Name: Name:JZL 195
Brand: AABLOCKS
SKU: AA008SP9
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA008SP9

Chemical Name: JZL 195

CAS Number: 1210004-12-8

Molecular Formula: C24H24ClN3O5

Molecular Weight: 469.9175

MDL Number: MFCD18382122

SMILES: O=C(N1CCN(CC1)Cc1cccc(c1)Oc1ccccc1)Oc1ccc(cc1)[N+](=O)[O-].Cl

Properties

Complexity: 605

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 32

Hydrogen Bond Acceptor Count: 6

Hydrogen Bond Donor Count: 0

Isotope Atom Count: 0

Rotatable Bond Count: 6

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 4.3

Literature fold

Title: Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine neuropathic pain model.

Journal: British journal of pharmacology20160101

Title: Full Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimimetic Side Effects in Mice.

Journal: The Journal of pharmacology and experimental therapeutics20150801

Title: The effect of FAAH, MAGL, and Dual FAAH/MAGL inhibition on inflammatory and colorectal distension-induced visceral pain models in Rodents.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society20150701

Title: A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity.

Journal: Nature chemical biology20140801

Title: Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model.

Journal: Neuropharmacology20140601

Title: Assay and inhibition of diacylglycerol lipase activity.

Journal: Bioorganic & medicinal chemistry letters20120715

Title: Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases.

Journal: Journal of medicinal chemistry20100225

Title: Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo.

Journal: Proceedings of the National Academy of Sciences of the United States of America20091201

Title: Long JZ, et al. Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20270-5.

Title: Anderson WB, et al. Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model. Neuropharmacology. 2014 Jun;81:224-30.

1210004-12-8 | JZL 195