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1047645-82-8,MFCD28167824
Catalog No.:AA008TAJ

1047645-82-8 | GSK2110183B

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$14.00   $10.00
- +
2mg
98+%
in stock  
$22.00   $15.00
- +
5mg
98+%
in stock  
$35.00   $25.00
- +
10mg
98+%
in stock  
$51.00   $36.00
- +
50mg
98+%
in stock  
$143.00   $100.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA008TAJ
Chemical Name:
GSK2110183B
CAS Number:
1047645-82-8
Molecular Formula:
C18H18Cl3FN4OS
Molecular Weight:
463.7841
MDL Number:
MFCD28167824
SMILES:
NC[C@@H](NC(=O)c1sc(c(c1)c1c(Cl)cnn1C)Cl)Cc1cccc(c1)F.Cl
Properties
Computed Properties
 
Complexity:
520  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  

Upstream Synthesis Route

[1]Patent:US2010/197754,2010,A1,.Locationinpatent:Page/Pagecolumn8-9

[2]Patent:WO2008/98104,2008,A1,.Locationinpatent:Page/Pagecolumn191-192

Downstream Synthesis Route

[1]Patent:US2010/197754,2010,A1.Locationinpatent:Page/Pagecolumn8-9

[2]Patent:WO2008/98104,2008,A1.Locationinpatent:Page/Pagecolumn191-192

[1]Patent:WO2008/98104,2008,A1.Locationinpatent:Page/Pagecolumn192

[1]Patent:WO2008/98104,2008,A1

[2]Patent:WO2008/98104,2008,A1

[1]Patent:WO2008/98104,2008,A1

[2]Patent:WO2008/98104,2008,A1

[1]Patent:WO2008/98104,2008,A1

Literature

Title: On the possible role of organic melanoidin polymers as matrices for prebiotic activity.

Journal: Journal of molecular evolution 19751229

Title: Yamaji M, et al. Novel ATP-competitive Akt inhibitor Afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017 Nov;6(11):2646-2659.

Title: Dumble M, et al. Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor. PLoS One. 2014 Jun 30;9(6):e100880

Quotation Request
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Additional Info:
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SDS
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Tags:1047645-82-8 Molecular Formula|1047645-82-8 MDL|1047645-82-8 SMILES|1047645-82-8 GSK2110183B
Catalog No.: AA008TAJ
1047645-82-8,MFCD28167824
1047645-82-8 | GSK2110183B
Pack Size： 1mg
Purity： 98+%
in stock
$14.00 $10.00
Pack Size： 2mg
Purity： 98+%
in stock
$22.00 $15.00
Pack Size： 5mg
Purity： 98+%
in stock
$35.00 $25.00
Pack Size： 10mg
Purity： 98+%
in stock
$51.00 $36.00
Pack Size： 50mg
Purity： 98+%
in stock
$143.00 $100.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA008TAJ
Chemical Name: GSK2110183B
CAS Number: 1047645-82-8
Molecular Formula: C18H18Cl3FN4OS
Molecular Weight: 463.7841
MDL Number: MFCD28167824
SMILES: NC[C@@H](NC(=O)c1sc(c(c1)c1c(Cl)cnn1C)Cl)Cc1cccc(c1)F.Cl
Properties
Complexity: 520  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 1  
Heavy Atom Count: 28  
Hydrogen Bond Acceptor Count: 5  
Hydrogen Bond Donor Count: 3  
Rotatable Bond Count: 6  
Upstream Synthesis Route
1047644-62-1    1047645-82-8 

[1]Patent:US2010/197754,2010,A1,.Locationinpatent:Page/Pagecolumn8-9

[2]Patent:WO2008/98104,2008,A1,.Locationinpatent:Page/Pagecolumn191-192

Downstream Synthesis Route
1047644-62-1    1047645-82-8 

[1]Patent:US2010/197754,2010,A1.Locationinpatent:Page/Pagecolumn8-9

[2]Patent:WO2008/98104,2008,A1.Locationinpatent:Page/Pagecolumn191-192

1047645-82-8    1047645-84-0 

[1]Patent:WO2008/98104,2008,A1.Locationinpatent:Page/Pagecolumn192

24065-33-6    1047645-82-8 

[1]Patent:WO2008/98104,2008,A1

[2]Patent:WO2008/98104,2008,A1

35475-03-7    1047645-82-8 

[1]Patent:WO2008/98104,2008,A1

[2]Patent:WO2008/98104,2008,A1

1047630-72-7    1047645-82-8 

[1]Patent:WO2008/98104,2008,A1

Literature fold

Title: On the possible role of organic melanoidin polymers as matrices for prebiotic activity.

Journal: Journal of molecular evolution19751229

Title: Yamaji M, et al. Novel ATP-competitive Akt inhibitor Afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017 Nov;6(11):2646-2659.

Title: Dumble M, et al. Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor. PLoS One. 2014 Jun 30;9(6):e100880

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