Home Other Building Blocks 1166827-44-6
1166827-44-6,MFCD23098776
Catalog No.:AA008TB0

1166827-44-6 | AZD-7687

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5mg
≥99%
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$445.00   $312.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008TB0
Chemical Name:
AZD-7687
CAS Number:
1166827-44-6
Molecular Formula:
C21H25N3O3
Molecular Weight:
367.4415
MDL Number:
MFCD23098776
SMILES:
OC(=O)CC1CCC(CC1)c1ccc(cc1)c1nc(C(=O)N)c(nc1C)C
Properties
Computed Properties
 
Complexity:
525  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
3.2  

Downstream Synthesis Route

[1]Patent:WO2009/81195,2009,A1.Locationinpatent:Page/Pagecolumn57

[1]Patent:WO2009/81195,2009,A1.Locationinpatent:Page/Pagecolumn58-59

[1]Patent:WO2009/81195,2009,A1.Locationinpatent:Page/Pagecolumn168-169

[1]Patent:WO2009/81195,2009,A1.Locationinpatent:Page/Pagecolumn51

[1]Patent:WO2009/81195,2009,A1

Literature

Title: Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687).

Journal: Journal of medicinal chemistry 20121213

Title: Barlind JG, et al. Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687). J Med Chem. 2012 Dec 13;55(23):10610-29.

Title: Denison H, et al. Diacylglycerol acyltransferase 1 inhibition with AZD7687 alters lipid handling and hormone secretion in the gut with intolerable side effects: a randomized clinical trial. Diabetes Obes Metab. 2013 Oct 4.

Title: Eike Floettmann, et al. Pharmacological inhibition of DGAT1 induces sebaceous gland atrophy in mouse and dog skin while overt alopecia is restricted to the mouse. Toxicol Pathol. 2015 Apr;43(3):376-83.

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