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117690-79-6,MFCD00876422
Catalog No.:AA007QR4

117690-79-6 | LY-255283

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1mg
≥98%
in stock  
$36.00   $25.00
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5mg
≥98%
in stock  
$135.00   $94.00
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10mg
≥98%
in stock  
$200.00   $140.00
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25mg
≥98%
in stock  
$375.00   $262.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA007QR4
Chemical Name:
LY-255283
CAS Number:
117690-79-6
Molecular Formula:
C19H28N4O3
Molecular Weight:
360.4506
MDL Number:
MFCD00876422
SMILES:
CCc1cc(C(=O)C)c(cc1OCCCCCC(c1n[nH]nn1)(C)C)O
Properties
Computed Properties
 
Complexity:
447  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
10  
XLogP3:
4.6  

Downstream Synthesis Route
7-(4-Acetyl-2-ethyl-5-hydroxy-phenoxy)-2,2-dimethyl-heptanimidicacid2-dimethylamino-ethylester;hydrochloride 
  117690-79-6 

[1]Herron,DavidK.;Goodson,Theodore;Bollinger,NancyG.;Swanson-Bean,Dorothy;Wright,IanG.;etal.[JournalofMedicinalChemistry,1992,vol.35,#10,p.1818-1828]

[1]Herron,DavidK.;Goodson,Theodore;Bollinger,NancyG.;Swanson-Bean,Dorothy;Wright,IanG.;etal.[JournalofMedicinalChemistry,1992,vol.35,#10,p.1818-1828]

[1]CurrentPatentAssignee:ELILILLY&CO;WILLIAMSSOCKETS-US4945099,1990,A

117690-79-6   
2,4-Diethyl-5-6-methyl-6-(1H-tetrazol-5-yl)heptyloxy}phenol 

[1]CurrentPatentAssignee:ELILILLY&CO;WILLIAMSSOCKETS-US4945099,1990,A

Literature

Title: Leukotriene B(4) receptors BLT1 and BLT2 are involved in interleukin-8 production in human neutrophils induced by Trichomonas vaginalis-derived secretory products.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120201

Title: Up-regulation of BLT2 is critical for the survival of bladder cancer cells.

Journal: Experimental & molecular medicine 20110331

Title: BLT2 promotes the invasion and metastasis of aggressive bladder cancer cells through a reactive oxygen species-linked pathway.

Journal: Free radical biology & medicine 20100915

Title: Discovery of novel and potent leukotriene B4 receptor antagonists. Part 1.

Journal: Journal of medicinal chemistry 20100513

Title: Pro-survival of estrogen receptor-negative breast cancer cells is regulated by a BLT2-reactive oxygen species-linked signaling pathway.

Journal: Carcinogenesis 20100401

Title: UVB radiation induces apoptosis in keratinocytes by activating a pathway linked to 'BLT2-reactive oxygen species'.

Journal: The Journal of investigative dermatology 20100401

Title: Blockade of airway inflammation and hyperresponsiveness by inhibition of BLT2, a low-affinity leukotriene B4 receptor.

Journal: American journal of respiratory cell and molecular biology 20100301

Title: Relationship between calcium release and NADPH oxidase inhibition in human neutrophils.

Journal: Biochemical and biophysical research communications 20090619

Title: Role of the low-affinity leukotriene B4 receptor BLT2 in VEGF-induced angiogenesis.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20090601

Title: Involvement of the BLT2 receptor in the itch-associated scratching induced by 12-(S)-lipoxygenase products in ICR mice.

Journal: British journal of pharmacology 20080701

Title: Itraconazole-mediated inhibition of calcium entry into platelet-activating factor-stimulated human neutrophils is due to interference with production of leukotriene B4.

Journal: Clinical and experimental immunology 20071001

Title: Leukotriene B4 stimulates human monocyte-derived dendritic cell chemotaxis.

Journal: Biochemical and biophysical research communications 20060922

Title: Cysteinyl leukotrienes and leukotriene B mediate vasoconstriction to arginine vasopressin in rat basilar artery.

Journal: Clinical and experimental pharmacology & physiology 20051201

Title: Modulation of leukotriene B4 receptor-1 expression by dexamethasone: potential mechanism for enhanced neutrophil survival.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20020401

Title: 5-Lipoxygenase products modulate the activity of the 85-kDa phospholipase A2 in human neutrophils.

Journal: The Journal of biological chemistry 19951103

Title: Synthetic and structure/activity studies on acid-substituted 2-arylphenols: discovery of 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5- hydroxyphenoxy]-propoxy]phenoxy]benzoic acid, a high-affinity leukotriene B4 receptor antagonist.

Journal: Journal of medicinal chemistry 19951027

Title: Stimulation of human neutrophils by 5-oxo-6,8,11,14-eicosatetraenoic acid by a mechanism independent of the leukotriene B4 receptor.

Journal: The Journal of biological chemistry 19930505

Title: Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy.

Journal: Inflammation 19920601

Title: Leukotriene B4 receptor antagonists: the LY255283 series of hydroxyacetophenones.

Journal: Journal of medicinal chemistry 19920515

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