Name: Name:Im-12
Brand: AABLOCKS
SKU: AA008SQC
Rating: 90 (10 reviews)

Catalog No.: AA008SQC

1129669-05-1 | Im-12

Pack Size： 1mg

Purity： 98%

in stock

$19.00 $13.00

Pack Size： 5mg

Purity： 98%

in stock

$46.00 $32.00

Pack Size： 10mg

Purity： 98%

in stock

$67.00 $47.00

Pack Size： 100mg

Purity： 98%

in stock

$324.00 $227.00

Quantity

- +

Add to Card

Order Now

bulk Quotation Request

Technical Information

Catalog Number: AA008SQC

Chemical Name: Im-12

CAS Number: 1129669-05-1

Molecular Formula: C22H20FN3O2

Molecular Weight: 377.4115

MDL Number: MFCD20527313

SMILES: Fc1ccc(cc1)CCNC1=C(C(=O)N(C1=O)C)c1c(C)[nH]c2c1cccc2

Properties

Complexity: 656

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 28

Hydrogen Bond Acceptor Count: 4

Hydrogen Bond Donor Count: 2

Isotope Atom Count: 0

Rotatable Bond Count: 5

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 3.9

Upstream Synthesis Route

885701-91-7

1583-88-6

1129669-05-1

[1]BioorganicandMedicinalChemistry,2010,vol.18,#18,p.6785-6795

[2]EuropeanJournalofOrganicChemistry,2009,#1,p.38-42

885701-91-7

201230-82-2

1583-88-6

1129669-05-1

1129668-95-6

[1]EuropeanJournalofOrganicChemistry,2009,#1,p.38-42

Literature fold

Title: Roles of glycogen synthase kinase 3 in Alzheimer's disease.

Journal: Current Alzheimer research20120901

Title: Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20120523

Title: Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells.

Journal: Bioorganic & medicinal chemistry20100915

Title: Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth.

Journal: Cell20041001

Title: Increased neuronal production, enlarged forebrains and cytoarchitectural distortions in beta-catenin overexpressing transgenic mice.

Journal: Cerebral cortex (New York, N.Y. : 1991)20030601

Title: The status of Wnt signalling regulates neural and epidermal fates in the chick embryo.

Journal: Nature20010517

Title: Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling.

Journal: Cell20000303

Title: Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.

Journal: Diabetes20000201

Title: Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice.

Journal: Diabetes19990801

Title: Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity.

Journal: Proceedings of the National Academy of Sciences of the United States of America19930815

Title: Schmole AC, et al. Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells. Bioorg Med Chem. 2010 Sep 15;18(18):6785-95.

Building Blocks More >

106658-10-0

iso-Propyl-d7-amine HCl

AA008SVZ | MFCD01073930

108646-71-5

Ac-met(o)-oh

AA008T47 | MFCD00236766

1186486-62-3

Evacetrapib (LY2484595)

AA008TDD | MFCD23105886

114899-77-3

Trabectedin

AA008THI | MFCD00874849

104391-26-6

CGP 25454A

AA008TLU | MFCD30343854

1119899-37-4

7-Cyanobenzo[b]thiophen-2-ylboronic acid

AA008TSS | MFCD16877453

1105187-44-7

4-(3-Bromophenyl)pyrrolidin-2-one

AA008U2V | MFCD11846198

1070879-29-6

4-Bromo-7-fluoroquinoline

AA008UBA | MFCD08063190

119290-61-8

Dl-phenylalanine benzyl ester 4-toluenesulfonate salt

AA008ULK | MFCD00035105

1189586-14-8

Dde-l-lys(boc)-oh

AA008UWO | MFCD05663747