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870843-42-8,MFCD11042274
Catalog No.:AA008FJD

870843-42-8 | E-2012

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Purity
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5mg
≥98%
in stock  
$139.00   $97.00
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10mg
≥98%
in stock  
$250.00   $175.00
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25mg
≥98%
in stock  
$586.00   $410.00
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50mg
≥98%(HPLC)
in stock  
$861.00   $603.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008FJD
Chemical Name:
E-2012
CAS Number:
870843-42-8
Molecular Formula:
C25H26FN3O2
Molecular Weight:
419.4912
MDL Number:
MFCD11042274
SMILES:
COc1cc(ccc1n1cnc(c1)C)/C=C/1\CCCN(C1=O)[C@H](c1ccc(cc1)F)C
Properties
Computed Properties
 
Complexity:
649  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
5  
XLogP3:
4.3  

Downstream Synthesis Route

[1]Patent:EP1950211,2008,A1.Locationinpatent:Page/Pagecolumn60

[1]Patent:EP1950211,2008,A1.Locationinpatent:Page/Pagecolumn56-57

[1]Patent:EP1950211,2008,A1.Locationinpatent:Page/Pagecolumn58-59

870837-18-6   
C31H30FNOP(1+)*I(1-) 
  870843-42-8 

[1]Patent:EP1950211,2008,A1.Locationinpatent:Page/Pagecolumn61

[1]Patent:EP1950211,2008,A1.Locationinpatent:Page/Pagecolumn62

Literature

Title: E2012-induced cataract and its predictive biomarkers.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20140101

Title: Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators.

Journal: Bioorganic & medicinal chemistry letters 20120415

Title: First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms.

Journal: The Journal of biological chemistry 20120406

Title: A canine model to evaluate efficacy and safety of γ-secretase inhibitors and modulators.

Journal: Journal of Alzheimer's disease : JAD 20120101

Title: Aminothiazoles as γ-secretase modulators.

Journal: Bioorganic & medicinal chemistry letters 20111101

Title: Acute effect on the Aβ isoform pattern in CSF in response to γ-secretase modulator and inhibitor treatment in dogs.

Journal: Journal of Alzheimer's disease : JAD 20100101

Title: Nakano-Ito K, et al. E2012-induced cataract and its predictive biomarkers. Toxicol Sci. 2014 Jan;137(1):249-58.

Title: Portelius E, Van Broeck B, Andreasson U, Gustavsson MK, Mercken M, Zetterberg H, Borghys H, Blennow K.Acute effect on the Aβ isoform pattern in CSF in response to γ-secretase modulator and inhibitor treatment in dogs.J Alzheimers Dis. 2010;21(3):1005-12.

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