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1032754-81-6,MFCD20527726
Catalog No.:AA008TDQ

1032754-81-6 | Gne-477

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$226.00   $158.00
- +
10mg
≥98%
in stock  
$428.00   $299.00
- +
25mg
≥98%
in stock  
$953.00   $667.00
- +
50mg
≥98%
in stock  
$1,455.00   $1,018.00
- +
  • Technical Information
  • Properties
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008TDQ
Chemical Name:
Gne-477
CAS Number:
1032754-81-6
Molecular Formula:
C21H28N8O3S2
Molecular Weight:
504.6288
MDL Number:
MFCD20527726
SMILES:
Nc1ncc(cn1)c1nc(N2CCOCC2)c2c(n1)c(C)c(s2)CN1CCN(CC1)S(=O)(=O)C
Properties
Computed Properties
 
Complexity:
779  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
0.3  

Literature

Title: GATA3 inhibits lysyl oxidase-mediated metastases of human basal triple-negative breast cancer cells.

Journal: Oncogene 20120419

Title: Rational design of phosphoinositide 3-kinase α inhibitors that exhibit selectivity over the phosphoinositide 3-kinase β isoform.

Journal: Journal of medicinal chemistry 20111124

Title: Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the treatment of cancer.

Journal: Journal of medicinal chemistry 20111110

Title: Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor.

Journal: Bioorganic & medicinal chemistry letters 20100415

Title: Heffron TP, et al. Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2408-11.

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SDS
Tags:1032754-81-6 Molecular Formula|1032754-81-6 MDL|1032754-81-6 SMILES|1032754-81-6 Gne-477