Home Other Building Blocks 1129669-05-1
1129669-05-1,MFCD20527313
Catalog No.:AA008SQC

1129669-05-1 | Im-12

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$18.00   $13.00
- +
5mg
98%
in stock  
$45.00   $32.00
- +
10mg
98%
in stock  
$66.00   $47.00
- +
100mg
98%
in stock  
$320.00   $224.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008SQC
Chemical Name:
Im-12
CAS Number:
1129669-05-1
Molecular Formula:
C22H20FN3O2
Molecular Weight:
377.4115
MDL Number:
MFCD20527313
SMILES:
Fc1ccc(cc1)CCNC1=C(C(=O)N(C1=O)C)c1c(C)[nH]c2c1cccc2
Properties
Computed Properties
 
Complexity:
656  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
3.9  

Upstream Synthesis Route

[1]BioorganicandMedicinalChemistry,2010,vol.18,#18,p.6785-6795

[2]EuropeanJournalofOrganicChemistry,2009,#1,p.38-42

[1]EuropeanJournalofOrganicChemistry,2009,#1,p.38-42

Literature

Title: Roles of glycogen synthase kinase 3 in Alzheimer's disease.

Journal: Current Alzheimer research 20120901

Title: Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120523

Title: Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells.

Journal: Bioorganic & medicinal chemistry 20100915

Title: Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth.

Journal: Cell 20041001

Title: Increased neuronal production, enlarged forebrains and cytoarchitectural distortions in beta-catenin overexpressing transgenic mice.

Journal: Cerebral cortex (New York, N.Y. : 1991) 20030601

Title: The status of Wnt signalling regulates neural and epidermal fates in the chick embryo.

Journal: Nature 20010517

Title: Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling.

Journal: Cell 20000303

Title: Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.

Journal: Diabetes 20000201

Title: Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice.

Journal: Diabetes 19990801

Title: Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19930815

Title: Schmole AC, et al. Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells. Bioorg Med Chem. 2010 Sep 15;18(18):6785-95.

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Tags:1129669-05-1 Molecular Formula|1129669-05-1 MDL|1129669-05-1 SMILES|1129669-05-1 Im-12