[1]ResearchonChemicalIntermediates,2020,vol.46,p.267-281
[2]JournalofMedicinalChemistry,2005,vol.48,p.1813-1822
[3]Patent:WO2016/193481,2016,A1.Locationinpatent:Page/Pagecolumn19
[4]BioorganicandMedicinalChemistryLetters,1998,vol.8,p.687-690
[5]JournalofOrganicChemistry,2004,vol.69,p.7822-7829
[6]Patent:US2015/203506,2015,A1.Locationinpatent:Paragraph0174;0175;0176;0177;0178
[7]Patent:WO2016/207907,2016,A1.Locationinpatent:Page/Pagecolumn23
[8]OrganicProcessResearchandDevelopment,2017,vol.21,p.98-106
[9]Patent:WO2018/91559,2018,A1.Locationinpatent:Page/Pagecolumn10
[1]JournalofMedicinalChemistry,2005,vol.48,p.1813-1822
[2]JournalofOrganicChemistry,2004,vol.69,p.7822-7829
[3]Patent:WO2011/92687,2011,A1
[4]Patent:WO2011/92687,2011,A1
[5]Patent:US2014/350270,2014,A1
[6]EuropeanJournalofOrganicChemistry,2016,vol.2016,p.1874-1880
[7]Patent:WO2016/207907,2016,A1
[8]OrganicProcessResearchandDevelopment,2017,vol.21,p.98-106
[9]Patent:WO2008/133734,2008,A2
[1]Ghosh,ArunK.;Leshchenko,Sofiya;Noetzel,Marcus[JournalofOrganicChemistry,2004,vol.69,#23,p.7822-7829]
[2]CurrentPatentAssignee:VIATRISINC-WO2011/48604,2011,A2
[3]CurrentPatentAssignee:VIATRISINC-US2012/251826,2012,A1
[4]CurrentPatentAssignee:VIATRISINC-US2012/251826,2012,A1
[5]CurrentPatentAssignee:AUROBINDOPHARMALIMITED-WO2013/108105,2013,A2
[6]CurrentPatentAssignee:AUROBINDOPHARMALIMITED-US2015/141382,2015,A1
[7]Kanemitsu,Takuya;Inoue,Mizuho;Yoshimura,Nono;Yoneyama,Kazutoshi;Watarai,Rie;Miyazaki,Michiko;Odanaka,Yuki;Nagata,Kazuhiro;Itoh,Takashi[EuropeanJournalofOrganicChemistry,2016,vol.2016,#10,p.1874-1880]
[8]CurrentPatentAssignee:AMNEALPHARMACEUTICALSLLC-WO2016/193481,2016,A1
[9]CurrentPatentAssignee:GRANULESINDIALTD.-WO2018/15929,2018,A1
[1]Ghosh,ArunK.;Leshchenko,Sofiya;Noetzel,Marcus[JournalofOrganicChemistry,2004,vol.69,#23,p.7822-7829]
[2]CurrentPatentAssignee:VIATRISINC-WO2011/48604,2011,A2
[3]CurrentPatentAssignee:VIATRISINC-US2012/251826,2012,A1
[4]CurrentPatentAssignee:VIATRISINC-US2012/251826,2012,A1
[5]CurrentPatentAssignee:AUROBINDOPHARMALIMITED-WO2013/108105,2013,A2
[6]CurrentPatentAssignee:VIATRISINC-US2014/350270,2014,A1
[7]CurrentPatentAssignee:AUROBINDOPHARMALIMITED-US2015/141382,2015,A1
[8]Kanemitsu,Takuya;Inoue,Mizuho;Yoshimura,Nono;Yoneyama,Kazutoshi;Watarai,Rie;Miyazaki,Michiko;Odanaka,Yuki;Nagata,Kazuhiro;Itoh,Takashi[EuropeanJournalofOrganicChemistry,2016,vol.2016,#10,p.1874-1880]
[9]CurrentPatentAssignee:AMNEALPHARMACEUTICALSLLC-WO2016/193481,2016,A1
[10]CurrentPatentAssignee:GRANULESINDIALTD.-WO2018/15929,2018,A1
[11]Girigani,Sathyanarayana;Singh,Harnam;Kola,SankarRao;DayanandYelmeli,Vijayalaxmi;Regula,VenuGopal;Shah,Sakshi;Jain,Neelu;Kumar,Pramod[ResearchonChemicalIntermediates,2020,vol.46,#1,p.267-281]
[1]Ghosh,ArunK.;Leshchenko,Sofiya;Noetzel,Marcus[JournalofOrganicChemistry,2004,vol.69,#23,p.7822-7829]
[2]CurrentPatentAssignee:VIATRISINC-WO2011/48604,2011,A2
[3]CurrentPatentAssignee:VIATRISINC-US2012/251826,2012,A1
[4]CurrentPatentAssignee:VIATRISINC-US2012/251826,2012,A1
[5]CurrentPatentAssignee:AUROBINDOPHARMALIMITED-WO2013/108105,2013,A2
[6]CurrentPatentAssignee:VIATRISINC-US2014/350270,2014,A1
[7]CurrentPatentAssignee:AUROBINDOPHARMALIMITED-US2015/141382,2015,A1
[8]Kanemitsu,Takuya;Inoue,Mizuho;Yoshimura,Nono;Yoneyama,Kazutoshi;Watarai,Rie;Miyazaki,Michiko;Odanaka,Yuki;Nagata,Kazuhiro;Itoh,Takashi[EuropeanJournalofOrganicChemistry,2016,vol.2016,#10,p.1874-1880]
[9]Girigani,Sathyanarayana;Singh,Harnam;Kola,SankarRao;DayanandYelmeli,Vijayalaxmi;Regula,VenuGopal;Shah,Sakshi;Jain,Neelu;Kumar,Pramod[ResearchonChemicalIntermediates,2020,vol.46,#1,p.267-281]
Title: Design, Synthesis, Biological Evaluation, and X-ray Studies of HIV-1 Protease Inhibitors with Modified P2' Ligands of Darunavir.
Journal: ChemMedChem 20171207
Title: Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.
Journal: Chemical research in toxicology 20150518
Title: GS-8374, a prototype phosphonate-containing inhibitor of HIV-1 protease, effectively inhibits protease mutants with amino acid insertions.
Journal: Journal of virology 20140301
Title: GRL-04810 and GRL-05010, difluoride-containing nonpeptidic HIV-1 protease inhibitors (PIs) that inhibit the replication of multi-PI-resistant HIV-1 in vitro and possess favorable lipophilicity that may allow blood-brain barrier penetration.
Journal: Antimicrobial agents and chemotherapy 20131201
Title: P2' benzene carboxylic acid moiety is associated with decrease in cellular uptake: evaluation of novel nonpeptidic HIV-1 protease inhibitors containing P2 bis-tetrahydrofuran moiety.
Journal: Antimicrobial agents and chemotherapy 20131001
Title: Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance.
Journal: Chemistry & biology 20130919
Title: Highly potent HIV-1 protease inhibitors with novel tricyclic P2 ligands: design, synthesis, and protein-ligand X-ray studies.
Journal: Journal of medicinal chemistry 20130912
Title: GRL-0519, a novel oxatricyclic ligand-containing nonpeptidic HIV-1 protease inhibitor (PI), potently suppresses replication of a wide spectrum of multi-PI-resistant HIV-1 variants in vitro.
Journal: Antimicrobial agents and chemotherapy 20130501
Title: In vitro and structural evaluation of PL-100 as a potential second-generation HIV-1 protease inhibitor.
Journal: The Journal of antimicrobial chemotherapy 20130101
Title: Design and synthesis of HIV-1 protease inhibitors for a long-acting injectable drug application.
Journal: Bioorganic & medicinal chemistry letters 20130101
Title: Relation between flexibility and positively selected HIV-1 protease mutants against inhibitors.
Journal: Proteins 20121201
Title: Influence of SLCO1B1 polymorphisms on the drug-drug interaction between darunavir/ritonavir and pravastatin.
Journal: Journal of clinical pharmacology 20121101
Title: Novel method to assess antiretroviral target trough concentrations using in vitro susceptibility data.
Journal: Antimicrobial agents and chemotherapy 20121101
Title: Treatment of HIV infection with once-daily regimens.
Journal: Expert opinion on pharmacotherapy 20121101
Title: Metabolic effects of darunavir/ritonavir versus atazanavir/ritonavir in treatment-naive, HIV type 1-infected subjects over 48 weeks.
Journal: AIDS research and human retroviruses 20121001
Title: Single- and multiple-dose pharmacokinetics of darunavir plus ritonavir and etravirine in semen and rectal tissue of HIV-negative men.
Journal: Journal of acquired immune deficiency syndromes (1999) 20121001
Title: Simplification to dual antiretroviral therapy including a ritonavir-boosted protease inhibitor in treatment-experienced HIV-1-infected patients.
Journal: The Journal of antimicrobial chemotherapy 20121001
Title: Antiretroviral neurotoxicity.
Journal: Journal of neurovirology 20121001
Title: Liquid chromatographic separation and thermodynamic investigation of stereoisomers of darunavir on Chiralpak AD-H column.
Journal: Journal of separation science 20121001
Title: Long-term glucose tolerance in highly experienced HIV-infected patients receiving nucleoside analogue-sparing regimens.
Journal: AIDS (London, England) 20120910
Title: Short communication: Phenotypic protease inhibitor resistance and cross-resistance in the clinic from 2006 to 2008 and mutational prevalences in HIV from patients with discordant tipranavir and darunavir susceptibility phenotypes.
Journal: AIDS research and human retroviruses 20120901
Title: Body fat distribution in HIV-infected patients treated for 96 weeks with darunavir/ritonavir monotherapy versus darunavir/ritonavir plus nucleoside reverse transcriptase inhibitors: the MONOI-ANRS136 substudy.
Journal: HIV medicine 20120901
Title: High frequency of vitamin D deficiency in HIV-infected patients: effects of HIV-related factors and antiretroviral drugs.
Journal: The Journal of antimicrobial chemotherapy 20120901
Title: Virological response to darunavir in patients infected with HIV is linked to darunavir resistance-associated mutations corrected by the count of mutations with positive impact and is not associated with pharmacological and combined virological/pharmacological parameters.
Journal: Fundamental & clinical pharmacology 20120801
Title: Minimal effects of Darunavir on adipocyte differentiation and metabolism in 3T3-L1 cells.
Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20120801
Title: Drug interaction profile for GSK2248761, a next generation non-nucleoside reverse transcriptase inhibitor.
Journal: British journal of clinical pharmacology 20120801
Title: The MONET trial: week 144 analysis of the efficacy of darunavir/ritonavir (DRV/r) monotherapy versus DRV/r plus two nucleoside reverse transcriptase inhibitors, for patients with viral load < 50 HIV-1 RNA copies/mL at baseline.
Journal: HIV medicine 20120801
Title: Boosting of HIV protease inhibitors by ritonavir in the intestine: the relative role of cytochrome P450 and P-glycoprotein inhibition based on Caco-2 monolayers versus in situ intestinal perfusion in mice.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20120801
Title: Liquid chromatographic separation of darunavir enantiomers on coated and immobilized amylose tris(3, 5-dimethylphenylcarbamate) chiral stationary phases.
Journal: Chirality 20120801
Title: Enamino-oxindole HIV protease inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20120801
Title: Determinants of darunavir cerebrospinal fluid concentrations: impact of once-daily dosing and pharmacogenetics.
Journal: AIDS (London, England) 20120731
Title: Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance.
Journal: Journal of medicinal chemistry 20120726
Title: Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society-USA panel.
Journal: JAMA 20120725
Title: Interleukin-6 and C-reactive protein levels after 3 years of treatment with darunavir/ritonavir monotherapy or darunavir/ritonavir + two nucleoside reverse transcriptase inhibitors in the MONET trial.
Journal: The Journal of antimicrobial chemotherapy 20120701
Title: Activity of human immunodeficiency virus type 1 protease inhibitors against the initial autocleavage in Gag-Pol polyprotein processing.
Journal: Antimicrobial agents and chemotherapy 20120701
Title: Tenofovir: quo vadis anno 2012 (where is it going in the year 2012)?
Journal: Medicinal research reviews 20120701
Title: Viral protease inhibitors affect the production of virulence factors in Cryptococcus neoformans.
Journal: Canadian journal of microbiology 20120701
Title: Optimising the manufacture, formulation, and dose of antiretroviral drugs for more cost-efficient delivery in resource-limited settings: a consensus statement.
Journal: The Lancet. Infectious diseases 20120701
Title: Virological failure at one year in triple-class experienced patients switching to raltegravir-based regimens is not predicted by baseline factors.
Journal: International journal of STD & AIDS 20120701
Title: Dual inhibitors for aspartic proteases HIV-1 PR and renin: advancements in AIDS-hypertension-diabetes linkage via molecular dynamics, inhibition assays, and binding free energy calculations.
Journal: Journal of medicinal chemistry 20120628
Title: Computational studies of darunavir into HIV-1 protease and DMPC bilayer: necessary conditions for effective binding and the role of the flaps.
Journal: Journal of chemical information and modeling 20120625
Title: Steady-state pharmacokinetic interactions of darunavir/ritonavir with lipid-lowering agent rosuvastatin.
Journal: Journal of clinical pharmacology 20120601
Title: Efficacy and safety outcomes among treatment-experienced women and men treated with etravirine in gender, race and clinical experience.
Journal: AIDS research and human retroviruses 20120601
Title: Genotypic resistance profiles associated with virological failure to darunavir-containing regimens: a cross-sectional analysis.
Journal: Infection 20120601
Title: Overall benefit of antiretroviral treatment on the risk of fracture in HIV: nested case-control analysis in a health-insured population.
Journal: AIDS (London, England) 20120601
Title: [Characteristics of human immunodeficiency virus-1 infected children receiving highly active antiretroviral therapy: a cross-sectional study].
Journal: Anales de pediatria (Barcelona, Spain : 2003) 20120601
Title: Dual therapy based on a ritonavir-boosted protease inhibitor as a novel salvage strategy for HIV-1-infected patients on a failing antiretroviral regimen.
Journal: The Journal of antimicrobial chemotherapy 20120601
Title: Resistant minority species are rarely observed in patients on darunavir/ritonavir monotherapy.
Journal: The Journal of antimicrobial chemotherapy 20120601
Title: High dose of darunavir in treatment-experienced HIV-infected adolescent results in virologic suppression and improved CD4 cell count.
Journal: Therapeutic drug monitoring 20120601
Title: Darunavir : a nonpeptidic protease inhibitor for antiretroviral-naive and treatment-experienced adults with HIV infection.
Journal: Expert opinion on pharmacotherapy 20120601
Title: A highly intensified ART regimen induces long-term viral suppression and restriction of the viral reservoir in a simian AIDS model.
Journal: PLoS pathogens 20120601
Title: Long-term efficacy and safety of raltegravir, etravirine, and darunavir/ritonavir in treatment-experienced patients: week 96 results from the ANRS 139 TRIO trial.
Journal: Journal of acquired immune deficiency syndromes (1999) 20120415
Title: Potent antiviral HIV-1 protease inhibitor GRL-02031 adapts to the structures of drug resistant mutants with its P1'-pyrrolidinone ring.
Journal: Journal of medicinal chemistry 20120412
Title: HIV-1 protease with 20 mutations exhibits extreme resistance to clinical inhibitors through coordinated structural rearrangements.
Journal: Biochemistry 20120403
Title: [Leucoencephalopathy in a patient with type I human immunodeficiency virus (HIV-1) infection and symptoms of a hypertensive emergency].
Journal: Enfermedades infecciosas y microbiologia clinica 20120401
Title: Frequency and patterns of protease gene resistance mutations in HIV-infected patients treated with lopinavir/ritonavir as their first protease inhibitor.
Journal: The Journal of antimicrobial chemotherapy 20120401
Title: Viremia and HIV-1 drug resistance mutations among patients receiving second-line highly active antiretroviral therapy in Chennai, Southern India.
Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20120401
Title: Library-based discovery and characterization of daphnane diterpenes as potent and selective HIV inhibitors in Daphne gnidium.
Journal: Journal of natural products 20120323
Title: Substituent effects on P2-cyclopentyltetrahydrofuranyl urethanes: design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20120315
Title: Efficacy and safety of once-daily ritonavir-boosted darunavir and abacavir/lamivudine for treatment-naïve patients: a pilot study.
Journal: AIDS (London, England) 20120313
Title: Efficacy of new antiretroviral drugs in treatment-experienced HIV-infected patients: a systematic review and meta-analysis of recent randomized controlled trials.
Journal: HIV medicine 20120301
Title: Long-term efficacy of darunavir/ritonavir monotherapy in patients with HIV-1 viral suppression: week 96 results from the MONOI ANRS 136 study.
Journal: The Journal of antimicrobial chemotherapy 20120301
Title: Once daily maraviroc 300 mg or 150 mg in combination with ritonavir-boosted darunavir 800/100 mg.
Journal: The Journal of antimicrobial chemotherapy 20120301
Title: Critical differences in HIV-1 and HIV-2 protease specificity for clinical inhibitors.
Journal: Protein science : a publication of the Protein Society 20120301
Title: Origin of decrease in potency of darunavir and two related antiviral inhibitors against HIV-2 compared to HIV-1 protease.
Journal: The journal of physical chemistry. B 20120301
Title: Budget impact analysis of switching to darunavir/ritonavir monotherapy for HIV-infected people in Spain.
Journal: Applied health economics and health policy 20120301
Title: Week 96 efficacy, virology and safety of darunavir/r versus lopinavir/r in treatment-experienced patients in TITAN.
Journal: Current HIV research 20120301
Title: Three-year evaluation of neuropsychiatric adverse events in the MONET trial of darunavir/ritonavir, with or without nucleoside analogues.
Journal: International journal of STD & AIDS 20120301
Title: Rational approaches to improving selectivity in drug design.
Journal: Journal of medicinal chemistry 20120223
Title: Interaction of I50V mutant and I50L/A71V double mutant HIV-protease with inhibitor TMC114 (darunavir): molecular dynamics simulation and binding free energy studies.
Journal: The journal of physical chemistry. B 20120216
Title: Terminal interface conformations modulate dimer stability prior to amino terminal autoprocessing of HIV-1 protease.
Journal: Biochemistry 20120207
Title: Co-administration of raltegravir reduces daily darunavir exposure in HIV-1 infected patients.
Journal: Pharmacological research 20120201
Title: Interpretation of genotypic resistance to predict darunavir/ritonavir failure in antiretroviral experienced patients.
Journal: Journal of acquired immune deficiency syndromes (1999) 20120201
Title: Interactions between buprenorphine and the protease inhibitors darunavir-ritonavir and fosamprenavir-ritonavir.
Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20120201
Title: The good, the bad and the twisted: a survey of ligand geometry in protein crystal structures.
Journal: Journal of computer-aided molecular design 20120201
Title: Cost-effectiveness of combination therapy with etravirine in treatment-experienced adults with HIV-1 infection.
Journal: AIDS (London, England) 20120128
Title: [Safety and effectiveness of salvage therapy in HIV patients].
Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20120101
Title: Decomposing the energetic impact of drug-resistant mutations: the example of HIV-1 protease-DRV binding.
Journal: Methods in molecular biology (Clifton, N.J.) 20120101
Title: First Universities Allied for Essential Medicines (UAEM) Neglected Diseases and Innovation Symposium.
Journal: The American journal of tropical medicine and hygiene 20120101
Title: Pharmacokinetics of abacavir and its anabolite carbovir triphosphate without and with darunavir/ritonavir or raltegravir in HIV-infected subjects.
Journal: Antiviral therapy 20120101
Title: Special aspects of the treatment of HIV-2-infected patients.
Journal: Intervirology 20120101
Title: Effects of ritonavir-boosted darunavir, atazanavir and lopinavir on adipose functions and insulin sensitivity in murine and human adipocytes.
Journal: Antiviral therapy 20120101
Title: The prevalence of darunavir-associated mutations in HIV-1-infected children in the UK.
Journal: Antiviral therapy 20120101
Title: Review of the safety, efficacy, and pharmacokinetics of elvitegravir with an emphasis on resource-limited settings.
Journal: HIV/AIDS (Auckland, N.Z.) 20120101
Title: Computable features required to evaluate the efficacy of drugs and a universal algorithm to find optimally effective drug in a drug complex.
Journal: PloS one 20120101
Title: Modulation of HIV-1 Gag NC/p1 cleavage efficiency affects protease inhibitor resistance and viral replicative capacity.
Journal: Retrovirology 20120101
Title: HIV-1 phenotypic reverse transcriptase inhibitor drug resistance test interpretation is not dependent on the subtype of the virus backbone.
Journal: PloS one 20120101
Title: Novel therapeutic strategies targeting HIV integrase.
Journal: BMC medicine 20120101
Title: Safety profile of maraviroc in patients coinfected with HIV-1 and hepatitis B or C included in the maraviroc expanded access program.
Journal: HIV clinical trials 20120101
Title: Stereoselective regulations of P-glycoprotein by ginsenoside Rh2 epimers and the potential mechanisms from the view of pharmacokinetics.
Journal: PloS one 20120101
Title: Pharmacokinetics and Pharmacodynamics of Darunavir and Etravirine in HIV-1-Infected, Treatment-Experienced Patients in the Gender, Race, and Clinical Experience (GRACE) Trial.
Journal: AIDS research and treatment 20120101
Title: New option for management of HIV-1 infection in treatment-naive patients: once-daily, fixed-dose combination of rilpivirine-emtricitabine-tenofovir.
Journal: HIV/AIDS (Auckland, N.Z.) 20120101
Title: Impact of low-level-viremia on HIV-1 drug-resistance evolution among antiretroviral treated-patients.
Journal: PloS one 20120101
Title: Prevalence of Drug Resistance and Associated Mutations in a Population of HIV-1(+) Puerto Ricans: 2006-2010.
Journal: AIDS research and treatment 20120101
Title: Impact of hepatitis C co-infection on response to antiretroviral treatment.
Journal: AIDS reviews 20120101
Title: Antiretroviral simplification with darunavir/ritonavir monotherapy in routine clinical practice: safety, effectiveness, and impact on lipid profile.
Journal: PloS one 20120101
Title: Antiretroviral drugs: critical issues and recent advances.
Journal: Indian journal of pharmacology 20120101
Title: Hypophosphatemic Osteomalacia Associated with Tenofovir: a Multidisciplinary Approach is Required.
Journal: Mediterranean journal of hematology and infectious diseases 20120101
Title: Darunavir: a critical review of its properties, use and drug interactions.
Journal: Pharmacology 20120101
Title: Assessing darunavir/ritonavir-based therapy in a racially diverse population: 48-week outcomes from GRACE.
Journal: Journal of the National Medical Association 20120101
Title: Plasma and intracellular pharmacokinetics of darunavir/ritonavir once daily and raltegravir once and twice daily in HIV-infected individuals.
Journal: Journal of acquired immune deficiency syndromes (1999) 20111215
Title: Differential effects of ethanol on spectral binding and inhibition of cytochrome P450 3A4 with eight protease inhibitors antiretroviral drugs.
Journal: Alcoholism, clinical and experimental research 20111201
Title: TMC310911, a novel human immunodeficiency virus type 1 protease inhibitor, shows in vitro an improved resistance profile and higher genetic barrier to resistance compared with current protease inhibitors.
Journal: Antimicrobial agents and chemotherapy 20111201
Title: Boosted tipranavir versus darunavir in treatment-experienced patients: observational data from the randomized POTENT trial.
Journal: Drugs in R&D 20111201
Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Journal: PLoS computational biology 20111201
Title: How much do antiretroviral drugs penetrate into the central nervous system?
Journal: Journal of medicine and life 20111114
Title: Efficacy of a nucleoside-sparing regimen of darunavir/ritonavir plus raltegravir in treatment-naive HIV-1-infected patients (ACTG A5262).
Journal: AIDS (London, England) 20111113
Title: In vitro activity of antiretroviral drugs against Plasmodium falciparum.
Journal: Antimicrobial agents and chemotherapy 20111101
Title: Raltegravir dosage adjustment in HIV-infected patients receiving etravirine.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20111101
Title: Emerging HIV-1 resistance to tipranavir and darunavir in patients with virological failure to first-generation protease inhibitors in Taiwan.
Journal: International journal of STD & AIDS 20111101
Title: Factors associated with virological failure in HIV-1-infected patients receiving darunavir/ritonavir monotherapy.
Journal: The Journal of infectious diseases 20111015
Title: Antiretroviral therapy for children in resource-limited settings: current regimens and the role of newer agents.
Journal: Paediatric drugs 20111001
Title: The higher barrier of darunavir and tipranavir resistance for HIV-1 protease.
Journal: Biochemical and biophysical research communications 20110909
Title: A retrospective study of HIV antiretroviral treatment persistence in a commercially insured population in the United States.
Journal: AIDS care 20110901
Title: Protease inhibitor monotherapy and the CNS: peace of mind?
Journal: The Journal of antimicrobial chemotherapy 20110901
Title: Efficacy and safety of raltegravir in treatment-experienced HIV-1-infected patients switching from enfuvirtide-based regimens: 48 week results of the randomized EASIER ANRS 138 trial.
Journal: The Journal of antimicrobial chemotherapy 20110901
Title: [Immune reconstitution syndrome related to a Mycobacterium avium complex infection, revealed by a mono-adenitis].
Journal: Medecine et maladies infectieuses 20110901
Title: Design of HIV-1 protease inhibitors with C3-substituted hexahydrocyclopentafuranyl urethanes as P2-ligands: synthesis, biological evaluation, and protein-ligand X-ray crystal structure.
Journal: Journal of medicinal chemistry 20110825
Title: Ritonavir-boosted atazanavir exposure is associated with an increased rate of renal stones compared with efavirenz, ritonavir-boosted lopinavir and ritonavir-boosted darunavir.
Journal: AIDS (London, England) 20110824
Title: Application of a validated ultra performance liquid chromatography-tandem mass spectrometry method for the quantification of darunavir in human plasma for a bioequivalence study in Indian subjects.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110815
Title: 96 week results from the MONET trial: a randomized comparison of darunavir/ritonavir with versus without nucleoside analogues, for patients with HIV RNA <50 copies/mL at baseline.
Journal: The Journal of antimicrobial chemotherapy 20110801
Title: Studies on adaptability of binding residues and flap region of TMC-114 resistance HIV-1 protease mutants.
Journal: Journal of biomolecular structure & dynamics 20110801
Title: Short communication: high effectiveness of etravirine in routine clinical practice in treatment-experienced HIV type 1-infected patients.
Journal: AIDS research and human retroviruses 20110701
Title: Changes in cerebral function parameters in HIV type 1-infected subjects switching to darunavir/ritonavir either as monotherapy or with nucleoside analogues.
Journal: AIDS research and human retroviruses 20110701
Title: Cell disposition of raltegravir and newer antiretrovirals in HIV-infected patients: high inter-individual variability in raltegravir cellular penetration.
Journal: The Journal of antimicrobial chemotherapy 20110701
Title: Hepatic safety profile of darunavir with low-dose ritonavir (DRV/r) in HIV/HCV coinfected and HIV monoinfected patients.
Journal: The new microbiologica 20110701
Title: Effect of continuous venovenous hemodiafiltration on darunavir and raltegravir exposure after administration via a gastroduodenal tube.
Journal: AIDS (London, England) 20110619
Title: Design and synthesis of potent HIV-1 protease inhibitors incorporating hydroxyprolinamides as novel P2 ligands.
Journal: Bioorganic & medicinal chemistry letters 20110615
Title: Tetherin and its viral antagonists.
Journal: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20110601
Title: Management of HIV infection in treatment-naive patients: a review of the most current recommendations.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20110601
Title: Effects of darunavir/ritonavir-based therapy on metabolic and anthropometric parameters in women and men over 48 weeks.
Journal: AIDS patient care and STDs 20110601
Title: Structural basis for drug and substrate specificity exhibited by FIV encoding a chimeric FIV/HIV protease.
Journal: Acta crystallographica. Section D, Biological crystallography 20110601
Title: Effects of tipranavir, darunavir, and ritonavir on platelet function, coagulation, and fibrinolysis in healthy volunteers.
Journal: Current HIV research 20110601
Title: Darunavir: an effective protease inhibitor for HIV-infected patients.
Journal: Expert review of anti-infective therapy 20110601
Title: The L76V drug resistance mutation decreases the dimer stability and rate of autoprocessing of HIV-1 protease by reducing internal hydrophobic contacts.
Journal: Biochemistry 20110531
Title: Risk of triple-class virological failure in children with HIV: a retrospective cohort study.
Journal: Lancet (London, England) 20110507
Title: Efficacy, tolerability and risk factors for virological failure of darunavir-based therapy for treatment-experienced HIV-infected patients: the Swiss HIV Cohort Study.
Journal: HIV medicine 20110501
Title: HIV-1 integrase inhibitor resistance and its clinical implications.
Journal: The Journal of infectious diseases 20110501
Title: [Characteristics of antiretroviral drugs].
Journal: Enfermedades infecciosas y microbiologia clinica 20110501
Title: Clinical evaluation of the determination of plasma concentrations of darunavir, etravirine, raltegravir and ritonavir in dried blood spot samples.
Journal: Bioanalysis 20110501
Title: CTL escape mediated by proteasomal destruction of an HIV-1 cryptic epitope.
Journal: PLoS pathogens 20110501
Title: Impact of adding enfuvirtide to the predictive value of the darunavir genotypic resistance score.
Journal: Journal of acquired immune deficiency syndromes (1999) 20110501
Title: Week 48 analysis of once-daily vs. twice-daily darunavir/ritonavir in treatment-experienced HIV-1-infected patients.
Journal: AIDS (London, England) 20110424
Title: Reply to 'Pharmacokinetics of etravirine, raltegravir and darunavir/ritonavir in treatment experienced patients'.
Journal: AIDS (London, England) 20110424
Title: Proper laboratory notebook practices: protecting your intellectual property.
Journal: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20110401
Title: Novel HIV-1 protease inhibitors (PIs) containing a bicyclic P2 functional moiety, tetrahydropyrano-tetrahydrofuran, that are potent against multi-PI-resistant HIV-1 variants.
Journal: Antimicrobial agents and chemotherapy 20110401
Title: Pharmacokinetic interaction of vicriviroc with other antiretroviral agents: results from a series of fixed-sequence and parallel-group clinical trials.
Journal: Clinical pharmacokinetics 20110401
Title: Clinical applications of drug desensitization in the Asia-Pacific region.
Journal: Asia Pacific allergy 20110401
Title: A HPLC-MS method for the simultaneous quantification of fourteen antiretroviral agents in peripheral blood mononuclear cell of HIV infected patients optimized using medium corpuscular volume evaluation.
Journal: Journal of pharmaceutical and biomedical analysis 20110325
Title: Long-term follow-up of 11 protease inhibitor (PI)-naïve and PI-treated HIV-infected patients harbouring virus with insertions in the HIV-1 protease gene.
Journal: HIV medicine 20110301
Title: Darunavir/ritonavir and raltegravir coadministered in routine clinical practice: potential role for an unexpected drug interaction.
Journal: Pharmacological research 20110301
Title: Levels of adherence required for virologic suppression among newer antiretroviral medications.
Journal: The Annals of pharmacotherapy 20110301
Title: Pharmacokinetic interactions between darunavir/ritonavir and opioid maintenance therapy using methadone or buprenorphine/naloxone.
Journal: Journal of clinical pharmacology 20110201
Title: The effect of lopinavir/ritonavir and darunavir/ritonavir on the HIV integrase inhibitor S/GSK1349572 in healthy participants.
Journal: Journal of clinical pharmacology 20110201
Title: Long-term successful control of super-multidrug-resistant human immunodeficiency virus type 1 infection by a novel combination therapy of raltegravir, etravirine, and boosted-darunavir.
Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20110201
Title: Emerging antiretroviral drug interactions.
Journal: The Journal of antimicrobial chemotherapy 20110201
Title: Protease inhibitor monotherapy.
Journal: Current opinion in infectious diseases 20110201
Title: Pharmacoeconomics of darunavir.
Journal: Expert review of pharmacoeconomics & outcomes research 20110201
Title: Design and synthesis of potent HIV-1 protease inhibitors incorporating hexahydrofuropyranol-derived high affinity P(2) ligands: structure-activity studies and biological evaluation.
Journal: Journal of medicinal chemistry 20110127
Title: Darunavir/ritonavir monotherapy in clinical practice.
Journal: AIDS (London, England) 20110102
Title: Recent advances in antiretroviral drugs.
Journal: Expert opinion on pharmacotherapy 20110101
Title: 800 mg Darunavir tablets prepared by hot melt extrusion.
Journal: Pharmaceutical development and technology 20110101
Title: Comparative evaluation of seven resistance interpretation algorithms and their derived genotypic inhibitory quotients for the prediction of 48 week virological response to darunavir-based salvage regimens.
Journal: The Journal of antimicrobial chemotherapy 20110101
Title: Transwell-grown HepG2 cell monolayers as in vitro permeability model to study drug-drug or drug-food interactions.
Journal: Journal of medicinal food 20110101
Title: Indications for the use of next-generation antiretroviral drugs in current clinical practice.
Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20110101
Title: Long-term safety from the raltegravir clinical development program.
Journal: Current HIV research 20110101
Title: Understanding diabetes in patients with HIV/AIDS.
Journal: Diabetology & metabolic syndrome 20110101
Title: Human Herpesvirus-8 Infection Associated with Kaposi Sarcoma, Multicentric Castleman's Disease, and Plasmablastic Microlymphoma in a Man with AIDS: A Case Report with Review of Pathophysiologic Processes.
Journal: Pathology research international 20110101
Title: Replicative phenotyping adds value to genotypic resistance testing in heavily pre-treated HIV-infected individuals--the Swiss HIV Cohort Study.
Journal: Journal of translational medicine 20110101
Title: Human immunodeficiency virus type 2 in two Saudi families.
Journal: Annals of Saudi medicine 20110101
Title: A biregional survey and review of first-line treatment failure and second-line paediatric antiretroviral access and use in Asia and southern Africa.
Journal: Journal of the International AIDS Society 20110101
Title: Analysis of drug resistance during HIV RNA viraemia in the MONET trial of darunavir/ritonavir monotherapy.
Journal: Antiviral therapy 20110101
Title: Virological characterization of patients failing darunavir/ritonavir or lopinavir/ritonavir treatment in the ARTEMIS study: 96-week analysis.
Journal: Antiviral therapy 20110101
Title: The L76V mutation in HIV-1 protease is potentially associated with hypersusceptibility to protease inhibitors Atazanavir and Saquinavir: is there a clinical advantage?
Journal: AIDS research and therapy 20110101
Title: Management of HIV-1 associated hepatitis in patients with acquired immunodeficiency syndrome: role of a successful control of viral replication.
Journal: AIDS research and therapy 20110101
Title: Drug efficacy by direct and adjusted indirect comparison to placebo: An illustration by Mycobacterium avium complex prophylaxis in HIV.
Journal: AIDS research and therapy 20110101
Title: 'Dynamic range' of inferred phenotypic HIV drug resistance values in clinical practice.
Journal: PloS one 20110101
Title: Genome-wide analysis of primary CD4+ and CD8+ T cell transcriptomes shows evidence for a network of enriched pathways associated with HIV disease.
Journal: Retrovirology 20110101
Title: Acute toxicity of second generation HIV protease-inhibitors in combination with radiotherapy: a retrospective case series.
Journal: Radiation oncology (London, England) 20110101
Title: Results of antiretroviral treatment interruption and intensification in advanced multi-drug resistant HIV infection from the OPTIMA trial.
Journal: PloS one 20110101
Title: Antiretroviral Therapy for HIV-2 Infection: Recommendations for Management in Low-Resource Settings.
Journal: AIDS research and treatment 20110101
Title: Protease Inhibitor Resistance Is Uncommon in HIV-1 Subtype C Infected Patients on Failing Second-Line Lopinavir/r-Containing Antiretroviral Therapy in South Africa.
Journal: AIDS research and treatment 20110101
Title: Identification of new, emerging HIV-1 unique recombinant forms and drug resistant viruses circulating in Cameroon.
Journal: Virology journal 20110101
Title: Added value of deep sequencing relative to population sequencing in heavily pre-treated HIV-1-infected subjects.
Journal: PloS one 20110101
Title: HIV Protease Inhibitors: Effect on the Opportunistic Protozoan Parasites.
Journal: The open medicinal chemistry journal 20110101
Title: A synthetic HIV-1 subtype C backbone generates comparable PR and RT resistance profiles to a subtype B backbone in a recombinant virus assay.
Journal: PloS one 20110101
Title: Contraception in HIV-positive female adolescents.
Journal: AIDS research and therapy 20110101
Title: HIV and HAART-Associated Dyslipidemia.
Journal: The open cardiovascular medicine journal 20110101
Title: Prevalence and factors associated with darunavir resistance mutations in multi-experienced HIV-1-infected patients failing other protease inhibitors in a referral teaching center in Brazil.
Journal: The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20110101
Title: Similar efficacy of raltegravir when used with or without a protease inhibitor in treatment-experienced patients.
Journal: HIV clinical trials 20110101
Title: Interpretation of genotypic HIV-1 resistance to darunavir and virological response: validation of available systems and of a new score.
Journal: Antiviral therapy 20110101
Title: Impact of small body weight on tenofovir-associated renal dysfunction in HIV-infected patients: a retrospective cohort study of Japanese patients.
Journal: PloS one 20110101
Title: Effectiveness of protease inhibitor monotherapy versus combination antiretroviral maintenance therapy: a meta-analysis.
Journal: PloS one 20110101
Title: Treatment simplification in HIV-infected adults as a strategy to prevent toxicity, improve adherence, quality of life and decrease healthcare costs.
Journal: Patient preference and adherence 20110101
Title: Modeling HIV/AIDS drug price determinants in Brazil: is generic competition a myth?
Journal: PloS one 20110101
Title: Recent developments of peptidomimetic HIV-1 protease inhibitors.
Journal: Current medicinal chemistry 20110101
Title: Selection of an M184V mutation in the cerebrospinal fluid of a treatment-naive HIV-infected individual starting darunavir-based therapy.
Journal: Antiviral therapy 20110101
Title: Protease inhibitors as preferred initial regimen for antiretroviral-naive HIV patients.
Journal: AIDS reviews 20110101
Title: Flexible catalytic site conformations implicated in modulation of HIV-1 protease autoprocessing reactions.
Journal: Retrovirology 20110101
Title: A win-win solution?: A critical analysis of tiered pricing to improve access to medicines in developing countries.
Journal: Globalization and health 20110101
Title: South Asian Consensus Guidelines for the rational management of diabetes in human immunodeficiency virus/acquired immunodeficiency syndrome.
Journal: Indian journal of endocrinology and metabolism 20110101
Title: Increase of transmitted drug resistance among HIV-infected sub-Saharan Africans residing in Spain in contrast to the native population.
Journal: PloS one 20110101
Title: Molecular analysis of hepatitis B virus (HBV) in an HIV co-infected patient with reactivation of occult HBV infection following discontinuation of lamivudine-including antiretroviral therapy.
Journal: BMC infectious diseases 20110101
Title: Pre-steady-state kinetics of interaction of wild-type and multiple drug-resistant HIV protease with first and second generation inhibitory drugs.
Journal: Doklady. Biochemistry and biophysics 20110101
Title: Safety, efficacy, and pharmacokinetics of rilpivirine: systematic review with an emphasis on resource-limited settings.
Journal: HIV/AIDS (Auckland, N.Z.) 20110101
Title: Characteristics of foot fractures in HIV-infected patients previously treated with tenofovir versus non-tenofovir-containing highly active antiretroviral therapy.
Journal: HIV/AIDS (Auckland, N.Z.) 20110101
Title: Role of raltegravir in the management of HIV-1 infection.
Journal: HIV/AIDS (Auckland, N.Z.) 20110101
Title: Can linear regression modeling help clinicians in the interpretation of genotypic resistance data? An application to derive a lopinavir-score.
Journal: PloS one 20110101
Title: The HIV-1 Vpu viroporin inhibitor BIT225 does not affect Vpu-mediated tetherin antagonism.
Journal: PloS one 20110101
Title: Deep Brain Stimulation of the Subthalamic Nucleus for Parkinson's Disease in a Patient with HIV Infection: Dual Clinical Benefit.
Journal: Case reports in neurology 20110101
Title: Prolonged control of replication-competent dual- tropic human immunodeficiency virus-1 following cessation of highly active antiretroviral therapy.
Journal: Retrovirology 20110101
Title: Cost-effectiveness analysis of initial HIV treatment under Italian guidelines.
Journal: ClinicoEconomics and outcomes research : CEOR 20110101
Title: A multifaceted analysis of HIV-1 protease multidrug resistance phenotypes.
Journal: BMC bioinformatics 20110101
Title: Effect of baseline characteristics on the efficacy and safety of once-daily darunavir/ ritonavir in HIV-1-infected, treatment-naïve ARTEMIS patients at week 96.
Journal: HIV clinical trials 20110101
Title: Nanomedicine as an emerging approach against intracellular pathogens.
Journal: International journal of nanomedicine 20110101
Title: A reduced dose of darunavir/ritonavir is effective in PI-experienced HIV-infected patients.
Journal: The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20110101
Title: Twice-daily versus once-daily antiretroviral therapy and coformulation strategies in HIV-infected adults: benefits, risks, or burden?
Journal: Patient preference and adherence 20110101
Title: Synthesis and Inhibiting Activity of Some 4-Hydroxycoumarin Derivatives on HIV-1 Protease.
Journal: ISRN pharmaceutics 20110101
Title: Clinical Use of Inhibitors of HIV-1 Integration: Problems and Prospects.
Journal: Acta naturae 20110101
Title: Nuclear receptor-mediated induction of CYP450 by antiretrovirals: functional consequences of NR1I2 (PXR) polymorphisms and differential prevalence in whites and sub-Saharan Africans.
Journal: Journal of acquired immune deficiency syndromes (1999) 20101215
Title: Darunavir outcomes study: comparative effectiveness of virologic suppression, regimen durability, and discontinuation reasons for three-class experienced patients at 48 weeks.
Journal: AIDS research and human retroviruses 20101201
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20101201
Title: HIV-2 goes global: an unaddressed issue in Indian anti-retroviral programmes.
Journal: The Indian journal of medical research 20101201
Title: A report from the XVIII International AIDS Conference. (July 18-23, 2010-Vienna, Austria).
Journal: Drugs of today (Barcelona, Spain : 1998) 20101201
Title: Resistance analyses in highly experienced patients failing raltegravir, etravirine and darunavir/ritonavir regimen.
Journal: AIDS (London, England) 20101113
Title: Structure-based design, synthesis, and structure-activity relationship studies of HIV-1 protease inhibitors incorporating phenyloxazolidinones.
Journal: Journal of medicinal chemistry 20101111
Title: Probing multidrug-resistance and protein-ligand interactions with oxatricyclic designed ligands in HIV-1 protease inhibitors.
Journal: ChemMedChem 20101108
Title: Pharmacokinetics, protein-binding-adjusted inhibitory quotients for atazanavir/ritonavir 300/100 mg in treatment-naïve HIV-infected patients.
Journal: HIV medicine 20101101
Title: Autocatalytic maturation, physical/chemical properties, and crystal structure of group N HIV-1 protease: relevance to drug resistance.
Journal: Protein science : a publication of the Protein Society 20101101
Title: Impact of drug transporters on cellular resistance towards saquinavir and darunavir.
Journal: The Journal of antimicrobial chemotherapy 20101101
Title: Characterization of genotypic and phenotypic changes in HIV-1-infected patients with virologic failure on an etravirine-containing regimen in the DUET-1 and DUET-2 clinical studies.
Journal: AIDS research and human retroviruses 20101101
Title: Pharmacokinetics and pharmacodynamics of the non-nucleoside reverse-transcriptase inhibitor etravirine in treatment-experienced HIV-1-infected patients.
Journal: Clinical pharmacology and therapeutics 20101101
Title: Broadening the perspective when assessing evidence on boosted protease inhibitor-based regimens for initial antiretroviral therapy.
Journal: Advances in therapy 20101101
Title: Increased aripiprazole concentrations in an HIV-positive male concurrently taking duloxetine, darunavir, and ritonavir.
Journal: The Annals of pharmacotherapy 20101101
Title: A 48-week pilot study switching suppressed patients to darunavir/ritonavir and etravirine from enfuvirtide, protease inhibitor(s), and non-nucleoside reverse transcriptase inhibitor(s).
Journal: AIDS research and human retroviruses 20101101
Title: HIV protease inhibitors: garlic supplements and first-pass intestinal metabolism impact on the therapeutic efficacy.
Journal: Biopharmaceutics & drug disposition 20101101
Title: Virological response with fully active etravirine: pooled results from the DUET-1 and DUET-2 trials.
Journal: International journal of STD & AIDS 20101101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20101101
Title: Role of HIV Subtype Diversity in the Development of Resistance to Antiviral Drugs.
Journal: Viruses 20101101
Title: Molecular Basis for Drug Resistance in HIV-1 Protease.
Journal: Viruses 20101101
Title: Darunavir concentrations exceed the protein-corrected EC₅₀ for wild-type HIV in the semen of HIV-1-infected men.
Journal: AIDS (London, England) 20101023
Title: Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy.
Journal: AIDS (London, England) 20101023
Title: Pharmacokinetics of etravirine, raltegravir and darunavir/ritonavir in treatment experienced patients.
Journal: AIDS (London, England) 20101023
Title: Co-administration of darunavir and a new pharmacokinetic booster: formulation strategies and evaluation in dogs.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20101009
Title: First antiretroviral patent in global drug pool puts pressure on companies to follow suit.
Journal: BMJ (Clinical research ed.) 20101005
Title: Efficacy, safety and pharmacokinetics of 900/100 mg of darunavir/ritonavir once daily in treatment-experienced patients.
Journal: The Journal of antimicrobial chemotherapy 20101001
Title: Efficacy of darunavir/ritonavir maintenance monotherapy in patients with HIV-1 viral suppression: a randomized open-label, noninferiority trial, MONOI-ANRS 136.
Journal: AIDS (London, England) 20100924
Title: Sex-based outcomes of darunavir-ritonavir therapy: a single-group trial.
Journal: Annals of internal medicine 20100921
Title: Novel antiretroviral combinations in treatment-experienced patients with HIV infection: rationale and results.
Journal: Drugs 20100910
Title: HPLC-MS method for the quantification of nine anti-HIV drugs from dry plasma spot on glass filter and their long term stability in different conditions.
Journal: Journal of pharmaceutical and biomedical analysis 20100905
Title: In situ intestinal perfusion in knockout mice demonstrates inhibition of intestinal p-glycoprotein by ritonavir causing increased darunavir absorption.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20100901
Title: Ultrafast and high-throughput mass spectrometric assay for therapeutic drug monitoring of antiretroviral drugs in pediatric HIV-1 infection applying dried blood spots.
Journal: Analytical and bioanalytical chemistry 20100901
Title: Novel protease inhibitors (PIs) containing macrocyclic components and 3(R),3a(S),6a(R)-bis-tetrahydrofuranylurethane that are potent against multi-PI-resistant HIV-1 variants in vitro.
Journal: Antimicrobial agents and chemotherapy 20100801
Title: A less sensitive detector does not necessarily result in a less sensitive method: fast quantification of 13 antiretroviral analytes in plasma with liquid chromatography coupled with tandem mass spectrometry.
Journal: Clinical chemistry and laboratory medicine 20100801
Title: Methadone, buprenorphine, and street drug interactions with antiretroviral medications.
Journal: Current HIV/AIDS reports 20100801
Title: Neither ritonavir nor darunavir affect cell surface expression of tetherin or Vpu-mediated tetherin down-modulation.
Journal: AIDS (London, England) 20100731
Title: A medicinal chemist's guide to molecular interactions.
Journal: Journal of medicinal chemistry 20100722
Title: Suboptimal adherence to darunavir/ritonavir has minimal effect on efficacy compared with lopinavir/ritonavir in treatment-naive, HIV-infected patients: 96 week ARTEMIS data.
Journal: The Journal of antimicrobial chemotherapy 20100701
Title: Analysis of resistance testing in South Trinidad.
Journal: The West Indian medical journal 20100701
Title: Role of Gag in HIV Resistance to Protease Inhibitors.
Journal: Viruses 20100701
Title: Species-specific interaction of HIV protease inhibitors with accumulation of cholyl-glycylamido-fluorescein (CGamF) in sandwich-cultured hepatocytes.
Journal: Journal of pharmaceutical sciences 20100601
Title: Susceptibility of HIV-1 to tipranavir and other antiretroviral agents in treatment-experienced patients: The UTILIZE Study.
Journal: Current HIV research 20100601
Title: Etravirine in combination with darunavir/ritonavir and optimized background regimen results in suppression of HIV replication in treatment-experienced patients. Evaluation of Katlama C, Haubrich R, Lalezari J, et al. Efficacy and safety of etravirine in treatment-experienced HIV-1 patients: pooled 48-week analysis of two randomized, controlled trials. AIDS 2009; 23: 2289-300.
Journal: Expert opinion on pharmacotherapy 20100601
Title: Validation of a rapid and sensitive high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) assay for the simultaneous determination of existing and new antiretroviral compounds.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100601
Title: HIV-protease inhibitors suppress skeletal muscle fatty acid oxidation by reducing CD36 and CPT1 fatty acid transporters.
Journal: Biochimica et biophysica acta 20100501
Title: Assessment of the susceptibility of mutant HIV-1 to antiviral agents.
Journal: Journal of virological methods 20100501
Title: Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance.
Journal: Journal of virology 20100501
Title: Pharmacokinetics of multiple-dose darunavir in combination with low-dose ritonavir in individuals with mild-to-moderate hepatic impairment.
Journal: Clinical pharmacokinetics 20100501
Title: Intracellular and plasma steady-state pharmacokinetics of raltegravir, darunavir, etravirine and ritonavir in heavily pre-treated HIV-infected patients.
Journal: British journal of clinical pharmacology 20100501
Title: Special issue: retroviral enzymes.
Journal: Viruses 20100501
Title: Use of darunavir/ritonavir once daily in treatment-naive pregnant woman: pharmacokinetics, compartmental exposure, efficacy and safety.
Journal: AIDS (London, England) 20100424
Title: Efficacy, safety, and tolerability of etravirine with and without darunavir/ritonavir or raltegravir in treatment-experienced patients: analysis of the etravirine early access program in the United States.
Journal: Journal of acquired immune deficiency syndromes (1999) 20100401
Title: Darunavir: in treatment-experienced pediatric patients with HIV-1 infection.
Journal: Paediatric drugs 20100401
Title: Report from the 17th Conference on Retroviruses and Opportunistic Infections. Randomized studies of once-daily darunavir and tenofovir/FTC + nevirapine.
Journal: Journal watch. AIDS clinical care 20100401
Title: Analysis of the effects of specific protease inhibitors on OPG/RANKL regulation in an osteoblast-like cell line.
Journal: The new microbiologica 20100401
Title: Formation of transient dimers by a retroviral protease.
Journal: The Biochemical journal 20100329
Title: Etravirine limits the emergence of darunavir and other protease inhibitor resistance-associated mutations in the DUET trials.
Journal: AIDS (London, England) 20100327
Title: Activity of elvitegravir, a once-daily integrase inhibitor, against resistant HIV Type 1: results of a phase 2, randomized, controlled, dose-ranging clinical trial.
Journal: The Journal of infectious diseases 20100315
Title: Clinical implications of genotypic resistance to the newer antiretroviral drugs in HIV-1-infected patients with virological failure.
Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20100315
Title: Insights into drug resistance of mutations D30N and I50V to HIV-1 protease inhibitor TMC-114: free energy calculation and molecular dynamic simulation.
Journal: Journal of molecular modeling 20100301
Title: Trends in uptake of recently approved antiretrovirals within a national healthcare system.
Journal: HIV medicine 20100301
Title: HIV RNA suppression rates after 24 weeks of treatment with etravirine, darunavir/ritonavir and raltegravir in the etravirine early access programme.
Journal: International journal of STD & AIDS 20100301
Title: Factors predictive of successful darunavir/ritonavir-based therapy in highly antiretroviral-experienced HIV-1-infected patients (the DARWEST study).
Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20100301
Title: Interaction of HIV protease inhibitors with OATP1B1, 1B3, and 2B1.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20100301
Title: HIV type 1 antiretroviral resistance mutations in subtypes B, C, and F in the City of São Paulo, Brazil.
Journal: AIDS research and human retroviruses 20100301
Title: [Current topics on drug-resistant HIV in Japan].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20100301
Title: Short communication: evaluation of the effect of enfuvirtide in 11 HIV-1 vertically infected pediatric patients outside clinical trials.
Journal: AIDS research and human retroviruses 20100301
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20100301
Title: FDA notifications. Labeling changed on Prezista.
Journal: AIDS alert 20100301
Title: Synthesis and biological evaluation of novel allophenylnorstatine-based HIV-1 protease inhibitors incorporating high affinity P2-ligands.
Journal: Bioorganic & medicinal chemistry letters 20100201
Title: Expanded postexposure prophylaxis for simultaneous multiple source HIV exposure in a health-care worker.
Journal: International journal of STD & AIDS 20100201
Title: Current drugs in clinical study.
Journal: Project Inform perspective 20100201
Title: HIV Genetic Diversity and Drug Resistance.
Journal: Viruses 20100201
Title: HIV-1 protease inhibitors with a transition-state mimic comprising a tertiary alcohol: improved antiviral activity in cells.
Journal: Journal of medicinal chemistry 20100128
Title: The MONET trial: darunavir/ritonavir with or without nucleoside analogues, for patients with HIV RNA below 50 copies/ml.
Journal: AIDS (London, England) 20100116
Title: Pharmacokinetics and drug-drug interactions of antiretrovirals: an update.
Journal: Antiviral research 20100101
Title: Analysis of CYP3A4-HIV-1 protease drugs interactions by computational methods for Highly Active Antiretroviral Therapy in HIV/AIDS.
Journal: Journal of molecular graphics & modelling 20100101
Title: One-, two-, and three-class resistance among HIV-infected patients on antiretroviral therapy in private care clinics: Mumbai, India.
Journal: AIDS research and human retroviruses 20100101
Title: Towards a Patent Pool for HIV Medicines: The Background.
Journal: The open AIDS journal 20100101
Title: Patent Pooling for Promoting Access to Antiretroviral Drugs (ARVs) - A Strategic Option for India.
Journal: The open AIDS journal 20100101
Title: Pooling ARV Drug Patents: A Pro-Access Fitting Strategy?
Journal: The open AIDS journal 20100101
Title: Decreased plasma levels of darunavir/ritonavir in a vertically infected pregnant woman carrying multiclass-resistant HIV type-1.
Journal: Antiviral therapy 20100101
Title: Profile of etravirine for the treatment of HIV infection.
Journal: Therapeutics and clinical risk management 20100101
Title: Pharmacokinetic interaction between indinavir and darunavir with low-dose ritonavir in healthy volunteers.
Journal: Intervirology 20100101
Title: Designing ARVs Patent Pool Up to Trade & Policy Evolutionary Dynamics.
Journal: The open AIDS journal 20100101
Title: [Approach to establishing and evaluating clinical relevance of drug interactions in HIV patients: 2009 update].
Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20100101
Title: Decreased NK Cell FcRgamma in HIV-1 infected individuals receiving combination antiretroviral therapy: a cross sectional study.
Journal: PloS one 20100101
Title: Raltegravir is a potent inhibitor of XMRV, a virus implicated in prostate cancer and chronic fatigue syndrome.
Journal: PloS one 20100101
Title: The effects of a nucleoside-sparing antiretroviral regimen on the pharmacokinetics of ritonavir-boosted darunavir in HIV type-1-infected patients.
Journal: Antiviral therapy 20100101
Title: Treatment simplification to once daily darunavir/ritonavir guided by the darunavir inhibitory quotient in heavily pretreated HIV-infected patients.
Journal: Antiviral therapy 20100101
Title: Darunavir/ritonavir and efavirenz exert differential effects on MRP1 transporter expression and function in healthy volunteers.
Journal: Antiviral therapy 20100101
Title: The HIV-1 integrase mutations Y143C/R are an alternative pathway for resistance to Raltegravir and impact the enzyme functions.
Journal: PloS one 20100101
Title: Raltegravir, tenofovir, and emtricitabine in an HIV-infected patient with HCV chronic hepatitis, NNRTI intolerance and protease inhibitors-induced severe liver toxicity.
Journal: European journal of medical research 20100101
Title: Forecasting drug utilization and expenditure in a metropolitan health region.
Journal: BMC health services research 20100101
Title: Recent key advances in human immunodeficiency virus medicine and implications for China.
Journal: AIDS research and therapy 20100101
Title: Dynamics of lamin-A processing following precursor accumulation.
Journal: PloS one 20100101
Title: An assay to monitor HIV-1 protease activity for the identification of novel inhibitors in T-cells.
Journal: PloS one 20100101
Title: Transmission of human immunodeficiency virus I drug resistance - a case report. What are the clinical implications?
Journal: European journal of medical research 20100101
Title: Use of newer antiretroviral agents, darunavir and etravirine with or without raltegravir, in pregnancy: a report of two cases.
Journal: Antiviral therapy 20100101
Title: The influence of aged garlic extract on the uptake of saquinavir and darunavir into HepG2 cells and rat liver slices.
Journal: Drug metabolism and pharmacokinetics 20100101
Title: Comparison of HIV-1 genotypic resistance test interpretation systems in predicting virological outcomes over time.
Journal: PloS one 20100101
Title: Autoprocessing of human immunodeficiency virus type 1 protease miniprecursor fusions in mammalian cells.
Journal: AIDS research and therapy 20100101
Title: High performance liquid chromatography using UV detection for the simultaneous quantification of the new non-nucleoside reverse transcriptase inhibitor etravirine (TMC-125), and 4 protease inhibitors in human plasma.
Journal: Biological & pharmaceutical bulletin 20100101
Title: Maraviroc in treatment-experienced patients with HIV-1 infection - experience from routine clinical practice.
Journal: European journal of medical research 20100101
Title: Pharmacokinetics of once-daily etravirine without and with once-daily darunavir/ritonavir in antiretroviral-naive HIV type-1-infected adults.
Journal: Antiviral therapy 20100101
Title: Comparative cost-efficacy analysis of darunavir/ritonavir and other ritonavir-boosted protease inhibitors for first-line treatment of HIV-1 infection in the United States.
Journal: HIV clinical trials 20100101
Title: Neuropsychiatric adverse events with ritonavir-boosted darunavir monotherapy in HIV-infected individuals: a randomised prospective study.
Journal: HIV clinical trials 20100101
Title: Susceptibility of the human retrovirus XMRV to antiretroviral inhibitors.
Journal: Retrovirology 20100101
Title: Boosted protease inhibitor monotherapy. What have we learnt after seven years of research?
Journal: AIDS reviews 20100101
Title: Clinical, virological and immunological responses in Danish HIV patients receiving raltegravir as part of a salvage regimen.
Journal: Clinical epidemiology 20100101
Title: Garlic flavonoids and organosulfur compounds: impact on the hepatic pharmacokinetics of saquinavir and darunavir.
Journal: Drug metabolism and pharmacokinetics 20100101
Title: Selective killing of human immunodeficiency virus infected cells by non-nucleoside reverse transcriptase inhibitor-induced activation of HIV protease.
Journal: Retrovirology 20100101
Title: The global pediatric antiretroviral market: analyses of product availability and utilization reveal challenges for development of pediatric formulations and HIV/AIDS treatment in children.
Journal: BMC pediatrics 20100101
Title: Progress in antiretroviral drug delivery using nanotechnology.
Journal: International journal of nanomedicine 20100101
Title: Impact of the background regimen on virologic response to etravirine: pooled 48-week analysis of DUET-1 and -2.
Journal: HIV clinical trials 20100101
Title: Efficacy and safety of etravirine at week 96 in treatment-experienced HIV type-1-infected patients in the DUET-1 and DUET-2 trials.
Journal: Antiviral therapy 20100101
Title: The initial step in human immunodeficiency virus type 1 GagProPol processing can be regulated by reversible oxidation.
Journal: PloS one 20100101
Title: Antiretroviral therapy optimisation without genotype resistance testing: a perspective on treatment history based models.
Journal: PloS one 20100101
Title: Virologic and immunologic effectiveness of tipranavir/ritonavir (TPV/r)- versus darunavir/ritonavir (DRV/r)-based regimens in clinical practice.
Journal: Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) 20100101
Title: In vitro susceptibility and virological outcome to darunavir and lopinavir are independent of HIV type-1 subtype in treatment-naive patients.
Journal: Antiviral therapy 20100101
Title: Early development of non-hodgkin lymphoma following initiation of newer class antiretroviral therapy among HIV-infected patients - implications for immune reconstitution.
Journal: AIDS research and therapy 20100101
Title: Transmitted drug resistance in persons with acute/early HIV-1 in San Francisco, 2002-2009.
Journal: PloS one 20100101
Title: Proteochemometric modeling of the susceptibility of mutated variants of the HIV-1 virus to reverse transcriptase inhibitors.
Journal: PloS one 20100101
Title: A review of economic evaluations of darunavir boosted by low-dose ritonavir in treatment-experienced persons living with HIV infection.
Journal: PharmacoEconomics 20100101
Title: Clinical management of treatment-experienced, HIV/AIDS patients in the combination antiretroviral therapy era.
Journal: PharmacoEconomics 20100101
Title: Costs to achieve undetectable HIV RNA with darunavir-containing highly active antiretroviral therapy in highly pretreated patients: the POWER experience.
Journal: PharmacoEconomics 20100101
Title: Cost effectiveness of darunavir/ritonavir in highly treatment-experienced, HIV-1-infected adults in the USA.
Journal: PharmacoEconomics 20100101
Title: Cost effectiveness of darunavir/ritonavir 600/100 mg bid in protease inhibitor-experienced, HIV-1-infected adults in Belgium, Italy, Sweden and the UK.
Journal: PharmacoEconomics 20100101
Title: US cost effectiveness of darunavir/ritonavir 600/100 mg bid in treatment-experienced, HIV-infected adults with evidence of protease inhibitor resistance included in the TITAN Trial.
Journal: PharmacoEconomics 20100101
Title: Cost effectiveness of darunavir/ritonavir 600/100 mg bid in treatment-experienced, lopinavir-naive, protease inhibitor-resistant, HIV-infected adults in Belgium, Italy, Sweden and the UK.
Journal: PharmacoEconomics 20100101
Title: Predicting direct costs of HIV care during the first year of darunavir-based highly active antiretroviral therapy using CD4 cell counts: evidence from POWER.
Journal: PharmacoEconomics 20100101
Title: Modelling the budget impact of darunavir in the treatment of highly treatment-experienced, HIV-infected adults in France.
Journal: PharmacoEconomics 20100101
Title: Lipid Metabolism and Cardiovascular Risk in HIV-1 Infection and HAART: Present and Future Problems.
Journal: Cholesterol 20100101
Title: Raltegravir in combination with other antiretroviral agents for the treatment of HIV infection.
Journal: Infection and drug resistance 20100101
Title: Extended use of raltegravir in the treatment of HIV-1 infection: optimizing therapy.
Journal: Infection and drug resistance 20100101
Title: New and improved strategies for the treatment of gout.
Journal: International journal of nephrology and renovascular disease 20100101
Title: Novel strategies in the use of lopinavir/ritonavir for the treatment of HIV infection in children.
Journal: HIV/AIDS (Auckland, N.Z.) 20100101
Title: Role of etravirine in the management of treatment-experienced patients with human immunodeficiency virus type 1.
Journal: HIV/AIDS (Auckland, N.Z.) 20100101
Title: Design, synthesis, protein-ligand X-ray structure, and biological evaluation of a series of novel macrocyclic human immunodeficiency virus-1 protease inhibitors to combat drug resistance.
Journal: Journal of medicinal chemistry 20091210
Title: Solid state characterization of the anti-HIV drug TMC114: interconversion of amorphous TMC114, TMC114 ethanolate and hydrate.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20091208
Title: Antiretroviral-induced toxic epidermal necrolysis in a patient positive for human immunodeficiency virus.
Journal: Clinical and experimental dermatology 20091201
Title: Revealing the dimer dissociation and existence of a folded monomer of the mature HIV-2 protease.
Journal: Protein science : a publication of the Protein Society 20091201
Title: Validation of an electrospray ionization LC-MS/MS method for quantitative analysis of raltegravir, etravirine, and 9 other antiretroviral agents in human plasma samples.
Journal: Therapeutic drug monitoring 20091201
Title: [Safety and tolerability of etravirine].
Journal: Enfermedades infecciosas y microbiologia clinica 20091201
Title: Structural basis for the resilience of Darunavir (TMC114) resistance major flap mutations of HIV-1 protease.
Journal: Interdisciplinary sciences, computational life sciences 20091201
Title: HIV-1 Protease: Structural Perspectives on Drug Resistance.
Journal: Viruses 20091201
Title: Current and Novel Inhibitors of HIV Protease.
Journal: Viruses 20091201
Title: How much ritonavir is needed to boost protease inhibitors? Systematic review of 17 dose-ranging pharmacokinetic trials.
Journal: AIDS (London, England) 20091113
Title: Raltegravir, etravirine and r-darunavir combination in adolescents with multidrug-resistant virus.
Journal: AIDS (London, England) 20091113
Title: [Status of anti-HIV drug development and an overview of combined chemotherapy].
Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20091110
Title: Identification of new genotypic cut-off levels to predict the efficacy of lopinavir/ritonavir and darunavir/ritonavir in the TITAN trial.
Journal: HIV medicine 20091101
Title: Raltegravir, etravirine, and ritonavir-boosted darunavir: a safe and successful rescue regimen for multidrug-resistant HIV-1 infection.
Journal: Journal of acquired immune deficiency syndromes (1999) 20091101
Title: Efavirenz: a decade of clinical experience in the treatment of HIV.
Journal: The Journal of antimicrobial chemotherapy 20091101
Title: High rate of virologic suppression with raltegravir plus etravirine and darunavir/ritonavir among treatment-experienced patients infected with multidrug-resistant HIV: results of the ANRS 139 TRIO trial.
Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20091101
Title: Drugs in traditional drug classes (nucleoside reverse transcriptase inhibitor/nonnucleoside reverse transcriptase inhibitor/protease inhibitors) with activity against drug-resistant virus (tipranavir, darunavir, etravirine).
Journal: Current opinion in HIV and AIDS 20091101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20091101
Title: A novel LC-ESI-MS method for the simultaneous determination of etravirine, darunavir and ritonavir in human blood plasma.
Journal: Talanta 20091015
Title: Influence of darunavir coadministration on nevirapine pharmacokinetics in HIV-infected patients: a population approach.
Journal: HIV medicine 20091001
Title: New antiretroviral drugs: a review of the efficacy, safety, pharmacokinetics, and resistance profile of tipranavir, darunavir, etravirine, rilpivirine, maraviroc, and raltegravir.
Journal: Expert opinion on pharmacotherapy 20091001
Title: A liquid chromatography-tandem mass spectrometry assay for quantification of nevirapine, indinavir, atazanavir, amprenavir, saquinavir, ritonavir, lopinavir, efavirenz, tipranavir, darunavir and maraviroc in the plasma of patients infected with HIV.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091001
Title: The Place of protease inhibitors in antiretroviral treatment.
Journal: The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20091001
Title: Pharmacokinetics, safety and efficacy of darunavir/ritonavir in treatment-experienced children and adolescents.
Journal: AIDS (London, England) 20090924
Title: Characterization of virologic failure patients on darunavir/ritonavir in treatment-experienced patients.
Journal: AIDS (London, England) 20090910
Title: Efficacy of darunavir despite low plasma trough levels during late pregnancy in an HIV-hepatitis C virus-infected patient.
Journal: AIDS (London, England) 20090910
Title: New developments in HIV drug resistance.
Journal: The Journal of antimicrobial chemotherapy 20090901
Title: The history of antiretrovirals: key discoveries over the past 25 years.
Journal: Reviews in medical virology 20090901
Title: P-glycoprotein mediates efflux transport of darunavir in human intestinal Caco-2 and ABCB1 gene-transfected renal LLC-PK1 cell lines.
Journal: Biological & pharmaceutical bulletin 20090901
Title: Intracellular 'boosting' of darunavir using known transport inhibitors in primary PBMC.
Journal: British journal of clinical pharmacology 20090901
Title: [Immunorecovery after prolonged HIV-related immunosuppression: opportunities of the new antiretroviral classes].
Journal: Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20090901
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20090901
Title: Once-daily darunavir/ritonavir vs. lopinavir/ritonavir in treatment-naive, HIV-1-infected patients: 96-week analysis.
Journal: AIDS (London, England) 20090824
Title: Improved bioavailability of darunavir by use of kappa-carrageenan versus microcrystalline cellulose as pelletisation aid.
Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20090801
Title: Human immunodeficiency virus: 25 years of diagnostic and therapeutic strategies and their impact on hepatitis B and C virus.
Journal: Medical microbiology and immunology 20090801
Title: Early virologic suppression with three-class experienced patients: 24-week effectiveness in the darunavir outcomes study.
Journal: AIDS (London, England) 20090731
Title: Design of HIV-1 protease inhibitors with pyrrolidinones and oxazolidinones as novel P1'-ligands to enhance backbone-binding interactions with protease: synthesis, biological evaluation, and protein-ligand X-ray studies.
Journal: Journal of medicinal chemistry 20090709
Title: Drug-drug interaction in a kidney transplant recipient receiving HIV salvage therapy and tacrolimus.
Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20090701
Title: Cytotoxicological analysis of a gp120 binding aptamer with cross-clade human immunodeficiency virus type 1 entry inhibition properties: comparison to conventional antiretrovirals.
Journal: Antimicrobial agents and chemotherapy 20090701
Title: HIV protease inhibitors: recent clinical trials and recommendations on use.
Journal: Expert opinion on pharmacotherapy 20090701
Title: Pharmacokinetic interaction between nevirapine and darunavir with low-dose ritonavir in HIV-1-infected patients.
Journal: British journal of clinical pharmacology 20090701
Title: Management of paediatric HIV-1 resistance.
Journal: Current opinion in infectious diseases 20090601
Title: Etravirine: new drug. Multidrug-resistant HIV: another option.
Journal: Prescrire international 20090601
Title: Interactions of different inhibitors with active-site aspartyl residues of HIV-1 protease and possible relevance to pepsin.
Journal: Proteins 20090515
Title: Effects of ritonavir-boosted darunavir vs. ritonavir-boosted atazanavir on lipid and glucose parameters in HIV-negative, healthy volunteers.
Journal: HIV medicine 20090501
Title: Provider prescribing of 4 antiretroviral agents after implementation of drug use guidelines in the Department of Veterans Affairs.
Journal: Journal of managed care pharmacy : JMCP 20090501
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20090501
Title: Harnessing nature's insight: design of aspartyl protease inhibitors from treatment of drug-resistant HIV to Alzheimer's disease.
Journal: Journal of medicinal chemistry 20090423
Title: 2-Pyridyl P1'-substituted symmetry-based human immunodeficiency virus protease inhibitors (A-792611 and A-790742) with potential for convenient dosing and reduced side effects.
Journal: Journal of medicinal chemistry 20090423
Title: A LC-tandem MS assay for the simultaneous measurement of new antiretroviral agents: Raltegravir, maraviroc, darunavir, and etravirine.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090415
Title: Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV.
Journal: International journal of antimicrobial agents 20090401
Title: Absorption, metabolism, and excretion of darunavir, a new protease inhibitor, administered alone and with low-dose ritonavir in healthy subjects.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20090401
Title: Darunavir concentrations in cerebrospinal fluid and blood in HIV-1-infected individuals.
Journal: AIDS research and human retroviruses 20090401
Title: Etravirine: a second-generation nonnucleoside reverse transcriptase inhibitor (NNRTI) active against NNRTI-resistant strains of HIV.
Journal: Clinical therapeutics 20090401
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20090401
Title: Pharmacokinetics of darunavir, etravirine and raltegravir in an HIV-infected patient on haemodialysis.
Journal: AIDS (London, England) 20090327
Title: Predicting drug resistance of the HIV-1 protease using molecular interaction energy components.
Journal: Proteins 20090301
Title: GRL-02031, a novel nonpeptidic protease inhibitor (PI) containing a stereochemically defined fused cyclopentanyltetrahydrofuran potent against multi-PI-resistant human immunodeficiency virus type 1 in vitro.
Journal: Antimicrobial agents and chemotherapy 20090301
Title: Mutations associated with virological response to darunavir/ritonavir in HIV-1-infected protease inhibitor-experienced patients.
Journal: The Journal of antimicrobial chemotherapy 20090301
Title: Transplacental passage of ritonavir-boosted darunavir in two pregnant women.
Journal: International journal of STD & AIDS 20090301
Title: Timing the emergence of resistance to anti-HIV drugs with large genetic barriers.
Journal: PLoS computational biology 20090301
Title: The fusion inhibitor enfuvirtide in recent antiretroviral strategies.
Journal: Current opinion in HIV and AIDS 20090301
Title: Prezista fares better than Kaletra in first line therapy.
Journal: Project Inform perspective 20090301
Title: Quantification of HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in peripheral blood mononuclear cell lysate using liquid chromatography coupled with tandem mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090215
Title: Changes in darunavir/r resistance score after previous failure to tipranavir/r in HIV-1-infected multidrug-resistant patients.
Journal: Journal of acquired immune deficiency syndromes (1999) 20090201
Title: Pharmacologic aspects of new antiretroviral drugs.
Journal: Current HIV/AIDS reports 20090201
Title: Is dual therapy with raltegravir and protease inhibitors a feasible option in rescue strategy in HIV-1 infection?
Journal: Journal of acquired immune deficiency syndromes (1999) 20090201
Title: FDA notifications. FDA OKs new pediatric dosing for darunavir.
Journal: AIDS alert 20090201
Title: Successful use of darunavir, etravirine, enfuvirtide and tenofovir/emtricitabine in pregnant woman with multiclass HIV resistance.
Journal: AIDS (London, England) 20090128
Title: The use of darunavir/ritonavir as intensification in low viremic HIV-infected patients treated with boosted protease inhibitor-containing regimens.
Journal: Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) 20090101
Title: Top stories of 2008. Beyond abacavir/3TC: good news on first-line regimens.
Journal: AIDS clinical care 20090101
Title: Raltegravir, elvitegravir, and metoogravir: the birth of 'me-too' HIV-1 integrase inhibitors.
Journal: Retrovirology 20090101
Title: Drug resistance mutations for surveillance of transmitted HIV-1 drug-resistance: 2009 update.
Journal: PloS one 20090101
Title: Darunavir: a review of its use in the management of HIV infection in adults.
Journal: Drugs 20090101
Title: Efficacy and safety of darunavir and etravirine in an antiretroviral multi-experienced youth with vertically HIV-1 infection.
Journal: European journal of medical research 20090101
Title: Role of atazanavir in the treatment of HIV infection.
Journal: Therapeutics and clinical risk management 20090101
Title: Drug interactions with new and investigational antiretrovirals.
Journal: Clinical pharmacokinetics 20090101
Title: Emerging role of integrase inhibitors in the management of treatment-experienced patients with HIV infection.
Journal: Therapeutics and clinical risk management 20090101
Title: Differences in resistance mutations among HIV-1 non-subtype B infections: a systematic review of evidence (1996-2008).
Journal: Journal of the International AIDS Society 20090101
Title: Hypersensitivity reaction to darunavir and desensitization protocol.
Journal: Journal of investigational allergology & clinical immunology 20090101
Title: Pharmacotherapy of pediatric and adolescent HIV infection.
Journal: Therapeutics and clinical risk management 20090101
Title: Managing treatment-experienced pediatric and adolescent HIV patients: role of darunavir.
Journal: Therapeutics and clinical risk management 20090101
Title: Discontinuation of enfuvirtide in heavily pretreated HIV-infected individuals.
Journal: HIV clinical trials 20090101
Title: Drugs associated with more suicidal ideations are also associated with more suicide attempts.
Journal: PloS one 20090101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20090101
Title: Efficacy and safety of darunavir/ritonavir in treatment-experienced HIV type-1 patients in the POWER 1, 2 and 3 trials at week 96.
Journal: Antiviral therapy 20090101
Title: First-line boosted protease inhibitor-based regimens in treatment-naive HIV-1-infected patients--making a good thing better.
Journal: AIDS reviews 20090101
Title: German-Austrian recommendations for HIV1-therapy in pregnancy and in HIV1-exposed newborn, update 2008.
Journal: European journal of medical research 20090101
Title: [Desensitization to tipranavir caused by toxicodermia].
Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20090101
Title: Raltegravir: The evidence of its therapeutic value in HIV-1 infection.
Journal: Core evidence 20090101
Title: Etravirine (TMC-125): The evidence for its place in the treatment of HIV-1 infection.
Journal: Core evidence 20090101
Title: Profile of darunavir in the management of treatment-experienced HIV patients.
Journal: HIV/AIDS (Auckland, N.Z.) 20090101
Title: Role of darunavir in the management of HIV infection.
Journal: HIV/AIDS (Auckland, N.Z.) 20090101
Title: Pharmacologic and nonpharmacologic options for the management of HIV infection during pregnancy.
Journal: HIV/AIDS (Auckland, N.Z.) 20090101
Title: Influence of baseline protease inhibitor resistance on the efficacy of darunavir/ritonavir or lopinavir/ritonavir in the TITAN trial.
Journal: Journal of acquired immune deficiency syndromes (1999) 20081215
Title: Structural evidence for effectiveness of darunavir and two related antiviral inhibitors against HIV-2 protease.
Journal: Journal of molecular biology 20081205
Title: Safety and efficacy of enfuvirtide in combination with darunavir-ritonavir and an optimized background regimen in treatment-experienced human immunodeficiency virus-infected patients: the below the level of quantification study.
Journal: Antimicrobial agents and chemotherapy 20081201
Title: An HPLC-PDA method for the simultaneous quantification of the HIV integrase inhibitor raltegravir, the new nonnucleoside reverse transcriptase inhibitor etravirine, and 11 other antiretroviral agents in the plasma of HIV-infected patients.
Journal: Therapeutic drug monitoring 20081201
Title: [Rational use of modern substances for the treatment of HIV-infection].
Journal: Der Internist 20081201
Title: Use of darunavir and enfuvirtide in a pregnant woman.
Journal: International journal of STD & AIDS 20081201
Title: [Pharmacological and clinical profile of Darnavir (Prezista)].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20081201
Title: FDA approves darunavir.
Journal: AIDS patient care and STDs 20081201
Title: FDA notifications. Darunavir label has these changes.
Journal: AIDS alert 20081201
Title: US FDA expands approval for Johnson & Johnson HIV drug.
Journal: The AIDS reader 20081201
Title: Report from the 2008 joint ICAAC/IDSA meeting. Darunavir and atazanavir: 96-week data from ARTEMIS and CASTLE.
Journal: AIDS clinical care 20081201
Title: Darunavir now approved for use in treatment-naive patients.
Journal: AIDS clinical care 20081201
Title: Once-daily fosamprenavir with ritonavir in the treatment of HIV infection in therapy-naïve patients.
Journal: Therapeutics and clinical risk management 20081201
Title: Switching to darunavir/ritonavir achieves viral suppression in patients with persistent low replication on first-line lopinavir/ritonavir.
Journal: AIDS (London, England) 20081112
Title: Adverse cutaneous reactions associated with the newest antiretroviral drugs in patients with human immunodeficiency virus infection.
Journal: The Journal of antimicrobial chemotherapy 20081101
Title: Impact of gag mutations on selection of darunavir resistance mutations in HIV-1 protease.
Journal: The Journal of antimicrobial chemotherapy 20081101
Title: Pharmacologic aspects of new antiretroviral drugs.
Journal: Current infectious disease reports 20081101
Title: Darunavir-etravirine-raltegravir as salvage combination therapy in a heavily pretreated HIV-infected patient.
Journal: AIDS patient care and STDs 20081101
Title: Clinical application of the inhibitory quotient: is there a role in HIV protease inhibitor therapy?
Journal: Current opinion in HIV and AIDS 20081101
Title: Approaches to the design of HIV protease inhibitors with improved resistance profiles.
Journal: Current opinion in HIV and AIDS 20081101
Title: [Role of the new molecules in antiretroviral therapy. Position of raltegravir].
Journal: Enfermedades infecciosas y microbiologia clinica 20081101
Title: Solution kinetics measurements suggest HIV-1 protease has two binding sites for darunavir and amprenavir.
Journal: Journal of medicinal chemistry 20081023
Title: Flexible cyclic ethers/polyethers as novel P2-ligands for HIV-1 protease inhibitors: design, synthesis, biological evaluation, and protein-ligand X-ray studies.
Journal: Journal of medicinal chemistry 20081009
Title: Efficacy of once-daily darunavir/ritonavir 800/100 mg in HIV-infected, treatment-experienced patients with no baseline resistance-associated mutations to darunavir.
Journal: Journal of acquired immune deficiency syndromes (1999) 20081001
Title: Effect of ritonavir-boosted tipranavir or darunavir on the steady-state pharmacokinetics of elvitegravir.
Journal: Journal of acquired immune deficiency syndromes (1999) 20081001
Title: Effect of baseline viral susceptibility on response to darunavir/ritonavir versus control protease inhibitors in treatment-experienced HIV type 1-infected patients: POWER 1 and 2.
Journal: AIDS research and human retroviruses 20081001
Title: [Introduction. Darunavir].
Journal: Enfermedades infecciosas y microbiologia clinica 20081001
Title: [Chemical characteristics, mechanism of action and antiviral activity of darunavir].
Journal: Enfermedades infecciosas y microbiologia clinica 20081001
Title: [Darunavir in treatment-naïve patients. The ARTEMIS study].
Journal: Enfermedades infecciosas y microbiologia clinica 20081001
Title: [Darunavir as first-line therapy. The TITAN study].
Journal: Enfermedades infecciosas y microbiologia clinica 20081001
Title: [Darunavir in patients with advanced HIV and multiresistance. The POWER, DUET and BENCHMRK studies].
Journal: Enfermedades infecciosas y microbiologia clinica 20081001
Title: [Safety and tolerability of darunavir].
Journal: Enfermedades infecciosas y microbiologia clinica 20081001
Title: [Darunavir in HIV/HVC/HVB coinfection].
Journal: Enfermedades infecciosas y microbiologia clinica 20081001
Title: [Pharmacological interactions with darunavir].
Journal: Enfermedades infecciosas y microbiologia clinica 20081001
Title: [Resistance to darunavir].
Journal: Enfermedades infecciosas y microbiologia clinica 20081001
Title: [Position of darunavir in antiretroviral therapy].
Journal: Enfermedades infecciosas y microbiologia clinica 20081001
Title: Lopinavir/ritonavir in the treatment of HIV-1 infection: a review.
Journal: Therapeutics and clinical risk management 20081001
Title: HIV-protease inhibitors block the enzymatic activity of purified Ste24p.
Journal: Biochemical and biophysical research communications 20080919
Title: Pattern and impact of emerging resistance mutations in treatment experienced patients failing darunavir-containing regimen.
Journal: AIDS (London, England) 20080912
Title: New therapeutic agents in the management of HIV: an overview of darunavir for clinicians.
Journal: Sexual health 20080901
Title: Pharmacokinetic interactions between ritonavir-boosted darunavir and NNRTIs: a report of 3 cases.
Journal: The AIDS reader 20080901
Title: A frontal mucocele caused by an immune reconstitution inflammatory syndrome in a patient with HIV infection.
Journal: Rhinology 20080901
Title: HIV infection in the elderly.
Journal: Clinical interventions in aging 20080901
Title: Inorganic polyhedral metallacarborane inhibitors of HIV protease: a new approach to overcoming antiviral resistance.
Journal: Journal of medicinal chemistry 20080814
Title: Pharmacokinetics of darunavir/ritonavir and ketoconazole following co-administration in HIV-healthy volunteers.
Journal: British journal of clinical pharmacology 20080801
Title: Follow-up of a multi-drug resistant HIV-1 infected patient successfully treated with darunavir and etravirine.
Journal: Journal of medical virology 20080801
Title: Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir.
Journal: Journal of molecular biology 20080801
Title: Two cases of multidrug-resistant human immunodeficiency virus infection treated with atazanavir and lopinavir/ritonavir combination therapy.
Journal: Journal of Korean medical science 20080801
Title: Combating HIV resistance - focus on darunavir.
Journal: Therapeutics and clinical risk management 20080801
Title: Raltegravir: new Drug. Alternative to enfuvirtide/darunavir in multidrug-resistant HIV.
Journal: Prescrire international 20080801
Title: The Relationship Between HIV Infection and Cardiovascular Disease.
Journal: Current cardiology reviews 20080801
Title: Efficacy and safety of once-daily darunavir/ritonavir versus lopinavir/ritonavir in treatment-naive HIV-1-infected patients at week 48.
Journal: AIDS (London, England) 20080731
Title: Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection.
Journal: The New England journal of medicine 20080724
Title: Cellular accumulation of cholyl-glycylamido-fluorescein in sandwich-cultured rat hepatocytes: kinetic characterization, transport mechanisms, and effect of human immunodeficiency virus protease inhibitors.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080701
Title: New treatment options for HIV salvage patients: an overview of second generation PIs, NNRTIs, integrase inhibitors and CCR5 antagonists.
Journal: The Journal of infection 20080701
Title: Induction effects of ritonavir: implications for drug interactions.
Journal: The Annals of pharmacotherapy 20080701
Title: Health Canada links darunavir to serious liver adverse effects.
Journal: The AIDS reader 20080701
Title: Quality control of protease inhibitors.
Journal: Journal of pharmaceutical sciences 20080601
Title: Darunavir: after multiple antiretroviral treatment failure: another option.
Journal: Prescrire international 20080601
Title: New protease inhibitors and non-nucleoside reverse transcriptase inhibitors.
Journal: Journal of HIV therapy 20080601
Title: Evaluating the potency of HIV-1 protease drugs to combat resistance.
Journal: Proteins 20080515
Title: Quantification of protease inhibitors and non-nucleoside reverse transcriptase inhibitors in dried blood spots by liquid chromatography-triple quadrupole mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080515
Title: HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants.
Journal: Journal of the American Chemical Society 20080514
Title: Effect of the active site D25N mutation on the structure, stability, and ligand binding of the mature HIV-1 protease.
Journal: The Journal of biological chemistry 20080509
Title: Dog model with implanted pump to test boosters for antiretroviral medication.
Journal: International journal of pharmaceutics 20080501
Title: Development of an implantable infusion pump for sustained anti-HIV drug administration.
Journal: International journal of pharmaceutics 20080501
Title: Updated prevalence of genotypic resistance among HIV-1 positive patients naïve to antiretroviral therapy: a single center analysis.
Journal: Journal of medical virology 20080501
Title: FDA alerts doctors to Prezista's possible link to liver damage, deaths.
Journal: The AIDS reader 20080501
Title: Inhibitory quotient in HIV pharmacology.
Journal: Current opinion in HIV and AIDS 20080501
Title: [Preserving future therapy options. Darunavir--the protease inhibitor for various patient groups].
Journal: MMW Fortschritte der Medizin 20080428
Title: [HIV therapy and adherence].
Journal: MMW Fortschritte der Medizin 20080428
Title: A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells.
Journal: The Journal of biological chemistry 20080411
Title: Characterization of a novel human immunodeficiency virus type 1 protease inhibitor, A-790742.
Journal: Antimicrobial agents and chemotherapy 20080401
Title: Inhibition of HIV-2 protease by HIV-1 protease inhibitors in clinical use.
Journal: Chemical biology & drug design 20080401
Title: Liver toxicity warning for darunavir.
Journal: AIDS patient care and STDs 20080401
Title: New approaches in the treatment of HIV/AIDS - focus on maraviroc and other CCR5 antagonists.
Journal: Therapeutics and clinical risk management 20080401
Title: Raltegravir: first in class HIV integrase inhibitor.
Journal: Therapeutics and clinical risk management 20080401
Title: FDA notifications. New 600 mg tablet strength for darunavir is approved by FDA.
Journal: AIDS alert 20080401
Title: FDA notifications. Tibotec issues Dear Health Care Professional letter.
Journal: AIDS alert 20080401
Title: Efficient synthesis of (3R,3aS,6aR)- hexahydrofuro[2,3-b]furan-3-ol from glycolaldehyde.
Journal: Organic letters 20080320
Title: Evidence for different susceptibility to tipranavir and darunavir in patients infected with distinct HIV-1 subtypes.
Journal: AIDS (London, England) 20080312
Title: Experience with darunavir in HIV-infected adults enrolled in a US expanded access program: results from a single center.
Journal: Current medical research and opinion 20080301
Title: Resistance profile of darunavir: combined 24-week results from the POWER trials.
Journal: AIDS research and human retroviruses 20080301
Title: [New drugs for HIV infection].
Journal: Revue de l'infirmiere 20080301
Title: Different evidence of key amprenavir resistance mutations on the efficacy of darunavir.
Journal: AIDS (London, England) 20080130
Title: [New therapeutic options in protracted HIV-infected patients with virological failure].
Journal: Medicina clinica 20080126
Title: Response to 'key amprenavir resistance mutations counteract dramatic efficacy of darunavir in highly experienced patients'.
Journal: AIDS (London, England) 20080102
Title: Design of HIV protease inhibitors targeting protein backbone: an effective strategy for combating drug resistance.
Journal: Accounts of chemical research 20080101
Title: HIV-1 protease inhibitors: effects on HIV-2 replication and resistance.
Journal: Trends in pharmacological sciences 20080101
Title: Darunavir/ritonavir pharmacokinetics following coadministration with clarithromycin in healthy volunteers.
Journal: Journal of clinical pharmacology 20080101
Title: Conformational analysis of TMC114, a novel HIV-1 protease inhibitor.
Journal: Journal of chemical information and modeling 20080101
Title: Drug interactions between HIV protease inhibitors and acid-reducing agents.
Journal: Clinical pharmacokinetics 20080101
Title: The incidence of multidrug and full class resistance in HIV-1 infected patients is decreasing over time (2001-2006) in Portugal.
Journal: Retrovirology 20080101
Title: Transmitted drug resistance, selection of resistance mutations and moderate antiretroviral efficacy in HIV-2: analysis of the HIV-2 Belgium and Luxembourg database.
Journal: BMC infectious diseases 20080101
Title: Fosamprenavir or atazanavir once daily boosted with ritonavir 100 mg, plus tenofovir/emtricitabine, for the initial treatment of HIV infection: 48-week results of ALERT.
Journal: AIDS research and therapy 20080101
Title: Ritonavir-boosted protease inhibitor monotherapy for the treatment of HIV-1 infection.
Journal: AIDS reviews 20080101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20080101
Title: Darunavir: pharmacokinetics and drug interactions.
Journal: Antiviral therapy 20080101
Title: Warning on hepatotoxicity of darunavir.
Journal: AIDS reviews 20080101
Title: Successful use of a tipranavir/ritonavir-based antiretroviral regimen following development of viral resistance to darunavir.
Journal: HIV clinical trials 20080101
Title: Virological response to darunavir/ritonavir-based regimens in antiretroviral-experienced patients (PREDIZISTA study).
Journal: Antiviral therapy 20080101
Title: Effect of repeated doses of darunavir plus low-dose ritonavir on the pharmacokinetics of sildenafil in healthy male subjects: phase I randomized, open-label, two-way crossover study.
Journal: Clinical drug investigation 20080101
Title: Pharmacokinetic interaction between ethinyl estradiol, norethindrone and darunavir with low-dose ritonavir in healthy women.
Journal: Antiviral therapy 20080101
Title: Resilience to resistance of HIV-1 protease inhibitors: profile of darunavir.
Journal: AIDS reviews 20080101
Title: Emerging resistance profiles of newly approved antiretroviral drugs.
Journal: Topics in HIV medicine : a publication of the International AIDS Society, USA 20080101
Title: Successful rescue therapy with a darunavir/ritonavir and etravirine antiretroviral regimen in a child with vertically acquired multidrug-resistant HIV-1.
Journal: Antiviral therapy 20080101
Title: Impending flop for brand antiretrovirals in the emerging markets?
Journal: The open AIDS journal 20080101
Title: Pharmacokinetics, efficacy, and safety of darunavir/ritonavir 800/100 mg once-daily in treatment-naïve and -experienced patients.
Journal: HIV clinical trials 20080101
Title: Raltegravir in the management of HIV-infected patients.
Journal: Drug design, development and therapy 20080101
Title: Darunavir, a conceptually new HIV-1 protease inhibitor for the treatment of drug-resistant HIV.
Journal: Bioorganic & medicinal chemistry 20071215
Title: Overview of boosted protease inhibitors in treatment-experienced HIV-infected patients.
Journal: The Journal of antimicrobial chemotherapy 20071201
Title: Impact of baseline protease genotype and phenotype on the response to darunavir outside clinical trials.
Journal: The Journal of antimicrobial chemotherapy 20071201
Title: Pharmacokinetic interaction between darunavir and saquinavir in HIV-negative volunteers.
Journal: Therapeutic drug monitoring 20071201
Title: HPLC-MS method for the simultaneous quantification of the new HIV protease inhibitor darunavir, and 11 other antiretroviral agents in plasma of HIV-infected patients.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071115
Title: Relative antiviral efficacy should not be inferred from cross-trial comparisons.
Journal: HIV medicine 20071101
Title: Randomized trials to optimize treatment of multidrug-resistant tuberculosis.
Journal: PLoS medicine 20071101
Title: Determinants of HIV-1 genotypic resistance to darunavir (TMC114) in a large Italian resistance database (Antiretroviral Resistance Cohort Analysis).
Journal: Journal of acquired immune deficiency syndromes (1999) 20071101
Title: How will CCR5 antagonists influence the recommendations for the antiretroviral treatment of HIV-1 infection.
Journal: European journal of medical research 20071015
Title: Defining HIV susceptibility to new antiretroviral agents--darunavir.
Journal: The Journal of infectious diseases 20071015
Title: Prevalence of darunavir resistance-associated mutations: patterns of occurrence and association with past treatment.
Journal: The Journal of infectious diseases 20071015
Title: Prevalence of darunavir resistance mutations in HIV-1-infected patients failing other protease inhibitors.
Journal: The Journal of antimicrobial chemotherapy 20071001
Title: Quantification of darunavir (TMC114) in human plasma by high-performance liquid chromatography with ultra-violet detection.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071001
Title: The validation of plasma darunavir concentrations determined by the HPLC method for protease inhibitors.
Journal: Biological & pharmaceutical bulletin 20071001
Title: Darunavir.
Journal: Drugs of today (Barcelona, Spain : 1998) 20071001
Title: Darunavir phase 3 study data released.
Journal: AIDS patient care and STDs 20071001
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20071001
Title: Potent inhibition of HIV-1 replication by novel non-peptidyl small molecule inhibitors of protease dimerization.
Journal: The Journal of biological chemistry 20070928
Title: Tipranavir: a new option for the treatment of drug-resistant HIV infection.
Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070915
Title: Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease.
Journal: Journal of medicinal chemistry 20070906
Title: In vitro antiviral activity of the novel, tyrosyl-based human immunodeficiency virus (HIV) type 1 protease inhibitor brecanavir (GW640385) in combination with other antiretrovirals and against a panel of protease inhibitor-resistant HIV.
Journal: Antimicrobial agents and chemotherapy 20070901
Title: Safety and efficacy of darunavir (TMC114) with low-dose ritonavir in treatment-experienced patients: 24-week results of POWER 3.
Journal: Journal of acquired immune deficiency syndromes (1999) 20070901
Title: Lessons Learned From 2 Patients With Multidrug-Resistant HIV-1 Infection Successfully Treated With a Darunavir-Containing Antiretroviral Treatment Regimen.
Journal: Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) 20070901
Title: Predicting HIV care costs using CD4 counts from clinical trials.
Journal: The American journal of managed care 20070901
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20070901
Title: [Epidemiology of genotypic resistance of HIV-1 in Valencia. A 4-year study].
Journal: Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20070901
Title: Development of therapeutics for AIDS: structure-based molecular targeting.
Journal: Tuberculosis (Edinburgh, Scotland) 20070801
Title: Darunavir: a second-generation protease inhibitor.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20070801
Title: Darunavir (TMC114): a new HIV-1 protease inhibitor.
Journal: Expert opinion on pharmacotherapy 20070801
Title: Trial of tipranavir versus darunavir in treatment-experienced patients enrolling.
Journal: AIDS patient care and STDs 20070801
Title: Darunavir: a nonpeptidic antiretroviral protease inhibitor.
Journal: Clinical therapeutics 20070801
Title: Review of tipranavir in the treatment of drug-resistant HIV.
Journal: Therapeutics and clinical risk management 20070801
Title: Pharmacokinetics and antiretroviral response to darunavir/ritonavir and etravirine combination in patients with high-level viral resistance.
Journal: AIDS (London, England) 20070711
Title: No patient left behind--better treatments for resistant HIV infection.
Journal: Lancet (London, England) 20070707
Title: Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomised, double-blind, placebo-controlled trial.
Journal: Lancet (London, England) 20070707
Title: Efficacy and safety of darunavir-ritonavir compared with that of lopinavir-ritonavir at 48 weeks in treatment-experienced, HIV-infected patients in TITAN: a randomised controlled phase III trial.
Journal: Lancet (London, England) 20070707
Title: A novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI), GRL-98065, is potent against multiple-PI-resistant human immunodeficiency virus in vitro.
Journal: Antimicrobial agents and chemotherapy 20070601
Title: Key amprenavir resistance mutations counteract dramatic efficacy of darunavir in highly experienced patients.
Journal: AIDS (London, England) 20070531
Title: Prediction of clinical benefits of ritonavir-boosted TMC114 from treatment effects on CD4 counts and HIV RNA.
Journal: HIV medicine 20070501
Title: Relative antiviral efficacy of ritonavir-boosted darunavir and ritonavir-boosted tipranavir vs. control protease inhibitor in the POWER and RESIST trials.
Journal: HIV medicine 20070501
Title: HIV-1 subtype B protease and reverse transcriptase amino acid covariation.
Journal: PLoS computational biology 20070501
Title: Tibotec and Aspen collaborate on Prezista.
Journal: AIDS patient care and STDs 20070501
Title: Darunavir: promising initial results.
Journal: Lancet (London, England) 20070407
Title: Efficacy and safety of darunavir-ritonavir at week 48 in treatment-experienced patients with HIV-1 infection in POWER 1 and 2: a pooled subgroup analysis of data from two randomised trials.
Journal: Lancet (London, England) 20070407
Title: Atomic resolution crystal structures of HIV-1 protease and mutants V82A and I84V with saquinavir.
Journal: Proteins 20070401
Title: The effect of different meal types on the pharmacokinetics of darunavir (TMC114)/ritonavir in HIV-negative healthy volunteers.
Journal: Journal of clinical pharmacology 20070401
Title: When and how to use tipranavir and darunavir.
Journal: The AIDS reader 20070401
Title: Consensus recommendation from a group of German experts for the use of enfuvirtide in heavily pretreated HIV patients.
Journal: European journal of medical research 20070326
Title: Darunavir: an overview of an HIV protease inhibitor developed to overcome drug resistance.
Journal: The AIDS reader 20070301
Title: Editorial comment: impact of darunavir for salvage therapy.
Journal: The AIDS reader 20070301
Title: Prezista gets EU approval.
Journal: AIDS patient care and STDs 20070301
Title: Resistance to newly approved and investigational protease inhibitors.
Journal: Current opinion in HIV and AIDS 20070301
Title: Efficacy and safety of TMC114/ritonavir in treatment-experienced HIV patients: 24-week results of POWER 1.
Journal: AIDS (London, England) 20070219
Title: Darunavir (TMC114) approved by the FDA.
Journal: AIDS alert 20070201
Title: A novel substrate-based HIV-1 protease inhibitor drug resistance mechanism.
Journal: PLoS medicine 20070101
Title: Anti-HIV agents. Darunavir and some antidepressants.
Journal: TreatmentUpdate 20070101
Title: Darunavir offers potent new combo when used with enfuvirtide in ritonavir-boosted regimen.
Journal: HIV clinician 20070101
Title: Key reports from the XV International HIV Drug Resistance Workshop 2006.
Journal: Antiviral therapy 20070101
Title: 48-week study results show DRV's staying power.
Journal: IAPAC monthly 20070101
Title: AIDS in the Third World: how to stop the HIV infection?
Journal: Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie 20070101
Title: Anti-HIV drugs.
Journal: Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie 20070101
Title: Antiretroviral treatment of HIV infection: Swedish recommendations 2007.
Journal: Scandinavian journal of infectious diseases 20070101
Title: Pharmacokinetics of darunavir (TMC114) and atazanavir during coadministration in HIV-negative, healthy volunteers.
Journal: Drugs in R&D 20070101
Title: Fast and simultaneous determination of darunavir and eleven other antiretroviral drugs for therapeutic drug monitoring: method development and validation for the determination of all currently approved HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in human plasma by liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
Journal: Rapid communications in mass spectrometry : RCM 20070101
Title: Analysis of treatment costs for HIV RNA reductions and CD4 increases for darunavir versus other antiretrovirals in treatment-experienced, HIV-infected patients.
Journal: HIV clinical trials 20070101
Title: Pharmacokinetic interaction between TMC114/r and efavirenz in healthy volunteers.
Journal: Antiviral therapy 20070101
Title: Pharmacokinetics of darunavir/ritonavir and TMC125 alone and coadministered in HIV-negative volunteers.
Journal: Antiviral therapy 20070101
Title: Clinical pharmacokinetics of darunavir.
Journal: Clinical pharmacokinetics 20070101
Title: Safety, tolerability, and efficacy of darunavir (TMC114) with low-dose ritonavir in treatment-experienced, hepatitis B or C co-infected patients in POWER 1 and 3.
Journal: HIV clinical trials 20070101
Title: Anti-HIV agents. Darunavir shows its strength.
Journal: TreatmentUpdate 20070101
Title: Analysis of costs by CD4 count category for the darunavir/r 600/100 mg bid and control protease inhibitor arms of the POWER 1 and 2 trials.
Journal: HIV clinical trials 20070101
Title: Darunavir: in the treatment of HIV-1 infection.
Journal: Drugs 20070101
Title: Darunavir in the treatment of HIV-1 infection: a viewpoint by Mark Holodniy.
Journal: Drugs 20070101
Title: Darunavir in the treatment of HIV-1 infection: a viewpoint by Renslow Sherer.
Journal: Drugs 20070101
Title: Enantioselective synthesis and selective monofunctionalization of (4R,6R)-4,6- dihydroxy-2,8-dioxabicyclo[3.3.0]octane.
Journal: Organic letters 20061207
Title: Screening and selecting for optimized antiretroviral drugs: rising to the challenge of drug resistance.
Journal: Current medical research and opinion 20061201
Title: British HIV Association (BHIVA) guidelines for the treatment of HIV-infected adults with antiretroviral therapy (2006).
Journal: HIV medicine 20061101
Title: XVI International AIDS Conference: Part 2.
Journal: The AIDS reader 20061101
Title: Clinical trials for heavily pretreated patients: update in 2006.
Journal: Current opinion in HIV and AIDS 20061101
Title: Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114.
Journal: Journal of molecular biology 20061013
Title: TMC114 approved for resistant patients.
Journal: AIDS patient care and STDs 20061001
Title: The latest in antiretroviral therapy.
Journal: Drug news & perspectives 20061001
Title: Darunavir (Prezista) for HIV infection.
Journal: The Medical letter on drugs and therapeutics 20060911
Title: Bis-tetrahydrofuran: a privileged ligand for darunavir and a new generation of hiv protease inhibitors that combat drug resistance.
Journal: ChemMedChem 20060901
Title: Management of the highly experienced patient.
Journal: Current opinion in HIV and AIDS 20060901
Title: Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance.
Journal: Journal of medicinal chemistry 20060824
Title: FDA approval: darunavir.
Journal: AIDS clinical care 20060801
Title: FDA clears HIV drug for patients with resistant virus.
Journal: The AIDS reader 20060801
Title: Successful rescue therapy with darunabir (TMC114) in HIV-infected patients who have failed several ritonavir-boosted protease inhibitors.
Journal: AIDS (London, England) 20060713
Title: Tribulations and trials in HIV disease, Part 2.
Journal: The AIDS reader 20060601
Title: The clinical pharmacology of antiretrovirals in development.
Journal: Expert opinion on drug metabolism & toxicology 20060601
Title: FDA approves new PI.
Journal: IAPAC monthly 20060601
Title: Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: the discovery of GW0385.
Journal: Bioorganic & medicinal chemistry letters 20060401
Title: Report from the 13th retrovirus conference. New data on TMC114 and TMC125.
Journal: AIDS clinical care 20060401
Title: Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M.
Journal: Journal of medicinal chemistry 20060223
Title: Prezista (darunavir, TMC-114) approved; may be important treatment advance.
Journal: AIDS treatment news 20060101
Title: Etravirine: R165335, TMC 125, TMC-125, TMC125.
Journal: Drugs in R&D 20060101
Title: New drugs: ranibizumab, posaconazole, and darunavir.
Journal: Journal of the American Pharmacists Association : JAPhA 20060101
Title: Anti-HIV agents. Darunavir shows its strength.
Journal: TreatmentUpdate 20060101
Title: Drug interactions. Interactions with TMC114 and TMC125.
Journal: TreatmentUpdate 20060101
Title: New HIV treatment.
Journal: FDA consumer 20060101
Title: Stereoselective and efficient synthesis of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol.
Journal: Organic letters 20051222
Title: [Protease inhibitors].
Journal: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 20051201
Title: Protease inhibitors: the current status.
Journal: Journal of HIV therapy 20051201
Title: Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
Journal: The FEBS journal 20051001
Title: HIV Pathogenesis and Treatment - Third International AIDS Society Conference.
Journal: IDrugs : the investigational drugs journal 20051001
Title: Meeting notes from the 3rd IAS Conference. New drugs.
Journal: AIDS clinical care 20051001
Title: New drugs.
Journal: HIV medicine 20050701
Title: TMC114/ritonavir substitution for protease inhibitor(s) in a non-suppressive antiretroviral regimen: a 14-day proof-of-principle trial.
Journal: AIDS (London, England) 20050610
Title: TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates.
Journal: Antimicrobial agents and chemotherapy 20050601
Title: Structure-based design: synthesis and biological evaluation of a series of novel cycloamide-derived HIV-1 protease inhibitors.
Journal: Journal of medicinal chemistry 20050519
Title: New PI may offer hope to triple class patients.
Journal: AIDS patient care and STDs 20050501
Title: [New drugs--hope for salvage patients?].
Journal: MMW Fortschritte der Medizin 20050425
Title: Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor.
Journal: Journal of medicinal chemistry 20050324
Title: Design of HIV-1 protease inhibitors active on multidrug-resistant virus.
Journal: Journal of medicinal chemistry 20050324
Title: Development of a capillary electrophoretic method for the separation of diastereoisomers of a new human immunodeficiency virus protease inhibitor.
Journal: Electrophoresis 20050201
Title: New protease inhibitor TMC-114. Preliminary 24-week late breaker results of the phase II trial.
Journal: Positively aware : the monthly journal of the Test Positive Aware Network 20050101
Title: A lame duck, a dark horse, and a goat.
Journal: GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies 20050101
Title: Anti-HIV agents. TMC114--an overview.
Journal: TreatmentUpdate 20050101
Title: Anti-HIV agents. Interactions with TMC114.
Journal: TreatmentUpdate 20050101
Title: Anti-HIV agents. What the future holds for TMC114.
Journal: TreatmentUpdate 20050101
Title: Stereoselective photochemical 1,3-dioxolane addition to 5-alkoxymethyl-2(5H)-furanone: synthesis of bis-tetrahydrofuranyl ligand for HIV protease inhibitor UIC-94017 (TMC-114).
Journal: The Journal of organic chemistry 20041112
Title: TMC-114 (Tibotec).
Journal: Current opinion in investigational drugs (London, England : 2000) 20040801
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20040501
Title: High resolution crystal structures of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) active against multi-drug-resistant clinical strains.
Journal: Journal of molecular biology 20040423
Title: Strategies for overcoming resistance in HIV-1 infected patients receiving HAART.
Journal: AIDS reviews 20040101
Title: Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro.
Journal: Antimicrobial agents and chemotherapy 20031001
Title: Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere.
Journal: Bioorganic & medicinal chemistry letters 19980317
Title: Dominique L N G Surleraux, et al. Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor. J Med Chem. 2005 Mar 24;48(6):1813-22.
Title: Yasuhiro Koh, et al. Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro. Antimicrob Agents Chemother. 2003 Oct;47(10):3123-9.
