SMILES|110025-28-0 Phenol,4-[1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-