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112362-50-2,MFCD00895414
Catalog No.:AA008T0Y

112362-50-2 | Dalfopristin

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Purity
Availability
Price(USD)
Quantity
  
1mg
98%(mixture of isomers)
in stock  
$499.00   $349.00
- +
5mg
98%(mixture of isomers)
in stock  
$1,559.00   $1,092.00
- +
25mg
98%(mixture of isomers)
in stock  
$6,816.00   $4,772.00
- +
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008T0Y
Chemical Name:
Dalfopristin
CAS Number:
112362-50-2
Molecular Formula:
C34H50N4O9S
Molecular Weight:
690.8472
MDL Number:
MFCD00895414
SMILES:
CCN(CCS(=O)(=O)[C@@H]1CCN2[C@H]1C(=O)O[C@@H](C(C)C)[C@H](C)/C=C/C(=O)NC/C=C\C(=C\[C@H](CC(=O)Cc1nc(C2=O)co1)O)\C)CC
Properties
Computed Properties
 
Complexity:
1340  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Defined Bond Stereocenter Count:
3  
Heavy Atom Count:
48  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
2.2  

Literature

Title: [In vitro activities of quinupristin/dalfopristin in combination with vancomycin and gatifloxacin against Staphylococcus aureus and Enterococcus faecium clinical isolates].

Journal: Mikrobiyoloji bulteni 20090101

Title: New treatment options and protocols for peritoneal dialysis-related peritonitis.

Journal: Contributions to nephrology 20090101

Title: [Persistent bacteremia caused by methicillin-resistant Staphylococcus aureus].

Journal: Enfermedades infecciosas y microbiologia clinica 20081101

Title: A comparative in-vitro evaluation of resistance selection after exposure to teicoplanin, vancomycin, linezolid and quinupristin-dalfopristin in Staphylococcus aureus and Enterococcus spp.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20080601

Title: Transposon characterization of vancomycin-resistant Enterococcus faecium (VREF) and dissemination of resistance associated with transferable plasmids.

Journal: The Journal of antimicrobial chemotherapy 20070801

Title: [Therapeutic perspectives of linezolid in the management of infections due to multiresistant Gram-positive pathogens].

Journal: Recenti progressi in medicina 20070301

Title: In vitro activity of antimicrobial agents against oxacillin resistant staphylococci with special reference to Staphylococcus haemolyticus.

Journal: Indian journal of medical microbiology 20070101

Title: Quinupristin/dalfopristin and voriconazole controlled Staphylococcus epidermidis pneumonia and chronic necrotizing aspergillosis in a patient with severe lung degradation consequent to multiple treatments for Hodgkin's lymphoma.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20061201

Title: Prevalence of macrolide resistance genes among staphylococci in Cyprus.

Journal: Journal of chemotherapy (Florence, Italy) 20061001

Title: Emergence of Enterococcus faecalis susceptible to quinupristin/dalfopristin in Greece.

Journal: International journal of antimicrobial agents 20060801

Title: Antimicrobial susceptibility and molecular analysis of Enterococcus faecalis originating from endodontic infections in Finland and Lithuania.

Journal: Oral microbiology and immunology 20060601

Title: In vitro activity of quinupristin and dalfopristin in combination and alone against coryneform bacteria.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20051101

Title: In-vitro activity of quinupristin/dalfopristin, levofloxacin and moxifloxacin against fusidic acid and rifampicin-resistant strains of methicillin-resistant Staphylococcus aureus (MRSA) from Malaysian hospitals.

Journal: The Medical journal of Malaysia 20051001

Title: Emergence of Staphylococcus hominis strains expressing low-level resistance to quinupristin/dalfopristin in Greece.

Journal: The Journal of antimicrobial chemotherapy 20050501

Title: In vitro activities of cefotaxime, vancomycin, quinupristin/dalfopristin, linezolid and other antibiotics alone and in combination against Propionibacterium acnes isolates from central nervous system infections.

Journal: The Journal of antimicrobial chemotherapy 20050201

Title: In vitro activity of linezolid & quinupristin/dalfopristin against Gram-positive cocci.

Journal: The Indian journal of medical research 20041201

Title: In vitro activity of telithromycin, quinupristin/dalfopristin, linezolid and comparator antimicrobial agents against Staphylococcus aureus clinical isolates.

Journal: Journal of chemotherapy (Florence, Italy) 20040601

Title: Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin.

Journal: BMC biology 20040101

Title: Sequence and genetic organization of the 19.3-kb erythromycin- and dalfopristin-resistance plasmid pLME300 from Lactobacillus fermentum ROT1.

Journal: Plasmid 20031101

Title: What is the role of streptogramins in intensive care?

Journal: Journal of chemotherapy (Florence, Italy) 20031101

Title: Role of quinupristin/dalfopristin in the treatment of Gram-positive nosocomial infections in haematological or oncological patients.

Journal: Cancer treatment reviews 20031001

Title: Quinupristin/dalfopristin-induced Sweet's syndrome.

Journal: The Korean journal of internal medicine 20030901

Title: Structural basis of Synercid (quinupristin-dalfopristin) resistance in Gram-positive bacterial pathogens.

Journal: The Journal of biological chemistry 20030808

Title: Endocarditis due to vancomycin-resistant Enterococcus faecium in an immunocompromised patient: cure by administering combination therapy with quinupristin/dalfopristin and high-dose ampicillin.

Journal: Southern medical journal 20030801

Title: Activities of therapeutic agents against Naegleria fowleri in vitro and in a mouse model of primary amebic meningoencephalitis.

Journal: The Journal of parasitology 20030801

Title: Treatment of central nervous system infection by vancomycin-resistant enterococcus faecium.

Journal: Diagnostic microbiology and infectious disease 20030301

Title: [Other antimicrobial agents (linezolid, quinupristin/dalfopristin, glycylcycline etc)].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20030301

Title: [Other antimicrobials (linezolid, quinupristin/dalfopristin)].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20030201

Title: Treatment of life-threatening multiresistant staphylococcal and enterococcal infections in patients with end-stage renal failure with quinupristin/dalfopristin: preliminary report.

Journal: Infection 20021001

Title: Comparative in vitro activity of penicillin G, levofloxacin, moxifloxacin, telithromycin, pristinamycin, quinupristin-dalfopristin and linezolid against ofloxacin-intermediate and -resistant Streptococcus pneumoniae.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20021001

Title: Safety and efficacy of quinupristin/dalfopristin for treatment of invasive Gram-positive infections in pediatric patients.

Journal: The Pediatric infectious disease journal 20021001

Title: Quinupristin/dalfopristin.

Journal: Expert opinion on pharmacotherapy 20020901

Title: Clinical experience with quinupristin-dalfopristin as rescue treatment of critically ill patients infected with methicillin-resistant staphylococci.

Journal: Intensive care medicine 20020801

Title: Combination of quinupristin/dalfopristin and glycopeptide in severe methicillin-resistant staphylococcal infections failing previous glycopeptide regimens.

Journal: Infection 20020601

Title: [symbol: see text]Quinupristin + dalfopristin for infections.

Journal: Drug and therapeutics bulletin 20020201

Title: Quinupristin-dalfopristin: a new antibiotic for severe gram-positive infections.

Journal: American family physician 20011201

Title: Quinupristin-dalfopristin-resistant Enterococcus faecium on chicken and in human stool specimens.

Journal: The New England journal of medicine 20011018

Title: Antibiotic resistance rates and macrolide resistance phenotypes of viridans group streptococci from the oropharynx of healthy Greek children.

Journal: International journal of antimicrobial agents 20010301

Title: Antistaphylococcal (MSSA, MRSA, MSSE, MRSE) antibiotics.

Journal: The Medical clinics of North America 20010101

Title: Quinupristin/dalfopristin: a therapeutic review.

Journal: Clinical therapeutics 20010101

Title: Macrolide resistance in Streptococcus pyogenes isolates from throat infections in the region of Aachen, Germany.

Journal: Microbial drug resistance (Larchmont, N.Y.) 20010101

Title: Quinupristin/dalfopristin and linezolid: spectrum of activity and potential roles in therapy--a status report.

Journal: Current clinical topics in infectious diseases 20010101

Title: [Quinupristin/dalfopristin].

Journal: Revista de medicina de la Universidad de Navarra 20010101

Title: Quinupristin/dalfopristin: a review of its use in the management of serious gram-positive infections.

Journal: Drugs 19991201

Title: Quinupristin-dalfopristin is active against Toxoplasma gondii.

Journal: Antimicrobial agents and chemotherapy 19990801

Title: Wang S, et al. Characteristic of Enterococcus faecium clinical isolates with quinupristin/Dalfopristin resistance in China. BMC Microbiol. 2016 Oct 21;16(1):246.

Title: Sacar M, et al. Comparison of antimicrobial agents as therapy for experimental endocarditis: caused by methicillin-resistant Staphylococcus aureus. Tex Heart Inst J. 2010;37(4):400-4.

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