Home Other Building Blocks 1032754-93-0
1032754-93-0,MFCD20274520
Catalog No.:AA0035WP

1032754-93-0 | Apitolisib

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$42.00   $29.00
- +
5mg
98+%
in stock  
$106.00   $75.00
- +
10mg
95%
in stock  
$189.00   $133.00
- +
25mg
95%
in stock  
$264.00   $185.00
- +
50mg
98+%
in stock  
$284.00   $199.00
- +
100mg
95%
in stock  
$548.00   $384.00
- +
250mg
95%
in stock  
$874.00   $612.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0035WP
Chemical Name:
Apitolisib
CAS Number:
1032754-93-0
Molecular Formula:
C23H30N8O3S
Molecular Weight:
498.6011
MDL Number:
MFCD20274520
SMILES:
O=C(N1CCN(CC1)Cc1sc2c(c1C)nc(nc2N1CCOCC1)c1cnc(nc1)N)[C@@H](O)C
Properties
Properties
 
BP:
718.6±70.0°C at 760 mmHg  
Form:
Solid  
MP:
>202°C (dec.)  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
715  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
0.2  

Literature

Title: Compound Selectivity and Target Residence Time of Kinase Inhibitors Studied with Surface Plasmon Resonance.

Journal: Journal of molecular biology 20170217

Title: Phosphoinositide 3-kinase (PI3K) pathway alterations are associated with histologic subtypes and are predictive of sensitivity to PI3K inhibitors in lung cancer preclinical models.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20121215

Title: Preclinical assessment of the absorption and disposition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor GDC-0980 and prediction of its pharmacokinetics and efficacy in human.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120901

Title: Modulation of Akt/mTOR signaling overcomes sunitinib resistance in renal and prostate cancer cells.

Journal: Molecular cancer therapeutics 20120701

Title: GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway.

Journal: Molecular cancer therapeutics 20111201

Title: Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the treatment of cancer.

Journal: Journal of medicinal chemistry 20111110

Title: The emerging mechanisms of isoform-specific PI3K signalling.

Journal: Nature reviews. Molecular cell biology 20100501

Title: mTOR signaling at a glance.

Journal: Journal of cell science 20091015

Title: Defining the role of mTOR in cancer.

Journal: Cancer cell 20070701

Title: The phosphoinositide 3-kinase pathway.

Journal: Science (New York, N.Y.) 20020531

Title: Screening hospital admissions from the emergency department for occult carbon monoxide poisoning.

Journal: The American journal of emergency medicine 19900701

Title: Sutherlin DP, et al. Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the treatment of cancer. J Med Chem, 2011, 54(21), 7579-7587.

Title: Wallin JJ, et al. GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway. Mol Cancer Ther, 2011, 10(12), 2426-2436.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 1032754-93-0
Tags:1032754-93-0 Molecular Formula|1032754-93-0 MDL|1032754-93-0 SMILES|1032754-93-0 Apitolisib