Title: Gamma tocotrienol, a potent radioprotector, preferentially upregulates expression of anti-apoptotic genes to promote intestinal cell survival.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20131001
Title: Modulation of microRNA 20b with resveratrol and longevinex is linked with their potent anti-angiogenic action in the ischaemic myocardium and synergestic effects of resveratrol and γ-tocotrienol.
Journal: Journal of cellular and molecular medicine 20121001
Title: A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products.
Journal: The Biochemical journal 20120901
Title: Vitamin E forms inhibit IL-13/STAT6-induced eotaxin-3 secretion by up-regulation of PAR4, an endogenous inhibitor of atypical PKC in human lung epithelial cells.
Journal: The Journal of nutritional biochemistry 20120601
Title: δ- and γ-tocotrienols induce classical ultrastructural apoptotic changes in human T lymphoblastic leukemic cells.
Journal: Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 20120601
Title: Distinct roles of different forms of vitamin E in DHA-induced apoptosis in triple-negative breast cancer cells.
Journal: Molecular nutrition & food research 20120601
Title: First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20120415
Title: Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide.
Journal: International journal of cancer 20120201
Title: γ-Tocotrienol protects against mitochondrial dysfunction and renal cell death.
Journal: The Journal of pharmacology and experimental therapeutics 20120201
Title: Tissue distribution of α- and γ-tocotrienol and γ-tocopherol in rats and interference with their accumulation by α-tocopherol.
Journal: Lipids 20120201
Title: Tocotrienols prevent hydrogen peroxide-induced axon and dendrite degeneration in cerebellar granule cells.
Journal: Free radical research 20120201
Title: Gamma-tocotrienol modulation of senescence-associated gene expression prevents cellular aging in human diploid fibroblasts.
Journal: Clinics (Sao Paulo, Brazil) 20120201
Title: Gamma-tocotrienol induced apoptosis is associated with unfolded protein response in human breast cancer cells.
Journal: The Journal of nutritional biochemistry 20120101
Title: Tocotrienols confer resistance to ischemia in hypercholesterolemic hearts: insight with genomics.
Journal: Molecular and cellular biochemistry 20120101
Title: Inhibition of mitochondrial cytochrome c release and suppression of caspases by gamma-tocotrienol prevent apoptosis and delay aging in stress-induced premature senescence of skin fibroblasts.
Journal: Oxidative medicine and cellular longevity 20120101
Title: γ-Tocotrienol inhibits HGF-dependent mitogenesis and Met activation in highly malignant mammary tumour cells.
Journal: Cell proliferation 20111201
Title: Induction of expression and functional activity of P-glycoprotein efflux transporter by bioactive plant natural products.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20111101
Title: Tocotrienamines and tocopheramines: reactions with radicals and metal ions.
Journal: Bioorganic & medicinal chemistry 20111101
Title: Direct inhibition of osteoclast formation and activity by the vitamin E isomer gamma-tocotrienol.
Journal: International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 20111101
Title: Role of immunoregulatory transcription factors in differential immunomodulatory effects of tocotrienols.
Journal: Free radical biology & medicine 20110701
Title: γ-Tocotrienol induces growth arrest through a novel pathway with TGFβ2 in prostate cancer.
Journal: Free radical biology & medicine 20110515
Title: Gamma-tocotrienol as an effective agent in targeting prostate cancer stem cell-like population.
Journal: International journal of cancer 20110501
Title: Development and validation of a reversed-phase HPLC method for the determination of γ-tocotrienol in rat and human plasma.
Journal: Biomedical chromatography : BMC 20110501
Title: γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent.
Journal: British journal of pharmacology 20110501
Title: Reduction of radiation-induced vascular nitrosative stress by the vitamin E analog γ-tocotrienol: evidence of a role for tetrahydrobiopterin.
Journal: International journal of radiation oncology, biology, physics 20110301
Title: Pentoxifylline enhances the radioprotective properties of γ-tocotrienol: differential effects on the hematopoietic, gastrointestinal and vascular systems.
Journal: Radiation research 20110301
Title: γ-Tocotrienol induces apoptosis in human T cell lymphoma through activation of both intrinsic and extrinsic pathways.
Journal: Current pharmaceutical design 20110101
Title: Tissue distribution of vitamin E metabolites in rats after oral administration of tocopherol or tocotrienol.
Journal: Journal of nutritional science and vitaminology 20110101
Title: Redox-silent tocotrienol esters as breast cancer proliferation and migration inhibitors.
Journal: Bioorganic & medicinal chemistry 20101115
Title: {Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment.
Journal: Cancer research 20101101
Title: Gamma delta tocotrienols reduce hepatic triglyceride synthesis and VLDL secretion.
Journal: Journal of atherosclerosis and thrombosis 20101027
Title: γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents.
Journal: The Journal of biological chemistry 20101022
Title: Co-ordinated autophagy with resveratrol and γ-tocotrienol confers synergetic cardioprotection.
Journal: Journal of cellular and molecular medicine 20101001
Title: The tocotrienol-rich fraction from rice bran enhances cisplatin-induced cytotoxicity in human mesothelioma H28 cells.
Journal: Phytotherapy research : PTR 20100901
Title: gamma-Tocotrienol reduces squalene hydroperoxide-induced inflammatory responses in HaCaT keratinocytes.
Journal: Lipids 20100901
Title: Gamma-tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/p53-mediated upregulation of death receptors.
Journal: Molecular cancer therapeutics 20100801
Title: Tocotrienol enriched palm oil prevents atherosclerosis through modulating the activities of peroxisome proliferators-activated receptors.
Journal: Atherosclerosis 20100701
Title: gamma-Tocotrienol controls proliferation, modulates expression of cell cycle regulatory proteins and up-regulates quinone reductase NQO2 in MCF-7 breast cancer cells.
Journal: Anticancer research 20100701
Title: Suppression of gamma-tocotrienol on UVB induced inflammation in HaCaT keratinocytes and HR-1 hairless mice via inflammatory mediators multiple signaling.
Journal: Journal of agricultural and food chemistry 20100609
Title: Intestinal absorption of gamma-tocotrienol is mediated by Niemann-Pick C1-like 1: in situ rat intestinal perfusion studies.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20100601
Title: Gamma-tocotrienol protects hematopoietic stem and progenitor cells in mice after total-body irradiation.
Journal: Radiation research 20100601
Title: Id1, inhibitor of differentiation, is a key protein mediating anti-tumor responses of gamma-tocotrienol in breast cancer cells.
Journal: Cancer letters 20100528
Title: Synergistic anticancer effects of combined gamma-tocotrienol and celecoxib treatment are associated with suppression in Akt and NFkappaB signaling.
Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20100501
Title: Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
Journal: Life sciences 20100424
Title: Inhibitory effects of gamma-tocotrienol on invasion and metastasis of human gastric adenocarcinoma SGC-7901 cells.
Journal: The Journal of nutritional biochemistry 20100301
Title: Vitamin E exhibits bone anabolic actions in normal male rats.
Journal: Journal of bone and mineral metabolism 20100301
Title: Synergistic actions of atorvastatin with gamma-tocotrienol and celecoxib against human colon cancer HT29 and HCT116 cells.
Journal: International journal of cancer 20100215
Title: Anti-proliferative effects of gamma-tocotrienol on mammary tumour cells are associated with suppression of cell cycle progression.
Journal: Cell proliferation 20100201
Title: Combined gamma-tocotrienol and erlotinib/gefitinib treatment suppresses Stat and Akt signaling in murine mammary tumor cells.
Journal: Anticancer research 20100201
Title: Design and preliminary structure-activity relationship of redox-silent semisynthetic tocotrienol analogues as inhibitors for breast cancer proliferation and invasion.
Journal: Bioorganic & medicinal chemistry 20100115
Title: Enhanced antiproliferative and apoptotic response to combined treatment of gamma-tocotrienol with erlotinib or gefitinib in mammary tumor cells.
Journal: BMC cancer 20100101
Title: In vivo evidence of gamma-tocotrienol as a chemosensitizer in the treatment of hormone-refractory prostate cancer.
Journal: Pharmacology 20100101
Title: gamma-Tocotrienol modulates the paracrine secretion of VEGF induced by cobalt(II) chloride via ERK signaling pathway in gastric adenocarcinoma SGC-7901 cell line.
Journal: Toxicology 20100101
Title: Effect of experimental treatment on GAPDH mRNA expression as a housekeeping gene in human diploid fibroblasts.
Journal: BMC molecular biology 20100101
Title: gamma-Tocotrienol prevents oxidative stress-induced telomere shortening in human fibroblasts derived from different aged individuals.
Journal: Oxidative medicine and cellular longevity 20100101
Title: Intersection of the tocopherol and plastoquinol metabolic pathways at the plastoglobule.
Journal: The Biochemical journal 20091223
Title: Deleterious effects of nicotine on the ultrastructure of oocytes: role of gamma-tocotrienol.
Journal: Medical science monitor : international medical journal of experimental and clinical research 20091201
Title: Endoplasmic reticulum stress mediates gamma-tocotrienol-induced apoptosis in mammary tumor cells.
Journal: Apoptosis : an international journal on programmed cell death 20091101
Title: Suppression in mevalonate synthesis mediates antitumor effects of combined statin and gamma-tocotrienol treatment.
Journal: Lipids 20091001
Title: Specific accumulation of gamma- and delta-tocotrienols in tumor and their antitumor effect in vivo.
Journal: The Journal of nutritional biochemistry 20090801
Title: Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector.
Journal: International journal of radiation biology 20090701
Title: Is vitamin E toxic to neuron cells?
Journal: Cellular and molecular neurobiology 20090601
Title: Combined treatment of gamma-tocotrienol with statins induce mammary tumor cell cycle arrest in G1.
Journal: Experimental biology and medicine (Maywood, N.J.) 20090601
Title: Inhibition of proliferation and induction of apoptosis by gamma-tocotrienol in human colon carcinoma HT-29 cells.
Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20090501
Title: gamma-Tocotrienol ameliorates intestinal radiation injury and reduces vascular oxidative stress after total-body irradiation by an HMG-CoA reductase-dependent mechanism.
Journal: Radiation research 20090501
Title: gamma-Tocotrienol induces mitochondria-mediated apoptosis in human gastric adenocarcinoma SGC-7901 cells.
Journal: The Journal of nutritional biochemistry 20090401
Title: Design and QSAR study of analogs of gamma-tocotrienol with enhanced antiproliferative activity against human breast cancer cells.
Journal: Journal of molecular graphics & modelling 20090401
Title: Beneficial effects of tocotrienol and tocopherol on bone histomorphometric parameters in sprague-dawley male rats after nicotine cessation.
Journal: Calcified tissue international 20090101
Title: Evidence of gamma-tocotrienol as an apoptosis-inducing, invasion-suppressing, and chemotherapy drug-sensitizing agent in human melanoma cells.
Journal: Nutrition and cancer 20090101
Title: Gamma-tocotrienol suppresses prostate cancer cell proliferation and invasion through multiple-signalling pathways.
Journal: British journal of cancer 20081202
Title: Suppression of cell proliferation and gene expression by combinatorial synergy of EGCG, resveratrol and gamma-tocotrienol in estrogen receptor-positive MCF-7 breast cancer cells.
Journal: International journal of oncology 20081001
Title: Gamma-tocotrienol-induced apoptosis in human gastric cancer SGC-7901 cells is associated with a suppression in mitogen-activated protein kinase signalling.
Journal: The British journal of nutrition 20080601
Title: Synergistic antiproliferative effects of gamma-tocotrienol and statin treatment on mammary tumor cells.
Journal: Lipids 20071201
Title: Preparation and in vivo evaluation of a water-soluble prodrug for 2R-gamma-tocotrienol and as a two-step prodrug for 2,7,8-trimethyl-2S-(beta-carboxyethyl)-6-hydroxychroman (S-gamma-CEHC) in rat.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20070901
Title: A short and convenient chemical route to optically pure 2-methyl chromanmethanols. Total asymmetric synthesis of beta-, gamma-, and delta-tocotrienols.
Journal: The Journal of organic chemistry 20070831
Title: Intestinal epithelial cells absorb gamma-tocotrienol faster than alpha-tocopherol.
Journal: Lipids 20070301
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Journal: Bioscience, biotechnology, and biochemistry 20070201
Title: Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis.
Journal: The Journal of biological chemistry 20070105
Title: In silico prediction of pregnane X receptor activators by machine learning approaches.
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Title: gamma-Tocotrienol inhibits ErbB3-dependent PI3K/Akt mitogenic signalling in neoplastic mammary epithelial cells.
Journal: Cell proliferation 20061201
Title: Apoptosis induction by gamma-tocotrienol in human hepatoma Hep3B cells.
Journal: The Journal of nutritional biochemistry 20061001
Title: Insig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase stimulated by delta- and gamma-tocotrienols.
Journal: The Journal of biological chemistry 20060901
Title: Comparative effects of alpha-tocopherol and gamma-tocotrienol against hydrogen peroxide induced apoptosis on primary-cultured astrocytes.
Journal: Journal of the neurological sciences 20060415
Title: Preferential radiation sensitization of prostate cancer in nude mice by nutraceutical antioxidant gamma-tocotrienol.
Journal: Life sciences 20060327
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Journal: Journal of plant physiology 20050701
Title: Intracellular signaling mechanisms mediating the antiproliferative and apoptotic effects of gamma-tocotrienol in neoplastic mammary epithelial cells.
Journal: Journal of plant physiology 20050701
Title: Gamma-tocotrienol inhibits neoplastic mammary epithelial cell proliferation by decreasing Akt and nuclear factor kappaB activity.
Journal: Experimental biology and medicine (Maywood, N.J.) 20050401
Title: Modulation of Cyp3a11 mRNA expression by alpha-tocopherol but not gamma-tocotrienol in mice.
Journal: Free radical biology & medicine 20050215
Title: Gamma-tocotrienol metabolism and antiproliferative effect in prostate cancer cells.
Journal: Annals of the New York Academy of Sciences 20041201
Title: Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20041001
Title: Nitric oxide synthase activity in blood vessels of spontaneously hypertensive rats: antioxidant protection by gamma-tocotrienol.
Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20030901
Title: Gamma-tocotrienol, a vitamin E homolog, is a natriuretic hormone precursor.
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Title: HPLC analysis of vitamin E isoforms in human epidermis: correlation with minimal erythema dose and free radical scavenging activity.
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Title: Influence of route of administration on the absorption and disposition of alpha-, gamma- and delta-tocotrienols in rats.
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Title: Effect of either gamma-tocotrienol or a tocotrienol mixture on the plasma lipid profile in hamsters.
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Title: Vitamin E inhibition of normal mammary epithelial cell growth is associated with a reduction in protein kinase C(alpha) activation.
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Title: Pharmacokinetics and bioavailability of alpha-, gamma- and delta-tocotrienols under different food status.
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Title: Alpha- and gamma-tocotrienols are metabolized to carboxyethyl-hydroxychroman derivatives and excreted in human urine.
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