85666-17-7,MFCD00058448
Catalog No.:AA008H1L

85666-17-7 | Furegrelate Sodium (U-63557A)

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥99%
in stock  
$82.00   $57.00
- +
10mg
≥99%
in stock  
$153.00   $107.00
- +
50mg
≥99%
in stock  
$625.00   $437.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA008H1L
Chemical Name:
Furegrelate Sodium (U-63557A)
CAS Number:
85666-17-7
Molecular Formula:
C15H10NNaO3
Molecular Weight:
275.2346
MDL Number:
MFCD00058448
SMILES:
[O-]C(=O)c1oc2c(c1)cc(cc2)Cc1cccnc1.[Na+]
Properties
Computed Properties
 
Complexity:
339  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Literature

Title: Kupffer cell depletion attenuates leptin-mediated methoxamine-stimulated portal perfusion pressure and thromboxane A2 release in a rodent model of NASH-cirrhosis.

Journal: Clinical science (London, England : 1979) 20121201

Title: Up-regulation of thromboxane A₂ impairs cerebrovascular eNOS function in aging atherosclerotic mice.

Journal: Pflugers Archiv : European journal of physiology 20110901

Title: Central mechanism underlying pressor and bradycardic effect of intracerebroventricularly injected arachidonic acid.

Journal: Canadian journal of physiology and pharmacology 20110201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Role of prostanoid production and receptors in the regulation of retinal endogenous amino acid neurotransmitters by 8-isoprostaglandin E2, ex vivo.

Journal: Neurochemical research 20091201

Title: Ovariectomy increases the formation of prostanoids and modulates their role in acetylcholine-induced relaxation and nitric oxide release in the rat aorta.

Journal: Cardiovascular research 20091101

Title: Inhibition of invasion-associated thromboxane synthase sensitizes experimental gliomas to gamma-radiation.

Journal: Journal of neuro-oncology 20090201

Title: Hypertension increases contractile responses to hydrogen peroxide in resistance arteries through increased thromboxane A2, Ca2+, and superoxide anion levels.

Journal: The Journal of pharmacology and experimental therapeutics 20090101

Title: Centrally administered neuromedin U elevates plasma adrenaline by brain prostanoid TP receptor-mediated mechanisms in rats.

Journal: European journal of pharmacology 20080911

Title: Orchidectomy increases the formation of non-endothelial thromboxane A2 and modulates its role in the electrical field stimulation-induced response in rat mesenteric artery.

Journal: The Journal of endocrinology 20080501

Title: Involvement of COX-1 in A3 adenosine receptor-mediated contraction through endothelium in mice aorta.

Journal: American journal of physiology. Heart and circulatory physiology 20071201

Title: A change in the redox environment and thromboxane A2 production precede endothelial dysfunction in mice.

Journal: American journal of physiology. Heart and circulatory physiology 20071001

Title: Dexamethasone decreases contraction to electrical field stimulation in mesenteric arteries from spontaneously hypertensive rats through decreases in thromboxane A2 release.

Journal: The Journal of pharmacology and experimental therapeutics 20070901

Title: Adrenal adrenaline- and noradrenaline-containing cells and celiac sympathetic ganglia are differentially controlled by centrally administered corticotropin-releasing factor and arginine-vasopressin in rats.

Journal: European journal of pharmacology 20070614

Title: Centrally administered histamine evokes the adrenal secretion of noradrenaline and adrenaline by brain cyclooxygenase-1- and thromboxane A2-mediated mechanisms in rats.

Journal: European journal of pharmacology 20060717

Title: The role of the central thromboxane A2 in cardiovascular effects of a phospholipase A2 activator melittin administrated intracerebroventricularly in normotensive conscious rats.

Journal: Neuropeptides 20060601

Title: Involvement of brain thromboxane A in hypotension induced by haemorrhage in rats.

Journal: Clinical and experimental pharmacology & physiology 20051101

Title: Testosterone treatment increases thromboxane function in rat cerebral arteries.

Journal: American journal of physiology. Heart and circulatory physiology 20050801

Title: Brain prostanoid TP receptor-mediated adrenal noradrenaline secretion and EP3 receptor-mediated sympathetic noradrenaline release in rats.

Journal: European journal of pharmacology 20050404

Title: Thromboxane A2 from Kupffer cells contributes to the hyperresponsiveness of hepatic portal circulation to endothelin-1 in endotoxemic rats.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20050201

Title: Gender difference in response to thromboxane A2/prostaglandin H2 receptor antagonism in spontaneously hypertensive rats.

Journal: Gender medicine 20041201

Title: Inhibition of the arachidonic acid metabolism blocks endothelial cell migration and induces apoptosis.

Journal: Acta neurochirurgica 20040501

Title: Inhibition of prostaglandin D2 clearance in rat hepatocytes by the thromboxane receptor antagonists daltroban and ifetroban and the thromboxane synthase inhibitor furegrelate.

Journal: Biochemical pharmacology 20030815

Title: Role of brain thromboxane A2 in the release of noradrenaline and adrenaline from adrenal medulla in rats.

Journal: European journal of pharmacology 20030425

Title: Angiotensin II constriction of rat vasa recta is partially thromboxane dependent.

Journal: Hypertension (Dallas, Tex. : 1979) 20021001

Title: Indomethacin protects permeability barrier from focal segmental glomerulosclerosis serum.

Journal: Kidney international 20020201

Title: Effects of selective cyclooxygenase-2 inhibition on vascular responses and thrombosis in canine coronary arteries.

Journal: Circulation 20010814

Title: In vitro modulation of interleukin-1 beta secretion by cultured rat doxorubicin-stimulated whole glomeruli and dissociated mesangial glomerular cells.

Journal: Immunology 19940101

Title: Gorman RR, et al. Inhibition of platelet thromboxane A2 synthase activity by sodium 5-(3'-pyridinylmethyl)benzofuran-2-carboxylate. Prostaglandins. 1983 Aug;26(2):325-42.

Title: Hirenallur-S DK, et al. Furegrelate, a thromboxane synthase inhibitor, blunts the development of pulmonary arterial hypertension in neonatal piglets. Pulm Circ. 2012 Apr-Jun;2(2):193-200.

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SDS
Related Products of 85666-17-7
Tags:85666-17-7 Molecular Formula|85666-17-7 MDL|85666-17-7 SMILES|85666-17-7 Furegrelate Sodium (U-63557A)
Catalog No.: AA008H1L
85666-17-7,MFCD00058448
85666-17-7 | Furegrelate Sodium (U-63557A)
Pack Size: 5mg
Purity: ≥99%
in stock
$82.00 $57.00
Pack Size: 10mg
Purity: ≥99%
in stock
$153.00 $107.00
Pack Size: 50mg
Purity: ≥99%
in stock
$625.00 $437.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA008H1L
Chemical Name: Furegrelate Sodium (U-63557A)
CAS Number: 85666-17-7
Molecular Formula: C15H10NNaO3
Molecular Weight: 275.2346
MDL Number: MFCD00058448
SMILES: [O-]C(=O)c1oc2c(c1)cc(cc2)Cc1cccnc1.[Na+]
Properties
Complexity: 339  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 20  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 3  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
Literature fold

Title: Kupffer cell depletion attenuates leptin-mediated methoxamine-stimulated portal perfusion pressure and thromboxane A2 release in a rodent model of NASH-cirrhosis.

Journal: Clinical science (London, England : 1979)20121201

Title: Up-regulation of thromboxane A₂ impairs cerebrovascular eNOS function in aging atherosclerotic mice.

Journal: Pflugers Archiv : European journal of physiology20110901

Title: Central mechanism underlying pressor and bradycardic effect of intracerebroventricularly injected arachidonic acid.

Journal: Canadian journal of physiology and pharmacology20110201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Role of prostanoid production and receptors in the regulation of retinal endogenous amino acid neurotransmitters by 8-isoprostaglandin E2, ex vivo.

Journal: Neurochemical research20091201

Title: Ovariectomy increases the formation of prostanoids and modulates their role in acetylcholine-induced relaxation and nitric oxide release in the rat aorta.

Journal: Cardiovascular research20091101

Title: Inhibition of invasion-associated thromboxane synthase sensitizes experimental gliomas to gamma-radiation.

Journal: Journal of neuro-oncology20090201

Title: Hypertension increases contractile responses to hydrogen peroxide in resistance arteries through increased thromboxane A2, Ca2+, and superoxide anion levels.

Journal: The Journal of pharmacology and experimental therapeutics20090101

Title: Centrally administered neuromedin U elevates plasma adrenaline by brain prostanoid TP receptor-mediated mechanisms in rats.

Journal: European journal of pharmacology20080911

Title: Orchidectomy increases the formation of non-endothelial thromboxane A2 and modulates its role in the electrical field stimulation-induced response in rat mesenteric artery.

Journal: The Journal of endocrinology20080501

Title: Involvement of COX-1 in A3 adenosine receptor-mediated contraction through endothelium in mice aorta.

Journal: American journal of physiology. Heart and circulatory physiology20071201

Title: A change in the redox environment and thromboxane A2 production precede endothelial dysfunction in mice.

Journal: American journal of physiology. Heart and circulatory physiology20071001

Title: Dexamethasone decreases contraction to electrical field stimulation in mesenteric arteries from spontaneously hypertensive rats through decreases in thromboxane A2 release.

Journal: The Journal of pharmacology and experimental therapeutics20070901

Title: Adrenal adrenaline- and noradrenaline-containing cells and celiac sympathetic ganglia are differentially controlled by centrally administered corticotropin-releasing factor and arginine-vasopressin in rats.

Journal: European journal of pharmacology20070614

Title: Centrally administered histamine evokes the adrenal secretion of noradrenaline and adrenaline by brain cyclooxygenase-1- and thromboxane A2-mediated mechanisms in rats.

Journal: European journal of pharmacology20060717

Title: The role of the central thromboxane A2 in cardiovascular effects of a phospholipase A2 activator melittin administrated intracerebroventricularly in normotensive conscious rats.

Journal: Neuropeptides20060601

Title: Involvement of brain thromboxane A in hypotension induced by haemorrhage in rats.

Journal: Clinical and experimental pharmacology & physiology20051101

Title: Testosterone treatment increases thromboxane function in rat cerebral arteries.

Journal: American journal of physiology. Heart and circulatory physiology20050801

Title: Brain prostanoid TP receptor-mediated adrenal noradrenaline secretion and EP3 receptor-mediated sympathetic noradrenaline release in rats.

Journal: European journal of pharmacology20050404

Title: Thromboxane A2 from Kupffer cells contributes to the hyperresponsiveness of hepatic portal circulation to endothelin-1 in endotoxemic rats.

Journal: American journal of physiology. Gastrointestinal and liver physiology20050201

Title: Gender difference in response to thromboxane A2/prostaglandin H2 receptor antagonism in spontaneously hypertensive rats.

Journal: Gender medicine20041201

Title: Inhibition of the arachidonic acid metabolism blocks endothelial cell migration and induces apoptosis.

Journal: Acta neurochirurgica20040501

Title: Inhibition of prostaglandin D2 clearance in rat hepatocytes by the thromboxane receptor antagonists daltroban and ifetroban and the thromboxane synthase inhibitor furegrelate.

Journal: Biochemical pharmacology20030815

Title: Role of brain thromboxane A2 in the release of noradrenaline and adrenaline from adrenal medulla in rats.

Journal: European journal of pharmacology20030425

Title: Angiotensin II constriction of rat vasa recta is partially thromboxane dependent.

Journal: Hypertension (Dallas, Tex. : 1979)20021001

Title: Indomethacin protects permeability barrier from focal segmental glomerulosclerosis serum.

Journal: Kidney international20020201

Title: Effects of selective cyclooxygenase-2 inhibition on vascular responses and thrombosis in canine coronary arteries.

Journal: Circulation20010814

Title: In vitro modulation of interleukin-1 beta secretion by cultured rat doxorubicin-stimulated whole glomeruli and dissociated mesangial glomerular cells.

Journal: Immunology19940101

Title: Gorman RR, et al. Inhibition of platelet thromboxane A2 synthase activity by sodium 5-(3'-pyridinylmethyl)benzofuran-2-carboxylate. Prostaglandins. 1983 Aug;26(2):325-42.

Title: Hirenallur-S DK, et al. Furegrelate, a thromboxane synthase inhibitor, blunts the development of pulmonary arterial hypertension in neonatal piglets. Pulm Circ. 2012 Apr-Jun;2(2):193-200.

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