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88107-10-2
Catalog No.:AA004G02

88107-10-2 | Ethanone,1-[2-hydroxy-3-propyl-4-[4-(2H-tetrazol-5-yl)butoxy]phenyl]-

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5mg
≥98%
in stock  
$58.00   $40.00
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10mg
≥98%
in stock  
$109.00   $76.00
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50mg
≥98%
in stock  
$446.00   $312.00
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100mg
≥98%
in stock  
$779.00   $545.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA004G02
Chemical Name:
Ethanone,1-[2-hydroxy-3-propyl-4-[4-(2H-tetrazol-5-yl)butoxy]phenyl]-
CAS Number:
88107-10-2
Molecular Formula:
C16H22N4O3
Molecular Weight:
318.3709
SMILES:
CCCc1c(OCCCCc2nnn[nH]2)ccc(c1O)C(=O)C
Properties
Computed Properties
 
Complexity:
369  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
9  
XLogP3:
3.7  

Literature

Title: Role of leukotrienes in N-(3,5-dichlorophenyl)succinimide (NDPS) and NDPS metabolite nephrotoxicity in male Fischer 344 rats.

Journal: Toxicology 20121009

Title: The G protein-coupled receptor CysLT1 mediates chemokine-like effects and prolongs survival in chronic lymphocytic leukemia.

Journal: Leukemia & lymphoma 20120401

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Molecular basis for reduced estrone sulfate transport and altered modulator sensitivity of transmembrane helix (TM) 6 and TM17 mutants of multidrug resistance protein 1 (ABCC1).

Journal: Drug metabolism and disposition: the biological fate of chemicals 20090701

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Inhibitors of the arachidonic acid pathway and peroxisome proliferator-activated receptor ligands have superadditive effects on lung cancer growth inhibition.

Journal: Cancer research 20050515

Title: Peroxisome proliferator-activated receptor and farnesoid X receptor ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro.

Journal: The British journal of dermatology 20041001

Title: Inverse agonist activity of selected ligands of the cysteinyl-leukotriene receptor 1.

Journal: The Journal of pharmacology and experimental therapeutics 20040401

Title: Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13.

Journal: American journal of respiratory cell and molecular biology 20030401

Title: Actions of cysteinyl leukotrienes in the enteric nervous system of guinea-pig stomach and small intestine.

Journal: European journal of pharmacology 20030110

Title: Enhanced activity of Ca2+-activated K+ channels by 1-[2-hydroxy-3-propyl-4-[(1H-tetrazol-5-yl)butoxyl]phenyl] ethanone (LY-171883) in neuroendocrine and neuroblastoma cell lines.

Journal: Journal of cellular physiology 20020801

Title: Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils.

Journal: The Journal of allergy and clinical immunology 20020601

Title: Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma.

Journal: Journal of neurochemistry 20020601

Title: Potentiation of TNF-alpha-stimulated group IIA phospholipase A(2) expression by peroxisome proliferator-activated receptor alpha activators in rat mesangial cells.

Journal: Journal of the American Society of Nephrology : JASN 20020301

Title: Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell.

Journal: The Journal of biological chemistry 20010112

Title: Pharmacology of leukotriene receptor antagonists.

Journal: American journal of respiratory and critical care medicine 19980601

Title: Peroxisome proliferator-activated receptor alpha required for gene induction by dehydroepiandrosterone-3 beta-sulfate.

Journal: Molecular pharmacology 19960701

Title: In vivo characterization of zymosan-induced mouse peritoneal inflammation.

Journal: The Journal of pharmacology and experimental therapeutics 19940601

Title: Anti-leukotriene effects of WY-50,295 tromethamine in isolated guinea pig pulmonary tissues.

Journal: European journal of pharmacology 19930406

Title: Endogenously formed leukotriene C4 activates LTC4 receptors in guinea pig tracheal strips.

Journal: European journal of pharmacology 19910326

Title: Mechanism of phosgene-induced lung toxicity: role of arachidonate mediators.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 19901101

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Tags:88107-10-2 Molecular Formula|88107-10-2 MDL|88107-10-2 SMILES|88107-10-2 Ethanone,1-[2-hydroxy-3-propyl-4-[4-(2H-tetrazol-5-yl)butoxy]phenyl]-