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81117-35-3,MFCD00905846
Catalog No.:AA008L3U

81117-35-3 | N-(n-Nonyl)deoxynojirimycin

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1mg
≥98%
in stock  
$52.00   $36.00
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5mg
≥98%
in stock  
$222.00   $155.00
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10mg
≥98%
in stock  
$342.00   $239.00
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25mg
≥98%
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$670.00   $469.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008L3U
Chemical Name:
N-(n-Nonyl)deoxynojirimycin
CAS Number:
81117-35-3
Molecular Formula:
C15H31NO4
Molecular Weight:
289.4109
MDL Number:
MFCD00905846
SMILES:
CCCCCCCCCN1C[C@H](O)[C@H]([C@@H]([C@H]1CO)O)O
Properties
Computed Properties
 
Complexity:
252  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
9  
XLogP3:
2.1  

Literature

Title: Conformationally-locked N-glycosides with selective β-glucosidase inhibitory activity: identification of a new non-iminosugar-type pharmacological chaperone for Gaucher disease.

Journal: Journal of medicinal chemistry 20120809

Title: Design, synthesis, and biological evaluation of N-alkylated deoxynojirimycin (DNJ) derivatives for the treatment of dengue virus infection.

Journal: Journal of medicinal chemistry 20120712

Title: Potent aminocyclitol glucocerebrosidase inhibitors are subnanomolar pharmacological chaperones for treating gaucher disease.

Journal: Journal of medicinal chemistry 20120510

Title: Synthesis of N-substituted ε-hexonolactams as pharmacological chaperones for the treatment of N370S mutant Gaucher disease.

Journal: Organic & biomolecular chemistry 20120421

Title: The many faces of the adamantyl group in drug design.

Journal: European journal of medicinal chemistry 20110601

Title: New glucocerebrosidase inhibitors by exploration of chemical diversity of N-substituted aminocyclitols using click chemistry and in situ screening.

Journal: Journal of medicinal chemistry 20110414

Title: Synthesis of N-alkylated noeurostegines and evaluation of their potential as treatment for Gaucher's disease.

Journal: Bioorganic & medicinal chemistry letters 20110301

Title: Glucosidase inhibition enhances presentation of de-N-glycosylated hepatitis B virus epitopes by major histocompatibility complex class I in vitro and in woodchucks.

Journal: Hepatology (Baltimore, Md.) 20101001

Title: Click chemistry approach to new N-substituted aminocyclitols as potential pharmacological chaperones for Gaucher disease.

Journal: Journal of medicinal chemistry 20100722

Title: Chaperone activity of bicyclic nojirimycin analogues for Gaucher mutations in comparison with N-(n-nonyl)deoxynojirimycin.

Journal: Chembiochem : a European journal of chemical biology 20091123

Title: Promising results of the chaperone effect caused by imino sugars and aminocyclitol derivatives on mutant glucocerebrosidases causing Gaucher disease.

Journal: Blood cells, molecules & diseases 20090101

Title: Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel.

Journal: Hepatology (Baltimore, Md.) 20081201

Title: A dengue fever viremia model in mice shows reduction in viral replication and suppression of the inflammatory response after treatment with antiviral drugs.

Journal: The Journal of infectious diseases 20070301

Title: Action of celgosivir (6 O-butanoyl castanospermine) against the pestivirus BVDV: implications for the treatment of hepatitis C.

Journal: Antiviral chemistry & chemotherapy 20040501

Title: Inhibition of glycogen breakdown by imino sugars in vitro and in vivo.

Journal: Biochemical pharmacology 20040215

Title: Imino sugars that are less toxic but more potent as antivirals, in vitro, compared with N-n-nonyl DNJ.

Journal: Antiviral chemistry & chemotherapy 20020901

Title: Inhibition of hepatitis B virus DNA replication by imino sugars without the inhibition of the DNA polymerase: therapeutic implications.

Journal: Hepatology (Baltimore, Md.) 20010601

Title: Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: implications for the development of broad spectrum anti-hepatitis virus agents.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19991012

Title: Andersson U, et al. Inhibition of glycogen breakdown by imino sugars in vitro and in vivo. Biochem Pharmacol. 2004 Feb 15;67(4):697-705.

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