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1094873-14-9,MFCD18782744
Catalog No.:AA008SQJ

1094873-14-9 | Jnj-31020028

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$13.00   $9.00
- +
5mg
98%
in stock  
$30.00   $21.00
- +
10mg
98%
in stock  
$46.00   $32.00
- +
25mg
98%
in stock  
$75.00   $53.00
- +
50mg
98%
in stock  
$126.00   $88.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA008SQJ
Chemical Name:
Jnj-31020028
CAS Number:
1094873-14-9
Molecular Formula:
C34H36FN5O2
Molecular Weight:
565.6803
MDL Number:
MFCD18782744
SMILES:
CCN(C(=O)C(c1ccccc1)N1CCN(CC1)c1ccc(cc1F)NC(=O)c1ccccc1c1cccnc1)CC
Properties
Computed Properties
 
Complexity:
857  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
42  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
9  
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0  
XLogP3:
5.3  

Literature

Title: Anorectic response to the trichothecene T-2 toxin correspond to plasma elevations of the satiety hormone glucose-dependent insulinotropic polypeptide and peptide YY(3-36).

Journal: Toxicology 20180601

Title: Role of Y(2) receptors in the regulation of gastric tone in rats.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20120401

Title: Effects of a selective Y2R antagonist, JNJ-31020028, on nicotine abstinence-related social anxiety-like behavior, neuropeptide Y and corticotropin releasing factor mRNA levels in the novelty-seeking phenotype.

Journal: Behavioural brain research 20110923

Title: The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y₂ receptor.

Journal: Bioorganic & medicinal chemistry letters 20110915

Title: The novel, selective, brain-penetrant neuropeptide Y Y2 receptor antagonist, JNJ-31020028, tested in animal models of alcohol consumption, relapse, and anxiety.

Journal: Alcohol (Fayetteville, N.Y.) 20110901

Title: In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptor.

Journal: Psychopharmacology 20100201

Title: Correlation of 14C-griseofulvin metabolism in rat liver microsomes, isolated perfused rat livers, and in rats with bile duct cannulas.

Journal: Drug metabolism and disposition: the biological fate of chemicals 19750101

Title: Shoblock JR, et al. In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4--(diethylamino)-2-oxo-1-phenylethylpiperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptor. Psychopharmacology (Berl). 2010 Feb;208(2):265-77.

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Tags:1094873-14-9 Molecular Formula|1094873-14-9 MDL|1094873-14-9 SMILES|1094873-14-9 Jnj-31020028
Catalog No.: AA008SQJ
1094873-14-9,MFCD18782744
1094873-14-9 | Jnj-31020028
Pack Size： 1mg
Purity： 98%
in stock
$13.00 $9.00
Pack Size： 5mg
Purity： 98%
in stock
$30.00 $21.00
Pack Size： 10mg
Purity： 98%
in stock
$46.00 $32.00
Pack Size： 25mg
Purity： 98%
in stock
$75.00 $53.00
Pack Size： 50mg
Purity： 98%
in stock
$126.00 $88.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA008SQJ
Chemical Name: Jnj-31020028
CAS Number: 1094873-14-9
Molecular Formula: C34H36FN5O2
Molecular Weight: 565.6803
MDL Number: MFCD18782744
SMILES: CCN(C(=O)C(c1ccccc1)N1CCN(CC1)c1ccc(cc1F)NC(=O)c1ccccc1c1cccnc1)CC
Properties
Complexity: 857  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 42  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 9  
Undefined Atom Stereocenter Count: 1  
Undefined Bond Stereocenter Count: 0  
XLogP3: 5.3  
Literature fold

Title: Anorectic response to the trichothecene T-2 toxin correspond to plasma elevations of the satiety hormone glucose-dependent insulinotropic polypeptide and peptide YY(3-36).

Journal: Toxicology20180601

Title: Role of Y(2) receptors in the regulation of gastric tone in rats.

Journal: American journal of physiology. Gastrointestinal and liver physiology20120401

Title: Effects of a selective Y2R antagonist, JNJ-31020028, on nicotine abstinence-related social anxiety-like behavior, neuropeptide Y and corticotropin releasing factor mRNA levels in the novelty-seeking phenotype.

Journal: Behavioural brain research20110923

Title: The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y₂ receptor.

Journal: Bioorganic & medicinal chemistry letters20110915

Title: The novel, selective, brain-penetrant neuropeptide Y Y2 receptor antagonist, JNJ-31020028, tested in animal models of alcohol consumption, relapse, and anxiety.

Journal: Alcohol (Fayetteville, N.Y.)20110901

Title: In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptor.

Journal: Psychopharmacology20100201

Title: Correlation of 14C-griseofulvin metabolism in rat liver microsomes, isolated perfused rat livers, and in rats with bile duct cannulas.

Journal: Drug metabolism and disposition: the biological fate of chemicals19750101

Title: Shoblock JR, et al. In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4--(diethylamino)-2-oxo-1-phenylethylpiperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptor. Psychopharmacology (Berl). 2010 Feb;208(2):265-77.

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