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58864-81-6,MFCD11045308
Catalog No.:AA0037F7

58864-81-6 | D-α-Tocotrienol

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1mg
≥98%
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$46.00   $32.00
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5mg
≥98%
in stock  
$188.00   $131.00
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10mg
≥98%
in stock  
$329.00   $230.00
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25mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0037F7
Chemical Name:
D-α-Tocotrienol
CAS Number:
58864-81-6
Molecular Formula:
C29H44O2
Molecular Weight:
424.6585
MDL Number:
MFCD11045308
SMILES:
C/C(=C\CC[C@]1(C)CCc2c(O1)c(C)c(c(c2C)O)C)/CC/C=C(/CCC=C(C)C)\C
Properties
Properties
 
Form:
Solid  
MP:
30-31℃  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
654  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
2  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
9  
XLogP3:
9.3  

Literature

Title: A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products.

Journal: The Biochemical journal 20120901

Title: δ- and γ-tocotrienols induce classical ultrastructural apoptotic changes in human T lymphoblastic leukemic cells.

Journal: Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 20120601

Title: Tissue distribution of α- and γ-tocotrienol and γ-tocopherol in rats and interference with their accumulation by α-tocopherol.

Journal: Lipids 20120201

Title: Tocotrienols prevent hydrogen peroxide-induced axon and dendrite degeneration in cerebellar granule cells.

Journal: Free radical research 20120201

Title: Induction of DNA damage and caspase-independent programmed cell death by vitamin E.

Journal: Nutrition and cancer 20120101

Title: Alpha-tocotrienol is the most abundant tocotrienol isomer circulated in plasma and lipoproteins after postprandial tocotrienol-rich vitamin E supplementation.

Journal: Nutrition journal 20120101

Title: Tocotrienamines and tocopheramines: reactions with radicals and metal ions.

Journal: Bioorganic & medicinal chemistry 20111101

Title: Natural vitamin E α-tocotrienol protects against ischemic stroke by induction of multidrug resistance-associated protein 1.

Journal: Stroke 20110801

Title: Role of immunoregulatory transcription factors in differential immunomodulatory effects of tocotrienols.

Journal: Free radical biology & medicine 20110701

Title: α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging.

Journal: Bioorganic & medicinal chemistry letters 20110615

Title: α-Tocotrienol inhibits osteoclastic bone resorption by suppressing RANKL expression and signaling and bone resorbing activity.

Journal: Biochemical and biophysical research communications 20110325

Title: Tissue distribution of vitamin E metabolites in rats after oral administration of tocopherol or tocotrienol.

Journal: Journal of nutritional science and vitaminology 20110101

Title: Cytoprotective effects of vitamin E homologues against glutamate-induced cell death in immature primary cortical neuron cultures: Tocopherols and tocotrienols exert similar effects by antioxidant function.

Journal: Free radical biology & medicine 20101130

Title: Redox-silent tocotrienol esters as breast cancer proliferation and migration inhibitors.

Journal: Bioorganic & medicinal chemistry 20101115

Title: Involvement of Ca2+ and ROS in alpha-tocopheryl succinate-induced mitochondrial permeabilization.

Journal: International journal of cancer 20101015

Title: Tocotrienol enriched palm oil prevents atherosclerosis through modulating the activities of peroxisome proliferators-activated receptors.

Journal: Atherosclerosis 20100701

Title: Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.

Journal: Life sciences 20100424

Title: Nanomolar vitamin E alpha-tocotrienol inhibits glutamate-induced activation of phospholipase A2 and causes neuroprotection.

Journal: Journal of neurochemistry 20100301

Title: Design and preliminary structure-activity relationship of redox-silent semisynthetic tocotrienol analogues as inhibitors for breast cancer proliferation and invasion.

Journal: Bioorganic & medicinal chemistry 20100115

Title: Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults.

Journal: Bioorganic & medicinal chemistry 20081215

Title: Effects of new combinative antioxidant FeAOX-6 and alpha-tocotrienol on macrophage atherogenesis-related functions.

Journal: Vascular pharmacology 20070601

Title: Apoptosis induction by gamma-tocotrienol in human hepatoma Hep3B cells.

Journal: The Journal of nutritional biochemistry 20061001

Title: Characterization of the potent neuroprotective properties of the natural vitamin E alpha-tocotrienol.

Journal: Journal of neurochemistry 20060901

Title: Chemoenzymatic synthesis of both enantiomers of alpha-tocotrienol.

Journal: Bioorganic & medicinal chemistry 20060801

Title: Vitamin E protected cultured cortical neurons from oxidative stress-induced cell death through the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase.

Journal: Journal of neurochemistry 20060501

Title: Dose-response impact of various tocotrienols on serum lipid parameters in 5-week-old female chickens.

Journal: Lipids 20060501

Title: Delivery of orally supplemented alpha-tocotrienol to vital organs of rats and tocopherol-transport protein deficient mice.

Journal: Free radical biology & medicine 20051115

Title: Neuroprotective properties of the natural vitamin E alpha-tocotrienol.

Journal: Stroke 20051001

Title: Antioxidant vitamin supplementation reduces benzo(a)pyrene-DNA adducts and potential cancer risk in female smokers.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20050101

Title: Characterization of cellular uptake and distribution of vitamin E.

Journal: Annals of the New York Academy of Sciences 20041201

Title: Vitamin E deficiency reduced lumbar bone calcium content in female rats.

Journal: The Medical journal of Malaysia 20041201

Title: Alpha-tocotrienol provides the most potent neuroprotection among vitamin E analogs on cultured striatal neurons.

Journal: Neuropharmacology 20041101

Title: Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20041001

Title: Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration.

Journal: The Journal of biological chemistry 20031031

Title: Inhibition of THP-1 cell adhesion to endothelial cells by alpha-tocopherol and alpha-tocotrienol is dependent on intracellular concentration of the antioxidants.

Journal: Free radical biology & medicine 20030615

Title: HPLC analysis of vitamin E isoforms in human epidermis: correlation with minimal erythema dose and free radical scavenging activity.

Journal: Free radical biology & medicine 20030201

Title: Vitamin E isoforms alpha-tocotrienol and gamma-tocopherol prevent cerebral infarction in mice.

Journal: Neuroscience letters 20030130

Title: Topical alpha-tocotrienol supplementation inhibits lipid peroxidation but fails to mitigate increased transepidermal water loss after benzoyl peroxide treatment of human skin.

Journal: Free radical biology & medicine 20030115

Title: Influence of route of administration on the absorption and disposition of alpha-, gamma- and delta-tocotrienols in rats.

Journal: The Journal of pharmacy and pharmacology 20030101

Title: Effect of sesaminol on plasma and tissue alpha-tocopherol and alpha-tocotrienol concentrations in rats fed a vitamin E concentrate rich in tocotrienols.

Journal: Lipids 20020401

Title: Protective effect of alpha-tocotrienol against free radical-induced impairment of erythrocyte deformability.

Journal: Bioscience, biotechnology, and biochemistry 20020201

Title: Tocotrienol is the most effective vitamin E for reducing endothelial expression of adhesion molecules and adhesion to monocytes.

Journal: Atherosclerosis 20020101

Title: Vitamin E inhibition of normal mammary epithelial cell growth is associated with a reduction in protein kinase C(alpha) activation.

Journal: Cell proliferation 20011201

Title: Oral toxicity of a tocotrienol preparation in rats.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20010801

Title: Determination of RS,E/Z-tocotrienols by HPLC.

Journal: Journal of chromatography. A 20010216

Title: Pharmacokinetics and bioavailability of alpha-, gamma- and delta-tocotrienols under different food status.

Journal: The Journal of pharmacy and pharmacology 20010101

Title: Alpha- and gamma-tocotrienols are metabolized to carboxyethyl-hydroxychroman derivatives and excreted in human urine.

Journal: Lipids 20010101

Title: Removal of fat from cow's milk decreases the vitamin E contents of the resulting dairy products.

Journal: Lipids 20010101

Title: Nitrofurantoin-induced hepatic and pulmonary biochemical changes in mice fed different vitamin E doses.

Journal: Pharmacology & toxicology 19961201

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