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300657-03-8,MFCD09991687
Catalog No.:AA007JIP

300657-03-8 | 2-((2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-[1,1'-biphenyl]-3-yl)oxy)acetic acid

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Purity
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1mg
≥98%
in stock  
$63.00   $44.00
- +
5mg
≥98%
in stock  
$125.00   $87.00
- +
10mg
≥98%
in stock  
$216.00   $151.00
- +
25mg
98%
in stock  
$445.00   $312.00
- +
100mg
96%
in stock  
$514.00   $360.00
- +
250mg
96%
in stock  
$976.00   $683.00
- +
1g
96%
in stock  
$1,901.00   $1,331.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007JIP
Chemical Name:
2-((2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-[1,1'-biphenyl]-3-yl)oxy)acetic acid
CAS Number:
300657-03-8
Molecular Formula:
C31H26N2O3
Molecular Weight:
474.5497
MDL Number:
MFCD09991687
SMILES:
CCc1c(c2ccccc2)c(nn1c1ccccc1c1cccc(c1)OCC(=O)O)c1ccccc1
Properties
Computed Properties
 
Complexity:
689  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
8  
XLogP3:
7.2  

Literature

Title: Design, synthesis and biological evaluation of thiazole- and indole-based derivatives for the treatment of type II diabetes.

Journal: European journal of medicinal chemistry 20120601

Title: Synthesis of BMS-309403-related compounds, including [¹⁴C]BMS-309403, a radioligand for adipocyte fatty acid binding protein.

Journal: Chemical & pharmaceutical bulletin 20120101

Title: BMS309403 stimulates glucose uptake in myotubes through activation of AMP-activated protein kinase.

Journal: PloS one 20120101

Title: BMS309403 directly suppresses cardiac contractile function.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20110901

Title: Fatty acid binding protein 4 regulates intracellular lipid accumulation in human trophoblasts.

Journal: The Journal of clinical endocrinology and metabolism 20110701

Title: Expression and function of fatty acid-binding protein 4 during mouse decidualization.

Journal: Fertility and sterility 20110630

Title: Identification of a potential biomarker for FABP4 inhibition: the power of lipidomics in preclinical drug testing.

Journal: Journal of biomolecular screening 20110601

Title: New aromatic substituted pyrazoles as selective inhibitors of human adipocyte fatty acid-binding protein.

Journal: Bioorganic & medicinal chemistry letters 20110515

Title: Chronic administration of BMS309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells.

Journal: British journal of pharmacology 20110401

Title: Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.

Journal: Nature 20070621

Title: Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP).

Journal: Bioorganic & medicinal chemistry letters 20070615

Title: Urea metabolism in the llama.

Journal: Comparative biochemistry and physiology. A, Comparative physiology 19751201

Title: Sulsky R, et al. Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP). Bioorg Med Chem Lett. 2007 Jun 15;17(12):3511-5.

Title: Lin W, et al. BMS309403 stimulates glucose uptake in myotubes through activation of AMP-activated protein kinase. PLoS One. 2012;7(8):e44570.

Title: Lee MY, et al. Chronic administration of BMS309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells. Br J Pharmacol. 2011 Apr;162(7):1564-76.

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Tags:300657-03-8 Molecular Formula|300657-03-8 MDL|300657-03-8 SMILES|300657-03-8 2-((2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-[1,1'-biphenyl]-3-yl)oxy)acetic acid